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Child Development and the Brain:
Promoting Resilience and Joy
Adele Diamond, PhD, FRSC
Canada Research Chair Professor of
Developmental Cognitive Neuroscience
University of British Columbia (UBC)
What abilities and
skills will children
need to be successful
in the 21st century?
What will it likely take to be successful in the
21st century?
1) Creative Problem-solving
• Coming up with new ideas, hypotheses and
Inventions.
• If one way of solving a problem isn’t
working, how else might we succeed here?
Can we think outside the box to come up
with a way of attacking this no one else has
considered before?
2) Flexibility
• Seeing opportunities and seizing them:
I was planning to do X, but an amazing
opportunity has arisen to do Y, do I have
the flexibility to take advantage of
serendipity?
• My opinion was X, but now that I see this
new information, I’m able to change my
opinion.
• Being able & willing to change course
when it seems you were wrong
When one door closes, another
door opens;
but we often look so long and so
regretfully upon the closed door,
that we do not see the ones which
open for us.
- Alexander Graham Bell
An example of poor
cognitive flexibility:
3) Self-control
Having the self-control to resist temptations and
not act impulsively -- be able to:
• think before you speak or act -- give a con-
sidered response instead of an impulsive one
• not over-indulge or indulge in the wrong things
• resist saying something socially inappropriate
(or hurtful)
• resist ‘tit for tat’ (hurting someone because
that person hurt you)
• resist jumping to an interpretation of what
something meant or why it was done
4) Discipline / Perseverance
Having the discipline to stay on task…
seeing it through to completion despite
unexpected problems, some aspects
being boring or perhaps frustratingly
difficulty, & tempted by lots of things far
more fun
continuing to work at something though the
reward may be a long time in coming
Evidence shows that discipline
accounts for over twice as
much variation in final grades
as does IQ, even in college.
(Duckworth & Seligman, 2005)
Question:
How do creativity,
flexibility, self-control, &
discipline map onto the 3
core EFs?
ALL of them are
“Executive Functions”
or rely on them
The 3 core Executive Functions are:
• Cognitive Flexibility
(including being able to switch perspectives
& see things in a new light)
• Inhibitory Control
(which includes self-control & discipline)
• Working Memory
Higher-order Executive Functions are:
• Problem-solving
• Reasoning
• Planning
Inhibitory control includes being able to
(1) stay focused despite distraction
SELECTIVE or FOCUSED ATTENTION
(2) stay on task (& complete task)
though tempted not to - DISCIPLINE
(3) inhibit acting impulsively & instead
make a more considered response (not
putting your foot in your mouth, not
hitting, not drinking too much, dieting)
SELF-CONTROL
Children with less inhibitory control (i.e.,
children who were less persistent, more
impulsive, and had poorer attention regulation)
as adults 30 years later have…
worse health
earn less
and commit more crimes
than those with better inhibitory control as
young children,
controlling for IQ, gender, social class, & home
lives & family circumstances growing up
across diverse measures of inhibitory control.
That’s based on a study of 1,000 children born
in the same city in the same year followed for 32
years with a 96% retention rate.
by Terrie Moffitt et al. (2011)
Proceedings of the Nat’l Academy of Sci.
Since inhibitory control’s “effects follow a linear
gradient, interventions that achieve even small
improvements in [inhibitory control ] for
individuals could shift the entire distribution of
outcomes in a salutary direction and yield large
improvements in health, wealth, and crime rate
for a nation.”
Inhibitory control predicts
academic performance in
the earliest elementary
grades through university
better than does IQ.
(b) Working Memory:
Holding information in mind
and mentally working with it
Working memory is critical for
making sense of anything that
unfolds over time, for that always
requires holding in mind what
happened earlier & relating that
to what is happening now.
relating one idea to another
relating what you read (or learned /
heard) earlier to what you are
reading (learning / hearing) now
mental math calculations
understanding cause and effect
remembering multi-step instructions
& executing them in the correct order
Reasoning would not be possible
without working memory, for
reasoning requires holding bits of
information in mind and seeing
how they relate. Working memory
enables us to consider the past
and possible future in making
plans and decisions.
being able to easily & quickly switch
perspectives or the focus of attention,
flexibly adjusting to changed demands
or priorities,
being able to think outside the box.
(c) COGNITIVE FLEXIBILITY
For example, try to think of as
many uses for a TABLE as you
can.
What are all the things you might
use a table for?
A table might be used to write on or to
eat food on.
It might be turned on its side and used
to keep a door closed or used as a
shield against bullets or snowballs.
You could get under it to hide or to keep
dry.
You could cut it up for firewood.
How can we stop ourselves from get really upset
when a child misbehaves? What we usually get
upset about is the intent we think is behind an
action.
Could use Cognitive Flexibility to re-frame:
A child might be acting in the most awful manner
because he has been terribly hurt and is afraid of
being hurt again, so he will push you away before
you have a chance to reject him or he will test you to
see if are really someone he can feel safe with.
If we see the misbehavior as coming from hurt,
we can react completely differently.
“Executive Functions”
depend on Prefrontal
Cortex and the other
neural regions with which
it is interconnected.
Unusual properties of the
prefrontal dopamine system
contribute to PFC’s
vulnerability to environmental
and genetic variations that
have little effect elsewhere.
The best mechanism from clearing
away released dopamine is by
dopamine transporter (DAT)
protein.
Dopamine transporter is
abundant in the striatum
but sparse in prefrontal cortex.
The dopamine transporter gene
(DAT1) and the striatum are
implicated most in the impulsive
& hyperactive aspects of ADHD
whereas PFC is implicated most
in the cognitive deficits.
