CHILEAN SOCIETY FOR CELL BIOLOGY XXVII … SOCIETY FOR CELL BIOLOGY XXVII ANNUAL MEETING October, 23 – 27th, 2013 Puerto Varas SPONSORS INSTITUTO MILENIO Y ANILLO CENTRO INTERDISCIPLINARIO

CHILEAN SOCIETY FOR CELL BIOLOGY

XXVII ANNUAL MEETING

October, 23 – 27th

, 2013

Puerto Varas

SPONSORS

INSTITUTO MILENIO Y ANILLO

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

CENTRO DE ENVEJECIMIENTO Y REGULACION CELULAR

CENTRO FONDAP DE REGULACION DEL GENOMA

FUNDACION CHILENA PARA BIOLOGIA CELULAR

FUNDACION CIENCIA & VIDA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

UNIVERSIDAD AUSTRAL DE CHILE

EXHIBITORS

ALATHEIA MEDICA SA – ANDES IMPORT LTDA – ARQUIMED SA

BD BIOSCIENCES – BIOCANT – BIOSCHILE IG SA – BIOSONDA

CINDER SERVICES – CIENTEC SA – FERMELO SA

GALENICA SA – GENEXPRESS – LABTEC

LIFE TECHNOLOGIES CHILE – LONCOTEC SA – TCL LTDA

TECNIGEN SA – STEMCEL – SUDELAB SA

Chilean Society for Cell Biology – XXVII Annual Meeting – October 23-27, 2013 1

CHILEAN SOCIETY FOR CELL BIOLOGY

XXVII ANNUAL MEETING

OCTOBER, 23-27, 2013

PUERTO VARAS

P R O G R A M


WEDNESDAY, OCTOBER 23, 2013

09:00 – 13:30 Registration

Convention Center Foyer

11:30 – 12:30 Technical Lecture - Calbuco Room

Bio-Rad and Galenica SA Evolución en la Cuantificación Absoluta de Genes: PCR Digital en Gotas.

Fabiana Godoy, Bio-Rad

Technical Lecture - Tronador Room

BioTek Instruments and BiosChile IGSA

Advances in Cell-based Assays for Drug Discovery Peter Banks, PhD, Scientific Director at BioTek Instruments, Inc. USA

12:30 – 13:30 Technical Lecture - Calbuco Room

Tecniplast and Arquimed

Modelos Animales en las Investigaciones Biomédicas, Influencia del Manejo y los Factores

Ambientales.

Juan Martín-Caballero, PhD, Director of Laboratory Animal Units, Parc de Recerca

Biomedica de Barcelona-PRBB, Spain.

13:30 – 15:30 Lunch

15:30 – 16:30 Inauguration

Volcanes Room

Chair: Mauricio Gonzalez C.

Plenary Lecture “Luis Izquierdo Fernandez”

Chilean Society for Cell Biology

Chair: Christian Gonzalez-Billaut

Iron and ROS on the Execution Step of Neurodegenerative Diseases. Marco Tulio Núñez. Biology Department, Faculty of Sciences, Universidad de Chile and Research Ring on Oxidative

Stress in the Nervous System.

16:30 – 17:30 Coffee Break – Exhibitors


17:30 – 19:30 Oral Presentations I

Volcanes Room

Chairs: Mauricio Gonzalez and Maite Castro

17:30 Epigenetic silencing of gene expression in neuronal cells: consequences of the forced

expression of Runx2. 1,2

Rodrigo Aguilar, 2Fernando J. Bustos,

2Brigitte van Zundert,

1,2Martin

Montecino. 1FONDAP Center for Genome Regulation and

2Center for Biomedical Research,

Universidad Andres Bello, Santiago, Chile. [email protected]

17:45 Wnt3a ligand prevents mitochondrial permeability transition pore opening induced by Aβ

oligomers. Macarena S. Arrázola and Nibaldo C. Inestrosa. Centro de Envejecimiento y

Regeneración (CARE). Departamento de Biología Celular y Molecular. Facultad de Ciencias

Biológicas. Pontificia Universidad Católica de Chile, Santiago, Chile. [email protected]


18:00 Formation of the posterior commissure: a multi-step journey of commissural axons. Stanic

K., Gonzalez M., Vera A., Montecinos H., Caprile T. Axon Guidance Laboratory, Department

of Cell Biology, University of Concepción, Chile. [email protected]

18:15 A failure in energy metabolism and antioxidant uptake precede the onset of Huntington's

disease. 1,2,

Aníbal I. Acuña, 1,2

Magdalena Esparza, 1,2

Carlos Kramm, 1,2

Felipe A. Beltrán, 1,2

Alejandra Parra, 3Carlos Cepeda,

4Carlos Toro,

5Rene Vidal,

5Claudio Hetz,

1Ilona I. Concha,

2,4Sebastián Brauchi,

3Michael S. Levine and

1,2Maite A. Castro.

1Instituto de Bioquímica y

Microbiología, Facultad de Ciencias, Universidad Austral de Chile; 2Centro de Investigación

Sur-Austral en Enfermedades del Sistema Nervioso (CISNe), Universidad Austral de Chile; 3Brain Research Institute, University of California Los Angeles;

4Instituto de Fisiología,

Facultad de Medicina; 5Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile.

[email protected]

18:30 tRNA modification and TOR kinase: a new feedback loop. Rojas-Benítez D, Ibar C and

Glavic A. Centro FONDAP de Regulación del Genoma. Facultad de Ciencias, Universidad de

Chile. [email protected]

18:45 Identification of an enzyme that crosslinks the 7S dodecamer, an structural domain of

collagen IV networks essential for tissue architecture. Carolina Añazco, Lorenzo Vega-

Montoto, Mohamed Rafi, Billy G. Hudson and Roberto Vanacore. Division of Nephrology and

Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville,

Tennessee, 37232, USA. [email protected] (Sponsor: M. Castro).

19:00 Characterization of Wnt/-catenin and BMP/Smad signaling pathways in an in

vitro model of amyotrophic lateral sclerosis. Cristina Pinto1, Pilar Cardenas

2, Nelson

Osses2 Juan Pablo Henríquez

1. Department of Cell Biology and CMA Bio-Bio,

Universidad de Concepción1, Institute of Chemistry, P. Universidad Católica de

Valparaiso. [email protected]

19:15 Functional contribution of the transcription factor ATF4 to the pathogenesis of

amyotrophic lateral sclerosis (ALS). Vicente Valenzuela1,2

, Melissa Nassif1,2

, Leslie

Bargsted1,2,3

, Yerko Fuentealba1,2

Claudio Hetz1,2,3

and Soledad Matus3. Biomedical

Neuroscience Institute1. Institute of Biomedical Sciences. University of Chile. Center for

Molecular Studies of the Cell. University of Chile2. Neurounion Biomedical Foundation,

Santiago, Chile3. [email protected]

20:00 Dinner

21:30 – 22:30 Plenary Lecture Universidad de Antofagasta

Volcanes Room

Chair: Pedro Zamorano

Mechanisms regulating the assembly and integrity of vertebrate synapse. Craig Garner.

Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences,

USA. [email protected]


THURSDAY, OCTOBER 24, 2013

08:00 Poster Mounting Session I: N° 1 to N° 84


09:00 – 11:00 Oral Presentations II

Volcanes Room

Chairs: Alexis Kalergis and Alejandra Alvarez

09:00 Surface expression of Pneumovirus nucleoprotein impairs immunological synapse

assembly and function. Pablo F. Céspedes1, Karen Bohmwald

1, Rodrigo A. Díaz

1, Janyra A.

Espinoza1, Claudia A. Rivera

1, Susan M. Bueno

1, and Alexis M. Kalergis

1,2.

1Millennium

Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y

Microbiología, Facultad de Ciencias Biológicas, and 2Departamento de Reumatología, Facultad

de Medicina, Pontificia Universidad Católica de Chile. [email protected]

09:15 Caveolin-1 is required for LPS-induced dendritic cell maturation. César Oyarce1,3

, Marioly

Müller1, Nicolás Bustamante

1, Felipe Gálvez

1, Francisco Contreras

2, Rodrigo Pacheco

2, Andrew

F.G. Quest3 and Alvaro Lladser

1.

1Laboratory of Gene Immunotherapy, and

2Laboratory of

Neuroimmunology, Fundación Ciencia & Vida. 3Laboratory of Cellular Communication,

Universidad de Chile. [email protected]

09:30 The missing link: mechanisms of action for the effect of complement proteins on human

neural stem cells. Francisca Benavente1,2,6

, Katja Piltti1-4,6

, Paul Gershon5,6

, Brian Cummings1-

4,6, and Aileen Anderson

1-4,6.

1Anatomy & Neurobiology,

2Sue & Bill Gross Stem Cell Research

Center, 3Physical & Medical Rehabilitation,

4Institute for Memory Impairments & Neurological

Disorders, 5Molecular Biology and Biochemistry,

6University of California Irvine, Irvine, CA

92697. [email protected]; [email protected] (Sponsor. J.P. Henriquez)

09:45 The unfolded protein response regulates axonal regeneration after sciatic nerve injury.

Oñate M.1,2,3

, Hetz C.1,2,4

and Court F.A.3,4

. 1Biomedical Neuroscience Institute,

2Center for

Molecular Studies of the Cell, ICBM, Faculty of Medicine, University of Chile. 3Millennium

Nucleus in Regenerative Biology (MINREB), Catholic University of Chile. 4Neurounion

Biomedical Foundation. [email protected], [email protected]

10:00 Calcium waves in hippocampal neurons and their modulation by endoplasmic reticulum

organization. Alex Córdova1,2,3

, Omar Ramírez1,2,3

, Mauricio Cerda1,2,3

, Andrés Couve1,2

,

Cecilia Hidalgo1,2,4

, Steffen Härtel1,2,3

. 1Programs of Anatomy and Developmental Biology and

of Physiology and Biophysics, ICBM, 2

Biomedical Neuroscience Institute (BNI), 3SCIAN-Lab,

4CEMC, Faculty of Medicine, Universidad de Chile, Santiago, Chile. [email protected]

10:15 The landscape of RNAs bound to the L1 retrotransposon ORF1p protein in vivo. Jorge

Vera-Otarola, Ashfaq Mir, Gaël Cristofari. Institute for Research on Cancer and Aging, Nice

(IRCAN), INSERM U1081, CNRS UMR 7284, University of Nice-Sophia-Antipolis, Faculty of

Medicine, Nice, France. [email protected] (Sponsor: N. Tischler)

10:30 Aβ-production overridden by c-Abl inhibition in Alzheimer's transgenic mice and

hippocampal neurons. Lisbell Estrada1,2

, David Chamorro1, Rommy von Bernhardi

3, Nibaldo

Inestrosa2, and Alejandra Alvarez

1,2.

1Laboratorio de Señalización Celular,

2CARE-ChileUC,

Depto. de Biología Celular y Molecular, 3Laboratorio de Neurociencias, Escuela de Medicina,

Pontificia Universidad Católica de Chile.


10:45 Regulators of phosphatidic acid (PA) levels modulate the specification of sense organs cell

types in Drosophila. Patricio Olguín, Jose de la Fuente, Macarena Brito, Amanda Carrasco,

Sophie Balmer, Ursula Weber and Marek Mlodzik. Programa de Genética Humana, ICBM,

Universidad de Chile, Chile. Mount Sinai School of Medicine, New York, NY, USA.

[email protected]

10:30 – 13:00 Schools and Science: Students from South of Chile at the Chilean Society for Cell Biology

Business Center Room

11:00 – 13:00 Poster Viewing Session I: 1-84 Odd Numbers


Coordinators: Marcela Bravo – Claudio Cabello – Mario Galindo – Carlos Gonzalez

(1) Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy.

Daniela Arroyo*, Emilia Gaviglio*, Javier Peralta Ramos*, Claudio Bussi*, Constanza Garcia-

Keller†, Liliana Cancela†, Maria Rodriguez-Galan* and Pablo Iribarren*. *CIBICI-CONICET

and † IFEC-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba,

Córdoba, Argentina. [email protected]

(3) Regulation of Na+-K

+-ATPase β3-subunit by mineralocorticoids in kidney collecting

duct cells. Pablo Díaz, Cristián de Gregorio, Andrea Cutiño, Magdalena González and Luis

Michea. Millennium Institute on Immunology and Immunotherapy, CEMC, ICBM, Facultad de

Medicina, Universidad de Chile. [email protected]

(5) Preliminary analysis of the Golgi apparatus proteome in human breast cancer cells.

Diego A. Acuña1, Cecilia Arriagada

1, Breyan H. Ross

1, Viviana Cavieres

1, Patricia V. Burgos

1,

Pamela Ehrenfeld2, and Gonzalo A. Mardones

1,

1Instituto de Fisiología, and

2Instituto de

Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral Chile, Valdivia,


(7) Role of the ER stress sensor IRE1α in DNA damage responses. Estefanie Dufey1,2, Hery

Urra1,2

, Diego Rodriguez1,2

, Diego

Rojas-Rivera1,2

and Claudio Hetz1,2,3

. 1Biomedical

Neuroscience Institute, 2Center for Molecular Studies of the Cell, Faculty of medicine, and

3Neurounion Biomedical Foundation, Santiago, Chile. [email protected]

(9) Detection of prostate specific mRNAs in bloodstream for prostate cancer diagnosis.

Sánchez, C.1; Fulla, J.

2; Campos, D.

1; Fleck, D.

1; Valdevenito, R.

3; García, V

1.; Oyanedel, F

1,

Sotelo, D1.; Ramos, C.

1.

1Urology Department, Clínica Las Condes,

2Urology Service, Hospital

San Borja Arriarán, 3Urology Service, Hospital Clínico de la Universidad de Chile.

[email protected] (Sponsor: Ch. Gonzalez).

(11) Avocado oil extracts protect C2C12 myoblasts against acute oxidative stress-induced

apoptosis. Marco Araya1, Arnaldo Gatica

2, and Hugo Olguín

1.

1Depto. Biología Celular y

Molecular, Fac. Ciencias Biológicas, P. Universidad Católica de Chile. 2INTA, Universidad de


(13) Pyronic, a fret nanosensor for the study of mitochondrial function in intact cells.

1Sebastián Ceballo,

1,2Alejandro San Martín,

1Baeza-Lehnert, F., and

1L. Felipe Barros.

1Centro

de Estudios Científicos (CECs), Valdivia, 2Universidad Austral de Chile, Valdivia.

[email protected]

mailto:[email protected]



(15) CCR7 expression and its effect on migration of Tumor Antigen Presenting Cells

(TAPCells). Ignacio Avalos, Fermin González, Israel Guerrero, Alejandra Gleisner, Flavio

Salazar-Onfray. Antitumoral Immunology Laboratory, Faculty of Medicine, University of Chile.

[email protected]

(17) Harmful CNS inflammation due to respiratory syncytial virus infection. Karen

Bohmwald1

, Janyra A. Espinoza1, Susan M. Bueno

1, Claudia A. Riedel

2 and Alexis M.

Kalergis1,3

. 1Millennium Institute on Immunology and Immunotherapy, Departamento de

Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad

Católica de Chile. 2Millenium Institute on Immunology and Immunotherapy, Departamento de

Ciencias Biológicas, Facultad de Ciencias Biológicas y Facultad de Medicina Universidad

Andrés Bello. 3Departamento de Reumatología, Facultad de Medicina, Pontificia Universidad

Católica de Chile. [email protected]

(19) Characterization of T cell receptor Vβ usage in response to the respiratory syncytial

virus. Hernán G. Correa1, Bruno A. Ramirez

1, Roberto S. Gomez

1,Jorge E. Mora

1and Alexis

M. Kalergis1,2

. 1

Millennium Institute on Immunology and Immunotherapy, Departamento de

Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, 2Departamento de

Reumatología, Facultad de Medicina, Pontificia Universidad Católica de Chile.

