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Chemistry is the called the centralscience because it not only impactsvirtually all fields of science andtechnology but also because it is acentral contributor to the modern lifethat society enjoys.
The PhD Program in Chemistry at theCity University of New York (CUNY)provides students with a strongfoundation in all areas of chemistry:analytical, biological, inorganic,materials, nano, organic, polymer,and physical.
Chemistry
Research Areas
• Analytical Chemistry • Inorganic Chemistry •Organometallic Chemistry• Biochemistry • Materials Chemistry • Polymer Chemistry• Biophysics • Medicinal Chemistry • Photochemistry• Chemical Biology • Nanoscience • Physical Chemistry• Computational Chemistry • Organic Chemistry • Radiochemistry
CUNY Chemistry• Diverse faculty• 100+ faculty mentors• 260+ papers per year
Interdisciplinary efforts• Molecular biophysics• Radiochemistry• Nanotechnology• Photonics• Medicinal chemistry• Computational chemistry
CUNY prides itself on the diversity of its faculty and students, in fact it receivedthe 2017 Stanley C. Israel Award for Advancing Diversity in the ChemicalSciences. Each student choses a research mentor from over 100 members of theCUNY doctoral faculty in Chemistry distributed among seven CUNY campusesand the CUNY Advanced Science Research Center that fosters interdisciplinaryinteractions. A flexible curriculum allows each student to personalize thecoursework to their specific needs. Additional training in professionalism, safety,pedagogy, and career opportunities are provided to ensure your career success.
The design principle that droveCUNY’s curriculum reform is thefact that the PhD is a researchdegree earned in the laboratorynot the classroom.
Our simple, flexible curriculumallows students to start theirthesis research in their firstsemester, complete theirclassroom coursework in the firstyear, and develop theprofessional and leadership skillsnecessary to be competitive intoday’s job market.
We provide innovative coursesincluding Chem 79051, ananofabrication laboratory taughtin the clean rooms of the ASRC.
The PhD is a research degree
Student comments
The chemistry Ph.D program at CUNY has allowed me to pursue my interest. I have greatlybenefited from my experience with my mentor, professors and fellow students.
Zhantong Mao (PhD 2015)
CUNY is dense with fantastic faculty, administrators and fellow students that collectivelyengender a strong likelihood of success.
Douglas Achan (PhD 2015)
Curriculum• five courses• two laboratory rotations• professional development• original research proposal
Innovative coursesChem 79051 “The Nanofab Lab”
All students admitted to the PhDProgram in Chemistry areawarded a CUNY ScienceScholarship. This five-year awardallows our student to concentrateon their research.
CUNY Science Scholars spendthe first year at the CUNYGraduate Center taking coursesand learning about the researchopportunities available to them.There is no teaching in year one.Students select a mentor andmove to their mentors campus bythe end of year one.
CUNY Science Scholars
Parental Accommodation
In recognition of the challenges of balancing the demands of doctoral study and parenting anew child, the Graduate Center’s Parental Accommodation Policy supports graduate studentparents in meet their family care obligations while they pursue their academic goals. The policyassists doctoral students immediately prior to and/or immediately following the birth oradoption of a young child by providing a semester of teaching reduction.
CUNY Science Scholarship• five year support package• no teaching in first year• competitive stipend• low-cost health insurance• tuition remission
Years 2-5 are spent at a CUNY campus focused on their dissertationresearch and perhaps teaching.
CUNY offers students theopportunity to do cutting-edgechemical research in a supportiveprogram that has the feel of asmall college while living in one ofthe world’s most dynamic cities.The PhD Program in Chemistry isunique amongst its peers in that itis a consortium of sevencampuses throughout New YorkCity. While all student receivetheir degree from the CUNYGraduate Center, they do theirresearch at one of the CUNYcolleges or the Advanced ScienceResearch Center. The size ofCUNY offers the resources to doworld-class science while workingat a campus with a small collegefeel.
World-Class Science + Intimate Setting
Research CentersThe jewel in the crown of CUNY’s multi-billion dollar investment in interdisciplinary scientific
research is the CUNY Advanced Science Research Center (http://asrc.cuny.edu). Brimming with
state-of-the-art instrumentation and expertise in nanoscience, structural biology, photonics,
environmental science, and neuroscience, it is open to all CUNY students and faculty. This
collaborative resource augments the resources and instrumentation found on each of the
CUNY campuses. In addition, students further their research efforts using the CUNY High
Performance Computing Center (http://www.csi.cuny.edu/cunyhpc/).
Participating Colleges• Brooklyn College• City College of New York• College of Staten Island• Hunter College• Lehman College• Queens College• York College
Publications
A.Bae, J.H., Wang, D., Hu, K., Mirkin, M.V.Surface-Charge Effects on Voltammetry inCarbon Nanocavities. Analytical Chemistry,2019, 91, 5530-5536.
B.Haddad, A., Comanescu, M.A., Green, O.,Kubic, T.A., Lombardi, J.R. Detection andQuantitation of Trace Fenanyl in Heroin bySurface-Enhanced Raman Spectroscopy.Analytical Chemistry, 2018, 12678-12685.
C.Li,W., Seredych, M., Rodrigues-Castellon, E.,Bandosz, T.J. Metal-free Nanoporous Carbon asa Catalyst for Electrochemical Reduction of CO2to CO and CH4 ChemSusChem 2016, 9, 606-616.
Research Areas
• Spectroscopy • Instrument development• Environmental Chemistry • Electroanalytical Chemistry• Art Conservation • Forensics
Analytical Chemistry is the science of measurement thatfocuses on the qualitative and quantitative analysis of chemicals.All types of instrumental analysis and electrochemistry can beused for the identification and quantitation of analytes. Theanalysis may require the separation of complex mixtures usingvaries types of chromatograph, data analysis, chemometrics andimproved experimental design. Modern analytical methodologiescan at times separate, identify and quantify the chemicalspresent in complex mixtures. Analytical chemistry is used invirtually all industries, government agencies, studies of agents inthe environment and forensics. In the American ChemicalSociety�s 2012 work survey, analytical chemistry was the mostpopular chemical specialty.
Analytical ChemistryProf. Robert P. Nolan, Subdiscipline [email protected]
PublicationsA. Kallontzi, S., Fabris, L., Jitianu, M.,
Hernendez, A., Jitianu, A., Klein, L.C. Goldnanoparticles in melting gels. Journal of Sol-Gel Science and Technology, 2019, 91,189-197.
B. Curado, N., Gimenez, N., Miachin, K.,Aliaga-Lavrijsen, M., Cornejo, M.A.,Jarzecki, A.A., Contel, M. Prepration ofTitanocene-Gold Compounds Based onHighly Active Gold(I)-N-HeterocyclicCarbene Anticancer Agents: Preliminary invitro Studies in Renal and Prostate CancerCell Lines, 2019, 14, 1086-1095.
C. Aussignargues, C., Pandelia, M.-E., Sutter,M., Plegaria, J.S., Zarzycki, J., Turmo, A.,Huang, J., Ducat, D.C., Hegg, E.L., Gibney,B.R., Kerfeld, C.A. Structure and Function ofa Bacterial Microcompartment Shell ProteinEngineered to Bind a [4Fe-4S] Cluster J.Am. Chem. Soc., 2016, 138 , pp. 5262-5270. (Issue Cover)
Research Areas• Coordination Chemistry • Organometallic chemistry• Synthesis and catalysis • Bioinorganic chemistry• Material science • Radiochemistry• Nanoscience • Surface science and catalysis
Inorganic Chemistry covers the synthesis and properties ofcompounds across the entire periodic table. This includesdiscrete coordination and organometallic compounds as well asnanoscale minerals. Eighteen faculty research groups at CUNYare studying various aspects of inorganic chemistry. Thisincludes its application in nanoscience, its importance inbiological systems, its role in catalysis, and its use in clinicalradiochemistry.
Inorganic ChemistryProf. Andrei Jitiano, Subdiscipline [email protected]
Publications
A. Dikiy, I., Edupugan0, U.R., Abzalimov,R.R., Borbat, P.P., Srivastava, M., Freed,J.H., Gardner, K.H. Insights into his0dinekinase ac0va0on mechanisms from themonomeric blue light sensor EL346.Proceedings of the Na0onal Academy ofSciences, USA, 2019, 116, 4963-4972.
B. Ben-Shalom, I.Y., Lin, C., Kurtzman, T.,Walker, R.C., Gilson, M.K. Simula0ngwater exchange to buried binding sites.Journal of Chemical Theory andComputa0on. 2019, 15, 2684-2691.
C. Perea, W., Schroeder, K.T., Bryant, A.N.,Greenbaum, N.L. Interac0on betweenthe Spliceosomal Pre-mRNA Branch Siteand U2 snRNP Protein p14Biochemistry, 2016, 55 (4), pp. 629-632.
Research Areas
• Biophysical mechanisms of ligand binding • Protein NMR• Structural Biology • Computational biophysical chemistry• Neutron scattering • Enzymology• X-ray Crystallography • Biotechnology
Molecular Biophysics seeks to understand essential biologicalprocesses in terms of physical chemistry. CUNY has over 30faculty working in this area. Research interests include themechanisms of signal transduction in cells, protein dynamics byneutron scattering and NMR, experimental and computationalanalysis of membrane protein structure and dynamics, andprotein design. Students are encouraged to contact anindividual faculty member to explore different researchopportunities.
Molecular BiophysicsProf. Thomas Kurtzman, Subdiscipline [email protected]
PublicationsA. Lampel, A., McPhee, S.A., Park, H—A.,
Scott, G.G., Humagain, S., Hekstra, D.R.,Yoo, B., Frederix, P.W.J.M., Li, T.-D.,Abzalimov, R.R., Greenbaum, S.G., Tuttle,T., Hu, C., Bettinger, C.J. Ulijn, R.V.Polymeric peptide pigments with sequenceencoded properties. Science, 2017, 356,1064-1068.
B. Moreira, I.P., Sasselli, I.R., Cannon, D.A.,Hughes, M., Lamprou, D.A., Tuttle, T., Ulijn,R.V. Enzymatically activated emulsionsstabilised by interfacial nanofibre networksSoft Matter, 2016, 12, 2623-2631.
C. Hernandez-Mainet, L.C., Chen, Z., Garcia,T.A., Bykov, A.B., Krusin-Elbaum, L.,Tamargo, M.C. Two-dimensional X-raydiffraction characterization of (Zn,Cd,Mg)Sewurtzite layers grown on Bi2Se3 Journal ofCrystal Growth, 2016, 433, pp. 122-127.
Research Areas• Nanotechnology • Materials Science• Surface chemistry and catalysis • Soft Materials and self-assembly• Quantum nanostructures • Energy technology• Light harvesting materials • Nanobiotechnology and nanomedicine
Nanotechnology and Materials Chemistry deals with innovation, design and discovery of materials for specific functions in the size regime, typically < 100 nm, in which physical properties (e.g. optical, electronic) are often significantly affected by size and structure. Nanotechnology has many potential applications, and continues to impact medicine, energy technology and electronics. The Advanced Science Research Center (ASRC) offers access to wide variety of techniques and training, enabling students to acquire a formidable skill set in materials fabrication and characterization.
Nanotechnology and Materials ChemistryProf. Stephen O’Brien, Subdiscipline [email protected]
PublicationsA. Valles, D.J., Naeem, Y., Carbonell, C.,
Wong, A.M., Mootoo, D.R., Braunschweig,A.B. Maskless Photochemical Printing ofMultiplexes Glycan Microarrays for High-Throughput Binding Studies. ACSBiomaterials Science & Engineering, 2019,5, 3131-3138.
B. Zhao, S., Gensch, T., Murray, B., Niemeyer,Z.L., Sigman, M.S., Biscoe, M.R.Enantiodivergent Pd-catalyzed C-C bondformation enabled through ligandparameterization. Science, 2018, 362, 670-674.
C. M.K., Akula, H.K., Satishkumar, S., Stahl, L.,Lakshman, M.K. Ruthenium-Catalyzed C-HBond Activation Approach to Azolyl Aminalsand Hemiaminal Ethers, MechanisticEvaluations, and Isomer InterconversionACS Catalysis, 2016, 6, 1921-1928. (IssueCover)
Research Areas• Organic Synthesis • Catalysis • Carbohydrate chemistry• Bioorganic Chemistry • Organometallic Chemistry • Synthetic methodology• Medicinal Chemistry • Materials Science • Natural products
Organic chemistry research at CUNY involves over 25 facultycovering the full range of modern organic chemistry from totalsynthesis of natural products, to novel method development, tomaterials and medicinal applications. Faculty have receivedprestigious national awards including Fulbright Fellowships andthe Harry Wasser Award. Our graduates go on to successfulpost-doctoral positions, careers in industry (Merck;GlaxoSmithKline; LivWell) and academia (Emory University,North Dakota State University).
Organic ChemistryProf. Ryan Murelli, Subdiscipline [email protected]
Publications
A. Sun, Y., Zhou, W., Moe, M.M., Liu, J.Reactions of water with radical cations ofguanine, 9-methylguanine, 2’-deoxyguanosine and guanosine: Keto-enolisomerization, C8-hydroxylation, and effectsof N9-substitution. Physical ChemistryChemical Physics. 2019, 20, 27510-27522.
B. Jang, S., Voth, G.A. Can quantum transitionstate theory be defined as an exact t = 0+limit? Journal of Chemical Physics, 2016,144, 084110.
C. Kang, M., Zhang, P., Cui, H., Loverde,S.M. π-π Stacking Mediated Chirality inFunctional Supramolecular FilamentsMacromolecules, 2016, 49, 994-1001.
D. Akinkunmi, F.O., Jahn, D.A.,Giovambattista, N., Effects of temperatureon the thermodynamic and dynamicalproperties of glycerol-water mixtures: Acomputer simulation study of three differentforce fields Journal of Physical Chemistry B,2015 , 119, 6250-6261.
E. Sharma, S.D., Kraft, J.J., Miller, W.A., Goss,D.J., Recruitment of the 40S ribosomalsubunit to the 3'-untranslated region (UTR)of a viral mRNA, via the eIF4 complex,facilitates cap-independent translationJournal of Biological Chemistry, 2015, 290,11268-11281.
Research Areas
• Spectroscopy • Energy conversion and storage• Kinetics and dynamics • Computational Chemistry• Fuel chemistry • Theoretical developments• Biophysical Chemistry • Chemical & dynamical processed in solution• Physical processes in nanomaterials
and nanostructures
Physical Chemistry focuses on the applications of state-of-the-art experimental and computational techniques and equipment,and theories of physics to the study of chemical and biologicalsystems. With over thirty experimental and theoretical physicalchemistry faculty, physical chemistry research ranges fromspectroscopy, kinetics and dynamics to material science, energyconversion, and life science.
Physical ChemistryProf. Jianbo Liu, Subdiscipline [email protected]
Publications
A.Drenscko, M., Loverde, S.M. Moleculardynamics simulations of the interactions ofphospholipid bilyaers with caprolactone.Molecular Simulation, 2019, 45, 859-867.
B. Ke, F., Yi, J., Zhang, S., Zhou, S.,Ravikovitch, P.I. Kruk, M. Structures anddimensions of micelle-templated nanoporoussilicase derived from swollen spherical micellesof temperature-dependent size. Journal ofColloid and Interface Science, 2019, 544, 312-320.
C.Liu, Y., Xu, Q., Lyons, A.M. Durable, opticallytransparent, superhydrophoic polymer films.Applied Surface Science, 2019, 470, 187-195.
