8/8/2019 CHINESE GENERAL HOSPITAL COLLEGE OF NURSING AND LIBERAL
ARTS
1/2
CHINESE GENERAL HOSPITAL COLLEGE OF NURSING AND LIBERAL ARTS
JOURNAL SUMMARY and NURSING IMPLICATION
Cancer is one of the leading causes of death worldwide. And
because of this,
biomarkers have been advanced nowadays, even innovations take
place in diagnosing
precancerous tumors and severity of the case. The usual tumor
markers like Carcinoembryonic
antigen, a-fetoprotein, prostate-specific antigen are low
sensitive. Same as through with Mass
Spectrometry (MS), Liquid Chromatography (LC) ---has also
limitations and maybe high risk for
low identification for possible tumor or precancerous tissues.
And with the advancement,
discovery of innovative set of Proteomic technologies appeared
---
2D difference Gel Electrophoresis, this kind of study is having
a cyanine solution
(flurophores) for which it serve as the protein markers and
mixing it with a specific protein
sample together and placing it on a single gel and this
indicates the initiation of fluoroscanning.
And one of its advantages are accessibility of usage and very
high sensitivity to protein marking
process.
Next one is the MALDI Imaging Mass Spectrometry,is a kind of
advanced proteomic
technology where the actual tissue is put on a matrix for some
tests on the imaging mass
spectrometry, it is also convenient for dual tests like having a
protein impression and a
histopathology impressions at the same time. Aside from mass
spectra, many analyses can be
made like background noise subtraction, spectral normalization
and spectral alignment.
The third one is the Electron Transfer Dissociation MS, it is an
analysis of peptides
through the use of mass spectrometry, with the identification of
loss of phosphoric acid and N-
linked glycans which Phosphorylation and glycosylation indicates
the development of cancer
cells/ precancerous tissues.
And the last one is the Reverse-Phase Protein Assay, which have
the principle of
spotting of the patient samples--- proteins and tissues in an
assay with a nitrocellulose support.
It traces pathways in due presence of developing cancers, it
also validate cellular pathways in
mathematical models and identification of Cancer antigens that
are capable of identifying an
antibody response in patients with cancer.
NURSING IMPLICATION:
Advancements and latest technologies are booming rapidly.
Healthcare has its own
innovations that would make care to the patients and diagnosis
convenient and accurate wise.
Nurses should be updated with these technologies and that we are
dealing today.
Reading latest journals regularly, doing researches, and
attending health related seminars
would make selves informed and on to date.