[email protected]

(21) Design of multi-epitope protein vaccine against B. abortus. Emilia Escalona, Darwin

Sáez, Ángel Oñate. Laboratorio de Inmunología Molecular, Universidad de Concepción.

[email protected]

(23) Impaired learning resulting from RSV infection. Janyra A. Espinoza1, Karen

Bohmwald1,Claudia M. Cortes

2, Pablo F. Céspedes

1,Roberto S. Gomez

1, Susan M. Bueno

1,

Claudia A. Riedel2 and Alexis M. Kalergis

1,3. 1

Millennium Institute on Immunology and

Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias

Biológicas, Pontificia Universidad Católica de Chile. 2Millennium Institute on Immunology and

Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas y

Facultad de Medicina Universidad Andrés Bello.3Departamento de Reumatología, Facultad de

Medicina, Pontificia Universidad Católica de Chile. [email protected]

(25) The tumor microenvironment favors the acquisition of a regulatory phenotype by

Th17 cells. D. Fernández1, J.J. Sáez1, F. Flores1, M.R. Bono1, M. Rosemblatt1,2, D. Sauma1,2.

1Departamento de Biología, Facultad de Ciencias, Universidad de Chile.

2Fundación Ciencia &

Vida. [email protected]

(27) Inactivation of infectious salmon anemia virus (ISAV) for vaccine development. Rivas-

Aravena, A1; Fuentes, Y

1; Castillo, T

1; Imarai, M

2, Spencer, E

1.

1Laboratorio de Virología,

2

Laboratorio de Inmunología, Centro de Investigación Acuícola, Universidad de Santiago de

Chile.

(29) In vivo analysis of synaptic toxicity mechanisms of amyloid-beta peptide and alpha-

synuclein aggregates in Caenorhabditis elegans models of Alzheimer and Parkinson disease.

Alicia N Minniti1, Rebeca Aldunate

1,2.

1P. Universidad Católica de Chile,

2Universidad Santo

Tomas, Santiago, Chile

(31) Characterization of the aggregation of the poly-glutamine domains of the presynaptic

proteins Piccolo and Bassoon through canonical yeast assay. Lucía Barra, Pedro Zamorano.

Faculty of Health Sciences, University of Antofagasta, Chile. [email protected]




(33) African-Mandenka APP mutant protects from neurodegeneration in Alzheimer´s

disease model. Bignante EA, Heredia F, Zamponi E, Pinotti JD, Helguera P, Lorenzo A.

Instituto de Investigación Médica “Mercedes y Martín Ferreyra” (INIMEC-CONICET-UNC).

Friuli 2434 – 5000 Córdoba-Argentina.

(35) Iron chelators induce Dopaminergic neuroregeneration in models of Parkinson

Disease. C. Carrasco1, N.P. Mena

1, P. Aguirre

1, P. Urrutia

1, V. Tapia

1, C. Gonzalez-Billault

1,2

and M.T. Nunez1,2

. 1Biology, Facultad de Ciencias, Universidad de Chile,

2Research Ring on

Oxidative Stress in the Nervous System, Santiago, Chile. [email protected]

(37) Effect of ERp57 overexpression on the pharmacological model of Parkinson´s disease

in vivo. Castillo V.1,2

, Valdez P.1,2

, Woehlbier U.1,2

, Mercado G.1,2

, Vidal R.3 and Hetz C.

1,2,3,4.

1Biomedical Neuroscience Institute. University of Chile.

2Center for Molecular Studies of the

Cell. University of Chile. 3Neurounion Biomedical Foundation, Santiago, Chile,

4Department of

Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA.

[email protected]

(39) Interactions between Schwann cells and peripheral axons during nerve regeneration.

Ceci ML, Mardones-Kurslovic C and Allende ML. FONDAP Center for Genome Regulation,

Facultad de Ciencias, Universidad de Chile, Santiago, Chile. [email protected]

(41) Time-dependent control of ROCK2 and SYNGAP1 by Wnt5a in hippocampal

neurons. Juan F. Codocedo and Nibaldo C. Inestrosa. Centro de Envejecimiento y

Regeneración (CARE). Departamento de Biología Celular y Molecular. Facultad de Ciencias

Biológicas. P. Universidad Católica de Chile, Santiago, Chile. [email protected]

(43) Astrocytes expressing ALS-causing mutants in SOD1 and TDP43 trigger motoneuron

death through a common pathogenic pathway involving activation of c-Abl and Nav

channels. Fabiola Rojas1, David Gonzalez

1, Sebastián Abarzua

1, Nicole Cortes

1, Elsa Fritz

1,

Brigitte van Zundert1.

1Universidad Andrés Bello. [email protected]

(45) Axonal protein trafficking in a Drosophila model of hereditary spastic paraplegia. Cristian De Gregorio, Jimena Sierralta, Andrés Couve. Program of Physiology and Biophysics,

ICBM and Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile.

[email protected].

(47) NMDAR in hippocampus: altered expression in knock-in mice for neuronal surface p

antigen. S Espinoza, F Segovia-Miranda, M Bravo-Zehnder, L Massardo, A González.

Departamento de Inmunología Clínica y Reumatología, Facultad Medicina. Centro de

Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular,

Facultad Ciencias Biológicas. P. Universidad Católica de Chile. [email protected]

(49) Characterization of spinal cord regeneration in zebrafish larvae. Consuelo Anguita,

Miguel L. Allende. FONDAP Center for Genome Regulation, Facultad de Ciencias, Universidad

de Chile. [email protected]; [email protected]

(51) Dynamic subcellular localization of Nedd4 may be required for the regulation of

myogenic progenitor cell fate. Eduardo de la Vega, Francisco Bustos and Hugo Olguín.

Molecular and Cell Biology Department, Faculty of Biological Sciences, P. Universidad

Católica de Chile, Santiago, Chile. [email protected]






(53) Determination of dopaminergic pathways over mushroom bodies involved in odor

discrimination in Drosophila melanogaster. Fuenzalida-Uribe N. and Campusano J.M. Lab of

Neurogenetic of Behavior, Dept of Cellular and Molecular Biology, Faculty of Biological

Science, Catholic University of Chile. [email protected]

(55) Effect of spinal cord transplantation in the regenerative capabilities of Xenopus laevis.

Emilio Méndez-Olivos, Rosana Muñoz, Mauricio Moreno, Gabriela Edwards, Juan Larraín.

Center for Aging and Regeneration, Pontificia Universidad Católica de Chile. [email protected]

(57) Ric-8A is required for neural crest cells induction. Rodríguez, M., Toro-Tapia, G.,

Olate, J., Torrejón, M. Laboratorio Genética Molecular Dpto. Bioquímica y Biología Molecular,

Universidad de Concepción. [email protected]

(59) Synthesis of nitric oxide in bipolar cells of dark adapted rat retina. Agurto A1, Vielma

AH1, Devia V

1,2 and Schmachtenberg O

1. 1

Centro Interdisciplinario de Neurociencia de

Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Chile. 2Laboratorio de

Microscopía Avanzada de Fluorescencia (LAMAF). [email protected]

(61) C/EBPbeta-LAP*-dependent SWI/SNF recruitment in osteoblasts. Cádiz M.I., Meza

D., Aguilar R., Sepúlveda H., Montecino M. FONDAP Center for Genome Regulation and

Center for Biomedical Research, Andres Bello University, Santiago, Chile.

(63) Post-transductional cleavage of C-terminal tail of BMP receptor type II in motor

neuron-like cells. Pilar Cárdenas1, Cristina Pinto

2, Juan Pablo Henríquez

2 and Nelson Osses

1.

1Institute of Chemistry, P. Catholic University of Valparaiso and

2Department of Cell Biology

and CMA Bio-Bio, University of Concepción, Chile. [email protected]

(65) The expression of RECK, a novel modulator of extracellular matrix integrity, is

regulated by TGF-β: possible clues for proper tissue remodeling. Osvaldo Contreras1,

Chiaki Takahashi2, Enrique Brandan

1 and Jaime Gutierrez

1.

1Pontificia Universidad Católica de

Chile. 2Cancer Research Institute, Kanazawa University, Japan. [email protected];

[email protected]

(67) Isolation, characterization, and gene expression of corticosteroid receptors in skeletal

muscle of fine flounder (Paralichthys adspersus). Escobar Daniela P., Eduardo N. Fuentes,

Diego Safián, Juan Antonio Valdés, Alfredo Molina. Laboratorio de Biotecnología Molecular,

Facultad de Ciencias Biologicas, Universidad Andrés Bello, Santiago, Chile.

[email protected]

(69) Angiotensin 1-7 decrease skeletal muscle atrophy induced by lipopolysaccharide.

Morales, MG, Simon, F. and Cabello-Verrugio, C. Laboratorio de Biología y Fisiopatología

Molecular, Facultad de Ciencias Biológicas, Universidad Andres Bello. [email protected]

(71) The RUNX2 transcription factor promotes angiogenesis in osteosarcoma via

increasing expression of pro-angiogenic genes. Andrés Stevenson1,2

, Sofia Jerez1,2

, Paola

Casanello3, Gary Stein

4, Andre van Wijnen

5, Mario Galindo

1,2.

1Millennium Institute on

Immunology and Immunotherapy, 2Programa de Biología Celular y Molecular, ICBM, Facultad

de Medicina, Universidad de Chile. 3Instituto de Investigaciones Medicas, Facultad de Medicina,

Pontificia Universidad Católica de Chile, Santiago, Chile. 4Department of Biochemistry,

Vermont Cancer Center for Basic and Translational Research, University of Vermont. 5Departments of Orthopedic Surgery & Biochemistry and Molecular Biology, Mayo Clinic.

[email protected]






(73) Putative mesenchymal stem cells derived from carcinoma-associated stroma of

invasive prostate cancer. Cerda-Infante Javier1, Zumarán Consuelo

1, Conejeros Paola

1,

Coronado Romina1, Alejandro Godoy

2 & Viviana Montecinos

1.

1Hematology-Oncology &

2Physiology Departments, P. Universidad Católica de Chile. [email protected]

(Sponsor: M.A. García).

(75) The presence of Coagulation FXa increases tumour volume and metastasis. Ibeth

Gonzalez1, Soledad Lange

1, Rodrigo Valenzuela

1, Kelly Cautivo

1, Alexis M. Kalergis

1,2,5,

Veronica Palma3, Miguel Allende

3, Fabian Tempio

4, Mercedes Lopez

4, Gareth I. Owen

1,5.

1Facultad de Ciencias Biológicas,

2Millennium Institute of Immunology and Immunotherapy

Pontificia Universidad Católica de Chile. 3FONDAP Center for Genome Regulation, Facultad de

Ciencias. 4Facultad de Medicina, Universidad de Chile.

5Biomedical Research Consortium Chile

(BMRC). [email protected]

(77) Reprimo, a p53 dependent G2 arrest mediator, is downregulated in advanced gastric

cancer. Saavedra K.1, 2

; Olivares W.1; Sandoval A.

1, 2; García B.

1; Cerda-Infante J.

1; Roa JC.

2, 3;

Corvalan A.1.

1Department of Hematology and Oncology and Centre for Translational Research

in Oncology , School of Medicine, P. Universidad Católica de Chile, Santiago, Chile; 2Department of Pathology, School of Medicine, Universidad de La Frontera , BIOREN-CEGIN,

Temuco, Chile; 3Pathological Anatomy Department, School of Medicine, P. Universidad


(79) Sub-cellular localization of BRCA1 and BARD1 in breast cancer tumors. 1David

Wiener, 1Cristóbal Herrera,

1Patricia Gajardo,

1Elías Blanco,

2Jorge Gamboa,

2Valeria Cornejo,

2Wanda Fernandez,

1Pilar Carvallo. Department of Cell and Molecular Biology, Faculty of

Biological Sciences, Pontificia Universidad Católica de Chile, Unidad de Anatomía Patológica,

Hospital San Borja Arriarán, Santiago, Chile. [email protected] (Sponsor: H. Olguín).

(81) PERK pathway characterization in labial salivary glands of Sjögren syndrome´s

patients. V. Bahamondes, S. Aguilera, S. Indo, S. González, C. Molina, C. Leyton, U. Urzúa

and MJ González. ICBM-Facultad de Medicina, Universidad de Chile.

[email protected]

(83) Vitamin E improves neurological symptoms of Niemann-Pick type C disease mice.

Tamara Marín1, Juan Castro

1, Elisa Balboa

1, Alejandra Alvarez R

2 and Silvana Zanlungo

1.

1Depto. de Gastroenterología, Facultad de Medicina. 2Depto. Biología Celular, Pontificia

Universidad Católica de Chile. [email protected]

13:00 – 14:00 Plenary Lecture Fundación Ciencia & Vida

Volcanes Room

Chair: Carolina Torrealba

Los Inicios de la Biología Experimental en Chile. Juan de Dios Vial Correa. Pontificia

Universidad Católica de Chile.

14:00 – 15:30 Lunch

15:30 – 17:30 Symposium “Novel Aspects of Lysosomes and Autophagy: From Autophagosome

Biogenesis to Regulation of Energy Metabolism, Protein Turnover, and Lysosome

Reformation”

Volcanes Room

Chairs: Gonzalo Mardones and Francisco Batiz






A coat that fits all sizes: molecular mechanism of autophagic scaffold assembly and

disassembly. Tomas Wollert, Max Planck Institute of Biochemistry, Germany.

Lysosomes as novel regulators of nutrient sensing and energy metabolism. Rosa

Puertollano, Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National

Institutes of Health, Bethesda, MD, USA.

Lysosomes sense early disturbances of the secretory pathway independent of

macroautophagy. Patricia Burgos, Laboratory of Cell and Molecular Biology, Department of

Physiology, School of Medicine, Universidad Austral de Chile, Chile.

Autophagic lysosome reformation. Li Yu, State Key Laboratory of Biomembrane and

Membrane Biotechnology, Tsinghua University, Beijing, China.



17:30 – 19:30 Poster Viewing Session I: 1-84 Even Numbers


Coordinators: Marcela Bravo – Claudio Cabello – Mario Galindo – Carlos Gonzalez

(2) Role of Panx1 hemichannels in the regulation of the secretory activity of

neuroendocrine chromaffin cells. Ximena Baéz1, María José Olivares

1, María José Guerra

1,

Juan C. Saez1,2

, Agustín D. Martínez1, Ana María Cárdenas

1, Fanny Momboisse

1. 1

Centro

Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaíso and 2Pontifícia


(4) Molecular and cellular changes of membrane transport machinery in response to a

secretory stimulus. García I.A.; Martinez H.; Sampieri L.; and Alvarez, C.I. Centro de

Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET). Facultad de

Ciencias Químicas. UNC. Córdoba-Argentina. [email protected]

(6) Intracellular trafficking of Sodium-dependent Vitamin C Transporter 2-SVCT2 is

modulated by increased extracellular ascorbic acid concentration. 1

Adriana Covarrubias, 1Eduardo Papic,

2Patricia Burgos and

1Maite A. Castro.

1Instituto de Bioquímica y

Microbiología, 2Instituto de Fisiología, UACh. [email protected]

(8) Local trafficking of voltage-gated sodium channels in peripheral axons. Carolina

González1,2

, María Javiera Fresno1,2

, José Cánovas1,2

, Eduardo Couve3, Felipe Court

4 and

Andrés Couve1,2

. 1Physiology and Biophysics, ICBM and

2Biomedical Neuroscience Institute

(BNI), Faculty of Medicine, Universidad de Chile. 3Faculty of Science, Universidad de

Valparaíso. 4Faculty of Biological Sciences, P. Universidad Católica de Chile.

[email protected]

(10) Involvement of ApoER2/Reelin in Schwan cell migration. Consuelo Pasten1 and María

Paz Marzolo2. Pontificia Universidad Católica de Chile.