Research Areas
• Polymer Synthesis • Materials Science• Biopolymers • Nanotechnology• Medical Applications •Computation & Simulation
Polymer Chemistry is is a multidisciplinary science thatdeals with the chemical synthesis and chemicalproperties of macromolecules. Over fifteen facultymembers conduct research in all areas of polymerchemistry from syntheses to application to nanosystems.Our students go on to careers in industry ( Merck, 3M,Agilent ) Government ( Navy & Army Research Labs) andacademia (SUNY Buffalo, Tsinghua, China).
Polymer ChemistryProf. Nan-Loh Yang & Michal Kruk, Subdiscipline [email protected]@csi.cuny.edu
Daniel L. Akins, Ph.D.Professor & Chair of Chemistry and BiochemistryThe City CollegeMarshak Science Building160 Convent AvenueNew York, NY [email protected]/~akins
Publications
"High-Yield Photolytic Generation of BrominatedSingle-walled Carbon Nanotubes and theirApplication for Gas Sensing," Deon Hines, MarkRümmeli, David Adebimpe and Daniel L. Akins,Chem. Commun., 50, 11568-11571 (2014).
"Controllable modification of electronic Structureof Carbon-Supported Core–Shell Cu@PdCatalysts for formic acid oxidation," Ren,Mingjun; Zhou, Yi; Tao, Feifei; Zou, Zhiqing;Akins, Daniel; Yang, Hui, J. Phys. Chem. C 118,12669−12675 (2014).
"Enhanced Raman Scattering by MolecularNanoaggregates (Invited Review Article)," DanielL. Akins, Nanomater Nanotechnol, 2014, 4:4.
"Highly alloyed PtRu black electrocatalysts formethanol oxidation prepared using magnesiananoparticles as sacrificial templates," LiangliangZou, Jing Guo, Juanying Liu, Zhiqing Zou, DanielL. Akins and Hui Yang, Journal of PowerSources, 248, 356-362 (2014).
"Vibrational and electronical properties offunctionalized single-walled carbon nanotubesand double-walled boron nitride nanotubes," M.Aydin and D. L. Akins in Physical and ChemicalProperties of Carbon Nanotubes. Edited by:Satoru Suzuki. ISBN 978-953-51-1002-6;Published 2013-02-27.
Dr. Akins has been aProfessor of Chemistryat The City College ofNew York since 1981,and director of theCUNY-Center forAnalysis of Structureand Interfaces since1988.
2014- current Professor & Chair, Department of Chemistry and Biochemistry.
1988-2015 Director, CUNY–Center for Analysis of Structures and Interfaces (CASI).
1981-2015 Professor of Physical Chemistry.1979-1981 Senior Scientist, Polaroid Corp.1968-1969 Postdoc: Institute of Molecular
Biophysics, The Florida State University.
1968 Ph.D.: University of California, Berkeley
Dr. Daniel L. Akins
Research Interests
Keywords:Syntheses of semiconductor and magnetic oxide nanoparticles and nanorods; spectroscopic anddynamical investigations of spontaneous and nonlinear laser Raman scattering by monomeric andaggregated molecules on surfaces; excited state dynamics and determination of photophysicalparameters for cyanine dyes and donor-acceptor Systems; quantum chemical calculations of porphyrinsand dye molecules.
Teresa J. BandoszProfessorDepartment of Chemistry and Chemical EngineeringMarshak Hall 1024160 Convent AveNew York NY, 10031tbandosz@ccny. cuny.eduwww.tbandosz.com
PublicationsJ.A. Arcibar –Orozco, T.J. Bandosz .Visible light enhanced removal of a sulfur mustard gas surrogate from a vapor phase on novel hydrous ferric oxide/graphite oxide composites. J. Mater. Chem. A, 2015,3, 220-231 N. A. Travlou, M. Seredych, E.Rodriguez-castellon, T. J. Bandosz. Activated carbon-based gas sensors: effects of surface features on the sensing mechanism J. Mater. Chem. A, 2015,3, 3821-3831C. Petit and T.J. Bandosz. Engineering adsorbent surfaces: Metal-organic framework/graphite oxide composites. C. Petit and T.J. Bandosz. J. Colloid Interface Sci., 2015 , 447, 139–151C. O. Ania, M. Seredych, E. Rodriguez-Castellon, T. J. Bandosz.Visible light driven photoelectrochemical water splitting on metal free nanoporous carbon promoted by chromophoric functional groups. Carbon 201479, 432–441.T. J. Band, E. Rodriguez-Castellon, J.M. Montenegro, M. Seredych. Photoluminescence of Nanoporous Carbons: Opening a New Application Route for Old Materials. Carbon 2014, 77, 651–659.
Research InterestsKeywords: nanomaterials, Graphene, separation, energy storage, sensing, photoactivity
Dr. Bandosz’s research focuses on development of new nanoengineered materials for environmentaland energy related applications. The research involves development of cutting edge carbonaceousnanomaterial for energy storage, visible light catalysts for oxygen reduction or water slitting, conductivitybased toxic gas sensors, and decontaminants for chemical warfare agents. We also work on the designof efficient separation media for removal of pollutants form gas and liquid phases. The materialssynthesized and investigated in our lab include: nanoporous carbons, graphite, graphene oxide,graphene, carbon nanotubes, Metal Organic Frameworks (MOFs), nanoporous metal (hydr)oxides, g-C3N4and various composites
2005- current Professor1996-2005 Assistant Prof. Associate Prof.1991-1996 Postdoc Syracuse University1989 PhD; Chem. Eng.Krakow Polytechnic
Dr. Teresa J. Bandosz
Elizabeth J. Biddinger, PhDAssistant ProfessorDepartment of Chemical EngineeringCity College of New York140th St. and Convent Ave., ST-311New York NY [email protected]://ebiddinger.ccny.cuny.edu/
Publications
• A.N. Karaiskakis, E.J. Biddinger, “Evaluation of Surface Reconstruction Impacts on Rough Electrodeposited Cu-Based Catalysts for CO2Electroreduction,” Energy Technology, 5 (2017), 901-910.
• S. Jung, E.J. Biddinger, “ElectrocatalyticHydrogenation and Hydrogenolysis of Furfural and the Impact of Homogeneous Side Reactions of Furanic Compounds in Acidic Electrolytes,” ACS Sustainable Chemistry & Engineering, 4 (2016), 6500-6508.
• S. Shrestha, M. Nagib, E.J. Biddinger, “Size-Controlled Synthesis of Palladium Nanospheres by Pulse Electrodeposition in 1-Butyl-3-MethylImidazolium Chloride Ionic Liquid,” Journal of The Electrochemical Society, 163 (2016), D74-D82.
• S. Shrestha, E.J. Biddinger, “Palladium Electrodeposition in 1-Butyl-1-Methylpyrrolidinium Dicyanamide Ionic Liquid,” Electrochimica Acta, 174 (2015), 254-263.
• J.D. Jimenez, S. Jung, E.J. Biddinger, “Ionicity of Silylamine-Type Reversible Ionic Liquids as a Model Switchable Electrolyte,” Journal of The Electrochemical Society, 162 (2015), H460-H465. Research Interests
Keywords: Electrochemistry, Catalysis, Electrocatalysis, Electrodeposition, Ionic Liquids,Carbonaceous Materials, Separations, Green Chemistry
The Biddinger Research Group utilizes a toolbox electrochemistry, catalysis and ionic liquids to tackle avariety of problems associated with green chemistry and sustainable engineering. Current projects includeinvestigation of copper electrocatalysts for CO2 electroreduction for synthesis of fuels and chemicals,electrochemical hydrogenation and hydrogenolysis of biomass for synthesis of fuels and chemicals,development of switchable electrolytes as reversible safety switches in batteries, electrodeposition in ionic
Prof. Biddinger is achemical engineerinterested in greenchemistry and sustainableengineering topics utilizingelectrochemistry, catalysisand novel solvents likeionic liquids.
2016 - current Assistant Professor, CUNY GraduateCenter Chemistry PhD Program
2012 - current Assistant Professor, CCNY ChemicalEngineering
2010 - 2012 Postdoctoral Fellow, Georgia Institute ofTechnology
2010 PhD Chemical Engineering, The OhioState University
Dr. Elizabeth J. Biddinger
liquids as a means of metal recovery and nanoparticle formation, andfunctionalization of carbons with ionic liquids as adsorbents in air filtration.
Mark R. BiscoeAssistant Professor of ChemistryThe City College of New York160 Convent Ave.New York, NY [email protected]://www.sci.ccny.cuny.edu/~mbiscoe/index.html
PublicationsLi, L.; Zhao, S.; Joshi-Pangu, A.; Diane, M.;Biscoe, M. R. J. Am. Chem. Soc. 2014, 136,14027-14030.
Li, L; Wang, C.-Y.; Huang, R.; Biscoe, M. R.Nature Chem. 2013, 5, 607-612.
Joshi-Pangu, A.; Biscoe, M. R. Synlett 2012, 23,1103-1107.
Joshi-Pangu, A.; Ma, X.; Diane, M.; Iqbal, S.;Kribs, R.; Huang, R.; Wang, C.-Y.; Biscoe, M. R.J. Org. Chem. 2012, 77, 6629-6633.
Joshi-Pangu, A.; Wang, C.-Y.; Biscoe, M. R. J.Am. Chem. Soc. 2011, 133, 8478-8481.
Joshi-Pangu, A.; Ganesh, M.; Biscoe, M. R. Org.Lett. 2011, 13, 1218-1221.
Research InterestsKeywords: Transition metal catalysis, Organic synthesis, Asymmetric synthesis
Broadly, research in the Biscoe group focuses on catalysis. The two major types of catalysis in which weare interested are transition metal catalysis and macromolecular catalysis. Our primary goals involve thedevelopment of practical and reliable processes for the construction of C–C and C–X (X = heteroatom)bonds. We are particularly interested in the development of new processes for the formation of commonstructural motifs of importance in medicinal chemistry and drug discovery.
Prof. Biscoe is anorganic/organometallicchemist interested in thedevelopment of newreaction methodologies forapplication in drugdiscovery.
2009- current Professor, City College of New York2005-2008 NIH Postdoctoral Fellow, MIT2000-2005 PhD, Columbia University
Dr. Mark R. Biscoe
Name: Zimei BuPosition: ProfessorAffiliation: City College of New YorkAddress: 160 Convent AvenueAddress: Marshak Science Bldg. Room 1336New York [email protected]: http://www.sci.ccny.cuny.edu/~zbu/
Publications• Controllable Activation of Nanoscale Dynamics in aDisordered Protein Alters Binding Kinetics. CallawayDJE, Matsui T, Weiss T, Stingaciu LR, Stanley CB,Heller WT, Bu Z., J Mol Biol. 2017;429(7):987-998.
• Visualizing the nanoscale: protein internal dynamicsand neutron spin echo spectroscopy. Callaway DJ, BuZ., Curr Opin Struct Biol. 2017; 42:1-5.
• Phosphatidylinositol 4,5-bisphosphate clusters thecell adhesion molecule CD44 and assembles aspecific CD44-Ezrin heterocomplex, as revealed bysmall angle neutron scattering. Chen X, Khajeh JA, JuJH, Gupta YK, Stanley CB, Do C, Heller WT,Aggarwal AK, Callaway DJ, Bu Z. J Biol Chem.2015;290(10):6639-52.
• Molecular conformation of the full-length tumorsuppressor NF2/Merlin--a small-angle neutronscattering study. Ali Khajeh J, Ju JH, Atchiba M,Allaire M, Stanley C, Heller WT, Callaway DJ, Bu Z., JMol Biol. 2014;426(15):2755-68.
• Ligand-induced dynamic changes in extended PDZdomains from NHERF1. Bhattacharya S, Ju JH,Orlova N, Khajeh JA, Cowburn D, Bu Z. J Mol Biol.2013;425(14):2509-28
Research Interests
•Keywords: Biophysics; Cell Signaling; Structure; Dynamics; Kinetics; Molecular Recognition; X-ray Scattering; Neutron Scattering
Our group studies the structure and dynamics of cell signaling proteins and macromolecular complexes that regulate cell adhesion, and the intracellular trafficking of membrane receptors and ion channels. These proteins function as molecular machines and switches that can fail to work properly for various reasons, causing diseases such as cancer. We employ biochemical, biophysical, and structural biology techniques, in particular small angle neutron and x-ray scattering (SAXS and SANS), to study the interactions of these proteins. We also develop methods of utilizing quasielastic neutron scattering, in particular neutron spin echo spectroscopy (NSE) to study protein dynamics and protein domain motions. We have developed a theoretical framework using non-equilibrium statistical mechanics to interpret the NSE data. These methods allow us to see, for the first time, the dynamics of protein complexes on nanometer scales. NSE fills an important information gap in our ability to study protein motion on sub-microsecond time scales and on nanometer length scales.
Dr. Bu’s group studiesthe structure anddynamics of proteincomplexes in cellsignaling, using neutronand X-ray scattering
2010- current Professor, CCNY2003-2010 Faculty, Fox Chase Cancer Center1999-2002 Chemist, NIST1994-1999 Postdoc, Yale University1994 PhD, Louisiana State University
Dr. Zimei Bu
Research Interests
Keywords: Actinides, f-block, Lanthanides, Luminescence, Mentoring relationships, Metal oxides, Nuclearfuel cycle, Radiochemistry, Redox chemistry
His research can be broadly defined as the fundamental chemistry of f-block and group VII metals. Thereare presently two major research aims associated with this theme:1. To develop the use of luminescence as a tool to understand the chemical speciation of lanthanides
and actinides in the environment, terrestrially and extra-terrestrially.2. To use soluble metal oxides (polyoxometalates) to fundamentally understand how actinide ions
interact with minerals at a molecular level.
He also studies the mentoring relationship and is working towards codifyingco- and multi-mentorship models in interdisciplinary research settings.
Dr. Benjamin P. Burton-Pye
Assistant ProfessorLehman College Department of Chemistry250 Bedford Park Blvd WestBronx, [email protected]
PublicationsM. Deri, S. Ponnala, P. Kozlowski, B.P. Burton-Pye,H. Cicek, C. Hu, J.S. Lewis, L.C. Francesconi, p-SCN-BN-HOPO: A Superior Bifunctional Chelator for ZrImmunoPET. Bioconj. Chem. 2015,DOI:10.1021/acs.bioconjchem.5b00572
F. Poineau, K.E. German, B.P. Burton-Pye, P.F.Weck, E. Kim, O. Kriyzhovets, A. Safonov, V. Ilin, L.C.Francesconi, A.P. Sattelberger, K.R. Czerwinski,Speciation of Technetium Peroxo Complexes inSulfuric Acid Revisited. J. Rad. Anal. Nucl. Chem.2015, 303(2), 1163-1167. DOI: 10.1007/s10967-014-3434-1
M.K. Bera, R.J. Ellis, B.P. Burton-Pye and M.R.Antonio, Structural Aspects of HeteropolyacidMicroemulsions, Phys. Chem. Chem. Phys., 2014, 6,22566-22574. DOI: 10.1039/c4cp03014a
D. McGregor, B.P. Burton-Pye, W. W. Lukens, andL.C. Francesconi, Insights into stabilization of the99TcVO core for synthesis of 99TcVO compounds. Eur.J. Inorg. Chem., 2014, 6, 1082-1089. DOI:10.1002/ejic.201301034
F. Poineau, B.P. Burton-Pye, A. Maruk, G.Kirakosyan, I. Denden, D.B. Rego, E.V. Johnston,A.P. Sattelberger, M. Fattahi, L.C. Francesconi, K.E.German and K.R. Czerwinski, On the Nature ofHeptavalent Technetium in Concentrated Nitric andPerchloric Acid, Inorg. Chimica Acta, 2013, 398, 147-150. DOI:10.1016/j.ica.2012.12.028
Benjamin Burton-Pyespecializes in the fundamentalchemistry of elements foundwithin the nuclear fuel cycle.His research focuses onmanipulating the coordinationenvironment around thesemetal ions and how that affectschemical, redox andphotophysical properties.
