Chemistry of Lipids Prostaglandins

8/9/2019 Chemistry of Lipids Prostaglandins

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CHEMISTRY OF LIPIDSPROSTAGLANDINS

Dr Vijay Marakala

Dr. Vijay Marakala, MBBS, MD. Assistant professor

BIOCHEMISTRY SIMS RC


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EICOSANOIDS

Eicosanoids ar

!or"d!ro" #$car%onP&FA

arac'idoni

Eicosa

Pros(anoids

Pros(a)landins

PG

Pros(acyclins

PGI

-'a( is Eicosanoids. Classi/ca


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PROSTAGLANDINS


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PROSTAGLANDINS

-'yPG.

S(r,c(,r

Loca(ion


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Pros(a)landins Classi/ca(io

A010C

2I

PG S,%classi/ca(ion

30#04 PGF3 5PGF#α β

PROSTAGLANDINS6PG

No"ncla(,r

Classi/ca(io

n

S,%scri8(


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No"ncla(,r

Classi/ca(ion

S,%scri8(


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No"ncla(,r

Classi/ca(ion

S,%scri8(


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PROSTAGLANDINS

Hor"ons.

Pri"ary PG

O('r PG

PG

Ac( lik local'or"ons

39 na(,rally occ,r

PG

: ar !o,nd('ro,)'o,( (' %o


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PROSTAGLANDINS ; F&NC

E


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PGI#

Vasodila(a(ion

In'i%i(s 8la(l( a))r)a(ionPGA and PGE class 8ros(a)landins

lo>r %lood 8rss,r?

E


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PGF#

Ind,cin) la%o

E


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PGF;1ronc'ocons(ric(ion

PGE;1ronc'odila(or

E


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PGE#

In@ol@d in in=a""a(oryrs8ons

E


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PGE#

s,88rss

)as(ric acidscr(ion

E


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Firs( isola(d !ro" %lood 8la(l(s0 ('ro"

T!AT!A

S,%scri8( n,"%r dno(s n,"%r o! do,%

Ca8i(al l((rs dsi)na( class

Mos(co""o

n

T'ro"%o*ans 6T+7


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Incras 8la(l( a))r)a(

Vasocons(ric(ion

Mo%iliB in(racll,lar calc

S"oo(' ",scl con(rac(

1ronc'ocons(ric(ion

T'ro"%o*ans ; F&NCTI


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#E$%OTRI&ES 'ERE SO &AMED BECA$

'ERE I&ITIA##Y DESCRIBED I& #E$COCY

Gro,8d in(o classs 6A (o E7

s*ript n(+)er enotes n(+)er of

LTC

L,ko(rins 6LT7


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Incras c'"o(a*is

Facili(a( in=a""a(ion 5 allrac(ions

Con(rac(ion o! s"oo(' ",sc

1ronc'ocons(ric(ion

Vasocons(ric(ion

L,ko(rins ; F,nc(ion


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-Ti+e for

a sort )reak

/

0

0

1

0

2

0

3

0

4

0

5

0

6

0

7

0

"

0

/

0

0


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HYDROLYSISSAPONIFICATIO

NRANC

O+IDATIONHYDROGENATI

ON

CHEMICAL PROPERTITES O


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SAPONIFICATION T' 'ydrolysis o! !a(s %y alkali is calld sa8oni/c

rac(ion rs,l(sin (' !or"a(ion o! )lycrol and sal(s o! !a((y acidscalld soa8s


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HYDROLYTIC RANCIDIT -'n %,((r or o('r !a(s ar s(ord0

o!(n %co" rancid and 'nc ,n8ala( Rancidi(y is ca,sd %y (' )ro>(

"icroor)anis"s >'ic' scr( nBy"li8ass?

T's s8li( (' !a(s in(o )lycrol and!a((y acids?

T' !a((y acids i"8ar( ,n8lasan( odo,=a@o,r (o (' !a(?


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O+IDATIVE RANCIDITY Oils con(ainin) 'i)'ly ,nsa(,ra(d !a((y

ar s8on(ano,sly o*idiBd %y a("oso*y)n a( ordinary ("8ra(,rs? T' o*ida(ion (aks 8lac slo>ly and r

in (' !or"a(ion o! s'or( c'ain !a((y C(o C3$ and ald'yds >'ic' )

rancid (as( and odo,r (o (' !a(s? O*ida(i@ rancidi(y is o%sr@d

!r,n(ly in ani"al !a(s ('an in @)!a(s?


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HYDROGENATION

I( con@r(s ,nsa(,ra(d !a((y acid(ri)lycrids in(o sa(,ra(d !a((y acids?

Co""rcially 'ydro)na(ion is ,scon@r( li,id !a(s o! 8lan( ori)in (o

cookin) !a(s? Vanas8a(i dalda is o%(aind !ro" @)

oils ('ro,)' ('is 8rocss?


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FATS FACTS AND FANTA Irrs8c(i@ o! (' so,rc0 !a( is (' "os( conc

!or" o! di(ary nr)y? T'r is no s,c' ('in) as lo>;calori !a(? For >i)'( rd,c(ion0 (' only r,l is (o a( l

*rcis "or? N,(ri(ionally0 8oly,nsa(,ra(d !a((y acids P&F

considrd s,8rior? Fa(s o! ani"al ori)in ar sa(,ra(d >'ras @oils ar ,nsa(,ra(d?

Fis' oils (oo ar ,nsa(,ra(d and 'a@ lon)ln)(' !a((y acids?


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D CHEMISTRY

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Chemistry of Lipids Prostaglandins