[email protected],

[email protected]

(12) MLN64 induces mitochondrial dysfunction associated with increased cholesterol

transport into mitochondria. Elisa Balboa1, María-José Pinochet

1, Juan Castro

1, José

Fernandez-Checa2, Silvana Zanlungo

1.

1Depto. de Gastroenterología, Pontificia Universidad

Católica, Santiago, Chile. 2Centro de Investigaciones Biomédicas Esther Koplowitz, Hospital

Clínic i Provincial, Barcelona, España.




(14) Down-regulation of glucose transport and metabolism by high extracellular glucose

concentration. Alejandra Pérez, Marianne Brenet, Carla X. Bittner, Carolina Villanueva, L.

Felipe Barros and Carlos B. González. Instituto de Fisiología, Universidad Austral de Chile and

Centro de Estudios Científicos.

(16) Treatment based on apoptotic bodies induces maturation of C57BL6 mice derived

dendritic cells. Barrientos C1., Diaz X

1., Mena J

1., Lopez X

1., Imarai M

1., Montoya M

1.,

Acuña-Castillo C1. Centro de Biotecnología Acuicola y Facultad de Química y Biología,

Universidad de Santiago de Chile. [email protected]

(18) Study of interleukin-2 like factors in Salmo salar. Cifuentes, P., Halçartégaray, N.,

Wilhelm, V., Rosemblatt, M. Fundación Ciencia & Vida, Universidad Andrés Bello.

[email protected]

(20) Reactionary dentin formation accompanies neuro-immune interactions in response to

bacterial invasion of dentinal tubules. Couve E(1,2)

, Osorio R(1)

, and Schmachtenberg O(2)

.

Departamento de Biología, Laboratorio de Microscopía Electrónica(1)

; Centro Interdisciplinario

de Neurociencia de Valparaíso (CINV)(2)

; Facultad de Ciencias, Universidad de Valparaíso,

Valparaíso, Chile. [email protected]

(22) Development of a model of vaccine against breast cancer. Escrig D.1, Mena J.1, Morales

J.1, Barrientos C.

1, Rojas JL

2, Mir S.

3, López X.

1, Acuña-Castillo C.

1

1Centro de Biotecnología

Acuícola y Facultad de Química y Biología, USACH. 2Facultad de Ciencias Médicas,

Universidad de Santiago de Chile. 3Centro Asistencial Barros Luco. [email protected]

(24) IFN-α delivers new signals to immunotherapeutic dendritic cell based immunotherapy

in vitro. Falcón-Beas C1, Tempio F

1, Falcón-Beas F

1, Pérez C

1, Flores I

1, Gatica J

1 Pereda C

1,

Salazar-Onfray F1, López MN

1.

1Millennium Institute on Immunology and Immunotherapy.

[email protected]

(26) Stimulation of dopamine receptors D3 and D5 expressed on CD4+ T-cells regulates

cellular activation and differentiation by mechanisms involving modulation of ERKs-

activation and cAMP production. Dafne Franz1, Francisco Contreras1, Hugo González1,

Daniela Elgueta1, Carolina Prado

1, Claudio Figueroa

1,2, and Rodrigo Pacheco

1,2.

1Fundación

Ciencia & Vida and 2Universidad San Sebastián. Santiago, Chile. [email protected]

(28) Hypothyroxinemia during gestation affects the outcome of experimental autoimmune

disease (EAE) in the progeny. Henny Haensgen1, Eduardo Albornoz

1, Susan Bueno

2, Alexis

Kalergis2, Claudia Riedel

1. Universidad Andres Bello. [email protected]

(30) Role of the Wnt receptor Frizzled-1 in adult hippocampal neurogenesis. Gabriela A.

Andaur1, Jenny F. Henríquez

1,2, Manuel Varas-Godoy

3, Nibaldo C. Inestrosa

2 and Lorena

Varela-Nallar1.

1Centro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas y

Facultad de Medicina, Universidad Andrés Bello. 2Centro de Envejecimiento y Regeneración

(CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, P.

Universidad Católica de Chile. 3Fundación Ciencia y Vida. [email protected]

(32) Acute depletion of GSK-3 modulates lysosomal biogenesis leading to a reduction in

amyloid precursor protein (APP) levels. Rafael R. Barraza1,2,3

, Viviana Cavieres3, Patricia V.

Burgos3 and Nibaldo C. Inestrosa1,2. 1Centro de Envejecimiento y Regeneración (CARE), 2Departamento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile,

3Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile

[email protected]








(34) Anti-ribosomal P protein antibodies impair memory once permeating the blood brain

barrier. M. Bravo-Zehnder1,2,3

, F. Segovia-Miranda1,2,3

, F. Serrano3, E. Toledo

3, N.C.

Inestrosa2,3

, L. Massardo1, A. González

1,2,3.

1Departamento de Inmunología Clínica y

Reumatología, Facultad Medicina, Chile. 2Centro de Envejecimiento y Regeneración, Chile.

3Facultad Ciencias Biológicas. Pontificia Universidad Católica de Chile. [email protected]

(36) Role of canonical Wnt signaling in age-related neurodegeneration in the CNS of

Octodon degu. Francisco J. Carvajal, Juvenal A. Ríos, Cheril Tapia-Rojas, Rocío M.

Retamales, Juan A. Godoy and Nibaldo C. Inestrosa. Center for Aging and Regeneration

(CARE), Departament of Cell and Molecular Biology, Faculty of Biological Sciences, P.

Catholic University of Chile. [email protected]

(38) Endothelial nitric oxide synthase: synaptic localization and interaction with the

neurotrophin receptor TrkB. Ariel Caviedes, Veronica Martinez-Paillama, Francisco Nualart,

Ursula Wyneken. Universidad de Concepción y Universidad de los Andes.

(40) Identification of new c-Abl kinase inhibitors by HTS assays for potential treatment of

Alzheimer disease. David Chamorro1, Lila González

2, Becky King

3, Chris Dextras

3, Xin Hu

3,

Marc Ferrer3, Andres Dulcey

3, Juan Marugan

3, Silvana Zanlungo

2, Alejandra Alvarez R

1.

1Laboratorio de Señalización Celular,

Depto. de Biología Celular,

2Depto. de Gastroenterología,

Escuela de Medicina, Pontificia Universidad Católica de Chile. 3National Center for Advancing

Translational Sciences, National Institutes of Health. [email protected]

(42) IRE1/XBP-1 pathway controls APP metabolism and A aggregation in experimental

models of Alzheimer’s disease. Víctor Hugo Cornejo3, Claudia Duran

3, Alexis González

2,

Rafael Barraza2, Andrea Paula-Lima

3, Patricia Burgos

2 and Claudio Hetz

1,3. 1

Harvard School of

Public Health, Boston, USA. 2Universidad Austral, Valdivia.

3Biomedical Neuroscience

Institute, Faculty of Medicine, University of Chile, Santiago, Chile. [email protected]

(44) The fine structure and organization of the membranous axonal organelles. Lillo J.1,

Pihan P.2,3

, González C.3, Canovas J.A.

3, Couve A.

3 and Court F.A.

2,4.

1Advanced Microscopy

Unit and 2Millennium Nucleus in Regenerative Biology (MINREB), Catholic University of

Chile; 3Physiology and Biophysics and Biomedical Neuroscience Institute (BNI), ICBM,

Faculty of Medicine, Universidad de Chile; 4Neurounion Biomedical Foundation.

[email protected]

(46) Analysis of brain glucose sensing mechanism using adenoviral-mediated inhibition of

MCT1 and MCT4 in tanycytes. Elizondo-Vega R, Carril C, Martinez F, Cortés-Campos C,

Nualart F, García-Robles M. Departamento de Biología Celular, Universidad de Concepción.

[email protected]

(48) Decreased expression of RECK, a novel matrix metalloproteinase inhibitor, improves

the efficiency of muscle stem cell therapy. Jaime Gutiérrez and Enrique Brandan. Pontificia


(50) Netrin-4 acts as a dependence factor for Neogenin1 in the human neuroblastoma cell

line, SH-SY5Y. Arros A., Espinoza N., Vásquez G., Palma V. Laboratory of Stem Cells &

Development, Faculty of Sciences, Universidad de Chile, Chile. [email protected]

(52) Rising stars in skeletal cell biology: a detailed morphometrical analysis of native

osteocytes. Alan Fritz, Patricia Hanna, Ariana Bertin, Francisco Nualart, Sylvain Marcellini.

Laboratorio de Desarrollo y Evolución, Universidad de Concepción. [email protected]






(54) Golgins and mitosis: role of p115 in Drosophila. Ibar, C. and Glavic, A. FONDAP CRG,

Facultad de Ciencias, Universidad de Chile. [email protected]

(56) Increased resistance to copper toxicity achieved through previous exposure to the

metal in zebrafish. Margarita Parada, Miguel Allende. FONDAP Center for Genome

Regulation, Facultad de Ciencias, Universidad de Chile. [email protected],

[email protected]

(58) Transforming growth factor type beta 1 (TGF-β1) produces skeletal muscle atrophy

by a mechanism dependent of NADPH oxidase-induced reactive oxygen species. Ábrigo, J.,

Morales, MG., Simon, F., Cabello-Verrugio, C. Laboratorio de Biología y Fisiopatología

Molecular, Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago.

[email protected]

(60) Tumor suppression by Caveolin-1 is linked to inhibition of nitric oxide synthase and

HIF-1α-dependent transcription. Sanhueza C., Avalos Y., Silva P., Diaz M.I., Leyton L.,

Quest A.F.G. Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la

Célula, ICBM, Facultad de Medicina, Universidad de Chile. [email protected]

(62) Role of the Phosphatidylinositol 3-kinase (PI3K)-AKT pathway in Helicobacter pylori-

induced HIF-1 stabilization and transcriptional activation. Canales J1, Bravo D

2, Leyton,

L1, Toledo H

3, Quest AFG

1.

1Laboratorio de Comunicaciones Celulares, Centro de Estudios

Moleculares de la Célula (CEMC), 2Laboratorio de Microbiología Molecular, Programa de

Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina,

Universidad de Chile, 3Laboratorio de Microbiología Oral, Departamento de Patología y

Medicina Oral, Facultad de Odontologia, Universidad de Chile.

(64) RAP250 is required for normal adipogenesis and TGF-β/SMAD3 signaling pathway

transduction. Cataldo LR1,2,3

, Sánchez M1, Santos JL

2, Cortés V

2, Zorzano A

1. 1

Institute for

Research in Biomedicine, Barcelona, Spain. 2

Department of Nutrition, Diabetes and

Metabolism, P. Universidad Católica de Chile. 3PhD program in Biomedical Sciences,

Universidad de Los Andes, Chile. [email protected], [email protected]

((6666)) TThhee ddeeaatthh--ddeeppeennddeennccee rreecceeppttoorr NNeeooggeenniinn--11 iiss uupp--rreegguullaatteedd iinn HHeeddggeehhoogg--aassssoocciiaatteedd

ttuummoorrss aanndd mmeeddiiaatteess SSoonniicc hheeddggeehhoogg--ddrriivveenn pprreeccuurrssoorr pprroolliiffeerraattiioonn.. FFaallccóónn PP..,, CCaassaass BB..,,

GGaalllleeggooss II..,, CCaabbaannéé PP,, GGaacc PP..,, LLaass HHeerraass FF.. && PPaallmmaa VV.. CTYBD Laboratory, Universidad de

Chile. FONDAP Center for Genome Regulation. [email protected],

[email protected]

(68) Wnt/Ca2+

signaling pathway modulates mitochondrial dynamics in hippocampal

neurons. Silva-Alvarez C., Ordenes D, Godoy J, Arrázola M. and Inestrosa N.C. Center for

Aging and Regeneration (CARE), Department of Cell and Molecular Biology, Faculty of

Biological Sciences, P. Catholic University of Chile, Chile. [email protected]

(70) Ovarian cancer cells induce pro-tumoral phenotype in macrophages in vitro. Abarzua-

Catalan, L1., Kato, S

1., Delpiano, AM

1., Owen, GI

2., Cuello, MA

1.

1Division of Obstetrics and

Gynecology,Faculty of Medicine. 2 Faculty of Biological Sciences, Pontificia Universidad







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(72) Characterization of Cancer Stem Cells (CSC) in human osteosarcoma cell lines.

Carolina Farfan1,2

, Nelson Varela1,2

, Barbara Pesce1,3

, Juan Carlos Aguillón1,3

, Mario

Galindo1,2

. 1Millennium Institute on Immunology and Immunotherapy,

2Programa de Biología

Celular y Molecular, 3Programa de Inmunología, ICBM, Facultad de Medicina, Universidad de


(74) BRCA1 and BARD1 expression and localization in breast cell lines. Cristóbal

Herrera, Alonso Quiroz, David Wiener, Elías Blanco, Carolina Álvarez, Pilar Carvallo.

Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia

Universidad Católica de Chile. [email protected] (Sponsor: K. Gysling).

(76) Expression of fructose transporters in prostate cancer. Verónica Torres-Estay1, Sarah

McEvoy4, Jaime Lizama

1, Pablo Rojas

3, Viviana P. Montecinos

2, Ignacio San Francisco

3,

Alejandro S. Godoy1,4

. Departments of Physiology1, Hematology-Oncology

2, and Urology

3,

Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Urology4, Roswell

Park Cancer Institute, Buffalo, NY. [email protected] (Sponsor: R. Moreno).

(78) Visualization of Moloney murine leukemia virus infection. Ana C. Abbott and Gloria

Arriagada. Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad

Andrés Bello, Viña del Mar. [email protected]

(80) Role of DCs in Angiotensin II-induced hypertension, inflammation and tissue damage.

Daniel Hevia1,2

, Carolina Prado3, Eugenia Fuentes

1,2, Rodrigo Pacheco

3 y Luis Michea

1,2.

1Center for Molecular Studies of the Cell;

2Millennium Institute on Immunology and

Immunotherapy, ICBM, Facultad de Medicina, Universidad de Chile; 3Neuroimmunology Lab,

Fundación Ciencia y Vida.

(82) Myostatin-induced skeletal muscle atrophy is decreased by Angiotensin 1-7 in skeletal

muscle cells. Vázquez, Y., Morales, MG., Cabello-Verrugio, C. Laboratorio de Biología y

Fisiopatología Molecular, Facultad de Ciencias Biológicas, Universidad Andres Bello.

[email protected]

(84) Gestational hypothyroidism affects the Blood-Brain-Barrier permeability in the

offspring. Luis Venegas*1, Beatriz Alvarez*

1, Henny Haensgen

1, Susan Bueno

2, Alexis

Kalergis2, Claudia Riedel

1. Universidad Andrés Bello. [email protected]

19:30 – 20:30 Plenary Lecture Chilean Society for Cell Biology

Volcanes Room

Chair: Andrés Couve

The genetic control of apoptosis and cellular reprogramming in the nematode

Caenorhabditis elegans. H. Robert Horvitz. H.H.M.I., Dept. Biology, M.I.T., Cambridge, MA,

U.S.A.

20:30 Dinner

22:00 – 23:30 Best Theses Awards Fundacion Chilena para Biologia Celular

Volcanes Room

Chairs: Arturo Yudelevich and Mauricio Gonzalez








Undergraduate

Vicente Cataldo von Bohlen

Bioquímico

P. Universidad Católica de Valparaíso

“P-53 related protein kinase (PRPK) es necesaria para la formación de lamelipodios y la

correcta mantención de la forma celular en hemocitos de Drosophila” Thesis Advisor: Alvaro Glavic, Universidad de Chile

Graduate

Noelia Escobedo Marambio

PhD in Biological Sciences

P. Universidad Católica de Chile

“Expression and function of syndecan-4 during mouse development”

Thesis Advisor: Juan Larraín, P. Universidad Católica de Chile.