2015-Present Assistant Professor, Lehman College2013-2015 Radiochemistry Research Scientist,
Hunter College2010-2013 Research Associate, Hunter College2005-2010 Postdoc, Hunter College2004-2005 Postdoc, U of Manchester, UK2001-2004 PhD, U of Manchester, UK
Dr. Benjamin P. Burton-Pye
Elise ChampeilAssociate ProfessorJohn Jay College of Criminal Justice524 west 59th streetNew York, [email protected]://www.jjay.cuny.edu/faculty/elise-champeil
Publications
1- Aguilar W., Paz M. M., Vargas A., Clement C. C., Cheng S.Y., Champeil E. “Sequence-Dependent Diastereospecific and Diastereodivergent Crosslinking of DNA by Decarbamoylmitomycin C”, Chemistry a European Journal, 24, 2018 6030.2- Napolitano T. , Cheng S.Y., Nielsen B. , Choi C. , Aguilar W. , Paz M.M., Sapse A.M., Champeil E. “Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine”,Tetrahedron Letters, 58, 2017 597. 3- Cheng S. Y., Seo J., Huang B.T., Napolitano T. Champeil E. “Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation” International Journal of Oncology, 49, 20161815. 4- Bose A., Surugihalli C., Pande P., Champeil E., Basu A. K. “Comparative error-free and error-prone translesion synthesis of the N2 -2'-deoxyguanosine adducts formed by mitomycin C and its metabolite, 2,7-diaminomitosene, in human cells” Chemical Research in Toxicology, 29, 2016933.5- Champeil E., Cheng S. Y., Huang B.T., Conchero-Guisan M., Martinez T. , Paz M.M., Sapse A.M. “Synthesis of MitomycinC and Decarbamoylmitomycin C N2
deoxyguanosine-adducts” Bioorganic Chemistry, 65, 2016 90.
Research Interests
Synthesis of Mitomycin C and Decarbamoyl mitomycin C DNA adducts: Our aim is to synthesize DNAinterstrand crosslinks generated by decarbamoyl mitomycin C (DMC) and mitomycin C (MC) (MC a-ICLand DMC b-ICLs). In addition, the role of p21 in the upstream p53-independent signaling pathway inresponse to these crosslinks is examined.
Analysis of drugs (recreational and medicinal) in bio fluids using NMR spectroscopy.
Prof. Champeil is a syntheticchemist interested in the DNAalkylating drug Mitomycin C(MC). She synthesized MC-DNA Interstrand crosslinks todetermine how the localstructure of these adducts isresponsible for the differentbiochemical responsesproduced by cancer cells upontreatment.
2014- 2010 Current position2006-2010 Assistant professor (John Jay College)2003-2006 Postdoc (CUNY)2002 PhD, Trinity College, Ireland
Dr. Elise Champeil
Yu ChenAssistant ProfessorDepartment of Chemistry & Biochemistry, QueensCollege65-30 Kissena Blvd.Flushing [email protected]://chem.qc.cuny.edu/~ychen/homepage.htm
Publications
Das, S.; Hong, D.; Chen, Z.; She, Z.; Hersh, W.H.; Subramaniam, G.; Chen, Y. “Auto-TandemPalladium Catalysis: From Isoxazole to 2-Azafluorenone”, Org. Lett., 2015, 17, 5578-5581.
Domaradzki, M. E.; Long, Y.; She, Z.; Liu, X.;Zhang, G.; Chen, Y. “Gold-Catalyzed AmmoniumAcetate Assisted Cascade Cyclization of 2-Alkynylarylketones”, J. Org. Chem., 2015, 80,11360-11368.
Chen, Y.; Huang, C.; Liu, X.; Perl, E.; Chen, Z.;Namgung, J.; Subramaniam, G.; Zhang, G.;Hersh, W. H. “Synthesis of Dibenzocyclohepten-5-ones by Electrophilic Iodocyclization of 1-([1,1'-Biphenyl]-2-yl)-alkynones”, J. Org. Chem. 2014,79, 3452-3464.
Chen, Y.; Liu, X.; Lee, M.; Huang, C.; Inoyatov,I.; Chen, Z.; Perl, A. C.; Hersh, W. H. “ICl-Induced Intramolecular Electrophilic Cyclizationof 1-(4'-Methoxy-[1,1'-biphenyl]-2-yl)-alkynones—A Facile Approach toSpiroconjugated Molecules”, Chem. Eur. J.2013, 19, 9795-9799.
Long, Y.; She, Z.; Liu, X.; Chen, Y. “Synthesis of1-Aminoisoquinolines by Gold(III)-MediatedDomino Reactions from 2-Alkynylbenzamidesand Ammonium Acetate”, J. Org. Chem. 2013,78, 2579-2588.
Research Interests
Keywords: late transition metal catalysis, heterocyclic chemistry, asymmetric catalysis
The Chen group is working in the area of late transition metal mediated catalysis, heterocyclicchemistry and asymmetric catalysis. They have been developing new synthetic methods forbiologically interesting frameworks using Lewis acid mediated transformations of alkynes, andhave successfully developed new atom-economical routes for the synthesis of a variety of corestructures, including isoxazoles, 2-azafluorenones, isoquinolines, indenones,dibenzocyclohepten-5-ones, and etc.
The Chen group isinterested in late transitionmetal catalysis, heterocyclicchemistry and asymmetriccatalysis.
2009-current Current position2007-2009 Postdoc1999-2004 PhD
Dr. Yu Chen
Xi ChenAssistant ProfessorCUNY ASRC; Chemical Engineering, CCNY85 St Nicholas TerraceG.332New York, NY 10031Email:[email protected]
Publications
Xi Chen, Davis Goodnight, Zhenghan Gao,Ahmet-Hamdi Cavusoglu , Nina Sabharwal,Michael Delay, Adam Driks and Ozgur Sahin,Scaling up nanoscale water-driven energyconversion into evaporation-driven engines andgenerators, Nature Communications, 2015, 6,7346Xi Chen, L Mahadevan, Adam Driks and OzgurSahin, Bacillus spores as building blocks forstimuli-responsive materials andnanogenerators, Nature Nanotechnology, 2014,9, 137-141Xi Chen, Anton Li, Nan Yao and Yong Shi,Adjustable stiffness of individual piezoelectricnanofibers by electron beam polarization,Applied Physics Letters, 2011, 99, 193102Xi Chen, Jinwei Li, Guitao Zhang and Yong Shi,PZT nano active fiber composites for acousticemission detection, Advanced Materials, 2011,23, 3965–3969Xi Chen, Shiyou Xu, Nan Yao and Yong Shi, 1.6Volt Nanogenerator for mechanical energyharvesting using PZT nanofibers, Nano Letters,2010, 10, 2133-2137.
Research Interests
Keywords: Evaporation energy harvesting, water-responsive materials, nanotechnology.
Professor Chen develops the next generation of sensors, actuators, energy conversion and storagedevices by using novel nanostructured and bio-inspired functional materials. His recent work on water-responsive materials and evaporation-driven engines opens up a new field in energy harvesting andprovides opportunities towards solving current challenges in sustainable energy, energy storage, cleanwater, robotics, and medical technologies.
Dr. Chen is recognized as aleading scientist in the field ofenergy harvesting and smartmaterials. His work has led to anumber of publications in leadingscientific and popular journals,and has been featured inmainstream media, such as TheNew York Times, The WallStreet Journal, the WashingtonPost, NBC News, BBC, andmany others.
2016- current Current position2012-2016 Postdoc, Columbia University2005-2007 PhD, Stevens Institute of Technology
Dr. Xi Chen
Junyong ChoiAssistant ProfessorDepartment of Chemistry and BiochemistryQueens College of the City University of New York65-30 Kissena Blvd.Queens, [email protected]
PublicationsJY Choi, et. al., Compara've structuralanalysis and molecular design for thedevelopment of highly potent and selec'veagents targe'ng Matrix Metalloproteinase13, J. Med. Chem., 2017, 60, 5816-5825
CM Calvet, JY Choi, et. al., 4-aminopyridyl-based lead compounds targe'ng CYP51prevent spontaneous parasite relapse in achronic model and improve cardiacpathology in an acute model ofTrypanosoma cruzi infec'on, PLoS Negl.Trop. Dis., 2017, 11: e0006132
JY Choi, et. al., Structure Based Design ofCYP51 Inhibitors, Curr. Top. in Med.Chem., 2017, 17, 30-39
JY Choi, et. al., Drug strategies targe'ngCYP51 in neglected tropical diseases, Chem.Rev., 2014, 114, 11242-11271
JY Choi, et. al., The R-Configura'on of 4-aminopyridyl-based inhibitors of CYP51confers superior efficacy againstTrypanosoma cruzi, ACS Med. Chem.Le:., 2014, 5, 434-439
Research InterestsKeywords: Medicinal Chemistry, Organic Synthesis, Computer-aided Drug Design, ChemicalBiology
My scientific objective is to develop specific, target-directed therapeutic candidates for human diseases.My laboratory integrates organic synthesis, medicinal chemistry, computer-aided drug design, andchemical biology to discover bioactive chemical probes. We are particularly interested in discovery of smallmolecule agents with novel mechanism of action to elucidate specific functions of biological targets. Thediscovery and techniques established in my laboratory will advance the chemical science in biomedicalresearch for the development of therapeutics
Junyong Choi is asynthetic and computationalmedicinal chemist. Hisresearch focuses ondevelopment of therapeuticcandidates by applyingorganic synthesis,computer-aided drugdesign, and chemicalbiology.
2017- current Assistant Professor, Queens College2012-2017 Sr. Research Associate, Scripps Florida2009-2012 Postdoc, Scripps Florida2009 PhD, Stony Brook University
Dr. Junyong Choi
Maria ContelProfessorBrooklyn College2900 Bedford AvenueBrooklyn, NY, [email protected]://mariacontel.blog.brooklyn.edu/
Publications
B.T. Elie, et al. Preclinical Evaluation of an Unconventional Ruthenium-Gold-Based Chemotherapeutic: RANCE-1, in Clear Cell Renal Cell Carcinoma. Cancer Medicine, 2019, https://doi.org/10.1002/cam4.2322
N. Curado et al. Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines. Chem. Commun. 2019, 55, 1394-1397.
N. Curado et al. Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in vitro Studies in Renal and Prostate Cancer Cell Lines. ChemMedChem. 2019, 14, 1086-1095.
J. Son et al. Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design. ACS Nano. 2019, 13 ,1555-1562.
M. Contel et al. Arene Ruthenium(II) Derivatives Containing Iminophosphorane Ligands and Their Use in Cancer Therapy. Patent 9,555,049 B2 (01/31/2017).
Research InterestsKeywords: Organometallic Chemistry, Medicinal Inorganic Chemistry, Homogeneous Catalysis
We synthesize compounds based mostly on gold, ruthenium, and titanium to study their potential asanticancer and antimicrobial agents. We study their biological activity in vitro and in vivo, their modes ofaction and delivery strategies based on nanotechnology. Catalytic studies focus on recyclable andbimetallic catalysts and on sustainable processes.
Maria Contel is aninorganic synthetic chemistfocused on the rationaldesign of metallodrugs andhomogeneous catalysts.She leads a multidisciplinarygroup involved in synthesis,nanotechnology,biochemical and biologicalstudies.
2016- current Professor Brooklyn College2011-2016 Associate Professor Brooklyn College2006-2010 Assistant Professor Brooklyn College2001-2006 Senior Researcher, CSIC-University of
Zaragoza, Spain1999-2000 Postdoc, University of Utrecht, Holland1997-1999 Postdoc, Australian National University,
Australia1993-1996 PhD, Public University of Navarra,
Spain
Dr. Maria Contel
Melissa DeriAssistant ProfessorLehman College250 Bedford Park Blvd WBronx, NY [email protected]://www.lehman.edu/academics/chemistry/faculty.php
PublicationsDeri, M. A.; Mills, P.; McGregor, D. Structure andEvaluation of a Flipped General Chemistry Courseas a Model for both Small and Large GatewayScience Course at an Urban Public Institution.Journal of College Science Teaching: 2018; Vol. 47,pp 46-55.
Deri, M. A.; McGregor, D.; Mills, P., UsingTechnology To Flip and Structure General ChemistryCourses at a Large Public University: Our Approach,Experience, and Outcomes. In Teaching and theInternet: The Application of Web Apps, Networking,and Online Tech for Chemistry Education, AmericanChemical Society: 2017; Vol. 1270, pp 75-97.
Deri, M. A.; Ponnala, S.; Kozlowski, P.; Burton-Pye,B. P.; Cicek, H. T.; Hu, C.; Lewis, J. S.; Francesconi,L. C. p-SCN-Bn-HOPO: A Superior BifunctionalChelator for 89Zr ImmunoPET. Bioconjugate Chem2015; 26(12):2579-2591. PMID: 26550847
Deri, M. A.; Ponnala, S.; Zeglis, B. M.; Pohl, G.;Dannenberg, J. J.; Lewis, J. S.; Francesconi, L. C.An Alternative Chelator for 89ZrRadiopharmaceuticals: Radiolabeling and Evaluationof 3,4,3-(LI-1,2-HOPO). J Med Chem 2014;57(11):4849-4860. PMID: 24814511
Deri, M. A.; Zeglis, B.M.; Francesconi L. C.; Lewis, J.S. PET imaging with 89Zr: From radiochemistry tothe clinic. Nucl Med Biol 2013; 40:3-14. PMID:22998840Research Interests
Keywords: Radiochemistry, Radiopharmaceuticals, Nuclear Medicine, Radiometals, Chelators,Chemical Education, Pedagogy
Prof. Deri’s research efforts are focused on addressing the following two questions:
How can radioactivity be used to improve human health? Research projects include:Radiometal chelation studies • Bifunctional chelator development • Radiopharmaceutical design
How can we get more people interested in chemistry? Teaching practices and strategies studied:Culturally relevant teaching practices • Use of technology in education • Onlinelearning tools • Flipped classroom pedagogy • Active learning strategies
The overarching goal ofthe Deri Lab is theintegration and applicationof radiochemistry towardstangible benefits to society.We focus on the intersectionof radiochemistry andbiomedical science, morespecifically in molecularimaging and radiotherapyusing radioactive metals.
2017- current Assistant Professor, Lehman College2015-2017 Postdoctoral Fellow, Lehman College2015 Postdoctoral Fellow, Memorial Sloan
Kettering Cancer Center2010-2015 PhD, Hunter College and The Graduate
Center, CUNY
Dr. Melissa A. Deri
Ruel Z. B. DesameroProfessorYork College, the Institute of MacromolecularAssembly, and the Graduate Center94-20 Guy R. Brewer Blvd.Jamaica, NY [email protected]/portal_college/rdesamero
PublicationsProfit A.A, Desamero R.Z.B. (2018) “Development of Peptide-Based Inhibitors of Amylin Aggregation Employing Aromatic and Electrostatic Repulsion. In: Mavromoustakos T. Kellici T. (eds) Rational Drug Design. Methods in Molecular Biology, vol 1824. Human Press, New York, NY
Lagarias P., Elkhou Y., Vedad J., Konstantinidi A., Profit A.A., Kellici T.F., Kolocouris A., Desamero R.Z.B., Mavromoustakos T. (2018) Molecular Dynamics Simulations on the Bioactive Molecules of hIAPP22-29(NFGAILSS) and Rational Drug Design. In: Mavromoustakos T. Kellici T. (eds) Rational Drug Design. Methods in Molecular Biology, vol 1824. Human Press, New York, NY
Vedad, J., Domaradzki, M. E., Mojica, E.-R. E., Chang, E. J., Profit, A.A., Desamero, R. Z. B.. (2017) "Conformational Differentiation of alpha-cyanohydroxycinnamic acid isomers: a Raman spectroscopic study." Journal of Raman Spectroscopy. 48: 1282-1288.