Levels of hyperactive-
impulsive symptoms are
correlated with the number
of DAT1 high-risk alleles
but levels of inattentive
symptoms are not
(Waldman et al., 1998)
Most children (about 90%) with ADHD
(combined or hyperactive types) - -
respond positively to methylphenidate
(Ritalin)
and over 67% of them respond positively
to methylphenidate in moderate to high
doses.
Barkley et al., 1991; Barkley, 2001; Milich
et al., 2001; Weiss et al., 2003
The dopamine transporter
moves dopamine from the
synapse back into the sending
neuron.
Methylphenidate blocks the
dopamine transporter (i.e.,
blocks re-uptake), causing an
increase in dopamine
concentration at the synapse.
Synapse
Dopamine
Dopamine receptor
Mechanism of Action of Methylphenidate in High Doses
A significant percentage of
children with ADHD-IA are not
helped by methylphenidate and
those who are helped often do
best at low doses.
(Barkley et al., 1991; Barkley, 2001;
Milich et al., 2001; Weiss et al., 2003)
The doses of MPH that are optimal
for controlling behavioral problems
are too high for aiding the
cognitive problems
indeed they can have the effect of
the patient being less able to
concentrate & attend (more in a
daze)
Recent research show that low
doses of MHP (dosages likely
to be effective in treating
ADHD-IA) preferentially
increase dopamine release in
the prefrontal cortex.
(Berridge et al., 2006)
I predict that many children with
ADHD are being prescribed a level of
MPH that is too high for optimal
performance in school
and that the high level of MPH is
actually impairing their ability to get
as much out of class (listening or
reading) as they could without
medication.
How do you usually determine whether
a particular dose of MHP is optimal
for a child?
Usually you ask his/her parents.
Usually parents base their answer on
whether the child’s behavior is
better.
No one uses cognitive measures to see
if the children’s attention, working
memory, or any other EFs are better.
My hypothesis is only that --
just a hypothesis
But I would encourage you to get
cognitive testing done to determine the
optimal medication type & dosage --
for a younger children it could be the
NEPSY; for a child 10 or older it could
be the Delis-Kaplan Battery, for ex.
Unusual properties of the
prefrontal dopamine system
contribute to PFC’s
vulnerability to environmental
and genetic variations that
have little effect elsewhere.
Prefrontal Cortex & Executive
Functions are the first to suffer,
& suffer disproportionately, if
we are
• sad or stressed
• lonely or
• not physically fit
To show the EFs they are capable of, to
achieve the academic outcomes they
are capable of, children need to
• feel joyful and relaxed (not stressed)
• feel they are in a supportive
community they can count on, and
• their bodies need to be fit and healthy.
Amy Arnsten, 1998 The biology of being frazzled
Science
This is particularly true for PFC & EFs.
Our brains work better
when we are not in a
stressed emotional state.
Even mild stress increases DA release
in PFC but not elsewhere in the brain
Stress and Prefrontal Cortex
(Roth et al., 1988)
Stress impairs EFs and can cause
anyone to look as if he or she has
an EF impairment (like ADHD)
when that is not at all the case.
(You may have noticed that when
stressed you cannot think as
clearly or exercise as good self-
control.)
In college students, one month of stress in
preparation for a major exam disrupts
prefrontal cortex functional connectivity.
Stress decreases coupling between left DL-PFC and right DL-
PFC, and between DL-PFC and premotor cortex, the ACC, the
insula, posterior parietal cortex (PPC), and the cerebellum.
Stress impairs their attention shifting (shifting
between attending to color or motion).
Liston et al. (2009) PNAS
Desseilles et al., 2009 von Hecker & Meiser, 2005
When we are sad we’re worse at
filtering out irrelevant information
(i.e., worse at selective attention).
When we are happy we are better at
selective attention.
Gable & Harmon-Jones, 2008
THE most heavily researched predictor of
creativity in social psychology is mood.
The most robust finding is that a happy mood
leads to greater creativity (Ashby et al. 1999).
It enables people to work more flexibly (Murray
et al. 1990) & to see potential relatedness
among unusual & atypical members of
categories (Isen et al. 1985, 1987).
People show more creativity
when they are happy
Hirt et al. 2008: 214
If you’re stressed,
you cannot be the parent
[or clinician] you want to be.
If you’re stressed,
your children [your clients] will
pick on it.
It will cause them to feel
stressed.
And if they’re stressed… their
EFs will suffer & therefore their
school performance will suffer.
You’re not perfect.
You’re going to make
mistakes.
That’s OK.
You don’t need to be perfect.
Besides, no one ever is.
I can guarantee that worrying
about whether you’re a good-
enough parent [or clinician] will
NOT improve your parenting
[therapeutic effectiveness] – it
will only make it worse.
RELAX
Imperfect ≠ Worthless
Your humanity is more
important than your
knowledge or skill or doing
the textbook-perfect thing.
Jerome Frank conducted a study
comparing several different forms of
psychotherapy to one another.
He concluded:
“A totally untrained therapist who
exercises a great capacity to love
will achieve psychotherapeutic
results equal to the best.”
Results of a poll by the British Medical
Journal:
The majority of respondents said:
“A good doctor, is first and
foremost, a good human being.”
Your caring -- your openness to
truly listen; being there for your
child [your client] when he or she
needs you -- is more important
than your knowledge or skill.
The spirit rather than the technique.
Who do you prefer to hear -- the musician who
plays from the heart or the musician with
absolutely perfect technique but no heart?
You can do the textbook-perfect thing, but if it
doesn’t come from the right place, it will not have
the desired result. You can mess up, but if it
comes from the right place, it will be all right.
Relax: Your ability to truly care, and to be
genuinely present for them, is what is most
important.
The most powerful way to
communicate to our children that we
care about them is to listen to them.
Truly listen.
Give them our time and our attention.
The quality of our listening, rather
than the wisdom of our words, is often
what has the most impact.