FRIDAY, OCTOBER 25, 2013

08:00 Poster Mounting Session II: N° 85 to N° 168


09:00 – 11:00 Oral Presentations III

Volcanes Room

Chairs: Francisca Bronfman and Juan Larraín

09:00 Targeted epigenetic silencing of PSD95 gene expression with artificial transcription

factors. Fernando J Bustos1,3,4

, Lorena Varela-Nallar3, Rodrigo Aguilar

3,4, Berta Henríquez

3,

Marianne Rots2, Martín Montecino

3,4, Brigitte van Zundert

3.

1University of Concepcion;

2UMCG, The Netherlands;

3Center for Biomedical Research, Andres Bello University;

4FONDAP C.G.R. [email protected]

09:15 Microtubule-associated protein 1B (MAP1B) role in synapse: Regulation of the structure

and functionality of presynaptic and postsynaptic terminals. Bodaleo Felipe1, Montenegro-

Venegas Carolina1, Court Felipe

2, Pérez Mónica

2, Hartel Steffen

3 and González-Billault

Christian1. (1)Laboratory of Cellular and Neuronal Dynamics, Department of Biology, Faculty

of Sciences, Universidad de Chile. (2) Laboratory of Neuroscience and Glial Biology,

Departament of Phisiology, Faculty of Biological Sciences, Pontificia Universidad Católica de

Chile. (3) Laboratory for Scientific Image Analysis, Faculty of Medicine, Universidad de Chile.

[email protected]

09:30 p75 neurotrophin receptor (p75) evades the endolysosomal route, favoring multivesicular

bodies (MVBs) specialized for exosomal release in neuronal cells. Escudero CA1,

Galleguillos C1, Parraguez JI

1, Lopez-Verrilli MA

1, Cabeza C

1, Saeed U

2, Marzolo MP

1, Carter

BD2, Court FA

1 and Bronfman FC

1.

1Millennium Nucleus in Regenerative Biology (MINREB),

Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. 2Department

of

Biochemistry and Vanderbilt Brain Institute. Vanderbilt University Medical School. Tennessee,


09:45 Nitric oxide activates ICAM-1 on the endothelium. Aguilar A1, Burboa P1, Sarmiento J3,

Ehrenfeld I2, Sánchez, FA

1.

1Immunology Institute,

2Histology and Pathology Institute,

3Physiology Institute, Medicine Faculty, UACh. [email protected]

10:00 EGFR-dependent tumoral growth is sensitive to phosphatidate phosphohydrolase

inhibition. Ronan Shaughnessy1,2

, Claudia Oyanadel1,2

, Andrés Norambuena1,2

, Claudio

Retamal1,2

, Claudia Metz1,2

, Andrea Soza1,2

and Alfonso González1,2

. Departamento de

Inmunología Clínica y Reumatología, Facultad Medicina1, Centro de Envejecimiento y

Regeneración (CARE), Facultad Ciencias Biológicas2, Pontificia Universidad Católica de Chile.

[email protected]

10:15 Inhibition of the reelin signaling pathway promotes dendritogenesis in mature

hippocampal neurons. Estibaliz Ampuero1, María Paz Marzolo

2 and Brigitte van Zundert

1.

1Universidad Andrés Bello;

2P. Universidad Católica de Chile. [email protected]

10:30 In vivo study of Sox2+ cells during spinal cord regeneration in Xenopus laevis. Gabriela

Edwards-Faret1,2

, Mauricio Moreno1,2

, Hollis Cline3, Juan Larraín

1,2.

1Center for Aging and

Regeneration, 2Millenium Nucleus in Regenerative Biology, P. Universidad Católica de Chile,

3The Scripps Research Institute, La Jolla-United States. [email protected]


10:45 E-cadherin mediated piggybacking drives tissue spreading during epiboly. Germán Reig1,2

,

Carolina Figueroa1,2

, Valeria Larenas1,2

, Steffen Härtel1,2

, and Miguel L. Concha1,2

. 1Laboratory

of Experimental Ontogeny and Laboratory for Scientific Image Analysis, ICBM, Faculty of

Medicine, University of Chile; 2Biomedical Neuroscience Institute, Santiago, Chile.

[email protected]



11:00 – 13:00 Poster Viewing Session II: 85-168 Odd Numbers


Coordinators: M. Julieta Gonzalez – Lisette Leyton – Claudia Metz – Rodrigo Pacheco

(85) Effect of PKC inhibitors on connexin-43 hemichannels. J.L. Vega1,2,3

, A. Vargas1, C.C.

Naus3, J.C. Sáez

1,4.

1Departamento de Fisiología, Pontificia Universidad Católica de Chile,

Santiago, Chile, 2Laboratorio de Fisiología Experimental (EPhyL), Universidad de Antofagasta,

Antofagasta, Chile, 3Department of Cellular and Physiological Sciences, Life Science Institute,

The University of British Columbia, Vancouver, BC, Canada, 4Centro Interdisciplinario de

Neurociencias de al araíso, al araíso, C ile uvega uc cl

(87) Biochemical and cellular characterization of the Golgi apparatus protein GOLPH3 in

human glioblastoma multiforme cells. Cecilia Arriagada, Breyan H. Ross, Viviana Cavieres,

Patricia V. Burgos, and Gonzalo A. Mardones, Instituto de Fisiología, Facultad de Medicina,

Universidad Austral Chile, Valdivia, Chile. [email protected]

(89) Characterization of the ER-to-Golgi intermediate compartment (ERGIC) in

hippocampal neurons. Juricic M.A.1,3

, Cerda M.2,3

, Cánovas J.A.1,3

, Kukuljan M.1,3

, Härtel

S.2,3

, Couve A.1,3

. 1Physiology and Biophysics,

2Anatomy and Developmental Biology,

3Biomedical Neuroscience Institute (BNI), ICBM, Faculty of Medicine, Universidad de Chile.

[email protected]

(91) Sorting behaviour of the different splice variants of ApoER2 and the role of the

adaptor complex AP4. Farfán P. 1, Benítez ML1, Larios J1, Cáceres 2 and Marzolo MP1 1Lab.

Tráfico Intracelular y Señalización, Depto. Biología Celular Molecular, Fac. Ciencias Biológicas

P. Universidad Católica de Chile, 2Instituto Investigación Médica Mercedes y Martin Ferreyra

Córdoba, Argentina. [email protected]

(93) Novel association of Nephrin with Pdlim2 in the murine glomerulus. Garmendia

Liliana, Acuña Stephanie, Valdés Gloria, Cuello Mauricio and Machuca Eduardo. Centro

Investigaciones Médicas, Escuela Medicina, Pontificia Universidad Católica, Santiago, Chile.

[email protected]

(95) Synthesis and evaluation of iron chelators directed to mitochondria of dopaminergic

neurons as potential therapeutic agents for Parkinson's disease. 1Fernanda Lourido,

2Olimpo García-Beltrán,

1Marco Tulio Núñez,

1Natalia P. Mena.

1Iron and Biology of Aging

Laboratory and 2Biodynamic Chemistry Laboratory, Faculty of Sciences, Universidad de Chile.

[email protected]

(97) TAPCells based vaccination induce specific anti NY-ESO1 immune response in

melanoma patients. Falcon-Beas F1; Tempio F

1; Guerrero P

1; Flores I; Falcon-Beas C; Gatica

J; Salazar-Onfray F1,2

; Mercedes L1,2

. (1) Immunology Program. Biomedical Science Institute.

Universidad de Chile. (2) Millennium Institute on Immunology and Immunotherapy, Faculty of

Medicine, University of Chile, 8380453 Santiago, Chile.




(99) NFκB activation during intradermal DNA vaccination controls migration of skin-

derived dendritic cells and induction of tumor-protective CTL responses. Felipe Gálvez-

Cancino, Nicole Rojas-Colonelli, Jonathan Roco, Camila Flores, Paola Murgas, Alvaro Lladser.

Laboratory of Gene Immunotherapy, Fundación Ciencia & Vida. [email protected]

(101) B cell-deficient mice infected with Trypanosoma cruzi develop a pro-inflammatory T

cell response potentially harmful for the host. Gorosito-Serrán, M., Tosello-Boari, J.,

Bermejo, D.; Ramello, M.C.; Fiocca-Vernengo, F.; Montes C.; Acosta-Rodríguez, E.; Gruppi, A.

CIBICI – FCQ, UNC. [email protected]

(103) Respiratory syncytial virus infection induces Heme Oxygenase-1 on dendritic cells

and modulates progression of disease. Miguel A. León1, Susan M. Bueno


2

and Alexis M. Kalergis1,3

. 1Millennium Institute of Immunology and Immunotherapy (MIII),

Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas,

Pontificia Universidad Católica de Chile. 2MIII, Departamento de Ciencias Biológicas, Facultad

de Ciencias Biológicas y Facultad de Medicina Universidad Andrés Bello. 3Departamento de

Reumatología, Facultad de Medicina. Pontificia Universidad Católica de Chile.

[email protected]

(105) Effect of tumor epithelial and normal stroma mammary cells on CD4+ T lymphocyte

differentiation. C. Miller1,3,, N. Tobar3, M.R. Bono1, M.Rosemblatt2, J. Martínez3. 1Facultad de

Ciencias, Universidad de Chile. 2Fundación Ciencia para la Vida.

3INTA, Universidad de Chile.

[email protected]

(107) Aldosterone modulates the surface expression of TLR-4/M2D in dendritic cells

enhancing their response to LPS in vivo. Natalia Muñoz-Durango1 and Alexis M. Kalergis

1,2.

1Millennium Institute on Immunology and Immunotherapy, Departamento de Genética

Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de

Chile. 2Departamento de Reumatología, Facultad de Medicina, Pontificia Universidad Católica

de Chile. [email protected]

(109) Regulation of cytokine expression in atlantic salmon is related to oxidative stress.

Rodríguez FE., Valenzuela B., Imarai M. Laboratorio de Inmunología, Centro de Biotecnología

Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile.

[email protected]

(111) Regulation of PSD-95 palmitoylation and APT-1 expression by Wnt signaling

pathways in hippocampal neurons. Juan F. Codocedo, Ting Cao and Nibaldo C. Inestrosa.

Centro de Envejecimiento y Regeneración (CARE). Departamento de Biología Celular y

Molecular. Facultad de Ciencias Biológicas. P. Universidad Católica de Chile, Santiago, Chile.

[email protected]

(113) The transition of the BDNF receptor TrkB from Rab5 to Rab11 endosomes is

required for BDNF-induced ramification and activation of CREB transcription factor in

hippocampal neurons. Andrés González, Iván Pinto, Oscar Lazo and Francisca Bronfman.

Neuronal Cell Biology and Regeneration Lab, Pontificia Universidad Católica de Chile.

[email protected]

(115) A novel model to study the cellular and molecular mechanisms of collateral sprouting

in the nervous system. Lemaitre D.1, Catenaccio A.

1, and Court, F.A.

1,2.

1Millennium Nucleus

in Regenerative Biology, (MINREB), P.Catholic University of Chile and 2Neurounion

Biomedical Foundation. [email protected] - [email protected]








(117) CoREST downregulates Notch pathway during cerebral cortex neurogenesis. Cecilia

Lopez, Katherine Saud, Daniela Peña, and Manuel Kukuljan. Biomedical Neuroscience Institute

(BNI), Facultad de Medicina, Universidad de Chile. [email protected]

(119) BDNF is expressed in a Wnt/β-catenin-dependent manner in hippocampal neurons

and HT-22 cell line. Cristobal Mejías-Reyes & Nibaldo C. Inestrosa. Center for Aging and

Regeneration (CARE), Department of Cell and Molecular Biology, Faculty of Biological

Sciences, P. Catholic University of Chile. [email protected]

(121) Non-canonical Wnt signaling increases AMPA receptor clusters in hippocampal

neurons. Carla Montecinos-Oliva & Nibaldo C. Inestrosa. Center for Aging and Regeneration

(CARE), Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic

University of Chile. [email protected]

(123) Wn5a ligand activates the mitochondrial fission protein Drp1 in hippocampal

neurons. Daniela Ordenes and Nibaldo C. Inestrosa. Center for Aging and Regeneration

(CARE), Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic

University of Chile, Chile. e-mail: [email protected]

(125) Blockade of Aβ-induced synaptotoxicity by a pentapeptide derived from the glycine

zipper region. Peters C1, Fernandez-Perez EJ1, Burgos CF1, Espinoza MP1, Castillo C1, Urrutia

JC1, Opazo C

2, Aguayo LG

1,3.

1Laboratory of Neurophysiology, Department of Physiology,

University of Concepción, Chile. 2Kenneth Myer Building, 30 Royal Parade, The University of

Melbourne, Parkville, Victoria 3010, Australia. [email protected] [email protected]

(127) Differential proliferation rates observed for human fibroblasts correlates with the

reported inverse association between cancer and Alzheimer disease. 1Ponce DP,

1,4Salech F,

1Merino D,

3Henríquez M,

2,3Quest AFG,

1,2,3Behrens MI.

1HCUCH,

2CEMC,

3ICBM,

4BNI,

Faculty of Medicine, Universidad de Chile. [email protected]

(129) The hypoxia factor Hif-1α is necessary for the outgrowth of peripheral axons of

primary sensory neurons. Santander L. and Reyes A.E. Laboratorio Biología del Desarrollo,

Facultad de Ciencias Biológicas, Universidad Andrés Bello, Santiago, Chile. [email protected]

(131) Influence of Schwann cells on single neuromast regeneration in zebrafish larvae.

Mario Sánchez, Daniela Gutiérrez, Miguel Allende. FONDAP CRG, Facultad de Ciencias,


(133) Dissecting the segmentation process: A whole embryo culture approach to

understand body segmentation in the beetle Tribolium castaneum. Loreto López-Gutiérrez,

Viviana A. Nuñez, Gabriel Maldonado, Constanza Macaya, Patricio Saavedra, Rodrigo Cepeda

& Andres F. Sarrazin. Institution: Instituto de Química, P. Universidad Católica de Valparaíso.

[email protected] - [email protected]

(135) Drosophila Frazzled regulates Hedgehog Signaling. 1,2

Luis Solano R., 1Consuelo Ibar

V., 2Verónica Palma A.

and

1Álvaro Glavic M.

1Laboratory of Developmental Biology.

2Laboratory of Stem Cells and Developmental Biology, Faculty of Sciences, University of Chile.

[email protected]

(137) Ric-8A regulates Gα13 signaling during neural crest cell migration in Xenopus

tropicalis embryos. Toro-Tapia G., Rodríguez M., Marcellini S., Torrejón M. Laboratorio

Genética Molecular Dpto. Bioquímica y Biología Molecular, Universidad de Concepción.

[email protected]









(139) PAR-3 participates in astrocyte migration induced by Thy-1. Areli Cárdenas1,2

,

Milene Kong1,2

, Álvaro Álvarez1,2

, Andrew F Quest1, Lisette Leyton

1,2.

1Cellular Communication

Laboratory, Faculty of Medicine. 2Biomedical Neuroscience Institute (BNI), Faculty of

Medicine, Universidad de Chile. [email protected]

(141) Identification of candidate downstream genes for the homeodomain transcription

factor Zen in Drosophila. Leandro Farías, Michael Pino and Verónica Cambiazo. Laboratorio

de Bioinformática y Expresión Génica. INTA-Universidad de Chile & Fondap Center for

Genome Regulation (CGR). [email protected]

(143) Interleukin-8 promotes microvascular permeability through eNOS activation.

Guequén A1, Burboa P

1, Marìn N

1, Quezada C

3, Sarmiento J

2, Sánchez FA

1. Instituto de

Inmunología1, Fisiología,

2 Facultad de Medicina; Instituto de Bioquímica

3, Facultad de Ciencias,

UACh, Valdivia. [email protected]

(145) In vivo reconfiguration of transcriptional regulatory network activated by copper.