Deng, H., Vedad, J., Desamero, R. Z. B., Callender R.. (2017) "Difference FTIR Studies of Substrate Distribution in Triosephosphate Isomerase." Journal of Physical Chemistry B. 121: 10036-10046.
Profit, A.A., Vedad, J. and Desamero, R.Z.B.. (2017) "Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation." Bioconjugate Chemistry. 28: 666-677.
Research Interests
Keywords: vibrational spectroscopy; fluorescence; circular dichroism; temperature-jumptechniques; structural biology; protein biochemistry; enzymology
My research is centered on investigating the structural and dynamical aspects of protein-small moleculeinteractions using techniques such as vibrational spectroscopy and temperature-jump relaxation. One aspect ofthe work is to understand at the molecular level how protein systems work. Enzyme-substrate interactions havelong been recognized as representing an extreme expression of structural complementarities in biologicalchemistry. Basic research geared towards understanding the inner workings of an enzyme system is important ifcures for the diseases caused by a malfunctioning or deficient enzyme are to be found. We have also startedinvestigating the mechanism behind amyloid formation with the goal of synthesizing peptide inhibitors thatdiminish protein aggregation.
Dr. Desamero is aspectroscopist by trainingcurrently investigatingprotein-ligand interaction aswell as protein-proteinaggregation using varioustechniques.
2015 – present Professor, York College - CUNY2010 - 2015 Associate Professor, York College - CUNY2003 - 2010 Assistant Professor, York College - CUNY2000 - 2003 Postdoc, Albert Einstein College of Medicine1998 - 2000 Postdoc, City College - CUNY1998 PhD, University of Connecticut
Dr. Ruel Desamero
Amedee des GeorgesAssistant Professor, ASRC Structural Biology InitiativeCity College, Dept. of Chemistry and BiochemistryCUNY Advanced Science Center, Room 3.31685 St. Nicholas TerraceNew York NY [email protected]
Publications
des Georges et al., Structure of mammalian eIF3in the context of the 43S preinitiation complex,Nature, 2015
R. Zalk, O. B. Clarke, A. des Georges et al.,Structure of a mammalian ryanodine receptor.Nature, 2014.
Y. Hashem, A. des Georges et al., Structure ofthe mammalian ribosomal 43S preinitiationcomplex bound to the scanning factor DHX29.Cell, 2013, 153, 1108-1119.
des Georges et al., Structure of the mammalianribosomal pre-termination complex associatedwith eRF1• eRF3• GDPNP, Nucleic acidsresearch, 2013, gkt1279.
Research Interests
Keywords:
Cell regulation • Cancer • Heart diseases • Biochemistry • Molecular biology • Structural biology • Cryo-electron microscopy • Image analysis • Modeling • Methods development • Translation initiation •Membrane proteins • Calcium signaling
The des Georges lab isinterested in the molecularmechanisms of cellregulation. We use cryo-electron microscopy todecipher at the atomic levelthe function of largemacromolecular complexesinvolved in calcium signalingand in the regulation ofprotein synthesis.
2015- current Assistant professor, Structural Biology Initiative, CUNY Advanced Science Research CenterAssistant professor, Department of Chemistry and Biochemistry, City College of New York
2008-2015 Postdoc – HHMI / Columbia University – (w/ Dr. Joachim Frank)2004-2008 PhD – MRC-Laboratory of Molecular Biology, Cambridge, UK – (w/ Drs. Linda Amos & Jan Lowe)
Dr. Amedee des Georges
Terry DowdAssociate ProfessorBrooklyn College2847 Old Ingersoll2900 Bedford Ave.Brooklyn, [email protected]://academic.brooklyn.cuny.edu/chem/howell/facultyWebPages/Dowd/Dowd_home.htm
Publications
Chan KL, Dowd TL, Gibney BR.,�Characterization of the Zn(II) binding propertiesof the human Wilms' tumor suppressor protein C-terminal zinc finger peptide. � (2014) InorgChem. 53:6309.
Malashkevich, V., Dowd, T.L., "The X-ray CrystalStructure of Bovine 3 Glu-Osteocalcin. �Biochemistry (2013) 52:8387.
B. Kalmatsky, T.L. Dowd, �Structural studies ofN-terminal mutants of connexin 32 using 1HNMR spectroscopy.� Arch. Biochem. Biophys.(2012) 526: 1-8.
A.U. Monir, T.L. Dowd, �The Effect of Lead onBone Mineral Properties From Female AdultC57/BL6 Mice.� Bone 2010 47:888-94.
B. Kalmatsky, T.L. Dowd, �Structural studies ofthe N-terminus of Connexin 32 using 1H NMRspectroscopy.� Arch. Biochim. Biophys. 2009490: 9-16.
Research Interests
My research involves investigating the role of the bone protein osteocalcin in bone mineraldiseases such as Pb2+ toxicity, low Mg2+ diets and diabetes. The research involves multipletechniques such as atomic absorption, FTIR Imaging and microCT to investigate alterations inmouse bone mineral properties. The second project involves NMR structural-functional studies ofthe gap junction molecule Connexin in health and diseases such as deafness, fatal skin diseaseand neuropathy. The project uses 2D NMR techniques on a high field magnet andelectrophysiological techniques characterizing the mutant gap junction channels.
Dr. Terry Dowd is involvedin two areas of research.One area is the alteration inbone mineral properties indisease. The second projectinvolves alterations instructure–functionrelationships in the gapjunction molecule Connexinin deafness, neuropathy andskin disease.
2014- current Associate Professor2005 Assistant Professor1992-1996 Instructor1986-1992 Postdoc1986 Ph.D.
Dr. Terry Dowd
Dr. Dorthe M. Eisele
Dr Dorthe M. EiseleDepartment of Chemistry, City CollegeCenter for Discovery and InnovationAdvanced Science Research Center85 Saint Nicolas Terrace, New York, NY [email protected]://eiselegroup.com/www.cuny.edu/asrc
Selected PublicationsEisele, D.M., Arias, D.H., Fu, X., Bloemsma, Steiner, C.P., Jensen, R., Rebentrost, P., Eisele, H., Llyod, S., Tokmakoff, A., Knoester, J., Nicastro, D., Nelson, K.A., & Bawendi, M.G. “Robust Excitons in Soft SupramolecularNanotubes.” PNAS 111 (2014) E3367-E3375.
Eisele, D.M., Cone, C.W., Bloemsma, E.A., Vlaming, C.G.F. van der Kwaak, S.M., Silbey, R.J., Bawendi, M.G., Knoester, J., Rabe, J.P., and Vanden Bout, D.A. “Utilizing Redox-Chemistry to Elucidate the Nature of ExcitonTransitions in Supramolecular Dye Nanotubes.”Nature Chem. 4 (2012) 655–662.
Eisele, D.M., v. Berlepsch, H., Böttcher, C., Stevenson, K.J., Vanden Bout, D.A., Kirstein, S., and Rabe, J.P. “Photoinduced growth of sub-7 nm silver nanowires within a chemically active organic nanotibular template.”JACS 132, (2010) 2104-2105.
Eisele, D.M., Knoester, J., Kirstein, S., Rabe, J.P., and Vanden Bout, D.A. “Uniform excitonfluorescence from individual molecular nanotubes immobilized on solid Substrates.”Nature Nanotech. 4 (2009) 658-663.
Research InterestsKeywords: New materials & design principles for solar energy systems; Artificial and biologicalmodel systems for light-harvesting (LH) in order to better understand the fundamental processesthat govern nature's highly efficient photosynthetic masterpieces;Collective phenomena found in self-assembled nanoscale systemssuch as supra-molecular assemblies (Frenkel exciton systems),semiconductor nanostructures (Wannier exciton systems),metallic nanostructures (plasmonic systems), and organic/inorganichybrid systems; Energy and electron transport processes innanoscale systems; steady-state and time-resolved spectroscopycombined with microscopy techniques.
Dorthe Eisele is a Professor of Chemistry at City College and a member of the Graduate Center. Her research interests are in materials research and nanoscience, with a focus on new materials and design principles for solar energy systems.
Current: Assistant Professor, Chemistry, City College of New York, Principal Investigator, CUNY Graduate Center (Chemistry).
Previously: Postdoctoral Associate, Massachusetts Institute of Technology,Cambridge, USA
Dr.rer.nat (Ph.D. equivalent), Humboldt University of Berlin, Berlin, Germany
Cherice M. EvansAssociate ProfessorQueens College -- CUNYDepartment of Chemistry and Biochemistry65-30 Kissena BlvdFlushing, NY [email protected]/~cevans
Publications
C. M. Evans, Kamil Krynski, Zachary Streeterand G. L. Findley, Energy of the quasi-freeelectron in H2, D2 and O2: Probing intermolecularpotentials within the local Wigner-Seitz model, J.Chem. Phys., submitted.
C. M. Evans, Holden T. Smith, Ollieanna Burke,Yevgeniy Lushtak and G. L. Findley, Fieldionization and photoionization of CH3I perturbedby diatomic molecules: Electron scattering in H2,HD, D2 and O2, J. Phys. B: At. Mol. Opt. Phys.47 (2014) 035204.
Yevgeniy Lushtak, C. M. Evans and G. L.Findley, The energy of the quasi-free electron innear critical point nitrogen, Chem. Phys. Lett.546 (2012) 18 – 23.
Yevgeniy Lushtak, Samantha B. Dannenberg, C.M. Evans and G. L. Findley, Quasi-free electronenergy in near critical point helium, Chem. Phys.Lett. 538 (2012) 46 – 49.
Yevgeniy Lushtak, C. M. Evans and G. L.Findley, Field enhanced photoemission: A newtechnique for the direct determination of thequasi-free electron energy in dense fluids,Chem. Phys. Lett. 515 (2011) 190 – 193.
Research Interests
Our lab is currently investigating the quasi-free electron energy in near criticalpoint anisotropic fluids with a focus on CO2, NH3 and H2O. The theoreticalwork on this problem will be performed at Queens College. The experimentalwork will be performed at the Center for Advanced Microstructures and Devicesin Baton Rouge, LA. We are also studying the mobility of electrons throughnear critical point fluids, with a focus on Ar, Xe, CH4 and C2H6. The theoreticalwork is being performed at Queens College and at the University of Louisianaat Monroe. The experimental work will be performed at Brookhaven NationalLaboratory and at Queens College.
Physical chemist investigatingthe effects of local solventstructure on reactivity in nearcritical point fluids. This workinvolves experimental andtheoretical studies performedat Queens College, the Centerfor Advanced Microstructuresand Devices (Baton Rouge, LA)and Brookhaven NationalLaboratory (Upton, NY).
2012 – current Associate Professor of Chemistry,Queens College
2004 – 2009 Assistant Professor of Chemistry,Queens College
2001 – 2003 Postdoctoral Fellow, Department ofPhysics. University of Virginia
1998 – 2001 Ph.D. in Physical Chemistry, LouisianaState University
Dr. Cherice M. Evans
Stephen Philip FearnleyAssociate ProfessorDepartment of ChemistryCUNY-York College94-20 Guy R. Brewer Blvd.Jamaica NY [email protected]/portal_college/sfearnley
PublicationsS. P. Fearnley* & P. M. Lory, “A concise synthesis of (�)-3-deoxyisoaltholactone�Tetrahedron Lett., 2014 55, 5207-5209.
S. P. Fearnley* & C. Thongsornkleeb, “Oxazolone Cycloadducts as Heterocyclic Scaffolds for Alkaloid Construction: Synthesis of (�)-2-epi-Pumiliotoxin C�J. Org. Chem. 2010 75, 933-936.
S. P. Fearnley* & P. M. Lory, “IntramolecularVinylsilane–Oxocarbenium Condensations –Concise Assembly of cis-Bicyclic Ether Arrays�Org. Lett. 2007 9, 3507-3510.
S. P. Fearnley*, "2-(3H)-oxazolone – A Simple Heterocycle with Manifold Potential” Current Organic Chemistry; Volume 8, Asymmetric Synthesis" 2004 8, 1289-1338.
S. P. Fearnley* & M. W. Tidwell, "Cyclization of Aryl Silanes with Unexpected Retention of Silicon”Org. Lett. 2002 4, 3797-3798.
S. P. Fearnley* & E. Market, “IntramolecularDiels-Alder Reactions of N-Substituted Oxazolones�Chem. Commun. 2002 438-439.
Research Interests
Keywords: Organic Synthesis • Organic Reactions • Natural Products• Investigation & use of oxazolone as a useful heterocyclic scaffold for alkaloid synthesis - studies of intramolecular Diels-Alder reactions with oxazolone as dienophile.
• Novel organosilane chemistry for approaches to bioactive ethers - concise assembly of cis-fused bicyclic ether arrays via intramolecular attack of vinylsilanes at tethered oxocarbenium ions. A related silyl-activated Friedel-Krafts process requires an unusual combination of electronic & steric effects.• Recently completed targets include 2-epi-pumiliotoxin C & deoxyaltholactone. Similar approaches to gephyrotoxin & dysiherbaine are underway.
As a synthetic organicchemist, my researchinvolves development ofnew methodology for theconstruction of bioactivenatural products: alkaloids,cyclic ether arrays, & C-glycosides.
2003- current York College1999-2003 Lamar University1998-1999 Postdoc, Penn State: Mike Coleman1995-1997 Postdoc, Penn State: Ray Funk1992-1994 Postdoc, Virginia Tech: Tomas Hudlicky1988-1992 Ph.D., University of Salford, U.K.
Dr. Stephen Philip Fearnley
Harry D. GafneyProfessorQueens CollegeDepartment of Chemistry, 206 Remsen Hall65-30 Kissena Blvd.Flushing, NY [email protected]/hgafney
PublicationsGafney, H.D.; Jagassar, P.; Perri, A.; Ibarrola, G. �Ligand Ini:ated Self-Assembly of Pt and Ir Nanopar:cles about Ru(II) Diimines in Room Temperature Fluid Solu:on� J. Phys. Chem. C (2013), 117(94), 1925-1934.
Gafney, H.D.; Look E.C. �Photocatalyzed Conversion of CO2 to CH4: An Excited State Acid-Base Mechanism� J. Phys. Chem. A (2013), 117(47), 12268-12279.
Gafney, H. D., Look, E. G. Zaitsev, V.; Xu, S.; �Nature and Distribu:on of Tungsten Oxides in Porous Vycor Glass� J. Non-Crystal. Solids, (2015), 409, 1-7.
Selmani, A.; Spadina, M.; Plodinec, M.; DelačMarion, I.; Willinger, M. G.; Lützenkirchen, J.; Gafney, H.D.; Redel, E. �An Experimental and Theore:cal Approach to Understanding the Surface Proper:es of One-Dimensional TiO2 Nanomaterials� J. Phys. Chem. C (2015), 119, 19729-19742.
J. L. Dominguez-Juarez, J.L.; Moocarme, M.; Lempel, A.; Singh, N.D.; Zhang, C.J. Gafney, H.D.; Vuong, L.T. �Influence of Solvent Polarity on Light-Induced Thermal Cycles in Plasmonic Nanofluids� OpAca (2015), 2, 447-453.
Research InterestsKeywords: Ru(II) Diimines, Transition Metal Oxides, Photocatalysis, Nanoporous Silica Matrices
Current research focuses on excited state electron-transfer and acid-base chemistry,photocatalysis of multi-electron, multi-proton conversions such as CO2 to CH4 and NOx to N2, synthesis ofmixed valent metal oxides in nanoporous silica matrices, absorption and emission properties of tungstenand molybdenum oxides, ground and excited state acid-base properties of tungsten and molybdenumoxides.