It is extremely important that
parents take time to SLOW DOWN
and give their child their undivided
attention. The importance of that
cannot be over-emphasized.
“Children who are truly loved…know
themselves to be valued. This knowledge is
worth more than any gold.
“The principal form that love takes is giving of
your time, and truly listening. When
something is of value to us we spend time with
it. When we love our children, we give them
our time.... True listening, total concentration
on the other, is always a manifestation of love.
-- Scott Peck, The Road Less Traveled
“Your willingness to listen is the best possible
concrete evidence of your esteem that you
can give your child. There is no better and
ultimately no other way to teach your children
that they are valuable people than by valuing
them.
When children know that they are valued…
they feel valuable….This feeling of being
valuable is the cornerstone of discipline
because when one considers oneself valuable
one will take care of oneself in all ways that
are necessary. Self-discipline is self-caring.”
-- Scott Peck, The Road Less Traveled
“Perhaps the most important thing
we ever give each other is our
attention. And especially if it's given
from the heart…”
“Listening is the oldest and perhaps
the most powerful tool of healing.”
-- Dr. Rachel Naomi Remen
Sometimes we’re so busy doing
for our children, we forget how
important it is to take time to
simply be with them.
(p.11)
Mindful Listening means staying fully in the
present moment, giving your child [your client]
your full, undivided attention.
That’s not so easy.
To do that you need to set aside your own worries
and preoccupations, thinking about what you
need to do next, even trying to anticipate where
your child’s train of thought is going or whether
you are sufficiently in tune with your child.
Listening with your heart as well as your head --
listening not just to the words but to what’s
unspoken.
“The greatest gift
I can conceive of
having
from anyone
is
to be seen by them,
heard by them,
to be understood.”
-- Virginia Satir
But it is so worth it:
It's so powerful is to be heard
/ understood –
and to be liked anyway
When we interrupt to try to show
we understand, we move the focus of
attention to ourselves.
Because we care, we are tempted
to want to do ‘more’ than ‘just’ listen.
But what a child needs most is for us to
listen. Truly listen.
Don’t rush to try to problem-solve or
suggest solutions. Be patient; give your
child time. Let solutions emerge from
the child.
Fire
What makes a fire burn
is space between the logs,
a breathing space.
Too much of a good thing,
too many logs
packed in too tight
can douse the flames
almost as surely
as a pail of water would.
So building fires
requires attention
to the spaces in between,
as much as to the wood.
When we are able to build
open spaces
in the same way
we have learned
to pile on the logs,
then we can come to see how
it is fuel, and absence of the fuel
together, that make fire possible.
We only need to lay a log
lightly from time to time.
A fire
grows
simply because the space is there,
with openings
in which the flame
that knows just how it wants to burn
can find its way. - Judy Brown
When a child doesn’t feel
understood, little things can
become BIG issues.
In Gottman’s studies, if the wife felt she
was being heard the marriage was
essentially divorce-proof.
Gottman JM & Levenson RW. (1999). Rebound
from marital conflict and divorce prediction.
Family Process. 38(3):287-92.
“Differences must be grasped, even if no
problems are solved. One of the reasons
empathy works so well is because it does
not require a solution. It requires only
understanding.”
John Medina, Brain Rules for Baby
We bring with us issues from our own past that
impair our ability to listen. Experiences that are
not fully processed may create unresolved and
leftover issues that influence how we react to
our children. These issues can easily get
triggered in the parent-child relationship.
At these times, we’re not acting like the parent
we want to be and are often left wondering why
parenting sometimes seems to “bring out the
worst in us.
Siegel & Hartzell (2004)
When we have an unresolved
issue...we’re not really listening to our
children because our own internal
experiences are being so noisy that’s all
we can hear.
We are no longer making thoughtful
choices about how we want to parent or
teach, but are reacting on the basis of
experiences in our past.
Siegel & Hartzell (2004)
The major insight of Mary Main et al. (1985): the direct
intergenerational transmission of relationship patterns,
while relatively common, is NOT inevitable.
Some parents who experienced abusive or rejecting
relationships growing up have children who are securely
attached to them.
What distinguished that group of parents, from other
parents with similarly unfortunate childhoods whose
own children were insecurely attached, was their ability
to discuss adverse childhood experiences with
emotional openness, coherence, and reflective insight.
They seemed to have come to terms with what had
happened to them, and had gained an understanding
why their parents had behaved as they did.
Inge Bretherton
Outcome of secure vs. insecure
attachment:
It’s better to be securely
attached.
But outcome is AS GOOD for
those insecurely attached IF they
have organized their attachment
experience into a coherent story.
Zeigarnik Effect: the mind
keeps working on things that
aren’t complete.
Coming to an understanding
allows closure.
Zeigarnik, 1967
One way to get closure is to write. Writing forces a
degree of structure and organization of one’s
thoughts. When writing, the thinking process has to
slow down.
The act of repeatedly telling about your experience
results in both an organization of the event and a
summarizing of it. Over days, the description of the
event is gradually shortened and summarized.
Constructing stories -- day by day, as you write, the
episode takes on shape as a coherent story.
Any type of event is less overwhelming and
easier to think about once it is summarized.
Once organized, events are often smaller and
easier to deal with.
If you can get people to talk or
write about their problems, their
psychological and physical health
improves.
--- James Pennebaker,
Opening Up: The Healing Power
of Expressing Emotions
Putting Feelings Into Words
Produces Therapeutic Effects
on the Brain
When you put feelings into words, you
increase activation in prefrontal cortex and
that produces a reduced response in the
amygdala.
PFC Stress
Matt Lieberman et al., 2007
Amygdala activation went up in ALL conditions when an
angry or fearful face was shown, but ONLY in the one
condition (a) where subjects had to assign a verbal label
to the emotion, did amygdala activation GO DOWN.