Mauricio Latorrea,b

, Marko Budinichc, Alejandro Maass

b,c, Mauricio González

a,b,c. aLaboratorio

de Bioinformática y Expresión Génica, INTA-Universidad de Chile. bCenter for Genome

Regulation, University of Chile. cDepartment of Mathematical Engineering and Center for

Mathematical Modeling (UMI2807CNRS). [email protected]

(147) BDNF increases axonal PPAR expression via the mTOR signaling pathway. Lezana

JP, Bronfman M and Bronfman FC. Faculty of Biological Sciences. MINREB and CARE

Center. P. Catholic University of Chile.

(149) GPR40/FFA1 agonists activate metalloproteinase-9 through ERK1/2 in bovine

neutrophils. Mena J.1,2

, Manosalva C.1, Burgos RA.

1, Hidalgo MA

1.

1Laboratory of Molecular

Pharmacology, Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral

de Chile, Chile. 2Department of Biology, Faculty of Exact and Natural Sciences, Universidad de

Nariño, Colombia. [email protected]

(151) Differential gene expression of the components of the IGF system, myosins, and

ribosomal RNAs in skeletal muscle during seasonal acclimatization of carp (Cyprinus

carpio). Zuloaga R., Fuentes EN., Álvarez M., Valdes JA, and Molina A. Laboratorio de

Biotecnología Molecular, Facultad de Ciencias Biológicas, Universidad Andrés Bello, Santiago

de Chile. [email protected]

(153) Generation of carcinoma-associated stroma like cells induced by TGF-β1 in primary

cultures of stroma cells from benign human prostate. Conejeros M. Paola1, Cerda-infante

Javier1, Coronado Romina

1, Godoy Alejandro

2, Montecinos Viviana

1. Hematology-Oncology

1 &

Fisiology2 Departments, Pontificia Universidad Católica de Chile. [email protected]

(Sponsor: F. Nualart).

(155) Effect of 2-methoxyestradiol in ovarian cancer initiating cells. Hormazabal K1., Kato

S1., Abarzua-Catalan L

1., Delpiano AM

1.,Castellon E

3., Owen G.

2, Cuello M

1. 1

Division of

Obstetrics and Gynecology, Faculty of Medicine, 2Department of Physiological Sciences,

Faculty of Biological Sciences. Pontificia Universidad Católica de Chile and 3

Division of

Obstetrics and Gynecology, Faculty of Medicine. Universidad de Chile. [email protected]





(157) Massive sequencing of EGF receptor signaling pathway in colon cancer. Paulina

Orellana1, Karin Álvarez

1, Cynthia Villarroel

1, Daniela Simian

1, Camila Estay

1, Maki

Kobayashi1, Hiroshi Kawashi

1, Udo Kronberg

1, Francisco López

1, Pilar Carvallo

2. Oncology and

Molecular Genetics Laboratory, Clínica Las Condes1. Department of Cell and Molecular

Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile2, Santiago,

Chile. [email protected] (Sponsor: E.O. Campos).

(159) Upregulation of mir-597 correlated with downregulated of RPRM in gastric cancer.

Sandoval A.1,2

, Riquelme I.2, Buchegger K.

2, Olivares W.

1, Saavedra K.

1,2, García B.

1, Roa

J.C.2,3

, Corvalán A.1.

1Department of Hematology and Oncology and Centre for Translational

Research in Oncology , School of Medicine, P. Universidad Católica de Chile, Santiago, Chile; 2Department of Pathology, School of Medicine, Universidad de La Frontera , BIOREN-CEGIN,

Temuco, Chile; 3 Pathological Anatomy Department, School of Medicine, P. Universidad


(161) Characterization of a new transgenic mouse model of amyotrophic lateral sclerosis

(ALS): TDP43A315T

. Bargsted L1,2,3

, Calegaro M1,2

, Torres M1,2

, Fuentealba Y1,2

., Valenzuela

V1,2

, Hetz C1234

. and Matus S3.

1Biomedical Neuroscience Institute. University of Chile.

2Center

for Molecular Studies of the Cell. University of Chile. 3Neurounion Biomedical Foundation,

Santiago, Chile, 4Department of Immunology and Infectious Diseases, Harvard School of Public

Health, Boston, USA. [email protected]

(163) Anticancer and antimicrobial activity of phytochemical extract from Senecio

graveolens (Chachacoma). Carlos Echiburú-Chau1,2

, Javier Santander3,4

, Susana Alfaro2,

Cristian Salas5, Mauricio Cuéllar

6, Viviana Varas

1 and Francisco Rothhammer

1,2. Centro de

Investigaciones del Hombre en el Desierto (CODECITE-CIHDE)1; Universidad de Tarapacá

2;

Arizona State University3; Universidad Mayor

4; Pontificia Universidad Católica de Chile

5; and

Universidad de Valaparaíso6. [email protected] (Sponsor: G. Cabello)

(165) Cardiac Rho kinase activation and cardiac hypertrophy markers in experimental

heart failure. Claudia Mera, Iván Godoy, Soledad Veliz, María Ocaranza, Jorge Jalil.

Departamento de Enfermedades Cardiovasculares, Laboratorio de Cardiología Molecular,

Escuela de Medicina, P Universidad Católica de Chile. [email protected] (Sponsor: S.

Lavandero).

(167) Low voltage electron microscopy as a tool for the morphological study of oral

microbial biofilms. D. Aguayo1, J. Salazar

1, J. Huerta

2, H. Mendoza

1, R. Polanco

2 and FD.

González-Nilo1.

1Center for Bioinformatics and Integrative Biology (CBIB) Facultad de

Ciencias Biológicas, Universidad Andrés Bello, Avda. República 217, Santiago, Chile. 2Departamento de Ciencias Biológicas, Universidad Andrés Bello, Avda. República 217,

Santiago, Chile. [email protected] (Sponsor: C. Riedel).

13:00 – 15:00 Lunch

15:00 – 17:00 Symposium “Cell Membrane Channels Made by Connexins or Pannexins are Key Players

in Genetic and Acquired Diseases”

Volcanes Room

Chairs: Agustin Martinez and Juan Carlos Saez

Gap junction hemichannel mediated vascular leak in the inflammatory response. Colin R

Green, Department of Ophthalmology, University of Auckland. New Zealand.







Lessons learned from disease-causing connexin mutations. Dale W Laird, Professor and

Canada Research Chair, The University of Western Ontario, London, ON, Canada

Connexins, pannexins and neuroprotection. Christian Naus, PhD, Department of Cellular

and Physiological Science, Life Sciences Institute, Faculty of Medicine, University of British

Columbia, Vancouver, BC, Canada.

The de novo expression of connexin hemichannels induced by diverse pathological

conditions leads to sarcolemma permeabilization and atrophy of fast skeletal muscles. Luis

A. Cea1,2

, Bruno A. Cisterna1, Carlos Puebla

1,2, Marina Frank

3,Klaus Willecke

3,Ramón Latorre

2

and Juan C. Sáez1,2

. 1Departamento de Fisiología, Pontificia Universidad Católica de Chile,

Santiago, Chile. 2Centro Interdisciplinario de Neurociencias de Valparaíso, Valparaíso, Chile.

3Life and Medical Sciences Institute, Molecular Genetics, University of Bonn, Bonn, Germany.



17:00 – 19:00 Poster Viewing Session II: 85-168 Even Numbers


Coordinators: M. Julieta Gonzalez – Lisette Leyton – Claudia Metz – Rodrigo Pacheco

(86) Role of hemichannels in fibroblast migration. 1Carolina Flores,

1Catherine Estay,

2Tomas Egaña,

3Donald Brown,

1Agustín D. Martínez.

1Centro Interdisciplinario de

Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso. 2Department of Plastic and

Hand Surgery, University of Lübeck, Germany. 3

Departamento de Biología, Facultad de

Ciencias, Universidad de Valparaíso, Chile.

(88) Galectin-8 induces endothelial hyperpermeability by S-nitrosation of adherens

junction proteins. 1Patricia Zamorano,

3Gonzalo Mardones,

2Alfonso Gonzàlez,

2Andrea

Soza, 1Fabiola Sánchez.

1Institulo de Inmunología e

3 Instituto de Fisiologìa, Universidad Austral

de Chile, Valdivia, Chile. 2Institulo de Reumatologìa, Pontificia Universidad Catòlica de Chile.

[email protected]

(90) The SNAREs SNAP23, VAMP4 and Syntaxin6 are necessary for the establishment of

neuronal polarity. Diego Grassi, Santiago Quiroga. CIQUIBIC (CONICET). Departamento de

Química Biológica. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba.

[email protected]

(92) Involvement of the long-chain fatty acid receptor GPR40 in calcium mobilization and

reactive oxygen species production in bovine neutrophils. C. Manosalva, M. Maimae, J.

Mena, RA. Burgos, MA. Hidalgo. Instituto de Farmacología y Morfofisiología, Facultad de

Ciencias Veterinarias, Universidad Austral de Chile, Valdivia. [email protected]

(94) Apical secretion of galectin-8 containing exosomes in MDCK cells. Oyanadel, C.

Lopez-Verrilli, M.A., Soza, A., González, A. Departamento de Inmunología Clínica y

Reumatología, Facultad Medicina, Chile. Centro de Envejecimiento y Regeneración,

Departamento de Biología Celular y Molecular. Facultad Ciencias Biológicas. Pontificia

Universidad Católica de Chile, Chile. [email protected]

(96) ATP and PMB-induced depletion of tregs is not mediated by P2X4R. López X.,

Barrientos C., Escrig D., Sáez JC.*, Imarai M., Acuña-Castillo C., [email protected].

CBA-USACH, Facultad de Química y Biología, Universidad de Santiago de Chile.

Departamento de Fisiología, Pontificia Universidad Católica de Chile*.




(98) K+ and glutamate trigger the release of lactate from astrocytes within seconds, as

detected by a lactate sniffer cell. 1,2

Sotelo-Hitschfeld, T., 1,2

Ruminot, I., 1,2

San Martín, A., 1Barros, LF.

1Centro de Estudios Científicos, Valdivia, Chile.

2Universidad Austral de Chile,

Valdivia, Chile.

(100) Ectonucleotidase expression and immunosuppressive ability on tumor infiltrating

CD8+ T cells. F. Flores1,3

, J.J. Sáez1, D. Fernández

1, M.R. Bono

1, M. Rosemblatt

1,2, D.

Sauma1,2

. 1Departamento de Biología, Facultad de Ciencias, Universidad de Chile,

2Fundación

Ciencia & Vida. [email protected]

(102) Establishment of a new humanized mouse model for immunotherapy evaluation

in malignant melanoma. Jimena Gatica1, Fabian Tempio

1, Paulina Ruiz

1, Luis Salazar, Flavio

Salazar-Onfray1 and Mercedes López

1. 1

Disciplinary Program of Immunology, Institute of

Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.

[email protected]

(104) Carbon monoxide exposure limits CD11b+ cells expansion and ameliorates disease in

lupus mice. Juan P. Mackern1, Carolina Llanos

1, Leandro J. Carreño

1, Sebastián A. Riquelme

1,

Camila B. Schmidt1, Sergio H. Jacobelli

1,2, Ignacio Anegon

3 and Alexis M. Kalergis

1,2.

1Millennium Institute on Immunology and Immunotherapy. Departamento de Genética

Molecular y Microbiología PUC. 2Departamento de Inmunología Clínica y Reumatología,

Facultad de Medicina, PUC. 3INSERM U643, France.

(106) Diphencyprone-based topical immunotherapy against melanoma. Mena J1., Escrig

D1., Morales J

1., Mateluna C

1., Lopez X

1., Escobar A

2., Montoya M

1., Acuña-CastilloC

1.

1Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de

Chile. 2Facultad de Odontología, Universidad de Chile. [email protected]

(108) Evaluation of viral fusion protein in antigen cross-presentation. Morales J., López X.,

Barrientos C., Ramírez S., Cortes-San Martin M., Spencer E, Acuña-Castillo C. Centro de

biotecnología acuícola y Facultad de Química y Biología, Universidad de Santiago de Chile

(110) Respiratory Syncytial Virus can directly impair T cell activation. Bruno A. Ramírez1,

Tomás A. Rivero, Susan M. Bueno1, Claudia A. Riedel

2 and Alexis M. Kalergis

1,3. 1

Millennium

Institute on Immunology and Immunotherapy (MIII), Departamento de Genética Molecular y

Microbiología, Pontificia Universidad Católica de Chile (PUC). 2MIII, Facultad de Ciencias

Biológicas y Facultad de Medicina Universidad Andrés Bello. 3

Departamento de Reumatología,

Facultad de Medicina, PUC. [email protected]

(112) Andrographolide increases cell proliferation and the generation of new neurons in

the adult hippocampus. Sebastián B. Arredondo1,2

, Cheril Tapia-Rojas2 Nibaldo C. Inestrosa

2

and Lorena Varela-Nallar1.

1Centro de Investigaciones Biomedicas, Facultad de Ciencias

Biologicas y Facultad de Medicina, Universidad Andrés Bello; 2Centro de Envejecimiento y

Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias

Biológicas, P. Universidad Católica de Chile. [email protected]

(114) Characterization of intracellular localization of neurotrophic factor CDNF by

bicistronic lentiviral vectors in neurons. Anllely Fernández, Sheyla Guzmán, Yocelin Cruz,

Jorge Escobar, Pedro Zamorano. Faculty of Health Sciences, University of Antofagasta, Chile.

[email protected]




(116) SCO-spondin: a protein with multiple interactions? González M., Stanic K., Vera A.,

Montecinos H., Caprile T. Departamento de Biología Celular, Universidad de Concepción.

[email protected]

(118) Vitamin C deficiency disrupts normal cellular activity within the subventricular zone

neurogenic niche. Nery Jara, Federico Rodríguez, Katterine Salazar, Fernando Martínez and

Francisco Nualart. Neurobiology and Stem Cells Laboratory, Center for Advanced Microscopy,

CMA BIO BIO, University of Concepción. [email protected]

(120) Regulation of protein S-nitrosylation by excitotoxic stimulation of cortical and

hippocampal cell cultures. Bárbara Maturana, Ariel Caviedes, Ursula Wyneken. Universidad

de los Andes.

(122) Iron chelator 7MH restores the neuritic tree of midbrain dopaminergic neurons

injured by oxidative insults. Pabla Aguirre1, 2

, Rodrigo Morales1, Carolina Méndez-Gálvez

3

Bruce K. Cassels3, and Marco Tulio Núñez

1,2. 1

Biology and 3Chemistry Departments, Faculty of

Sciences, Universidad de Chile; 2Research Ring on Oxidative Stress in the Nervous System.

[email protected]

(124) The Wnt/β-catenin pathway promotes the maturation of the postsynaptic apparatus

at the vertebrate NMJ. Jorge Ojeda, Verónica Miranda, Daniel Hertzberg(2), Giancarlo V. De

Ferrari(3), Juan Pablo Henríquez. Department of Cell Biology and CMA Bio-Bio, (2)

Department of Clinical Sciences and Clinical Veterinary, Universidad de Concepción,

Concepción; (3) Center for Biomedical Research, Universidad Andrés Bello, Santiago; Chile.

[email protected]

(126) Myelin-associated glycoprotein modulates apoptosis of motoneurons via NgR-

mediated RhoA activation. Palandri, A(1); Rozés Salvador, MV(1); Wojnacki, JI(1);

Vivinetto, AL(1); Heredia, MF(1); Schnaar, R(3) and Lopez, PHH(1,2). (1)INIMEC-CONICET-

UNC; (2)Facultad de Psicología-UNC; (3)Johns Hopkins University-USA.

[email protected]

(128) Role of Gαi/0 activation in Wnt-5a non-canonical pathway and dendritic spine

formation in hippocampal neurons. Valerie T. Ramírez and Nibaldo C. Inestrosa. P.