Coordination Chemistry Photochemistry PhotophysicsMaterial Science Integrated Optics
1981- current Professor1970-1973 Postdoc, Northwestern, USC1970 PhD
Dr. Harry D. Gafney
Emilio GallicchioAssistant ProfessorDepartment of Chemistry, Brooklyn College2900 Bedford AvenueBrooklyn, [email protected]/site/emiliogallicchiolab
Publications
Emilio Gallicchio, et al. BEDAM Binding FreeEnergy Predictions for the SAMPL4 Octa-AcidHost Challenge. J. Comp. Aided Mol. Des. 29,315-325 (2015).
Emilio Gallicchio, et al. Virtual Screening ofIntegrase Inhibitors by Large Scale Binding FreeEnergy Calculations: the SAMPL4 Challenge. JComp Aided Mol Design, 28, 475-490 (2014).
Guohua Yi, Mauro Lapelosa, Emilio Gallicchio,Gail Ferstandig Arnold et al. ChimericRhinoviruses Displaying MPER Epitopes ElicitAnti-HIV Neutralizing Responses. PLoS ONE8(9), e72205 (2013).
Gallicchio E. Role of Ligand Reorganization andConformational Restraints on the Binding FreeEnergies of DAPY Non-Nucleoside Inhibitors toHIV Reverse Transcriptase. ComputationalMolecular Bioscience, 2, 7-22 (2012).
Research Interests
-Thermodynamics of protein-protein and protein-ligand binding- Virtual drug screening- Protein conformational equilibria- Statistical thermodynamics of protein folding and misfolding- Thermodynamics of solvation of biological macromolecules- Force field development and high resolution protein modeling- Design of high performance computational chemistry algorithms- Parallel and distributed computing
Emilio Gallicchio’s research is in the area of computational molecular biophysics. He uses advanced computational models to investigate the dynamics and thermodynamics of biological systems.
2013- current Asst. Professor, Dept. Chemistry, Brooklyn College2012-2013 Research Professor, Dept. Chemistry, Rutgers University2001-2012 Associate Director, BioMaPS Institute, Rutgers University1997-2000 Postdoctoral, Rutgers University1991-1996 PhD Columbia University, Chemical Physics
Dr. Emilio Gallicchio
Kevin H. GardnerDirector, Structural Biology InitiativeCUNY Advanced Science Center, Room 3.32285 St. Nicholas TerraceNew York, NY [email protected] • kglab.org
PublicationsY. Guo et al., Coiled-coil coactivators play astructural role mediating interactions in hypoxiainducible factor heterodimerization. J. Biol.Chem., 2015, online now.
V. Ocasio et al., Ligand-induced folding of a twocomponent signaling receiver domain.Biochemistry, 54, 1353-1363.
G. Rivera-Cancel et al., Full-length structure of amonomeric histidine kinase reveals basis forsensory regulation, Proc. Natl. Acad. Sci USA,2014, 111, 17839-17844.
L.B. Motta-Mena et al., An optogenetic geneexpression system with rapid activation anddeactivation kinetics. Nat. Chem. Biol., 2014,10, 196-202.
T.H. Scheuermann et al., Allosteric inhibition ofHypoxia Inducible Factor 2 with small molecules.Nat. Chem. Biol., 9, 271-276.
Research Interests
Keywords: environmental sensing • protein/protein interactions • ligand binding • allostery • NMRspectroscopy • X-ray diffraction • biochemistry • photosensors • cancer • protein engineering
The Gardner lab studieshow cells perceive andrespond to changes in theenvironment around them.Such information providesinsights into fundamentalprinciples of proteinstructure and signaling,guides the engineering ofnew protein-based tools,and lays the foundation fornew therapeutic strategies.
2014- current Director, Structural Biology Initiative, CUNY Advanced Science Research CenterEinstein Professor of Chemistry, City College of New York
1998-2014 Professor of Biophysics and Biochemistry, UT Southwestern Medical Center1995-1998 Postdoc – Biomolecular NMR methods development, University of Toronto (w/ Dr. Lewis E.
Kay)1989-1995 Ph.D. – Molecular Biophysics & Biochemistry, Yale University (w/ Dr. Joseph E. Coleman)
Dr. Kevin H. Gardner
PublicationsAlexandratos, S.D. et al. “Sustaining WaterResources: Environmental and EconomicImpact” ACS Sustainable Chemistry &Engineering, 2019, 7, 2879-2888.
Gibney, B.R. “Equilibrium Studies of DesignedMetalloproteins” Methods in Enzymology,Peptide, Protein and Enzyme Design, Pecoraro,V.L. Ed., 2016, 580. 417-438.
Assignargues, C. et al. “Structure and Functionof a Bacterial Microcompartment Shell ProteinEngineered to Bind a [4Fe-4S] Cluster”, J. Am.Chem. Soc. . 2016, 138, 5262-5270.
Reddi A.R. et al. “Evaluation of the Intrinsic Zn(II)Affinity of a Cys3His1 Site in the Absence ofProtein Folding Effects”, Inorg. Chem. 2015, 54,5942-5948.
Chan, K.L. et al. Characterization of the Zn(II)Binding Properties of the Wilms’ TumorSuppressor Protein C-Terminal Zinc FingerPeptide”, Inorg. Chem. 2014, 53, 6309-6320.
Gibney, B.R. Metallopeptides as Tools toUnderstand Metalloprotein Folding and Stabilityin Protein Folding and Metal Ions – Mechanisms,Biology and Disease, Gomes, C and Wittung-Stafshede, P. Eds. 2011, 227-245.Research Interests
Keywords: De novo metalloprotein design, inorganic coordination chemistry, biophysics,bioenergetics, electrochemistry
Our research focuses on the role of metal ions in biological systems from both an inorganic coordinationchemistry and biophysical perspective. We are currently investigating the role of zinc in controlling geneexpressions in human cancer, and the role of heme proteins in cardiovascular disease.
The Gibney Lab usesmetalloprotein design toinvestigate the fundamentalengineering of biologicalsystems. These studiesprovide insight into metal-induced protein folding,heme electrochemistry, andthe role of chemicallymodified hemes in biology.
2008- current Associate Professor Brooklyn College2005-2008 Associate Professor Columbia University2000-2005 Assistant Professor Columbia University1995-2000 NIH Postdoc University of Pennsylvania1990-1995 PhD University of Michigan1986-1990 BS (ACS Certified) Florida State University
Dr. Brian R. Gibney
Brian R. GibneyAssociate ProfessorBrooklyn College2900 Bedford AvenueBrooklyn, NY [email protected]://www.biochemistry.nyc
Dr. Dixie GossHunter College Chemistry Dept.695 Park AveNew York, NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Dixie/goss-group-1/resume
PublicationsRecruitment of 40S Ribosome to the 3'Untranslated Region (UTR) of a Viral mRNA, viathe eIF4F Complex, Facilitates Cap-independentTranslation.Das Sharma S, Kraft JJ, Miller WA, Goss DJ.J Biol Chem. 2015 Mar 19.
Pokeweed antiviral protein, a ribosome inactivatingprotein: activity, inhibition and prospects.Domashevskiy AV, Goss DJ.Toxins (Basel). 2015 Jan 28;7(2):274-98.
Rapid kinetics of iron responsive element (IRE)RNA/iron regulatory protein 1 and IRE-RNA/eIF4Fcomplexes respond differently to metal ions.Khan MA, Ma J, Walden WE, Merrick WC, TheilEC, Goss DJ.Nucleic Acids Res. 2014 Jun;42(10):6567-77.
Eukaryotic initiation factor (eIF) 4F binding to barleyyellow dwarf virus (BYDV) 3'-untranslated regioncorrelates with translation efficiency.Banerjee B, Goss DJ.J Biol Chem. 2014 Feb 14;289(7):4286-94.
Poly(A) binding proteins: are they all createdequal?Goss DJ, Kleiman FE.Wiley Interdiscip Rev RNA. 2013 Mar-Apr;4(2):167-79.
Research InterestsKeywords: protein synthesis, virus, protein-nucleic acid interactions
We use biophysical approaches to understand how non-coding regions of mRNA regulate function.Miss regulation of protein synthesis in responsible for many diseases including cancer. We areinterested in how unique structures in viral RNA allow viruses to take over host cell protein synthesis.
Prof. Goss is a professor ofChemistry and Biochemistryand Elion Endowed Scholar
1990- current Professor of Chemistry1989-1990 Associate Professor of Chemistry1984-1989 Assistant Professor
Post-Doc. U. of Nebraska and U. ofGeorgia
1975 Ph.D U. of Nebraska
Dr. Dixie J. Goss
Michael E GreenProfessorCity College of New YorkDept. of Chemistry160 Convent AveNew York NY [email protected]://forum.sci.ccny.cuny.edu/people/science-division-directory/b009
PublicationsA. M. Kariev and M. E. Green, "Caution is required in interpretation of mutations in the voltage sensing domain of voltage gated channels as evidence for gating mechanisms.," Int'l J. Molec. Sci. (2015) 16, 1627-1643.
A. M. Kariev and M. E. Green, "Quantum Effects in a Simple Ring with Hydrogen Bonds " J. Phys. Chem. B (2015)119,5962-5969
A. M. Kariev, P. Njau, and M. E. Green, "The Open Gate of the Kv1.2 Channel: Quantum Calculations Show The Key Role Of Hydration," Biophys J. (2014). 106, 548-555
A. M. Kariev and M. E. Green, "Voltage Gated Ion Channel Function: Gating, Conduction, and the Role of Water and Protons," Int'l J. Molec. Sci. (2012) 13, 1680-1709
S. Liao and M. E. Green, "Quantum calculations on salt bridges with water: Potentials, structure, and properties," Comput. Theo. Chem. (2011) 963, 207-214.
Dr. Green is acomputational chemist, witha principal interest inbiophysical problems,especially related to a classof proteins, ion channels,responsible for the nerveimpulse, among other things.
Dr. Green has been a faculty member inChemistry at CCNY since Sept 1966.
Research Interests
Keywords: Quantum calculations, proteins, water structure, hydrogen bonds, salt bridges, membranes, water transport through membranes
Research Strategy: Primarily we carry out quantum calculations on overlapping sections of proteins, such as voltage sensing domains of ion channels, to determine structure, bonding, energetics, and transitions of protein, water, hydrogen bonds, and salt bridges, leading to mechanisms, for example, of sensing voltage.
Dr. Michael Green
ProfessorHunter College of CUNYDept. of Chemistry & Biochemistry695 Park AvenueNew York NY [email protected]/chemistry/faculty/nancy/greenbaum
PublicationsRiskowski, R.A., Armstrong, R.E., Greenbaum,N.L, and Strouse, G.F. (2016) TriangulatingNucleic Acid Conformations Using MulticolorSurface Energy Transfer (McSET) ACS Nano10:1926-1938.
Zhao, C, Devany, M, Greenbaum, NL (2014)Measurement of Chemical Exchange betweenRNA Conformers by 19F NMR. Biochem.Biophys. Res. Comm. 453,692-695.
Popović, M, Greenbaum, NL (2014) Role ofhelical constraints of the EBS1-IBS1 duplex of agroup II intron on demarcation of the 5′ splicesite. RNA 20, 24-35.
Zhao, C*, Bachu, R*, Popović, M, Devany, M,Brenowitz, M, Schlatterer, JC, Greenbaum, NL(2013) Conformational heterogeneity of theprotein-free human spliceosomal U2-U6 snRNAcomplex. RNA 19, 561-573. *these authorscontributed equally to the work.
Popović, M, Nelson, JD, Schroeder, KT,Greenbaum, NL (2012) Impact of base pairidentity 5¢ to the spliceosomal branch siteadenosine on branch site conformation. RNA18, 2093-2103.Research Interests
Keywords: RNA, spliceosome, NMR
We a%empt to answer ques0ons about how RNA molecules fold and interact with other RNA, metal ions, and proteins in order to carry out the complex ac0vity of precursor messenger (pre-m)RNA splicing. This process, by which noncoding intron sequences of pre-mRNA molecules are excised and flanking coding exons are ligated together, is an essen0al step in prepara0on of mRNA transcripts prior to transla0on of their message into protein sequences.
Pre-mRNA splicing in eukaryo0c cells is performed by the spliceosome, a dynamic nuclear supramolecular assembly that comprises five recyclable small nuclear (sn)RNA molecules and many proteins. Similari0es between spliceosomal snRNAs of and func0onally analogous regions of Group II introns, which excise themselves even in the absence of proteins, suggests shared evolu0onary ancestry and the likelihood that the spliceosomal reac0on is also catalyzed by its RNA components. Using a combina0on of biochemistry, biophysical, and spectroscopy techniques, we characterize the molecular basis of recogni0on and conforma0onal dynamic leading RNA splicing in the two systems.
Prof. Greenbaum is astructural biologist whoseresearch addresses the roleof biomolecular structure andfunction in biochemicalactivity of noncoding RNAmolecules. We incorporatesolution NMR, fluorescencetechniques, and biochemicalapproaches in our studies.
2007- current Professor, Hunter College2004-2007 Associate Professor, Florida State Univ.1997-2004 Assistant Professor, Florida State Univ.1992-1996 Postdoc, Columbia University1985-1989 Postdoc, Rockefeller University1981-1984 PhD, University of Pennsylvania
Dr. Nancy Greenbaum
Publications
“Review of Recent Nuclear Magnetic Resonance Studies of Ion Transport in Polymer Electrolytes”, Stephen Munoz and Steven Greenbaum, Membranes, 2018, 8, 120; doi:10.3390/membranes8040120
“Ion Transport and Association Study of Glyme-Based Electrolytes, with Lithium and Sodium Salts”, Daniel Morales, Rose E. Ruther, Frank M. Delnick, Jagjit Nanda, and Steven Greenbaum, Electrochimica Acta, 304, 239-245 (2019). doi.org/10.1016/j.electacta.2019.02.110
“Atomistic-scale simulations of the chemical dynamics of Kapton Polyimide damaged by electron beam irradiation”, Ali Rahnamoun, Daniel P. Engelhart, Sunita Humagain, Elena Plis, W. Joshua Kennedy, Hilmar Koerner, Russell Cooper, Steven G. Greenbaum, Ryan Hoffmann, and Adri C.T. van Duin, Polymer, Volume 176, 2 August 2019, Pages 135-14 doi.org/10.1016/j.polymer.2019.05.035
Research Interests
Keywords:Nuclear magnetic resonance, electron paramagnetic reson-ance, structure of disordered solids battery and fuel cellMaterials characterization
We inves(gate the structure and func(on of solid materials at the atomic and molecular level by solid state NMR. Most of these materials have applica(on in renewable energy technologies. I value diversity in the scien(fic workforce as reflected by my lab group members.
1983- current Current position2014-15 Jefferson Science Fellow, State Dept.1997-98 NASA Senior Research Fellow, JPL1990-91 Fulbright Scholar, Weizmann Institute1981-83 Postdoc, Naval Research Lab1976-81 PhD, Brown University
Dr. Steve Greenbaum
Steve GreenbaumPosition: CUNY Distinguished Professor of PhysicsAffiliation Hunter CollegeAddress 695 Park AvenueAddress 1220NNew York NY [email protected]/physics/faculty/greenbaum
Dr. Alexander Greer Publications
A. A. Ghogare; A. Greer “Synthesis of a Poly(ethylene glycol) Galloyl Sensitizer Tip for an ‘All-in-one’ Photodynamic Device” J. Biophotonics 2016 (in press).