Inverse Relation between Activation in PFC and
the Amygdala in the Lieberman et al. study
(When activation in PFC goes up, activation in the
amygdala goes down.)
Translating an emotional
experience into language,
talking or writing about, alters
the way it is represented and
understood in our mind and our
brain (gets prefrontal cortex
more involved).
To reduce stress in
children’s lives…
Pets can reduce stress
The presence of a dog in the classroom
reduces stress and helps children
perform better.
Gee, N. R., Church, M. T., & Altobelli, C. L. (2010). Preschoolers make
fewer errors on an object categorization task in the presence of a dog.
Anthrozoös, 23, 223-230.
Gee, N. R., Crist, E. N., & Carr, D. N. (2010). Preschool children require
fewer instructional prompts to perform a memory task in the presence of
a dog. Anthrozoös, 23, 173-184.
Gee, N. R., Harris, S. L., & Johnson, K. L. (2007). The role of therapy dogs
in speed and accuracy to complete motor skills tasks for preschool
children. Anthrozoös, 20, 375-386.
Beetz, A., Julius, H., Turner, D., & Kotrschal, K. (2012). Effects of social support by
a dog on stress modulation in male children with insecure attachment. Frontiers in Psychology, 3.
Beetz, A., Kotrschal, K., Turner, D. C., Hediger, K., Uvnäs-Moberg, K., & Julius, H.
(2011). The effect of a real dog, toy dog and friendly person on insecurely attached
children during a stressful task: An exploratory study. Anthrozoös, 24, 349-368.
Pets teach us about
gentleness, patience, &
never holding a grudge
Animals love us unconditionally,
ask little in return, & don’t even
require eye contact.
Exercise Reduces Stress
Exercise in almost any form can
act as a stress reliever.
Being active can boost your feel-
good endorphins and distract
you from daily worries.
Virtually any form of exercise, from
aerobics to a nature hike to yoga, can act
as a stress reliever.
Regular exercise can lower symptoms
associated with mild depression or
anxiety.
Exercise can also improve your sleep,
which is often disrupted by stress,
depression and anxiety.
All this can ease your stress levels and
give you a sense of command over your
body and your life. Mayo Clinic
Williamson et al. (2001) Mood change through physical exercise in
nine- to ten-year-old children. Perceptual Motor Skills. 93(1):311-6.
64 9 & 10-year-old children responded to a self-report mood
measure after two different types of aerobic exercise of 15 min.
Significant increases in positive mood and significant decreases in
negative mood were found after each exercise treatment
Annals of Behavioral Medicine (1999): College students who
exercised regularly coped with stress better and had 37% fewer
physical symptoms than those who did not exercise regularly.
Sedentary students had 21% more anxiety than the students who
exercised regularly.
Lane & Lovejoy (2001) The effects of exercise on mood changes:
the moderating effect of depressed mood. Journal of Sports
Medicine and Physical Fitness, 41:539-545
Exercise improved the mood of depressed individuals. 80
volunteers took a mood test prior to an aerobics class; 52 were
determined to be in a depressed mood. The questionnaire was
given again after the class. Participating in the class improved the
mood of depressed individuals and reduced feelings of anger.
Predictability
Consistency
Clear expectations
Clarity about what is & is not permitted
Stable routine
Things in their place
Know what to expect
It is inevitable that misunderstandings, arguments,
& other breakdowns in communication will occur.
Being aware that this has happened is essential
before you can repair your relationship with your
child [client].
We have to take responsibility for our actions. An
important aspect of repair is to acknowledge our
own role in the disrupted connection: “I’m sorry I
was cross with you when you came in late without
even listening to what you had to say about why you
were late.”
Several Montessori activities are
essentially walking meditation,
though Montessori never called
them that.
Walking meditation is more age-
appropriate for little kids than
sitting meditation.
An activity from
Montessori schools, that
is essentially a type of
walking meditation.
Everyone (even the
grown-ups) gets a bell
and walks in a line or
circle. The goal is
for no one’s bell to
make a sound.
You've never failed until you've tried for the
last time, and you've never lost until you quit.
-- Samuel Proctor Massie
Few people have attained the respect, admiration, and degree of
excellence achieved by Samuel Massie, born in the segregated South.
Born in Little Rock, Arkansas in 1919, Samuel
Massie was the grandson of slaves. In 1966 he
became the first African-American professor at
the US Naval Academy. He was named 1 of the
6 best college chemistry professors in the US &
one of the 75 premier chemists of the 20th
century, along with Marie Curie, James Watson,
and Francis Crick. In 1995 Dr. Massie’s portrait
was hung in the National Academy of Science
gallery and in 2002 the US Dept. of Energy
chose to name its Chairs of Excellence in the
environmental sciences in his honour.
It should help to ease one’s stress & self-recriminations to remember:
It’s never over
‘til it’s over
One of the most important findings
to emerge from neurobiology is
that biology is not “destiny.”
Neuroscience research has shown
that experience plays a far larger
role in shaping the mind, brain, and
even gene expression than ever
imagined.
Very little is fixed or unchangeable.
90% of our genes are switched off.
To a large extent, our experiences, and
our reactions to them, determine which
genes get turned on (& off), when this
happens, & which genes stay on
(epigenetics).
Experience also sculpts the brain,
and the brain changes throughout life
(neuroplasticity).
We need to let children know
that it is okay to make a
mistake; everyone makes
mistakes.
The only alternative is to
stay with what you already
know, to stop growing.
Anyone who has never
made a mistake has never
tried anything new.
- Albert Einstein
Children need to feel safe
…to push the limits of what they know,
…to venture into the unknown,
…to take the risk of making a mistake or of
being wrong.
Children cannot relax if they’re
worried you might embarass them.
“No matter if he does it wrong – do
not correct him or he will retire into
his shell.” -- Maria Montessori
When a toddler falls while trying to
learn to walk, we don’t say he gets
a ‘D’; we say, “Don’t worry; I know
you’re going to be able to do this.”