Universidad Católica de Chile, Centro de Envejecimiento y Regeneración (CARE), Santiago,


(130) Role of Wnt-5a and Aβ in the GluN2B expression. Eva Ramos-Fernández, Francisco

J. Muñoz and Nibaldo C. Inestrosa. Centro de Envejecimiento y Regeneración (CARE).

Departamento de Biología Celular y Molecular. Facultad de Ciencias Biológicas. P. Universidad


(132) Human Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSC) promote angiogenesis

and dermal regeneration. Edwards S1, Zavala G

1, Prieto C

1, Egaña T

1, Bono MR

2, Palma V

1.

CTYBD1 and Immunology

2 Laboratories, Faculty of Sciences, Universidad de Chile.

[email protected]

(134) Copper deficiency causes a delay in erythroid differentiation and involves

mitochondrial physiology changes. Erik Jensen and Alvaro A. Elorza. Center for Biomedical

Research, Universidad Andrés Bello. [email protected]





(136) SOX2+ cells are necessary for spinal cord regeneration in Xenopus laevis. Muñoz,

Rosana; Edwards, Gabriela; Moreno, Mauricio; Méndez, Emilio; Farías, Marjorie and Larraín,

Juan. Center for Aging and Regeneration, Millennium Nucleus in Regenerative Biology.

Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Chile. [email protected]

(138) Role of sema3aa and its relationship with sdf1a during migration of the zebrafish

lateral line primordium. Karina Tapia, Camila Mardones, Leonardo Valdivia, Miguel

Allende. FONDAP Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile.

[email protected]; [email protected]

(140) Caveolin-1 inhibits starvation-induced autophagy in a melanoma model. Ávalos, Y.

1,2, Troncoso, R.

2, Leyton, L.

1, Lavandero, S.

2 and Quest, A.F.G.

1.

1Laboratorio de

Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula (CEMC), ICBM,

Facultad de Medicina, Universidad de Chile. 2Laboratorio de Transducción de Señales

Moleculares, Centro de Estudios Moleculares de la Célula (CEMC), Facultad de Ciencias

Químicas y Farmacéuticas, Universidad de Chile. [email protected]

(142) Participation of AKT signaling in the anti-atrophic effects mediated by Angiotensin

1-7 in cachectic skeletal muscle. Cisternas, F., Meneses, C., Morales, M.G., Cabello-Verrugio,

C. Laboratorio de Biología y Fisiopatología Molecular, Facultad de Ciencias Biológicas,

Universidad Andrés Bello. [email protected]

(144) Activated alpha-2 macroglobulin induces cellular migration by regulating MT1-

MMP activity through LRP1. Ferrer Darío, Jaldín-Fincati Javier, Barcelona Pablo, Sánchez

María C, Chiabrando Gustavo A. CIBICI-CONICET. Departamento de Bioquímica Clínica.

Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Córdoba. Argentina.

[email protected]

(146) In vivo ChIP-seq and RNA-seq illuminate how transcriptional repression controls the

loss of pluripotency during osteogenesis. Hanna P.1, Godoy F.

1, Contreras P.

1, Bertin A.

1,

Otárola G.1, Fritz A.

1, Muñoz D.

1, Buisine N.

2, Sach L.

2 and Marcellini S.

1. Faculty of Biological

Sciences, University of Concepcion, Chile1, Muséum National d'Histoire Naturelle, CNRS,

France2. [email protected]

(148) Characterization of primary neuronal culture from mouse trigeminal ganglia: Study

of regulation of Cdk5 signaling pathway mediated by TGF-1. Lazcano P., Rozas P.,

Barrios M., Gonzalez-Billault C., Utreras E. Department of Biology, Faculty of Science,


(150) Jitterbug(jbug)/Filamin and Protein Tyrosine Phosphatase 69D (PTP69D) are

required for layer specific targeting of photoreceptor axons. Miguel Maureira, Claudia

Molina, Estefanía López, Jose Canovas, Carlos Oliva, Jimena Sierralta, Patricio Olguín.

Programa de Genética Humana, Programa de Fisiología y Biofísica, ICBM, Facultad de

Medicina, Universidad de Chile. [email protected]

(152) Epigenetic control during vitaminD3-mediated transcriptional activation of the 24-

hydroxylase gene in osteoblasts. D. Moena and M. Montecino. Center for Biomedical

Research and FONDAP Center for Genome Regulation, Faculty of Biological Sciences and

Faculty of Medicine, Universidad Andres Bello, Santiago, Chile.





(154) Human Equilibrative Nucleoside Transporter 1 (hENT1) upregulation by an

artificial transcription factor (ATF) sensitizes ovarian cancer cells to Gemcitabine

chemotherapy. Alejandra Alarcón1, Benjamín García

1, Alejandro Corvalán

1, Miguel

Bronfman2, and Andrea V Leisewitz

1.

1Hematology-Oncology Department, School of Medicine,

2Cellular and Molecular Biology Department, Faculty of Biological Sciences, P. Universidad


(156) Methylation of RPRM in plasma can differentiate initial stages of gastric cancer. Fry

J, Valdes S, Maturana MJ, Olivares W, Schneider B, El Rifai W, Hernández G, Martínez T,

Corvalán AH. Pontificia Universidad Católica de Chile. [email protected]

(158) Characterization of exosomes from human osteosarcoma cell lines. Sofía Jerez1,2

,

Andrés Stevenson1,2

, Pablo Céspedes1,4

, Alexis Kalergis1,4,5

, Flavio Salazar1,3

, Mario Galindo1,2

. 1Millennium Institute on Immunology and Immunotherapy;

2Programa de Biología Celular y

Molecular, 3Programa de Inmunología, ICBM, Facultad de Medicina, Universidad de Chile;

4 e arta ento de enética Molecular y Micro iología, Facultad de Ciencias iológicas,

5 e arta ento de In unología Clínica y Reu atología, Facultad de Medicina, onti icia

niversidad Católica de C ile

(160) Characterization of vasculogenic mimicry in ovarian cancer. Dusan Racordon1,2

,

Bárbara Oliva 1,2, Juan Carlos Sáez1, Gareth I. Owen1,2. Departamento de Fisiología, Facultad de

Ciencias Biológicas, Pontificia Universidad Católica de Chile1. Biomedical Research

Consortium2. [email protected]

(162) Hepatic alterations of iron and copper metabolism in a murine model of Niemann-

Pick C disease. Graciela Argüelloa, Felipe Olivares

a, Pablo Martinez

b, Silvana Zanlungo

b,

Mauricio Gonzáleza. a

Laboratory of Bioinformatics and Gene Expression, INTA-University of

Chile. bDepartment of Gastroenterology, P. Catholic University of Chile.

[email protected]

(164) Activation of the ATF6 pathway in salivary glands of Sjögren’s syndrome patients.

Barrera MJ, Castro I, Sepúlveda D, Aguilera S, Indo S, Molina C, González S, Urzúa U,

Leyton C and González MJ. ICBM-Facultad de Medicina, Universidad de Chile.

[email protected]

(166) RECK a novel matrix-metalloproteinase inhibitor is up-regulated in dystrophic

muscles of mdx mice. David González, Jaime Gutiérrez, Enrique Brandan. Pontificia


(168) De novo assembly and characterization of red conger eel (Genypterus chilensis)

transcriptome using next generation sequencing. Jorge Aedo1, Jonathan Maldonado

2,

Herman Silva2, Rodrigo Zuloaga

1, Eduardo Fuentes

1, Alfredo Molina

1 y Juan Antonio Valdés

1.

1Universidad Andrés Bello, Facultad de Ciencias Biológicas, Laboratorio de Biotecnología

Molecular. 2Universidad de Chile, Facultad de Ciencias Agronómicas, Laboratorio de Genómica

Funcional y Bioinformática. [email protected]


Volcanes Room

Chair: Brigitte van Zundert

LTP/LTD: A possible link between activity-dependent development, brain circuitry and

behavior. Martha Constantine-Paton, PhD, Professor Departments of Brain and Cognitive

Science and Biology. Massachusetts Institute of Technology, Cambridge, MA, USA.






20:00 Dinner

21:30 – 22:30 Plenary Lecture “Federico Leighton Puga”

Fundación Chilena para Biología Celular

Volcanes Room

Chairs: Arturo Yudelevich and Alfonso González

A Personal Account of my Journey Through Cell Biology. David D. Sabatini. Frederick L.

Ehrman Professor, Department of Cell Biology, School of Medicine, New York University,

USA.


SATURDAY, OCTOBER 26, 2013

08:00 Poster Mounting Session III: N° 169 to N° 251


09:00 – 11:00 Oral Presentations IV

Volcanes Room

Chairs: Hugo Olguín and Miguel Allende

09:00 Ubiquitin-proteasome system mediated stability regulation of PAX7 during muscle

satellite cell differentiation. Francisco Bustos1, Eduardo de la Vega

1, Dawn Cornelison

2, John

Yates III3 and Hugo Olguín

1.

1Facultad de Ciencias Biológicas, P. Universidad Católica de

Chile. 2Christopher Bond Life Sciences Center, University of Missouri. Columbia MO, USA.

3Department of Chemical Physiology, the Scripps Research Institute; La Jolla CA. USA.

[email protected]

09:15 Identification and characterization of neural progenitor cells in the lateral line of

zebrafish. Cristian A. Undurraga and Miguel L. Allende. FONDAP Center for Genome

Regulation, Faculty of Sciences, University of Chile. [email protected]

09:30 Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of

dopaminergic neurons during Parkinson’s disease. Hugo González1, Francisco Contreras

1,2,

Carolina Prado1, Daniela Elgueta

1, Dafne Franz

1 and Rodrigo Pacheco

1,3.

1Fundación Ciencia y

Vida, 2Universidad Andrés Bello.

3Universidad San Sebastián, Santiago, Chile.

[email protected]

09:45 Regulation of AA uptake in neuronal precursor cells by a novel short form of SVCT2.

Karina Oyarce1, Vijay Chandrasekar

2, Luciano Ferrada

1, Juan Carlos Tapia

3, Francisco

Nualart1.

1Neurobiology and Stem Cells Laboratory, Center for Advanced Microscopy, CMA

BIO- BIO, University of Concepción. 2Department of Biochemistry and Molecular Biophysics,

Columbia University, NYC, USA. 3Department of Neuroscience, Columbia University, NYC,


10:00 Platelet interaction with ovarian cancer cells promotes a pro-metastatic phenotype. R.

Orellana1,3

, B. Oliva1,3

, S. Kato2,3

, P. Gonzalez1,3

, M. Cuello2,3

, G.I. Owen1,3

. 1Faculty Biological

Science, 2Faculty of Medicine, P. Universidad Católica de Chile &

3Biomedical Research

Consortium Chile (BMRC). [email protected]

10:15 Plasma membrane-bound sialidase Neu3 impairs the clathrin-mediated endocytosis. Vilcaes A.A, Rodríguez-Walker M. and Daniotti J.L. CIQUIBIC-(UNC-CONICET), Fac. de Cs.

Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. [email protected]

10:30 Adaptive responses of mitochondria under mild copper deprivation involve changes in

morphology, oxphos remodeling, and bioenergetics. Lina Ruiz, Erik Jensen, Rodrigo Bustos

and Alvaro Elorza. Center for Biomedical Research, University Andres Bello, Chile.

[email protected]

10:45 TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Utreras E1,2

,

Prochazkova M2, Terse A

2, Gross J

2, Keller J

2, Iadarola MJ

2, Kulkarni AB

2.

1Department of

Biology, Faculy of Sciences, Universidad de Chile, 2NIDCR, NIH, USA.

[email protected]




11:00 – 13:00 Poster Viewing Session III: 169-251 Odd Numbers


Coordinators: Cecilia Riquelme – Andrea Soza – Elías Utreras – Soledad Matus

(169) Mineralocorticoids downregulate Na+-K

+-ATPase β3-subunit expression in

cardiomyocytes. Alvaro Plaza, Pablo Díaz, Víctor Barrientos and Luis Michea. Center for

Molecular Studies of the Cell; Millennium Institute on Immunology and Immunotherapy, ICBM,

Facultad de Medicina, Universidad de Chile. [email protected]

(171) Role of TSG101 and Rab27a in the incorporation of the amyloid precursor protein

into multivesicular bodies. Viviana Cavieres1, Hianara Bustamante

1, Alexis González

1, Matías

Ostrowski2, Gonzalo Mardones

1 and Patricia V. Burgos

1.

1Instituto de Fisiología, Facultad de

Medicina, Universidad Austral de Chile, Valdivia, and 2Instituto de Investigaciones Biomédicas

en Retrovirus y SIDA, Universidad de Buenos Aires, Argentina. [email protected]

(173) BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic

branching. Oscar M. Lazo1, Andrés González

1, María Ascaño

2, Rejji Kuruvilla

2, Andrés

Couve3 and Francisca C. Bronfman

1.

1Neuronal Cell Biology and Regeneration Laboratory,

MINREB, CARE-Chile and Departamento de Fisiología, Facultad de Ciencias Biológicas,

Pontificia Universidad Católica de Chile. 2Department of Biology, John Hopkins University.

3Programa de Fisiología y Biofísica, ICBM and BNI, Facultad de Medicina, Universidad de


(175) Sodium-dependent vitamin C transporter 2 (SVCT2) translocation to plasma

membrane is Huntingtin-dependent. Alejandra Parra, Adriana Covarrubias, Eduardo Papic,

Rodrigo Maldonado, Ilona I. Concha and Maite Castro. Instituto de Bioquímica y

Microbiología, Universidad Austral de Chile. [email protected]

(177) Adaptive responses to copper imbalance in erythroid cells. Rodrigo Bustos, Lina Ruiz,

Alvaro Elorza. Experimental Bioenergetics Laboratory, Center for Biomedical Research,

Universidad Andrés Bello [email protected]

(179) Metabolic compartmentalization in neurons. Martinez N.W.1,3

, Court F.A. 1,2, L. Felipe

Barros3.

1Millennium Nucleus in Regenerative Biology, (MINREB), Catholic University of

Chile. 2Neurounion Biomedical Foundation and

3Center for Scientific Studies CECs.

[email protected], [email protected], [email protected]

(181) Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen

presentation by dendritic cells to T cells. Sebastián A. Riquelme1*

, Virginie Tardif2,*

Séverine

Remy2, Leandro J. Carreño

1, Claudia M. Cortés

3, Thomas Simon


3, Philippe

Blancou2, Susan M. Bueno

1, Ignacio Anegon

2,** and Alexis M. Kalergis

1,4**.

1Millennium

Institute of Immunology and Immunotherapy, PUC; 2INSERM, UMR 1064, Université de

Nantes, France; 3Millennium Institute of Immunology and Immunotherapy, UNAB;

4Departamento de Reumatología, PUC. *These authors contributed equally to this work. **Both

authors share senior authorship. [email protected]






(183) Digoxin reduces the in vitro generation of Th17. Jocelyn C. Neira1, Valeria

Manríquez2, Paz Reyes

1, Alejandra Loyola

1, María Rosa Bono

2 and, Mario Rosemblatt

1,2,3.

1Fundación Ciencia & Vida,

2Laboratorio de Inmunología, Facultad de Ciencias, Universidad de

Chile and 3Facultad de Ciencias Biológicas, Universidad Andrés Bello.

[email protected]

(185) Kinetics of growht and survival in vitro of mutants of Brucella abortus 2308 to genes

BAB1:0267 and BAB1_0270. Luisa Ortiz, Roberto Riquelme, Roberto Vidal, Ángel Oñate.

Laboratorio de Inmunología Molecular, Facultad de Ciencias Biológicas, Universidad de

Concepción. Chile. [email protected]

(187) DNA vaccination with a shRNA silencing STAT3 improves antitumor T cell responses

in a mouse melanoma model. Nicole Rojas-Colonelli, Felipe Gálvez, Paola Murgas, Camila

Flores, Alvaro Lladser. Laboratory of Gene Immunotherapy, Fundación Ciencia & Vida.