A. A. Ghogare; A. Greer “Using Singlet Oxygen to Synthesize Natural Products and Drugs” Chem. Rev. 2016 (in press).
B. Malek; W. Fang; I. Abramova; N. Walalawela; A. A. Ghogare; A. Greer “Ene Reactions of Singlet Oxygen at the Air-Water Interface” J. Org. Chem. 2016, 81, 6395-6401 .
A. Mahendran; A. A. Ghogare; R. Bittman; G. Arthur; A. Greer “Synthesis and AntiproliferativeProperties of a New Ceramide Analog of Varacin” Chem. Phys. Lipids 2016, 194, 165-170.
A. A. Ghogare; D. Bartusik; G. Ghosh; N. Walalawela; I. Abramova; K. A. Cengel; J. M. Miller; T. M. Busch; A. Greer “Photodynamic Therapy by a Device Probe Tip” Photonics, Lasers in Medicine 2015, 4, 362-365.
M. S. Oliveira; A. A. Ghogare; I. Abramova; E. M. Greer; F. M. Prado; et al. “Mechanism of Photochemical O-Atom Exchange in Nitrosamines with Molecular Oxygen” J. Org. Chem. 2015, 80, 6119-6127.
Research Interests
We focus on synthesis and organic photochemical reactions to study molecular oxygen that are toxic to organisms and damaging to materials. Photo-generating intermediates in a clean and pure fashion is one goal, including the physical isolation of sensitizer and molecules at surfaces to “separate” reactive oxygen species (ROS) that can damage membranes and enzymes. Oxygen-dependent toxic effects are common in nature and our mechanistic studies have also focused on thiophene sulfoxides and mutagenic nitrosamines. We have also synthesized sulfanes related to natural product varacin, such as thianthrene, tetrathiocin, trithiole, and pentathiepin anticancer agents.
Our research areas are organic chemistry, synthesis,interfacial chemistry, photochemistry, natural products, and nano-technology
Alexander GreerProfessorCUNY Brooklyn College, Dept. ChemistryBrooklyn, NY 11210718-951-5000 ext [email protected]://academic.brooklyn.cuny.edu/chem/agreer/FirstPage.html
1999-current ProfessorPrevious UCLA and University of Wyoming
Rupal GuptaAssistant ProfessorDepartment of ChemistryCollege of Staten Island2800 Victory Blvd.Staten Island [email protected]
Publications
Rupal Gupta, et al.: “Dynamic Nuclear PolarizationEnhanced MAS NMR Spectroscopy for StructuralAnalysis of HIV-1 Protein Assemblies”, The Journal ofPhysical Chemistry B, 2016, 120, 329-339.Rupal Gupta, Taketo Taguchi, Benedikt Lassalle-Kaiser, Emile Bominaar, Junko Yano, Michael P.Hendrich, A. S. Borovik: “High-Spin Mn-OxoComplexes and their Relevance to the Oxygen-Evolving Complex within Photosystem II”,Proceedings of the National Academy of Science ofthe United States of America, 2015, 112, 5319-5324.Rupal Gupta, Guangjin Hou, Rokus Renirie, TatyanaPolenova: “51V NMR Crystallography of VanadiumChloroperoxidase and its Directed EvolutionP395D/L241V/T343A Mutant: ProtonationEnvironment of the Active Site”, Journal of theAmerican Chemical Society, 2015, 137, 5618-5628.Rupal Gupta, David C. Lacy, Emile Bominaar, A. S.Borovik, and Michael P. Hendrich: “ElectronParamagnetic Resonance and MössbauerSpectroscopy and Density Functional TheoryAnalysis of a High-Spin FeIV-oxo Complex”, Journal ofthe American Chemical Society, 2012, 134, 9775–9784.Rupal Gupta, Rong Fu, Aimin Liu and Michael P.Hendrich: “EPR and Mössbauer Spectroscopy ShowInequivalent Hemes in Tryptophan Dioxygenase”,Journal of the American Chemical Society, 2010, 132,1098–1109.Research Interests
Keywords: Bioinorganic Chemistry, Spectroscopy, Biophysical Chemistry, Magnetic Resonance,Quantum Chemical Calculations
Transition metal homeostasis is one of mechanisms through which the human body combats microbialattack. We are investigating both the processes undertaken by pathogens during invasion of a host celland the responses executed by the host cell during such an attack. The research projects aim to study themechanisms of zinc and copper homeostasis, incorporation of native metal ions by metallochaperones,and pathogenic machinery of zinc acquisition. Investigation of these physiological events at the interfaceof chemistry and biology will provide atomic-level understanding of fundamental processes in the humanbody during microbial invasion, which will have significant implications for human health and in the designof efficient therapeutics.
Elucidation of transition metal-mediated processesundertaken by pathogens andthe corresponding immuneresponse by the human bodyduring infection usingbioinorganic, biophysical andcomputational methodologies
2017- current Assistant Professor2013-2016 Postdoc, University of Delaware2006-2012 PhD, Carnegie Mellon University
Dr. Rupal Gupta
Wayne W. Harding, PhDAssociate ProfessorHunter CollegeChemistry Dept.695 Park AvenueNew York NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Harding/Wayne
Publications
Research InterestsKeywords: Medicinal chemistry, drug design, organic synthesis, central nervous system, CNS,receptor, serotonin, dopamine
Dr. Harding is aorganic/medicinalchemist with interests inthe design, synthesisand evaluation ofligands for centralnervous systemreceptors.
2013- current Associate Professor, Hunter College2006-2013 Assistant Professor, Hunter College2004-2006 Postdoctoral Fellow, University of Iowa1994-1999 Ph.D.
Dr. Wayne HardingAporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C. S. Ponnala, N. Kapadia, H. A. Navarro, W. W. Harding, Chem. Biol. Drug Des. 2014, 84, 558 - 566.
Evaluation of structural effects on 5-HT2Areceptor antagonism by aporphines: identification of a new aprophine with 5-HT2Aantagonist activity. S. Ponnala, J. Gonzales, N. Kapadia, H. A. Navarro, W. W. Harding, Bioorg. Med. Chem. Lett. 2014, 24, 1664 -1667.
New Aporphinoid 5-HT2A and���� antagonists via structural manipulations of nantenine. S. Chaudhary, S. Ponnala, O. LeGendre, J. Gonzales, H. A. Navarro, W. W. Harding, Bioorg. Med. Chem. 2011, 19, 5861-5868.
Affinity of aporphines for the human 5-HT2Areceptor: insights from homology modeling and molecular docking studies. S. Pecic, S. Chaudhary, P. Makkar, B. J. Reddy, H. A. Navarro, W. W. Harding, Biorg. Med. Chem. 2010, 18, 5562 - 5575.
(±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners, S. Chaudhary, O. LeGendre, S. Pecic, H. A. Navarro, W. W. Harding Biorg. Med. Chem. Lett. 2009, 19, 2530 -2532.
Yi HeProfessorDepartment of SciencesJohn Jay College524 W59th StreetNew York NY [email protected]://www.jjay.cuny.edu/faculty/yi-he
PublicationsHe, Y., Concheiro-Guisan, M., Microextractionsample preparation techniques in forensictoxicology, Biomedical Chromatography, 2019,33, e4444
Kurti, M., von Lampe, K., He, Y., Khanzada, H.,Kostara, K., Da, Q., Schroth, K. R. J.,Categorizing Characteristics of CounterfeitMarlboro Cigarettes: A Systematic Review ofTobacco Industry Documents, Tobacco Control,2019, (accepted)
Kurti, M., He, Y., Silver, D., Giorgio, M., vonLampe, K., Macinko, J., Ye, H., Tan, F., Mei, V.,Presence of Counterfeit Marlboro Gold Packs inLicensed Retail Stores in New York City:Evidence from Test Purchases, Nicotine &Tobacco Research, 2018, (Accepted)
Fan, C., Li, K., He, Y., Wang, Y.-L., Qian, X., Jia,J.-P., Evaluation of magnetic chitosan beads foradsorption of heavy metal ions, Science of theTotal Environment, 2018, 627, 1396-1403
He, Y., Microextraction and Its Application toForensic Toxicology Analysis, LCGC NorthAmerica, 2017, 35: 14-20
Research InterestsKeywords: Sample preparation; Environmental Analysis, Forensic Analysis
- Counterfeit tobacco product identification through chemical and physical examination using methodssuch as elemental fingerprint, pollen analysis, packaging and printing analysis
- Micro-scale extraction methods development and application to forensic and environmental analysis- New electrochemcial system used for pollutant treatment
Dr. Yi He is a professor inthe analytical chemistrydiscipline with primaryresearch interests in thefield of forensic andenvironmental analysis.Her research mainlyfocuses on developmentof new analytical methodsand their applications.
2016- current Professor2009-2016 Associate Professor2004-2008 Assistant Professor2005 PhD, CUNY
Dr. Yi He
William H. HershProfessorDepartment of Chemistry and BiochemistryQueens College65-30 Kissena Blvd.Queens, NY [email protected]://chem.qc.cuny.edu/~whersh
PublicationsS. Malik, A. Tarpanova, D. Lichtman, Y. Wallach,J. A. Mukhlall, W. H. Hersh, “Synthesis ofDixanthates and Dithiocarbonyl Disulfides asModels for Poly(disulfide)s, in preparation, 2015.
W. H. Hersh, “Synthesis of dinucleosideacylphosphonites by phosphonodiamiditechemistry and investigation of phosphorusepimerization,” Beilstein J. Org. Chem. 2015, 11,184-191.
W. H. Hersh, S. T. Lam, D. J. Moskovic, A. J.Panagiotakis, “A Non-Karplus Effect: Evidencefrom Phosphorus Heterocycles and DFTCalculations of the Dependence of VicinalPhosphorus-Hydrogen NMR Coupling Constantson Lone-Pair Conformation,” J. Org. Chem.2012, 77, 4968-4979.
J. A. Mukhlall, W. H. Hersh, “Sulfuriza5on ofDinucleoside Phosphite Triesters with ChiralDisulfides,” Nucleosides, Nucleo+des &Nucleic Acids 2011, 30, 706-725.
Dr. Hersh is an organic chemist with current research projects on synthesis of chiral oligonucleotide phosphorothioates and helical disulfide polymers. Specialties include NMR, X-ray crystallography, and DFT calculations.
1989 - current Queens College1982 - 1989 UCLA1980 – 1982 Postdoc, UC Berkeley1980 PhD, Columbia University
Dr. William Hersh
Edward G. HohensteinAssistant ProfessorCity College of New YorkMarshak Science Building, Rm. 1032160 Convent AvenueNew York, NY [email protected]://www.hohenstein-chem.com
PublicationsE.G. Hohenstein, Mechanism for the EnhancedExcited-State Lewis Acidity of Methyl Viologen,J. Am. Chem. Soc., 2016, 10.1021/jacs.5b08177
E.G. Hohenstein, M.E.F. Bouduban, C. Song, N.Luehr, I.S. Ufimtsev, and T.J. Martínez, AnalyticFirst Derivatives of Floating OccupationMolecular Orbital-Complete Active SpaceConfiguration Interaction on GraphicalProcessing Units, J. Chem. Phys., 2015, 143,014111
E.G. Hohenstein, N. Luehr, I.S. Ufimtsev, andT.J. Martínez, An Atomic Orbital-BasedFormulation of the Complete Active Space Self-Consistent Field Method on GraphicalProcessing Units, J. Chem. Phys., 2015, 142,224103
E.G. Hohenstein, R.M. Parrish, C.D. Sherrill, andT.J. Martínez, Tensor Hypercontraction. III.Least-Squares Tensor Hypercontraction for theDetermination of Correlated Wavefunctions, J.Chem. Phys., 2012, 137, 221101
Research InterestsKeywords: Theoretical, Computational, Photochemistry
The accurate treatment of excited electronic states is a uniquely challenging and important problem inelectronic structure theory. We are actively developing new methods for treating excited states as well ashighly efficient and scalable implementations of these methods that exploit modern advances in computerhardware. We apply these methods to problems in photochemistry. Processes occurring in the condensedphase, such as excited-state proton transfer, are of particular interest. We are also working to applysimilar methodology to design light harvesting complexes.
Prof. Hohenstein is atheoretical chemistspecializing in thedevelopment andimplementation of newelectronic structuremethodology and theapplication of thesemethods to problems inexcited-state chemistry.
2014- current Assistant Professor, CCNY2011-2014 Postdoc, Stanford University2007-2011 PhD, Georgia Institute of Technology
Dr. Edward G. Hohenstein
Qiao-Sheng HuProfessor and ChairDepartment of ChemistryCollege of Staten Island2800 Victory Blvd.Staten Island, NY [email protected]://www.csi.cuny.edu/departments/chemistry
PublicationsH.-H. Zhang, C.-H. Xing, G. B.Tsemo, Q.-S.Hu,t-Bu3P-Coordinated 2-Phenylaniline-BasedPalladacycle Complex as a Precatalyst for theSuzuki Cross-Coupling Polymerization of ArylDibromides with Aryldiboronic Acids, ACSMacroLett. 2013, 2, 10-13.
H.-H. Zhang, C.-H. Xing, Hu, Q.-S., ControlledPd(0)/t-Bu3P-Catalyzed Suzuki Cross-CouplingPolymerization of AB-Type Monomers withPhPd(t-Bu3P)I or Pd2(dba)3/t-Bu3P/ArI as theInitiator, J. Am. Chem. Soc. 2012, 134, 13156-13159.
T.-P. Liu, Y.-X. Liao, C.-H. Xing, Q.-S. Hu,Fluorenone Synthesis by Palladacycle-Catalyzed Sequential Reactions of 2-Bromobenzaldehydes with Arylboronic Acids,Org. Lett. 2011, 13, 2452-2455.
T.-P. Liu, C.-H. Xing, Q.-S. Hu, TandemReaction Synthesis of Fluorenes/Indenofluorenes Based on Pd(OAc)2/PCy3-Catalyzed Suzuki Cross-Coupling and C-H BondActivation Strategy, Angew. Chem. Int. Ed.2010, 49, 2971-2974.
C.-G. Dong, Q.-S. Hu, Preferential OxidativeAddition in Palladium(0)-Catalyzed SuzukiCross-Coupling Reactions of Dihaloarenes withArylboronic Acids, J. Am. Chem. Soc. 2005,127, 10006-10007.Research Interests
Keywords: catalysis, palladium, cross-coupling reaction, polymerization, conjugated polymers
The Hu group are interested in the development of new catalysts including transition metal and organiccatalysts for cross-coupling reactions and addition reactions, and novel reactions/processes from readilyavailable and cost-effective small organic molecules. These new reactions/processes and catalysts havepotential applications in chemical synthesis and polymer/materials synthesis.The approach is interdisciplinary, ranging from fundamental understandingof reaction mechanisms, reaction methodology development topolymer/materials synthesis.
Qiao-Sheng Hu isProfessor and Chair ofChemistry Department atthe College of Staten Island.His research is focused onthe development of newreactions/processes andcatalysts for chemicalsynthesis including polymer/materials synthesis.
2008- current Professor, CSI-CUNY2005-2007 Associate Professor, CSI2000-2005 Assistant Professor, CSI1997-2000 Postdoc, University of Virginia1995-1997 Postdoc, North Dakota state Univ.1991-1994 PhD, Shanghai Institute of Organic Chemistry,
Chinese Academy of Sciences
Dr. Qiao-Sheng Hu
Seogjoo JangProfessorDepartment of Chemistry and Biochemistry, QueensCollege of the City University of new York65-30 Kissena Blvd, Queens,[email protected]://chem.qc.cuny.edu/~sjjang
PublicationsS. Jang, “Generalized quantum Fokker-Planckequation for photoinduced nonequilibriumprocesses with positive definiteness condition,”Journal of Chemical Physics, 2016, 144, 214102.