Communicate loud and
clear the faith and
expectation that your
child [client] will succeed.
Powerful Role of
Expectations (by others AND yourself)
and Attitude
Pygmalion in the Classroom -- powerful
role of expectations Robert Rosenthal
Stereotype threat - female performance on
math exams Claude Steele
“Treat people as if they
were what they ought to be
and you help them become
what they are capable of
being.”
– Johann W. van Goethe
Children need to believe in themselves.
They need to have confidence that they
will succeed.
Two routes to that:
• They need to feel you believe in them -
that you fully expect them to succeed.
&
• They need do-able challenges. We need
to give children the opportunity to do
things that enable them to see for
themselves that they are capable.
Children need opportunities to do
things that enable them to see for
themselves that they are capable:
do-able challenges.
(research studies by Duckworth, 2010; Lewis
& Goldberg, 1969; White, 1960)
Pride and self-confidence (and joy)
come from seeing yourself succeed at
something that you know is not easy.
Another way to show children
we believe in them and have
faith in them is to give them an
important responsibility.
the ‘Coca Cola’ study
Because PFC does not have much
dopamine transporter, PFC is more
dependent on secondary mechan-
isms (such as the COMT [catechol-
O-methyltransferase] enzyme) for
clearing dopamine from extra-
cellular space than are other brain
regions, such as the striatum.
COMT Gene
catechol-O-methyltransferase
gene
codes for the COMT enzyme,
which methylates released
dopamine.
It’s located on chromosome 22.
A single base pair substitution
CGTG to CATG
translates into a substitution of
Methionine for Valine at codon 158
Catechol-O-methyltransferase (COMT) Val158 Met
High dopamine
Zalsman et al.
Low activity
enzyme
High activity
enzyme Low dopamine
SYNAPSE
The Methionine variant of
the COMT gene is
associated with better PFC
function and better
executive functions.
This is specific to EFs:
There is no relation
between COMT genotype
and IQ or other non-PFC
functions.
too little too much
Optimal level of DA in PFC
PF
C F
un
cti
on
ing
Dopamine:
The Optimum Level of Dopamine
in PFC is an Intermediate Level
too little too much Met-158
Val-158
Optimal level of DA in PFC
Differences in COMT Genotypic
lead to Differences in PFC DA Levels
Dopamine:
What’s the downside
of Met variant of
COMT?
Even mild stress increases DA release in
PFC but not elsewhere in the brain
Stress and Prefrontal Cortex
(Roth et al., 1988)
Genotypic Difference in PFC DA Levels
leads to Genotypic Differences in Stress
Reactivity
too little too much Met-158
Val-158
Effect
of Mild
Stress
Val/ Val COMT
Met / Met COMT
Buckert et al. (2012): Under stress, young adults homozy-
gous for COMT-Met158 showed worse EF performance
than young adults homozygous for COMT-Val158
Persons homozygous for
COMT-Met158 tend to
be more sensitive to stress Buckert et al. 2012; Armbuster et al. 2012
have higher anxiety Olsson et al. 2005
and have heightened pain stress
responses Zubieta et al., 2003
Diatchenko et al., 2005
It has long been known that some of
the brightest people also have the
most fragile personalities and are
highly reactive to stress.
Here’s a possible mechanism for
why the two might go together.
Persons homozygous for the MET
variant of the COMT gene (which
results in more DA in PFC), tend to
have better executive function, but
also tend to be more sensitive to
stress, have higher anxiety, and
higher pain stress responses.
Zubieta et al., Science (2003)
It has long been known that some of
the brightest people also have the
most fragile personalities and are
highly reactive to stress.
Here is a possible mechanism for
why the two might go together.
re: dandelion & orchid children
‘Dandelions’ are children who do okay
wherever they are planted. They are
often seen as models of resilience.
Perhaps children homozygous for
COMT Val-158 are the dandelions;
they will do okay even in a stressful
environment, but might lack the
exquisite fine-tuning of prefrontal
cortex needed to achieve the
brilliance of which a COMT Met-158
child might be capable.
Research shows that some of the
children who look the worst when they
are in an unsupportive, stressful
environment are exactly those who
blossom the most when in a good
environment.
Perhaps some children homozygous
for COMT Met-158 are among the
orchids -- they might look like a
disaster when in a stressful
environment, yet might blossom
brilliantly in the right environment.
The COMT Met-158 genotype, which
confers risk on individuals when they
are in adverse, stressful
circumstances, holds out promise of
extraordinary potential if only the
right fit of circumstances can be
found for the individual.
A child who is not doing well in
one environment, or with a particular
instructional style, might shine in
another environment or with a
different teaching approach.
We’re not just intellects,
we have emotions
we have social needs
& we have bodies
Our brains work better when we are
not feeling lonely or socially
isolated.
Loneliness: Human Nature and
the Need for Social Connection 2008
a book by John Cacioppo & William Patrick
This is particularly true for PFC & EFs.
Roy Baumeister et al. (2002, Journal of Personality and Social Psychology)
- One group of subjects were told beforehand they’d
have close relationships throughout their lives;
- another group was told the opposite;
- a third group was told unrelated bad news.
On simple memorization questions, the groups were
comparable.
On sections involving logical reasoning (EF),
subjects told they’d be lonely performed much worse.
Campbell et al. (2006) found that during math tests
there was Prefrontal Cortex worked less efficiently
among participants who felt isolated.
We are not just intellects,
we have emotions
we have social needs
& we have bodies
You need your sleep.
Lack of sleep will produce
deficits in EF skills, and cause
someone to look as if he or she
has an EF
impairment,
like ADHD.
Our brains work better when our
bodies are physically fit.