[email protected]

(189) TLR7/8 agonist improves TAPCell activation. Paulina Ruiz1, Iván Flores

1, Fabián

Tempio, Andrea Pardo, Flavio Salazar-Onfray1 and Mercedes López

1.

1Disciplinary Program of

Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile,

Santiago, Chile. [email protected]

(191) Over-expression of heme oxygenase-1 contributes to the immunological tolerance in a

murine model of multiple sclerosis. Camila B. Schmidt1, María Cecilia Opazo

2, Eduardo A.

Albornoz2, Claudia A. Riedel

2, Alexis M. Kalergis

1,3.

1Millennium Institute on Immunology and

Immunotherapy (MIII), Departamento de Genética Molecular y Microbiología, Pontificia

Universidad Católica de Chile (PUC). 2MIII, Departamento de Ciencias Biológicas, Facultad de

Ciencias Biológicas y Facultad de Medicina Universidad Andrés Bello. 3Departamento de

Reumatología, Facultad de Medicina, PUC. [email protected]

(193) Pro-inflammatory cytokines, TNFα and IL-1, are related with muscle atrophy in the

fine flounder. Cristián A. Valenzuela, Eduardo N. Fuentes, Diego Safian, Juan Antonio

Valdés, Alfredo Molina. Laboratorio de Biotecnología Molecular, Facultad de Biología,

Universidad Andrés Bello, Santiago, Chile. [email protected]

(195) Loss of pannexin 1 modifies the threshold for synaptic plasticity induction in

hippocampus. Alvaro O. Ardiles1, Carolina Flores1, Juan Ahumada2, Juan Carlos Sáez1,3,

Marco Fuenzalida2 & Agustín Martínez

1. 1

Centro Interdisciplinario de Neurociencias de

Valparaíso, Universidad de Valparaíso. 2Centro de Neurobiología y Plasticidad Cerebral,

Universidad de Valparaíso. 3Departamento de Fisiología, Pontificia Universidad de Católica de

Chile. [email protected] (Sponsor: J.C. Sáez).

(197) Toxic factors released by ALS astrocytes induce alterations in spontaneous calcium

activity and mitochondrial dysfunction. Elsa Fritz1,2

, Nicole Cortes1, Fabiola Rojas

1, Alvaro

Elorza1, Felipe A. Court

2, Rodolfo Madrid

3, Brigitte van Zundert

1.

1Universidad Andrés Bello;

2Pontificia Universidad Católica de Chile;

3Universidad de Santiago de Chile. [email protected]

(199) Necroptosis triggers mitochondrial failure and neurite degeneration in hippocampal

neurons subjected to excitotoxicity. Hernández D.E.1 and Court, F.A.

1,2.

1Millennium

Nucleus in Regenerative Biology, (MINREB), P. Catholic University of Chile and 2Neurounion

Biomedical Foundation. [email protected]; [email protected]








(201) Wnt3a induces the fragmentation of complex postsynaptic structures in vitro. Viviana

Pérez, Juan Pablo Henríquez. Department of Cell Biology and CMA Bio-Bio, University of

Concepcion. [email protected]

(203) ROS and Nav channel activity are key in triggering motoneuron death induced by

exposure of spinal cord cultures to media conditioned by astrocytes expressing ALS-

causing mutants in SOD1 and TDP43. Nicole Cortés1, Fabiola Rojas

1, Sebastián Abarzua

1,

Elsa Fritz1, Brigitte van Zundert

1.

1Universidad Andrés Bello. [email protected]

(205) Secreted Frizzled Related Protein-2 (sFRP2) is reduced during events of memory and

learning, facilitating long-term depression (LTD) induction. Felipe G. Serrano, Cheril

Tapia-Rojas and Nibaldo C. Inestrosa. Centro de Envejecimiento y Regeneración (CARE),

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas Pontificia


(207) Chronic treatment of wild-type mice with high doses of methionine induces

neurodegeneration. Cheril Tapia-Rojas1, Carla Montecinos-Oliva

1, Carolina B. Lindsay

2,

Sandra Hirsch3, Nibaldo C. Inestrosa

1.

1Centro de Envejecimiento y Regeneración (CARE),

Departamento de Biología Celular y Molecular, P. Universidad Católica de Chile, 2Facultad de

Ciencias Químicas y Farmacéuticas, Universidad de Chile, 3Instituto de Nutrición y Tecnología

de los Alimentos (INTA), Universidad de Chile. [email protected]

(209) Role of inflammation on peripheral axon regeneration. Daniela Ureta, María Laura

Ceci, Oscar A. Peña, Miguel L. Allende. FONDAP Center for Genome Regulation, Facultad de

Ciencias, Universidad de Chile. [email protected]

(211) Interaction between lipoproteins and SCO-spondin and its role in early neurogenesis.

Vera A., González M., Stanic K., Montecinos H., Caprile T. Departamento Biología Celular,


(213) NADPH-oxidase and endoplasmic reticulum Ca2+

regulate hippocampal neuronal

polarity in vitro. Carlos Wilson R.1,2

, Daniel Bórquez1,2

, Marco Tulio Núñez1 and Christian

González-Billault1,2. 1Cellular and Neuronal Dynamics Laboratory (CENEDYN), 2Department

of Biology, Faculty of Sciences, Universidad de Chile, Chile. [email protected]

(215) Characterization of a putative monocarboxylic acid transporter in Drosophila

melanogaster. María Graciela Delgado and Jimena Sierralta. Cell and molecular Neurobiology

laboratory, Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile.

[email protected]

(217) The brainbow strategy: a lineage tracing tool for live single cell tracking in zebrafish.

Nicole Reynaert, Salomé Muñoz S, Lázaro Centanin, Joachim Wittbrodt, Miguel L Allende.

Centro FONDAP de Regulación del Genoma. Universidad de Chile. [email protected]

(219) Lipodystrophy is caused by post natal adipose tissue loss associated with impaired

adipogenic differentiation in Agpat2-/-

mice. Kelly Cautivo1, Pablo Tapia

1 and Víctor Cortés

1.

1Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad

Católica de Chile.

(221) Sonic Hedgehog (SHH)/Gli improves angiogenic potential of human umbilical cord

mesenchymal stem cells (WJ-MSC). Zavala, G., Palma, V. CTYBD Laboratory, Faculty of

Sciences, Universidad de Chile. Chile. [email protected]






(223) RIC-8B is phosphorylated in response to Gαs signaling pathway activation. Beyer,

A.1, Pastén, P.

1, Olate, J.

1, Torrejón, M.

1, Hinrichs, M.V.

1.

1Laboratorio Genética Molecular

Dpto. Bioquímica y Biología Molecular, Universidad de Concepción. [email protected]

(225) Canonical Wnt/-catenin signaling stimulates the expression of fibrotic markers and

triggers the disorganization of the primary cilium structure in MDCK cells. Pedro

Cisternas, Carlos P. Vio and Nibaldo C. Inestrosa. Centro de Envejecimiento y Regeneración

(CARE). Departamento de Biología Celular y Molecular. Facultad de Ciencias Biológicas. P.


(227) Transcriptomic analysis of Musca domestica embryos and the origin of new elements

of dorsal patterning network in dipterans. Christian Hodar, Dante Travisany, Alejandro

Maass, Veronica Cambiazo. Laboratorio de Bioinformática y Expresión Génica, INTA.

Laboratorio de Bioinformática y Matemática del Genoma, CMM. Universidad de Chile. Fondap

Center for Genome Regulation (CGR) [email protected]

(229) A transcriptomics analysis of spinal cord regeneration in Xenopus laevis. Mauricio

Moreno1, Dasfne Lee-Liu

1, Leonardo I. Almonacid

2, Víctor Tapia

1, Javier von Marées

1, Rosana

Muñoz1, Gabriela Edwards

1, Francisco Melo

2, Juan Larraín

1. 1

Center for Aging and

Regeneration and Millennium Nucleus in Regenerative Biology; 2Molecular Bioinformatics

Laboratory, Millennium Institute on Immunology and Immunotherapy; Pontificia Universidad

Católica de Chile. [email protected]

(231) Internalization of dopamine transporter induced by arachidonic acid in PC12 cells:

role of G-protein coupled receptor 120. 1Pino JA,

2Torres GE,

1Reyes JG,

1Osses N.

1Instituto

de Química, P. Universidad Católica de Valparaíso, Chile; 2Department of Neurobiology,

University of Pittsburg, USA. [email protected]

(233) Galectin-8 increases cell proliferation through different pathways in MDCK and

HeLa cells. Remziye Döger1, Claudia Oyanadel

1, Elizabeth Riquelme

1, Yimo Lin

3, Breyan

Ross3, Gonzalo Mardones

3, Andrea Soza

1,2, Alfonso Gonzalez

1,2. Instituto de Fisiología Facultad

de Medicina, Centro de Investigación Sur-Austral en Enfermedades del Sistema Nervioso

(CISNe), Universidad Austral de Chile, Valdivia3. Departamento de Inmunología Clínica y

Reumatología, Fac. Medicina1. Centro de Envejecimiento y Regeneración (CARE) Fac. Ciencias

Biológicas2. Pontificia Universidad Católica de Chile.

(235) Curcumin inhibits both hypoxia-induced VEGF up regulation in retinal pigment

epithelium cells and angiogenesis of choroidal vascular cells. Vasquez D1,2,3

, Diaz MI1,4

,

Sanhueza C1,2

, Castiglione E3, Gonzalez I

4, Valenzuela R

4, Owen GI

4,5, Leyton L

1,2.

1Laboratorio

de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula. 2Instituto de

Neurociencias Biomédicas (BNI). 3Servicio de Oftalmología, Hospital Clínico, Universidad de

Chile. 4Laboratorio de Estrés Celular y Biomedicina, ICBM, Facultad de

Medicina.4Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad

Católica de Chile. Santiago, Chile. 5Biomedical Research Consortium Chile (BMRC), Alameda

440, Piso 13. Santiago, Chile.

(237) Role of androgens in the angionenesis induced by carcinoma-associated stroma from

invasive human prostate cancer. Coronado R, Montecinos V, Cerda-Infante J, Conejeros P,

Godoy A. Hematology-Oncology & Physiology Departments. Pontificia Universidad Católica de

Chile. [email protected] (Sponsor: V. Torres).




(239) Active/latent TGF-beta ratio correlates with invasive grade in human mammary

tumors. Méndez N1., Tobar N

1., Bustamante E

2. and Martínez J

1.

1Laboratorio de Biología

Celular, INTA, U de Chile and 2Fundación Arturo López Pérez. [email protected]

(241) Detection of prostate specific mRNAs in bloodstream for prostate cancer diagnosis.

Sánchez, C.1; Fulla, J.

2; Campos, D.

1; Fleck, D.

1; Valdevenito, R.

3; García, V

1.; Oyanedel, F

1,

Sotelo, D1.; Ramos, C.

1.

1Urology Department, Clínica Las Condes,

2Urology Service, Hospital

San Borja Arriarán, 3Urology Service, Hospital Clínico de la Universidad de Chile.

[email protected] (Sponsor: Ch. Gonzalez).

(243) Clinical-molecular characterization of colon cancer tumors presenting microsatellite

instability. Cynthia Villarroel1, Ana María Wielandt

1, Daniela Simian

1, María Angélica

Garmendia2, Luis Contreras

2, Karin Alvarez

1, Francisco López

1, Pilar Carvallo

3.

1Oncology and

Molecular Genetics Laboratory. 2Anatomy Pathology Laboratory, Clínica Las Condes.

3Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia

Universidad Católica de Chile. [email protected] (Sponsor: F. Muñoz).

(245) Decreased Sulfo-Lewis moieties correlate with low sulfotransferase activity and high

cytokine levels in salivary glands from Sjögren’s syndrome patients. I. Castro, MJ Barrera,

S. Aguilera, S. Indo, S. González, C. Molina, C. Leyton, U. Urzúa and MJ González. ICBM-

Facultad de Medicina, Universidad de Chile. [email protected]

(247) Restoration of nNOSμ function in the mdx mouse model of Duchenne muscular

dystrophy. Rebolledo DL1, Adams ME

2, Whitehead NP

2, Kim MJ

2, Inestrosa NC

1, Froehner

SC2.

1P. Universidad Católica de Chile.

2University of Washington. [email protected]

(249) Novel multiplex real-time PCR for specific detection of Piscirickettsia salmonis. Ronie

Haro, Alejandro Yáñez, Paulina Calquín. Instituto de Bioquímica, Universidad Austral de

Chile, Valdivia, Chile. [email protected]

(251) Effects of fucoidan from Macrocystis pyrifera on proliferation, adhesion and

migration of MDCK cells. Sebastian Ramirez1,2

, María Elena Reyes2, Betty Matsuhiro

2 y

Pablo Nelson2. 1Universidad Santo Tomás. 2 Universidad de Santiago. (Sponsor: C. Acuña).

SPECIAL POSTER

Iniciativa Escolar-Científica: el pez cebra, un medio didáctico para acercar la enseñanza

de las ciencias experimentales a los colegios. 1Torres D.,

1Valenzuela J.,

1González C.,

2Velásquez G.,

2Montaña N.,

2Munzenmayer E.,

3Ríos I.,

1Bravo I.,

2Mansilla L.,

2Hernández S.,

3,4Ubillo L.,

4Soto C.,

4Pereiro L. &

4Allende M.

1Colegio Carlos Oviedo Cavada, Fundación

Belén Educa. Av. Agua Santa 2800, Maipú, Santiago. Chile. 2Liceo Comercial El Pilar. Anibal

Pinto 550, Ancud, Chiloé. Chile. 3Instituto Nacional José Miguel Carrera. Arturo Prat 33,

Santiago. Chile. 4Centro FONDAP de Regulación del Genoma, Facultad de Ciencias,

Universidad de Chile. Las Encinas 3370, Santiago. Chile.

13:00 – 14:30 Lunch

14:30 – 16:30 Symposium “Wnt Signaling Pathway in Postsynaptic Region”

Volcanes Room

Chair: Nibaldo C. Inestrosa

Role of Wnt pathways on late stages of postsynaptic development at the vertebrate NMJ. Juan Pablo Henríquez, Jessica Mella, Jorge Ojeda, Viviana Pérez, Daniel Sandoval.






Department of Cell Biology and CMA Bio-Bio, Universidad de Concepción, Concepción, Chile.

[email protected]

Participation of Ror2 in the regulation of NMDA-receptor synaptic transmission by Wnt

signaling. Waldo Cerpa. Departamento de Biología Celular y Molecular, Facultad de Ciencias

Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. Department of Physiology

and Biophysics, University of Washington, Seattle, WA, USA. [email protected]

Wnt signaling in the hippocampus: from synapse assembly to adult neurogenesis. Lorena

Varela-Nallar. Centro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas y

Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile. [email protected]

Wnt-Dvl signalling regulates dendrite morphogenesis. Silvana B. Rosso. Facultad de

Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Rosario, Argentina.

[email protected]



16:30 – 18:30 Poster Viewing Session III: 169-251 Even Numbers


Coordinators: Cecilia Riquelme – Andrea Soza – Elías Utreras – Soledad Matus

(170) Actin cytoskeleton regulation of Cx26 and Cx43 hemichannels. Jara O., Maripillán J.,

Garcia IE, Ewer J., and Martinez AD. Centro Interdisciplinario de Neurociencia de Valparaíso.

Universidad de Valparaíso, Valparaíso, Chile. [email protected]

(172) α-SNAP regulates N-cadherin-based adherens junctions and survival of granulosa

cells: insights from an in vivo model. Zahady D. Velásquez1, Alexis Arcos

1, Diego Gianetti

1,

Gabriela Toro1, Matilde De Paola

3, Marcela A. Michaut

3, Luis F. Batiz

1,2.