S. Jang and G. A. Voth, “Can quantum transitionstate theory be defined as an exact t=0+ limit?”,Journal of Chemical Physics, 2016, 144, 084110.
E. Block, S. Jang, H. Matsunami, S. Sekharan, B.Dethier, M. Z. Ertem, S. Gundala, Y. Pan, S. Li, S.N. Lodge, M. Ozbil, H. Jiang, S. F. Penalba, V.Batista, and H. Zhuang, “Implausibility of thevibrational theory of olfaction,” Proceedings of theNational Academy of Sciences, USA, 2015, 112,E2766.
S. Jang, E. Rivera, and D. Montemayor,“Molecular level design principle behind optimalsizes of photosynthetic LH2 complex: Tamingdisorder through cooperation of hydrogen bondingand quantum delocalization”, Journal of PhysicalChemistry Letters, 2015, 6, 928.
S. Jang, S. Hoyer, B. Whaley, and G. R. Fleming,“Generalized master equation with non-MarkovianFörster resonance energy transfer for modularexciton densities”, Physical Review Letters, 2014,113, 188102.
Research InterestsKeywords: Quantum Dynamics, Energy Transfer, Electron Transfer, Light Harvesting
Seogjoo Jang combines mathematical formulation and computational approaches to address importantissues concerning quantum dynamics calculation and energy/electron transfer processes in complexenvironments. A particular area of application of these efforts, is theoretical elucidation of efficient lightharvesting mechanisms in natural and artificial photosynthetic complexes. These research projects arebeing supported by the National Science Foundation and the Department of Energy.
Seogjoo Jang is a theoreticaland computational chemist.His research expertise includesdevelopment of quantum ratetheories, quantum dynamicscalculation in condensedmedia, and computationalmodeling of energy and chargetransfer processes in complexenvironments.
2012 – current Professor, Queens College2010 – 2012 Associate Professor, Queens College2005 – 2010 Assistant Professor, Queens College2003 – 2005 Goldhaber Fellow, Brookhaven Natl. Lab.1999 – 2002 Postdoctoral Associate, MIT 1999 PhD, University of Pennsylvania
Dr. Seogjoo Jang
Urs JansAssociate ProfessorDepartment of Chemistry and BiochemistryCity College of New York160 Convent AvenueNew York NY, [email protected]/profiles/urs-jans
Publications
D. Saint-Hilaire, U. Jans, Reactions of three halogenated organophosphorus flame retardants with reduced sulfur species. Chemosphere, 2013, 93, 2033-2039.
L. Yang, X. Li, P. Zhang, M. Melcer, Y. Wu, U. Jans. Concentrations of DDTs and dieldrin in Long Island Sound sediment, Journal of Environmental Monitoring, 2012, 14, 878-885.
K.W. Lo, S.C. Saha-Roy, U. Jans. Investigation of the reaction of hexabromocyclododecane with polysulfide in methanol/water solutions, Chemosphere, , 2012, 87, 158-162.
D. Saint-Hilaire, K.Z. Ismail, U. Jans. Reactions of tris(2-chloroethyl)phosphate with reduced sulfur species, Chemosphere, 2011, 83, 941-947.
L. Yang, X. Li, J. Crusius, U. Jans, M. E. Melcer, P. Zhang. Persistent chlordane concentrations in Long Island Sound sediment: Implications for chlordane, 210Pb, and 137Cs depth profiles. Environ. Sci. Technol., 2007, 41, 7723-7729.
Research Interests
Keywords: Environment, emerging contaminants, abiotic transformation, analytical chemistry
My research program at CCNY is addressing questions concerning environmental organic chemistry, witha focus on the mechanisms through which organic contaminants undergo abiotic transformations innatural aquatic environment (freshwater, seawater). We also determine the concentration of organiccontaminants in sediments and soils as a tool to understand their accumulation in the environment.
Dr. Jans is interested inthe fate of organic conta-minants (e.g., pesticides,flameretardants) in theenvironment.
1999- current City College of New York1996-1998 Postdoc, Johns Hopkins University1992-1996 PhD, ETH Zürich, Switzerland
Dr. Urs Jans
David JeruzalmiProfessor of Chemistry Marshak 1219 • City College of New York • Graduate Center of the City University of New York160 Convent Avenue New York, NY [email protected]
Publications
Lu, M., Yang, J., Ren, Z., Sabui, S., Espejo, A.,Bedford, M. T., et al. (2009). Crystal structure ofthe three tandem FF domains of thetranscription elongation regulator CA150.Journal of Molecular Biology, 393(2), 397–408.
Pakotiprapha, D., & Jeruzalmi, D. (2013).Small-angle X-ray scattering revealsarchitecture and A(2) B(2) stoichiometry of theUvrA-UvrB DNA damage sensor. Proteins:Structure, Function, and Bioinformatics, 81(1),132–139.
Pakotiprapha, D., Liu, Y., Verdine, G. L., &Jeruzalmi, D. (2009). A structural model for thedamage-sensing complex in bacterialnucleotide excision repair. The Journal ofBiological Chemistry, 284(19), 12837–12844.
Pakotiprapha, D., Samuels, M., Shen, K., Hu, J.H., & Jeruzalmi, D. (2012). Structure andmechanism of the UvrA–UvrB DNA damagesensor. Nature Structural & MolecularBiology, 1–9.
Samuels, M., Gulati, G., Shin, J.-H., Opara, R.,McSweeney, E., Sekedat, M., et al. (2009). Abiochemically active MCM-like helicase inBacillus cereus. Nucleic Acids Research,37(13), 4441–4452.Research Interests
The faithful transmission of gene1c information is an important biological imperative. To carry out thisfunction, organisms have evolved processes to replicate their genomes and defend them from attack. Westudy important mechanisms associated with the processes of DNA replica1on and repair. The centralchallenge in understanding these processes stems from the large size of the involved multi-protein DNAcomplexes; these entities also populate many conformational states. Together, these complications placelimits on insights that can be revealed by static crystallographic structures or solution methods alone; bothsources of information are essential for defining underlying mechanisms.To this end, my group applies X-ray crystallography, supplemented withelectron microscopy, to understand these long-standing problems in DNAbiology. We also use biochemical studies to inform these approaches andfollow up on the resulting insights.
2012- current Professor of Chemistry, CCNY2002-2012 Molecular and Cellular Biology, Harvard1996-2002 The Rockefeller University1994 Ph.D., Yale University
Dr. David JeruzalmiJeruzalmi’s group appliesX-ray crystallography,supplemented with electronmicroscopy, to understandthese long-standing problemsin DNA biology. We also usebiochemical studies to informthese approaches and followup on the resulting insights.
Shi JinAssociate ProfessorCollege of Staten Island2800 Victory BlvdStaten Island, NY [email protected]://www.csi.cuny.edu/faculty/JIN_SHI.html
PublicationsD. D. Gunbas, C. Xue, S. Patwardhan, M. C.Fravventura, H. Zhang, W. F. Jager, E. J. R.Sudholter, L. D. A. Siebbeles, T. J. Savenije, S.Jin, F. C. Grozema, High charge carrier mobilityand efficient charge separation in highly solubleperylenetetracarboxyl-diimides ChemicalCommunications 2014, 50, 4955.
N. Jin, H. Zhang, S. Jin, M. D. Dadmun, B. Zhao,Shifting Sol-Gel Phase Diagram of a DoublyThermosensitive Hydrophilic Diblock CopolymerPoly(methoxytri(ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol)acrylate-co-acrylic acid) in Aqueous SolutionMacromolecules 2012, 45, 4790.
C. Xue, S. Jin, Exceptionally Strong ElectronicCoupling in Crystalline Perylene Diimides viaTuning Chemistry of Materials 2011, 23, 2689.Y. J. Xu, S. W. Leng, C. M. Xue, R. K. Sun, J.Pan, J. Ford, S. Jin, A room-temperature liquid-crystalline phase with crystalline π stacksAngewandte Chemie-International Edition 2007,46, 3896.
Research Interests
Keywords: Soft Matter, organic optoelectronic materials
Dr. Jin is aphysical/materials chemistwho is working on structuredesign, synthesis,characterization andoptimization of organicoptoelectronic materials forimproved performance indevices such organic solarcells, light emitting diodesand field effect transistors,.
2004- 2011 Assistant Prof. of Chemistry, CUNY2012-current Associate Prof. of Chemistry, CUNY
Dr. Shi Jin
Andrei JitianuProfessor and ChairLehman CollegeDavis Hall, 250 Bedford Park Boulevard WestBronx, NY [email protected]/academics/chemistry/prof-jitianu.php
Publications
1. M. Aparicio, J. Mossa, G. Rodriguez, J.Guzman, Q. Picard, L.C. Klein, A. Jitianu,submitted “Consolidated Melting-Gel Coatingson AZ31 Magnesium Alloy with ExcellentCorrosion Resistance in NaCl solutions–AnInterface study” ACS Applied Materials &Interfaces, 11, 2019.2. V.H Fragal, E.H Fragal, T. Zhang, X. Huang,T.S.P. Cellet, G.M. Pereira, A. Jitianu, A.FRubira, R. Silva, T. Asefa,” Deriving EfficientPorous Heteroatom-Doped CarbonElectrocatalysts for Hydrazine Oxidation fromTransition Metal Ions-Coordinated Casein”,Advanced Functional Materials, 2019, 180486(1-12).3. L. C. Klein, S. Kallontzi, L. Fabris, A. Jitianu,C. Ryan, M. Aparicio, L. Lei and J. P. Singer,“Applications of melting gels” J. Sol-Gel Science& Technology, 89, 2019, 66-774. L. Lei, D.A. Kovacevich, M.P. Nitzsche, J.Ryu, K. Al-Marzoki, G. Rodriguez, L.C. Klein, A.Jitianu , J.P. Singer, Obtaining Thickness-Limited Electrospray Deposition for 3D Coating”ACS Applied Materials & Interfaces 10, 2018,11175-11188,5. A. Jitianu, S. Cadars, F. Zhang, G. Rodriguez,Q. Picard, M. Aparicio, J. Mosa, L.C. Klein “29SiNMR and SAXS investigation of the hybridorganic-inorganic glasses obtained byconsolidation of the melting gels”, DaltonTransaction 46, 2017, 3729-3741
Research Interests
Keywords: Dr. Jitianu’s research goals are to develop new materials or composite materials for hermeticbarriers for electronic industry, anticorrosive materials for airspace and automotive industry, hydroxyapatitebased nanocomposite for biomedical bone regeneration and prosthetic applications and Layerd DoubleHydroxides for metal air batteries. Our studies range from the elucidation of early stages of formation ofthe hybrid materials by sol-gel process to the design of hybrid nanocomposite materials with magnetic,gas-sensing, electric and optical properties. The research of my lab is fully collaborative with national andinternational universities and is focused to developing a new class of materials called Hybrid Melting Gelsfor hermetic barriers, anticorrosive and optical applications.
Dr. Jitianu’s research isfocused on materialschemistry, specifically onsol-gel chemistry withdirect applications inanticorrosive, hermeticcoatings andnanomaterals forelectronic industry.
2017- current Professor and Chair2013-2017 Associate Professor2008-2013 Assistant Professor2002-2003 Postdoc University of Orleans, France2001 PhD, university of Bucharest, Romania
Dr. Andrei Jitianu
George JohnProfessor of ChemistryThe City College of New YorkCenter for Discovery and Innovation (CDI) -1430285 St. Nicholas Terrace, New York, NY [email protected]/~john/
Publications
Faure, L.; Nagarajan, S.; Hwang, H.; Montgomery, C.L.; Khan, B. R.; John, G.; Koulen, P.; Blancaflor, E. B.;Chapman, K. D. Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid AmideHydrolase Activity, J. Biol. Chem, 2014, 289, (13):9340-51.
Vijai Shankar, B.; Jadhav. S. R.; Vemula, P. K; John.G. Recent Advances in Cardanol Chemistry in aNutshell: From a Nut to Nanomaterials, Chem. Soc.Rev., 2013, 42, 427-438, Cover Page feature.
Reddy, A. L.M.; Nagarajan, S.; Chumyim, P.; Gowda,S. R.; Dubey, M.; Jadhav, S. R.; John, G.; Ajayan, P.M. Lithium storage mechanisms in purpurin basedorganic lithium ion battery electrodes, ScientificReports (Nature) 2012, 2, 960-964.
Shankar, B. V.; Jadhav, S. R.; Pradhan, P.; De Carlo,S.; John, G. Adhesive vesicles through adaptiveresponse of a biobased surfactant, Angew. Chem. Int.Ed., 2010, 49, 9509 –9512. Cover Page feature.
Jadhav, S. R.; Vemula, P. K.; Kumar, R.; Raghavan,S.; John, G. Sugar-derived phase-selective moleculargelators as model solidifiers for oil spills, Angew.Chem. Int. Ed., 2010, 49, 7695-7698, Cover Page.
Research Interests
Keywords: biobased materials, green chemistry, soft materials, biorefinery, biomimetics, phaseselective gels, oil structuring agents (food/cosmetics), antibacterial coatings, batterycomponents/energy storage, green surfactants
John’s research is rooted in the idea that innovation can be inspired by nature to develop economical andsustainable technologies for a greener future. The group has harnessed crop-based precursors such assugars, fatty acids and plant lipids to design a unique set of multifunctional soft-materials includingpolymers, gels and green surfactants. His group has successfully developed environmentally benignantibacterial paints, polymer-coatings, molecular gel technologies, oil spill recovery materials, batterycomponents and oil thickening agents. As soft materials researchis highly interdisciplinary and collaborative, John’s lab encouragesthe blending of such diverse elements including organic synthesis,green chemistry, material chemistry, interfacial phenomena, colloidscience and biomimetics.
George John is a Professorof Chemistry/the Center forDiscovery and Innovation,the City College of New York-CUNY. His research isfocused on molecular designof synthetic lipids, membranemimics, soft nanomaterials,green energy technologiesand organic materialschemistry.
Dr. George John
2012- current Professor of Chemistry, CCNY2004-2012 Associate Prof. of Chemistry, CCNY2002-2004 Research Faculty, RPI, NY1996-2002 JSPS Fellow/Scientist, Japan1994-1995 Postdoc, University of Twente, NL1993 PhD Kerala University, India
Laura JuszczakAssociate ProfessorBrooklyn College3119 Ingersoll Hall2900 Bedford Ave.New York [email protected]
Publications
For a complete list of publications, seeMyBibliography:h.p://www.ncbi.nlm.nih.gov/sites/myncbi/laura jeanne.juszczak.1/bibliography/40598288/public/?sort=date&direcIon=descending
Research Interests
Keywords:
Tryptophan photophysics, cation-pi interactions, fluorescence and UV resonance Raman spectroscopy,molecular dynamics/quantum mechanics calculations
Laura Juszczak is aphysical chemist withextensive experience in thespectroscopic study oftryptophan in proteins. Herrecent discovery of visibleabsorption and fluorescencein aromatic cation-piinteractions constitutes aparadigm shift for the studyof numerous classes ofprotein-ligand interactions.