Nature Reviews Neuroscience (January 2008)
“Be Smart, Exercise Your Heart:
Exercise Effects on Brain and Cognition”
Charles Hillman, Kirk Erickson & Art Kramer
“There is little doubt that leading a sedentary life
is bad for our cognitive health.”
This is particularly true for PFC & EFs.
Nature Reviews Neuroscience (January 2008)
“Be Smart, Exercise Your Heart:
Exercise Effects on Brain and Cognition”
Charles Hillman, Kirk Erickson & Art Kramer
Evidence shows that physical activity (especially aerobic
exercise) robustly improves cognition and brain function.
In particular, the frontal lobe and the executive functions
that depend on it show the largest benefit from improved
fitness.
The positive effects of aerobic physical activity on
cognition and brain function are evident at the molecular,
cellular, systems, and behavioral level.
and there have been many more review papers
since 2008 including:
Streiner, D. L. (2009). The effects of exercise programs
on cognition in older adults: A review. Clinical Journal of
Sport Medicine, 19(5), 438.
Tseng, C. N., Gau, B. S., & Lou, M. F. (2011). The
effectiveness of exercise on improving cognitive function
in older people: A systematic review. The Journal of
Nursing Research, 19(2), 119-130.
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T. , &
Kramer, A. F. (2011). Exercise, brain, and cognition across
the lifespan. Journal of Applied Physiology, 111(5), 1505-
1513.
The brain doesn’t recognize the
same sharp division between
cognitive and motor function that
we impose in our thinking.
The SAME or substantially
overlapping brain systems subserve
BOTH cognitive and motor function.
For example, the pre-Supplementary
Motor Area (SMA) is important for
sequential tasks,
whether they are sequential motor
tasks or
sequential numerical, verbal, or
spatial cognitive tasks.
Hanakawa et al., 2002
Motor development and
cognitive development appear
to be fundamentally intertwined.
Diamond, A. (2000)
Close interrelation of
motor development and cognitive development
and of the cerebellum and prefrontal cortex.
Child Development, 71, 44-56
When cognitive development
is perturbed,
as in a neurodevelopmental
disorder,
motor development is often
adversely affected as well.
For example……
At least half of all children with ADHD have
poor motor coordination & fit the diagnosis
for developmental coordination disorder.
At least half of all children with develop-
mental coordination disorder have ADHD.
Similarly for dyslexia, autism, and other
disorders.
Diamond, A. & Lee, K.
(2011)
Interventions shown to Aid
Executive Function Development
in Children 4-12 Years Old
Science, vol. 333
accompanying online tables
Science asked me to write a review of all interven-
tions shown to improve EFs in young children
Diverse activities including
computer training, aerobics,
martial arts, yoga, mindfulness,
& school curricula have all been
shown to improve children’s
executive functions..
Exercise alone appears not to
be as effective in improving EFs
in children as exercise-plus-
character-development (tradi-
tional martial arts) or exercise-
plus-mindfulness (yoga).
Lakes & Hoyt (2004) randomly
assigned children in grades K
thru 5 (roughly 5-11 years-old)
by homeroom class to Tae-
Kwon-Do martial arts (N = 105)
or standard physical education
(N = 102).
Children who had been assigned to Tae-
Kwon-Do training showed greater gains
than children in standard phys. ed. on all
dimensions of EFs studied (e.g., cognitive
[distractible —focused] and affective
[quitting —persevering] - subtests of the
Response to Challenge Scale). This
generalized to multiple contexts and was
found on multiple measures. They also
improved more on mental math (which
requires working memory).
Traditional martial arts
emphasize self-control,
discipline (inhibitory control),
and character development.
In a study with adolescent juvenile
delinquents (Trulson, 1986), one
group was assigned to traditional
Tae-Kwon-Do (emphasizing qualities
such as respect, humility,
responsibility, perseverance, honor
as well as physical conditioning).
Another group was assigned to
modern martial arts (martial arts as a
competitive sport).
Those in traditional Tae-Kwon-Do
showed less aggression and anxiety
and improved in social ability and
self-esteem.
Those in modern martial arts
showed more juvenile delinquency
and aggressiveness, and decreased
self-esteem and social ability.
Whether EF gains are
seen depends on the
way an activity is done.
A few principles hold
across all programs.
Such as:
EFs need to be
continually challenged
to see improvements -
not just used, but
challenged.
Groups assigned to the same
program, but without difficulty
increasing, do not show EF gains.
Setting aside a time to work on EFs
is less effective than working on
EFs as part & parcel of everything
you do.
The Importance of
Repeated Practice
Whether EF gains are seen
depends on the amount of time
spent practicing, working on
these skills, pushing oneself to
improve.
To learn something new, we need
prefrontal cortex.
But after something is no longer
new, persons who perform best
recruit prefrontal cortex least.
Prefrontal cortex
(what I specialize in)
is over-rated.
Prefrontal
Cortex
TT
NS MT
DO
DC KO
RB
The DLPFC
Slice for
8 Individuals
CB
When something is new, those who
recruit PFC most, usually perform
best.
(Duncan & Owen 2000, Poldrack et al. 2005)
But when you are really good at it,
you are NOT using PFC.
(Chein & Schneider 2005, Garavan et al. 2000,
Landau et al. 2007, Milham et al. 2003, Miller et
al. 2003)
Older brain regions have had far longer to
perfect their functioning; they can subserve
task performance ever so much more
efficiently than can prefrontal cortex (PFC).
A child may know intellectually (at the level of
PFC) that he shouldn’t hit another, but in the
heat of the moment if that knowledge has not
become automatic (passed on from PFC to
subcortical regions) the child hit another
(though if asked, he knows he shouldn’t do
that).
knowing what one should do
vs.
2nd nature (automatic)
(i.e., NOT dependent on PFC)
The only way something
becomes automatic
(becomes passed off from
PFC) is through action,
repeated action.