1IAHP and

2CISNe,

UACh, Valdivia, Chile. 3IHEM, UNCuyo, Mendoza, Argentina. [email protected]

(174) Impact of CNM-linked dynamin-2 mutations on actin cytoskeleton dynamics in

muscle cells. Fernando Hinostroza1, Valentina Haro-Acuña

1,2, John Ewer, Pablo Caviedes

2, Ana

María Cardenas1, Arlek González-Jamett

1,2. (1)Centro Interdisciplinario de Neurociencias de

Valparaíso, Universidad de Valparaíso, Chile. (2)Instituto de Ciencias Biomédicas, Universidad

de Chile, Chile. [email protected]

(176) ApoER2 degradation is regulated by ligand binding, ubiquitination and the splice

variant expressed. Fernanda Navarro A, María Karla Ramirez, Maria Luisa Benitez, Pamela

Farfán, Jorge Larios and María Paz Marzolo. Depto. Biología Celular. Molecular, Fac.

Ciencias Biológicas. Pontificia Universidad Católica de Chile. [email protected]

(178) Implementation of a pulse-chase system to study ER to Golgi trafficking in neurons.

Daniela A. Salas, Andrés Couve. Physiology and Biophysics and Biomedical Neuroscience

Institute, ICBM, Faculty of Medicine, University of Chile. [email protected]

(180) Role of androgens in human endothelial cell homeostasis. Jaime Lizama1, Verónica

Torres-Estay1, Paula Sotomayor

2, Javier Cerda-Infante

3, Viviana P. Montecinos

3, Gary J. Smith

4

and Alejandro S. Godoy1,4

. Departments of Physiology1 and Hematology-Oncology

3, Pontificia

Universidad Católica de Chile, Santiago, Chile; Departments of Medicine2 and Urology

4,

Roswell Park Cancer Institute, Buffalo, NY. (Sponsor: G. Owen).






(182) In stromal mammary cells, TGF-β1 and Glucose availability stimulate lactate

production and expression of Glucose and monocarboxylates transporters. Tobar N. and

Martinez J. Laboratorio de Biología Celular y Molecular, INTA, Universidad de Chile.

[email protected]

(184) Morphological studies of phagocytic cells from salmon (Salmo salar). Karen

Navarrete1,2

, Paz Reyes2, Vivian Wilhelm

2, Mario Rosemblatt

1,2,3.

1Facultad de Ciencias

Biológicas; Universidad Andrés Bello; 2Fundación Ciencia & Vida;

3Facultad de Ciencias,


(186) Astrocytes, microglia and oligodendrocytes of animals gestated under

hipothyroxinemia have altered their response to an inflammatory insult. Ma. Cecilia

Opazo1,2

, Gabriela Zúñiga1,2

, Pablo Gonzalez1,2

, Eduardo Albornoz1,2

, Pablo Cisternas1,2

, Susan

Bueno2,3

, Alexis M. Kalergis2,3

and Claudia Riedel1,2

. 1Universidad Andrés Bello.

2 Instituto

Milenio de Inmunología e Inmunoterapia. 3 Pontificia Universidad Católica de Chile.

[email protected]

(188) Dopamine receptor D5 expressed on CD4+ T-cells differentially regulates the

development of autoimmunity. Carolina Prado1, Francisco Contreras

1,2, Rodrigo Pacheco

1,3.

1Fundación Ciencia y Vida,

2Universidad Andrés Bello.

3Universidad San Sebastián, Santiago,


(190) Systemic and local immune characterization of conditional transgenic mice which

over-express TNF-specifically in nociceptive tissues. Rozas, P., Lazcano, P., Barrios, M.,

Gonzalez-Billault, C. and Utreras, E. Department of Biology, Faculty of Science, Universidad de


(192) Contribution in cellular immunity of B1b cells against an intracellular pathogen

model. Darwin Sáez, Giovanni Concha, Emilia Escalona y Ángel Oñate. Laboratorio de

Inmunología Molecular. Departamento de Microbiología. Facultad de Ciencias Biológicas.


(194) Modulation of the antiviral response in cells of atlantic salmon in vitro. Soto-Aguilera

S1., Valenzuela B

1., Cortez-San Martin M

2., Modak B

3., Imarai M

1.

1Laboratorio de

Inmunología, 2

Laboratorio de Virología, 3Laboratorio de Química de Productos Naturales.

Centro de Biotecnología Acuícola. Facultad de Química y Biología. Universidad de Santiago de

Chile.

(196) Selenium and resistance to Piscirickettsia salmonis infection in Atlantic salmon.

Rodrigo Pulgar, Francisco Altimiras, Verónica Cambiazo. Laboratorio de Bioinformática y

Expresión Génica, INTA-Universidad de Chile and Center for Genome Regulation (CGR).

[email protected]

(198) Characterization of SRPKs expression in neurons and their role in synaptic

assembly. Yocelin Cruz, Duxan Arancibia, Pedro Zamorano. Faculty of Health Sciences,

University of Antofagasta, Chile. [email protected]

(200) Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-

nicotinic acetylcholine receptor activation. Juan A. Godoy and Nibaldo C. Inestrosa. Center

for Aging and Regeneration (CARE), Department of Cell and Molecular Biology, Faculty of

Biological Sciences, P. Catholic University of Chile. [email protected]






(202) Novel function of the UPR transcription factor XBP1 in the regulation of learning

and memory. G. Martínez, F.G. Serrano, R.L. Vidal, C. Wirth, P. Valdés, C. Molina, P.

Thielen, C. Hidalgo, B. Schneider, B. Kerr, J.L. Valdés, L.H. Glimcher, N.C. Inestrosa and C.

Hetz. BNI, University of Chile - CARE, P. Catholic University of Chile, HSPH, Harvard, USA

and WCMC, Cornell University, USA. [email protected]

(204) Octodon degu: brain evidence of the oxidative and metabolic stress age dependent

related with Alzheimer-like pathology. Juvenal A. Ríos, Cheril Tapia-Rojas, and Nibaldo C.

Inestrosa. Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas,

Departamento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile.

[email protected]

(206) LSD1 associated complexes in the early development of the cerebral cortex. Saud K1,

López C1, Aguilar R

2, Bustos F

2, Montecino M

2, Kukuljan M

1.

1Biomedical Neuroscience

Institute, Faculty of Medicine, Universidad de Chile. 2FONDAP Center for Genome Regulation

and Center for Biomedical Research, Universidad Andrés Bello. [email protected]

(208) Analysis of a new allosteric c-Abl tyrosine kinase inhibitor for the potential treatment

of Alzheimer disease. Andreas Tapia L.1

, Lisbell Estrada1,2

, David Chamorro1, Silvana

Zanlungo3 and Alejandra Alvarez R.

1,2.

1Laboratorio Señalización Celular, Depto. de Biología

Celular, 2CARE-Chile-UC, 3Depto. de Gastroenterología, Escuela de Medicina, Pontificia


(210) Neuronal antioxidant defense contribution of astrocytes-derived exosomes Paulina

Troncoso-Escudero1, Felipe Beltrán

1, Leandro Torres-Diaz

1, Felipe Court

2, Maite A. Castro

1.

1I.

Bioquímica y Microbiología, Universidad Austral de Chile, 2D. Fisiología, Pontificia


(212) Lithium induces changes in the neuronal activity and distribution of the Wnt

pathway components. Roxana M. Ureta, Carolina A. Oliva and Nibaldo C. Inestrosa. Center

for Aging and Regeneration (CARE), Department of Cell and Molecular Biology, Faculty of

Biological Sciences, P. Catholic University of Chile. [email protected]

(214) Electrophysiological characterization of OFF bipolar cells in rat retina. Alex Vielma

and Oliver Schmachtenberg. Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad

de ciencias, Universidad de Valparaíso, Chile. [email protected]

(216) c-Abl tyrosine kinase promotes amyloidogenic APP processing in Niemann-Pick type

C disease model. Yáñez MJ1,2,3

, Beblin O4, Lleó A

4, Alvarez AR

1,2, Zanlungo S

3.

1Cell

Signaling Lab, Cellular & Molecular Biology, Biological Sciences Faculty, 2CARE-Chile-UC,

3Departament of Gastroenterology, School of Medicine, P. Universidad Catolica de Chile,

Santiago, Chile. 4Neurology Department, IIB-Santpau, Hospital de la Santa Creu i Sant Pau,

Barcelona, Spain. [email protected]

(218) The mitochondrial fission protein Fis1 is required for proliferation and

differentiation of erythropoietic cells. Alvaro Gonzalez, Erik Jensen, Rodrigo Bustos and

Alvaro A. Elorza. Experimental Bioenergetics Laboratory, Center for Biomedical Research,

Universidad Andres Bello. [email protected]

(220) Pulling forces drive tissue morphogenesis and protect cell fate specification during

zebrafish laterality organ development. Eduardo Pulgar1,2

, Felipe Santibañez1,2

, Steffen

Härtel1,2

, Miguel Concha1,2

. 1Laboratory of Experimental Ontogeny & Laboratory for Scientific

../../../../../../../David/AppData/Local/Temp/[email protected]




Image Analysis, ICBM, Faculty of Medicine, University of Chile; 2Biomedical Neuroscience

Institute, Santiago, Chile. [email protected]; [email protected]

(222) STAT3 activation in response to spinal cord injury in Xenopus laevis. Víctor Tapia and Juan Larraín. Center for Aging and Regeneration and Millennium Nucleus in Regenerative

Biology. [email protected]

(224) C-terminal tail of BMP receptor type II modulate morphological differentiation of

motor neuron-like cells. Diego Zelada1, Daniela Díaz

1, Juan Pablo Henríquez

2 and Nelson

Osses1. 1

Institute of Chemistry, P. Catholic University of Valparaiso and 2Department of Cell

Biology and CMA Bio-Bio, University of Concepción, Chile. [email protected]

(226) The astrocyte proteoglycan Syndecan-4 participates in Thy-1-dependent inhibition of

neurite outgrowth. Burgos-Bravo F.1.2.

, Maldonado H.1.2.

, Quest A.F.G.1., Leyton L.

1.2.

1.Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula

(CEMC), 2.Instituto de Neurociencias Biomédicas (BNI), ICBM-Facultad de Medicina,


(228) Pax7 is phosphorylated during the myogenic progression of muscle satellite cells.

Natalia González1, John Yates III

2 and Hugo Olguín

1.

1 Departamento de Biología Celular y

Molecular, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile. 2Department of

Chemical Physiology, the Scripps Research Institute; La Jolla CA. USA. [email protected]

(230) Angiotensin 1-7 decreases myonuclear apoptosis in skeletal muscle atrophy induced

by Angiotensin II. Meneses, C., Morales, M.G., Cabello-Verrugio, C. Laboratorio de Biología

y Fisiopatología Molecular, Facultad de Ciencias Biológicas, Universidad Andrés Bello.

[email protected]

(232) Evolution the osteogenic regulatory network: dramatically different fates for recently

duplicated genes. David Muñoz1, Patricia Hanna

1, Laurent Sachs

2, Nicolas Buisine

2, Sylvain

Marcellini1.

1Laboratory of Development and Evolution, University of Concepción;

2CNRS,

Paris, France. [email protected]

(234) The Osterix gene promoter sequence is demethylated through a DNA-

hidroxymethylation step mediated by Tet1. Hugo Sepúlveda and Martín Montecino. Center

for Biomedical Research and FONDAP Center for Genome Regulation, Faculty of Biological

Sciences and Faculty of Medicine, Andres Bello University.

[email protected]

(236) Down-regulation of Rab5 decreases characteristics associated with cell

transformation. Patricio Silva1, Nicolás Soto

1, Jorge Díaz

1,2, Andrew F.G. Quest

2 and Vicente

A. Torres2. 1

Laboratory of Cellular and Molecular Biology, Faculty of Dentistry, Universidad de

Chile. 2Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Faculty

of Medicine, Universidad de Chile. [email protected]

(238) Gene mutations and deletions inactivate PTEN tumor suppressor in chilean colon

cancer patients. Karin Álvarez1, Paulina Orellana

1, Ana María Wielandt

1, Cynthia Villarroel

1,

Carolina Rehbein1, Rodrigo Oyarzún

1, Daniela Simian

1, María Angélica Garmendia

2, Luis

Contreras2, Udo Kronberg

1, Francisco López

1, Pilar Carvallo

3.

1Oncology and Molecular

Genetics Laboratory. 2Anatomy Pathology Laboratory, Clínica Las Condes.

3Department of Cell

and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de

Chile. [email protected] (Sponsor: M.S. Depix).









(240) Effect of Cx43 expression in the proliferation and metastasis of human melanoma

cells. Israel Guerrero, Sebastian Sabanegh, Alejandra Gleisner, Ignacio Avalos, Joaquín López,

Flavio Salazar-Onfray. Antitumoral Immunology Laboratory, Faculty of Medicine, University of


(242) A viral dsRNA analog inhibits tumor growth and increases tumor-bearing mice

survival. David Nocera; Nicolás Núñez; Gerardo Gatti; Estefania Zacca; Gabriel Moron;

Mariana Maccioni. CIBICI-CONICET. Fac.de Cs. Qcas. UNC. Córdoba. Argentina.

[email protected]

(244) Characterization of the process of vasculogenic mimicry in human trophoblasts.

Andrés Valdivia1, Barbara Oliva

1, Dusan Racordon

1, Juan Carlos Saez

1, Gareth I. Owen

1,2.

1Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

2Biomedical

Research Consortium of Chile (BMRC). [email protected]

(246) Location of survivin as a potential indicator of ovarian cancer progression. 1,5

Bravo,

ML., 2,5

Kato, S., 2Abarzua-Catalan, L.,

3Barriga, MI.,

3Le-Cerf, P.,

1,5Oliva, B.,

4Alonso, C.,

4Bravo, E.,

1,5Owen, GI.,

2,5Cuello, M.

1Facultad de Ciencias Biológicas

2Facultad de Medicina,

Pontificia Universidad Católica de Chile. Hospitales: 3Sotero del Rio,

4Gustavo Fricke.

5Biomedical Research Consortium of Chile.

(248) Evaluation of the effects of non-filter coffee on the development of non-alcoholic

steatohepatitis (NASH) in a murine model. Oyarzún J.E., Balboa E., Quintero P,. Solís N.,

Pizarro M., Zanlungo S., Arrese M. Departamento de Gastroenterología, Facultad de Medicina,

Pontifícia Universidad Católica de Chile. [email protected]

(250) ACE2 overexpression correlates with a decreased expression of fibronectin in

dystrophic skeletal muscle. Riquelme, CA, Torrejon, J, Acuña, MJ and Brandan, E. Center for

Aging and Regeneration (CARE), School of Biological Sciences; Catholic University of Chile.

[email protected]

18:30 – 19:30 Plenary Lecture Programa Doctorado en Ciencias Fisiológicas

P. Universidad Católica de Chile

Volcanes Room

Chairs: Nibaldo C. Inestrosa and Renán Orellana

Exercise and Eating Patterns as Determinants of Brain Health. Mark P. Mattson.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program,

Baltimore, USA.

19:30 – 20:30 Society Members Meeting


Volcanes Room

Chair: Mauricio Gonzalez

Essential fatty acids to support brain development. Ricardo Uauy. Public Health Nutrition

Division, Instituto Nutrición y Tecnología de Alimentos (INTA), Universidad de Chile.

Santiago, Chile.



21:30 Awards Ceremony

Volcanes Room

Nikon - Loncotec: Best Images in Cell Biology

Genexpress: Best Presentations in Oral and Poster Communications

22:00 Dinner

Documents

CHILEAN SOCIETY FOR CELL BIOLOGY XXVII … SOCIETY FOR CELL BIOLOGY XXVII ANNUAL MEETING October, 23 – 27th, 2013 Puerto Varas SPONSORS INSTITUTO MILENIO Y ANILLO CENTRO INTERDISCIPLINARIO