Nothing else will do.
“We are what we repeatedly do.
Excellence, then, is not an act, but a habit.
We don’t act rightly because we have virtue
or excellence, but we rather have these
because we have acted rightly; these
virtues are formed in a person by doing the
actions;
we are what we repeatedly do.”
Aristotle, Ethica Nicomachea, 4th century BC
How can someone practice
a skill he or she is not yet
capable of performing?
The answer: Scaffolds
Scaffolds enable people to
practice skills they would not
otherwise be able to practice.
Buddy Reading
a scaffold
Almost any activity can be the
way in, can be the means for
disciplining the mind and
enhancing resilience.
MANY activities not yet
studied might well improve EFs.
It all depends on the spirit in which an
activity is presented, the way one does
the activity, and the amount of time
spent doing it, pushing oneself to do
better. The most important element is
probably that the child really want to do
it, so s/he will spend a lot of time at it.
It’s the discipline, the practice, that
produces the benefits.
Might as well have children
do something they can put
their heart and soul into.
El Sistema Orchestra
National Dance Institute
Provided free. It takes all children (even those
in wheelchairs). Has reached over half a million
children in some of the poorest areas.
Circus Arts
could be caring for an animal….
SERVICE ACTIVITIES
activities where the children are working to help
their community or people elsewhere
a goal larger than oneself --
helping children in Haiti, helping a
local family whose home burned
down, lobbying to get a new
playground for the neighborhood
These are acts of caring and generosity,
They require forethought , planning, and
perseverance even in the face of setbacks,
creativity and flexibility when unexpected
obstacles or opportunities arise, and
putting into use what they’ve learned in school.
Each is a member of a group working toward
an important shared goal.
Free the Children
Children Changing the World
More than 1.7 million youth involved
in innovative education and develop-
ment programs in 45 countries.
Educates, engages, and empowers
young people to be confident young
change-makers and lifelong active
citizens.
97% of their students now believe they
can make a difference in the world. 89%
confirm that their students are
more confident in their goal-setting
and completion.
85% find a greater atmosphere of caring
and compassion in the school. 90%
of their students have
demonstrated increased leadership
among their peers.
Educators whose students are engaged in Free the Children report:
In 2011, Mission Measurement conducted a survey of Free the
Children alumni to assess lasting impacts. The survey found that:
90% now believe they are responsible for
addressing social justice issues. 68%
gained a clear sense of their
aspirations and life’s intentions.
80% volunteered >150 hours the previous
year. 79%
of those of voting age voted in the
most recent national election—
double the rate of their peers.
For 10's of 1,000's of years, across all
cultures, storytelling, dance, art, & play
have been part of the human condition.
People in all cultures made music,
sang, danced, and played games.
There are good reasons why those
activities have lasted so long and been
found so ubiquitously.
Music-making, singing, dance, and
play address our physical,
cognitive, emotional, and social
needs.
They
challenge our executive functions,
make us happy & proud,
address our social needs, &
help our bodies develop
Because they challenge EFs directly,
and indirectly support EFs by
increasing joy,
a sense of belonging, &
physical exercise,
I predict they should improve EFs.
(and we’re hoping to get funding to test my prediction for
El Sistema Orchestra & for social, communal dance)
The Best of these Programs
Engage Child’s Hearts & Minds
JOY, PASSION – engage & motivate EMOTIONS
These are fun, rewarding activities!
HARD WORK, PERSISTENCE, DISCIPLINE
practice, practice, practice
HIGH STANDARDS – challenge the children
COGNITIVELY DEMANDING – challenge
concentration, sustained attention,
working memory (remember complicated
sequences), self-control COGNITIVE
SELF-CONFIDENCE, PRIDE
PROGRESS AT THEIR OWN RATE
SOCIAL SUPPORT / BELONGING – part of a
team or an ensemble of dancers or musicians.
Children help one another, listen to one other, &
respect one another. “We’re in this together.”
Each is an important part of the whole. SOCIAL
CLOSE MENTORING RELATIONSHIPS
“I care about you”
Only competition is with your own past perform-
ance - NO LOSERS - only winners - Children are
not left to flounder (scaffolds) or feel embarassed
PHYSICAL ACTIVITY - develop cardio fitness,
balance, coordination, strength, & flexibility)
PHYSICAL
Research shows that what brings people
the most happiness is not money or creature
comforts,
but rather feeling that what you are doing has
meaning, that it benefits others, that you are
united with others in trying to achieve an
important shared goal.
Happiness runs in a circular motion.
Often, what makes us happiest is making
others happy. Being kind to others is not only
good for others; it is good for YOU -- it is the
best route to genuine happiness.
Carol Ryff
to recap:
‘Executive Functions’ are
needed whenever going ‘on
automatic’ or relying on
instinct or intuition would be
ill-advised, insufficient, or not
possible.
“Brain-based” does NOT mean
immutable or unchangeable.
Experience and activity change the
brain.
EFs depend on the brain --
but they can be improved
by the proper activities
“We are what we repeatedly do.”
Aristotle
• The importance of repeated practice.
The only way something becomes automatic
(becomes passed off from PFC) is through
practice, repeated practice.
Nothing else will do.
Scaffolds can help someone practice a skill
that he or she could not perform unaided.
We are not just intellects,
we also have emotions
social needs
& bodies.
The different parts of the
human being are fundamentally
interrelated.
Each part (cognitive, spiritual,
social, emotional, & physical)
probably develops best when
no part is neglected.
Diamond, 2000
Our brains work better when
• we’re not stressed or sad
• we’re not feeling lonely or isolated
• we’re physically fit
Nowhere is the importance of
social, emotional, and physical
health for cognitive health more
evident than with PFC & EFs.
PFC & EFs are the first to suffer,
and suffer disproportionately, if
anything is wrong in our lives
(canary in the coal mine).
If we ignore that a child is
stressed, lonely, or not healthy
because of poor nutrition, lack
of sleep or lack of exercise
those unmet needs will work
against achievement of our goals
for this children’s development.
LISTEN
• Children need to feel understood and heard.
• They need to feel loved - that you care about
them.
• Slow down & take time to listen with your
undivided, complete attention. Don‘t rush to
try to problem-solve or suggest solutions.
Listen. Let the solutions emerge from the
child. When we try to fix others, we focus on
what’s wrong with them, instead of trusting
their strengths and potential.
RELAX
• You don’t have to be perfect, & worrying
about it won’t help.
• You are going to make mistakes & that’s
okay.
• It’s okay to be wrong. Imperfect ≠
worthless.
• If you’re stressed you can’t be the parent
you want to be.
• If you’re stressed, your children will be
stressed.
CHILDREN NEED TO
BELIEVE IN THEMSELVES.
THEY NEED TO KNOW YOU
BELIEVE IN THEM.
What nourishes the human
spirit may also be best for
Executive Functions.
Perhaps we can learn something
from the traditional practices of
people across many cultures &
1,000’s of years.
thank you for your attention
Mary
Gordon
Dan
Siegel
Susan
Goldin-Meadow
4th conference in the series:
Westin Bayshore Hotel, Vancouver, BC
w w w . b r a i n d e v e l o p m e n t a n d l e a r n i n g . c o m
Michael
Stryker
“For years I have seen people try to bring educa-tors together with health specialists, or either with researchers.
I have never seen any effort work as well as what you put together in Vancouver.”
-- Michael Meaney
Themes & Speakers for our July 2013 conference include:
CHILDHOOD TRAUMA: understanding its deep and diverse effects
but especially how we can help children recover, prosper, and shine
Speakers include:
Bessel van der Kolk, MD, his book Psychological Trauma was the first
integrative text on the subject, setting out far ranging impact of trauma
on the entire person and the range of therapeutic issues that need to
be addressed for recovery.
How Traumatic Memories Can be Stored in the Body & Released
Bruce Perry, MD, PhD, Senior Fellow (Child Trauma Academy), whose
work shows how childhood experiences, including neglect & traumatic
stress, change the biology of the brain, &, thereby, the health of the child.
The Impact of Trauma and Neglect on the Developing Child
Gabor Maté, MD, an expert on mind-body interrelations, and author of
When the Body Says No: The Cost of Hidden Stress
The Biology of Loss and Early Life Stress
PARENTING AND ATTACHMENT: how to help parents develop and
foster that important bond
Speakers include:
Dan Siegel, MD, Clinical Professor (UCLA), the author of The Mindful
Brain, Parenting from the Inside Out, Mindsight, The Developing Mind,
The Whole-Brain Child, and more.
Interpersonal Neurobiology of the Developing Mind: How Relationships and the Brain Interact to Shape Who We Are
Gordon Neufeld, PhD, is an expert on the wisdom & science behind
successful parenting. He has constructed a coherent model of
attachment and is able to convey it in a way that is understandable to all.
Relationship Matters: Harnessing the Power of Attachment
Mary Gordon, Founder of Roots of Empathy and an Ashokan Fellow, studies empathy in infants less than one year old.
Building on the Love between Parents and Newborns to Help Families Succeed
THE SOCIAL BRAIN: We are built for sociability; our mental and
physical health declines without it.
Speakers include:
John Cacioppo, PhD, Tiffany and Margaret Blake Distinguished Service
Professor of Cognitive and Social Neuroscience (U. of Chicago), author of
Loneliness: Human Nature and the Need for Social Connection.
Social Relationships Matter and Why We Need One Another
Matt Lieberman, PhD, Professor of Psychology (UCLA), uses
neuroimaging to unlike secrets of the human mind & personality.
The Social Brain and its Implications
Michael Elkin, MA, LMFT, practices and trains others across North
America and abroad in Internal Family Systems therapy.
Knowing and Healing Your Internal Family
The Importance of Self-Respect, of Deriving Pride and Self-
Confidence from seeing yourself accomplish something difficult
versus the Detrimental Effects of Paternalism.
(Remember the old attitude toward women, “Don’t worry your little
head, we’ll take care of you.”) Well, that paternalistic attitude can still
be found too often toward indigenous peoples and toward people with
disabilities such as blindness. That needs to change. Three impressive
and accomplished Native American speakers and 3 impressive and
accomplished blind individuals will speak at the conference and will
demonstrate by their very being the fallacy of that point of view.
Speakers include:
Joseph Gone, PhD, Professor of Psychology (U. of Michigan), of the
Gros Ventre tribal nation of Montana, explores the intersection of
evidence-based practices and cultural competence in mental
health services for Native peoples of North America.
Re-thinking Cultural Competence in Mental Health Treatment
The conference series began in 2006 & has doubled in size
each time because people find it so valuable.
99% of those who attended the last
meeting rated it *OUTSTANDING*!!
“One of the best conferences I have ever attended –
it was inspiring. I came away with new ideas to work on
and things to put directly into my pediatric practice.”
“Finally a conference that successfully bridges the gap
between Research & Practice.”
“I want to thank you for organizing a conference that I
consider to be the best of any conference I have attended
in my 22 years of working at GF Strong Rehabilitation
Centre. I have never spent 4 days straight sitting inside
dark rooms, wide awake, engaged and amazed.”
“Research and implications presented wonderfully well
with clarity and enthusiasm.”
Conference website: www.braindevelopmentandlearning.com
My thanks to the NIH (NIMH, NICHD, & NIDA), which has continuously funded our work since 1986, & to the Spencer Fdn, CFI, & IES for recently adding to our funding - and especially to all the members of my lab.