2013- current associate professor2006-2013 assistant professor1999-2006 research associate, A. Einstein Coll. of Med.1992-1999 Postdoc, AECOM1992 PhD, New York University
Dr. Laura Juszczak
Akira KawamuraAssociate ProfessorHunter College695 Park AvenueNew York NY [email protected]/chemistry/faculty/Kawamura
Publications
Mihai, D.M., Hall, S., Deng, H., Welch, C.J., Kawamura, A. Bioorg. Med. Chem. Lett. 2015, Nov 15;25(22):5349-51. PMID: 26420066
Li, X., Kawamura, A., Andrews, C.D., Miller, J.L., Wu, D., Tsao, T., Zhang, M., Oren, D., Padte, N.N., Porcelli, S.A., Wong, C.H., Kappe, S.H., Ho, D.D., Tsuji, M. J. Immunol. 2015;195(6):2710-21. PMID: 26254338
Montenegro, D., Kalpana, K., Chrissian, C., Sharma, A., Takaoka, A., Iacovidou, M., Soll, C.E., Aminova O., Heguy, A., Cohen, L., Shen, S., Kawamura, A. Bioorg. Med. Chem. Lett. 2015;25(3):466-9. PMID: 25547935
Takaoka, A., Iacovidou, M., Hasson, T.H., Montenegro, D., Li, X., Tsuji, M., Kawamura, A. Planta Med. 2014;80(4):283-9. PMID: 24549928
Hasson, T.H., Takaoka, A., de la Rica, R., Matsui, H., Smeureanu, G., Drain, C.M. and Kawamura, A. Chem. Biol. Drug Design, 2014;83(4):493-7. doi: 10.1111/cbdd.12250. PubMed PMID: 24495243
Research Interests
Keywords: Natural Products, Phytobacteria, Glycolipids, Immunology
We currently focus on immunomodulatory glycolipids of phytobacteria that were detected in severalmedicinal plants. In addition to medicinal plants, these lipids exist in many other edible plants. At presentlittle is known about their potential health benefits and risks. This is an important problem because humanbody is continually exposed to various phytobacterial metabolites through consumption of vegetables,fruits, and herbs. To address this problem, we conduct structural and immunological characterization ofphytobacterial glycolipids with immunomodulatory activity.
Natural products chemistryfocused on phytobacterialmetabolites.
Chemical messages formicrobial interactions.
2008- current Associate Professor, Hunter College2002-2007 Assistant Professor, Hunter College1999-2002 Postdoc, Scripps Research Institute1994-1999 PhD, Columbia University
Dr. Akira Kawamura
Daniel A. KeedyAssistant ProfessorCity College of New York, Chemistry & BiochemistryAdvanced Science Research Center, Structural Biology85 St. Nicholas TerraceRoom 3.314New York, NY [email protected]
Publications
DA Keedy*, ZB Hill*, et al. “An expandedallosteric network in PTP1B by multitemperaturecrystallography, fragment screening, andcovalent tethering.” eLife (2018).
DA Keedy*, LR Kenner*, M Warkentin*, RAWoldeyes*, et al. "Mapping Energy Landscapesof Dynamic Proteins by Multitemperature andXFEL Crystallography." eLife (2015).
DA Keedy, JS Fraser, H van den Bedem.“Improved automated modeling of alternativeprotein backbone conformations in X-raycrystallography.” PLoS Comp Biol (2015).
DA Keedy. “Conformational and connotationalheterogeneity: A surprising relationship betweenprotein structural flexibility and puns.” Proteins:Struct Funct Bioinf (2015).
Research Interests
Keywords: structural biology, X-ray crystallography, allostery, bioinformatics, protein design
The Keedy Lab develops experimental and computational methods to control proteins by biasing towardspecific conformations that underlie functions such as allostery, ligand binding, and catalysis. Our workreveals new opportunities to modulate the activities of therapeutic targets such as tyrosine phosphataseswith small molecules and protein engineering, and also offers insights into more general evolutionaryprocesses that led to functional diversity in the human genome.
The Keedy Lab isinterested in how atomicmotions imbue proteinmolecules with biologicalfunctions. We use novel X-ray experiments pluscomputational modeling toexplore dynamic processeslike ligand binding andallostery in proteins.
2018-current Assistant Professor, CUNY Advanced Science Research Center , Structural Biology InitiativeAssistant Professor, City College of New York, Department of Chemistry and Biochemistry
2012-2018 Postdoctoral Fellow, University of California, San Francisco (with James Fraser)2006-2012 PhD, Duke University (with David & Jane Richardson)
Dr. Daniel A. Keedy
Reza KhayatAssistant ProfessorCity College of New YorkCenter for Discovery and Innovation85 Saint Nicholas Terrace; 12316New York, NY [email protected]
Publications
Veesler D, Khayat R, Architecture of a dsDNAviral capsid in complex with its maturationprotease. Structure 2014 Feb 4 (22): 1-8
Khayat R, Lee JH, Structural characterization ofcleaved, soluble human immunodeficiency virustype-1 envelope glycoprotein trimers. J. Virology,2013 Sep;87(17):9865-72
Pejchal R, Khayat R, A potent and broadneutralizing antibody recognizes and penetratesthe HIV glycan shield, Science 2011 Nov.25:334(6059):1097-103
Khayat R, Brunn N, The 2.3-angstrom structureof porcine circovirus 2, 2011 J. Virology Aug;85(15):7856-62
Khayat R, Lander GC, An automated procedurefor detecting protein folds from sub-nanometerresolution electron density, 2010 J. Struct. Bio.Jun; 170(3); 513-21
Research Interests
Keywords: cryo-electron microscopy, X-ray crystallography, biophysics, biochemistry, cellularbiologyWe seek to understand the structural and chemical mechanism by which pathogens hijack the cellularmachinery of their host for infection and replication. We use a combination of techniques to understandthis mechanism at the atomic resolution to relate how chemistry drives biology, and a number oftechniques to understand how biology feeds back into chemistry for new pathways to be exploited by thepathogen for infection and replication. We are also interested in developing computational methods tofurther combine X-ray crystallography with cryo-electron microscopy.
Khayat group studies thestructure and function ofproteins encoded for andutilized by pathogens toinfect and replicate. We usea combination of X-raycrystallography, cryo-electron microscopy,biophysics, biochemistry,and cellular biology tocomplete these studies.
2012- current Current position2008-2012 Sr. Research Associate, TSRI2003-2008 Research Associate, The Scripps
Research Institute1998-2003 PhD, Columbia University
Dr. Reza Khayat
Mark N. KobrakProfessorDepartment of Chemistry, Brooklyn College -- CUNY2900 Bedford Ave.Brooklyn, NY [email protected]://userhome.brooklyn.cuny.edu/mkobrak/
Publications
M. N. Kobrak and K. G. Yager, X-Ray Scatteringand Physicochemical Studies ofTrialkylamine/Carboxylic Acid Mixtures:Nanoscale Structure in Pseudoprotic IonicLiquids and Related Solutions, Phys. Chem.Chem. Phys., 2018, 20, 18639.
C. H. C Janssen, N. A. Macias-Ruvalcaba, M. A.Aguilar-Martinex, and M. N. Kobrak, CopperExtraction Using Protic Ionic Liquids: Evidence ofthe Hofmeister Effect, Sep. Pur. Tech. 2016,168, 275.
C. H. C. Janssen, A. Sanchez and M. N. Kobrak,Selective Extraction of Metal Ions from AqueousPhase to Ionic Liquids: A Novel ThermodynamicApproach to Separations, ChemPhysChem,2014, 15, 3536.
C. H. C. Janssen, A. Sanchez, G.-J. Witkampand M. N. Kobrak, A Novel Mechanism for theExtraction of Metals from Water to Ionic Liquids,ChemPhysChem, 2013, 14, 3806.
M. N Kobrak, A Proposed Voltage Dependenceof the Ionic Strength of a Confined ElectrolyteBased on a Grand Canonical Ensemble Model,J. Phys. Cond. Matt., 2013, 25, 095006.
Research Interests
Keywords: Ionic Liquids, nanostructured liquids, interfaces, molecular dynamics, thermodynamics
The group’s interest in ionic liquids and liquid mixtures center on using both theoretical and experimentaltechniques to understand liquid systems. The group has uncovered structure-property relationshipsrelevant to both viscosity and solvent polarity in ionic liquids, aiding in the development of ionic liquids withoptimal properties for applications of interest. Recent projects consider the use of ionic liquids for theextraction of metals from the aqueous phase, and study nanoscale structure in liquids.
Additional interests center on using thermodynamics to understand solid-liquidinterfaces. The results demonstrate linkages between macroscopically-observableproperties such as surface tension and the microscopic structure of the interface.
Mark Kobrak is a physicalchemist with expertise inclassical and quantumdynamics simulations andphysical studies of liquids.Current work centers onionic liquids and relatedmixtures, and on studies ofsolid-liquid interfaces.
2013- current Professor, Brooklyn College2006- 2013 Associate Professor, Brooklyn College2001- 2006 Assistant Professor, Brooklyn College2000-2001 Post-doctoral fellow, Notre Dame
University and The Pennsylvania StateUniversity
1998-1999 Post-doctoral fellow, University ofHouston
1992-1997 PhD, University of Chicago
Dr. Mark N. Kobrak
Michal KrukProfessorCollege of Staten Island and Graduate CenterDepartment of Chemistry, Building 6S-2412800 Victory BoulevardStaten Island, NY [email protected]://www.csi.cuny.edu/faculty/departments/chemistry/kruk_michal.html
PublicationsHuang, L.; Kruk, M. �VersatileSurfactant/Swelling-Agent Template forSynthesis of Large-Pore OrderedMesoporous Silicas and Related HollowNanoparticles�, Chem. Mater. 2015, 27,679.
Kruk, M. �Access to Ultra-large-poreOrdered Mesoporous Materials ThroughSelection of Surfactant/Swelling-AgentMicellar Templates�, Acc. Chem. Res.2012, 45, 1678.
Mandal, M.; Kruk, M. �Family of Single-micelle-templated Organosilica HollowNanospheres and Nanotubes Synthesizedthrough Adjustment ofOrganosilica/Surfactant Ratio�, Chem.Mater. 2012, 24, 123.
Cao, L.; Kruk, M. �Grafting of PolymerBrushes from Nanopore Surface via AtomTransfer Radical Polymerization withActivators Regenerated by ElectronTransfer�, Polym. Chem. 2010, 1, 97.
Research Interests
Keywords: ordered mesoporous materials, hollow nanoparticles, controlled surface-initiatedradical polymerization
• Design of ordered nanoporous materials.• Application of controlled polymerizations in the synthesis of nanostructured materials, including porous
inorganic/polymer nanocomposites.• Development of methods for accurate characterization of nanoporous materials.• Synthesis of nanoporous materials with closed pores.• Synthesis of single-micelle-templated hollow nanoparticles.
Michal Kruk is a professor inchemistry. His researchinterest is in design of well-defined nanoporous andnanostructured materialsusing surfactant micelletemplating, nanocasting andcontrolled surface-initiatedpolymerization.
2013- current Professor2011-2013 Associate Professor2005-2010 Assistant Professor2003-2005 Visiting Assistant Professor1998-2003 Postdoctoral fellow1994-1998 PhD Student in Chemistry
Dr. Michal Kruk
Thomas KurtzmanAssistant ProfessorLehman College250 Bedford Park Boulevard WestBronx,10468 NYhttp://www.lehman.edu/faculty/tkurtzman/
Publications
Wickstrom, L. et al. Parameterization of an effective potential for protein-ligand binding from host-guest affinity data. J. Mol. Recognit. (Accepted Journal of Molecular Recognition)
Nguyen, C. N., Cruz, A., Gilson, M. K. &Kurtzman, T. Thermodynamics of Water in anEnzyme Active Site: Grid-Based HydrationAnalysis of Coagulation Factor Xa. J. Chem.Theory Comput. (2014). doi:10.1021/ct401110x
Armaiz-Pena, G. N. et al. Src activation by β-adrenoreceptors is a key switch for tumourmetastasis. Nat. Commun. 4, 1403 (2013).
Nguyen, C. N., Kurtzman Young, T. & Gilson, M. K. Grid inhomogeneous solvation theory: Hydration structure and thermodynamics of the miniature receptor cucurbit[7]uril. J. Chem. Phys.137, 044101–044101–17 (2012)*Young, T., Abel, R., Kim, B., Berne, B. J. & Friesner, R. A. Motifs for molecular recognition exploiting hydrophobic enclosure in protein–ligand binding. Proc. Natl. Acad. Sci. 104, 808 –813 (2007).
*Formerly published as T. Young
Research Interests
Keywords: Solvation Thermodynamics, Statistical Mechanics, Computer Aided Drug DesignResearch in the Kurtzman lab focuses on the development of computational tools that can aidin the discovery and rational design of new drugs. His approach applies statistical mechanicaltheory and computer simulations to better understand the physical principles that govern themolecular recognition between proteins and small molecule ligands (drugs). A particularemphasis is placed on the role that water plays in the molecular recognition process. Aprincipal goal of this research is to help design and discover drugs that bind with high affinityand selectivity to given protein targets
The Kurtzman group focuses on the development of methodologies to characterize the structure and thermodynamics of water on the surface of proteins and the exploitation of solvation properties for the discovery and design of new drugs.
2010- Present Assistant Professor, Lehman College-CUNY2008-2010 AsssistantProfessor, San José State Univ.2007-2008 Visiting Professor, Yeshiva University2004-2007 Postdoctoral Fellow, Columbia University2002 Doctorate, Stanford University
Dr. Tom Kurtzman
Mahesh LakshmanProfessor and Former Executive Officer2018 Presidential Award for ExcellenceThe City College of New YorkDepartment of Chemistry160 Convent AvenueNew York [email protected]/~mkl
Publications
§ S. Satishkumar and M. K. Lakshman: Benz-imidazopurine nucleosides from N6-aryl adenosinederivatives by PhI(OAc)2-mediated C–N bondformation, no metal needed, ChemicalCommunications 2017, 53, 2226. (Featured onthe front cover)§ V. Basava, et al.: A novel bis(pinacolato)-diboron-mediated N–O bond deoxygenative routeto C6 benzotriazolyl purine nucleoside derivatives,Organic and Biomolecular Chemistry 2016, 14,7069.§ M. K. Singh et al.: Ruthenium-catalyzed C–Hbond activation approach to azolyl aminals andhemiaminal ethers, mechanistic evaluations, andisomer interconversion, ACS Catalysis 2016, 6,1921. (Featured on the front cover)§ P. F. Thomson et al.: Modular, metal-catalyzedcycloisomerization approach to angularly fusedpolycyclic aromatic hydrocarbons and theiroxidized derivatives, The Journal of OrganicChemistry 2015, 80, 7435.§ M. K. Lakshman et al.: Synthesis and biologicalproperties of C-2 triazolylinosine derivatives, TheJounal of Organic Chemistry 2012, 77, 5870.(Editor-selected featured article)§ M. K. Lakshman et al.: Direct arylation of 6-phenylpurine and 6-arylpurine nucleosides byruthenium-catalyzed C–H bond activation,Angewandte Chemie, International Edition 2011,50, 11400–11404. (Inside cover feature)Research Interests
Keywords: Chemical Methodology, Metal catalysis, Nucleoside Modification, Biomolecules
The program has many facets but can be broadly divided into the following areas.A. Development of new chemical methodology, ligand design for catalysis. B. Nucleoside modifications by metal-catalysis, uncatalyzed methods, and hypervalent iodine reagents. B. Unusual applications of peptide coupling agents. C. New chemistry of planar and nonplanar polycyclic aromatic hydrocarbons for novel studies. C. Novel reactions involving arynes. D. Development of new chemical methodology.Every aspect entails a detailed understanding of chemical process via mechanism studies involving various spectroscopic methods, multinuclear NMR, isotopic labeling, etc.
Lakshman is anorganic/bioorganic chemistwith interests in nucleosidemodification via metalcatalyzed, uncatalyzed, andhypervalent iodinereactions, new chemicalmethods, synthesis ofbiologically interestingentities,novel applicationsof peptide coupling agents,and arynes.
20008–current Professor2004–2008 Associate Professor2000–2004 Assistant Professor1998–2000 Assistant Professor (U North Dakota)1994–1997 Senior Scientist (Private Sector)1990–1994 Fogarty Fellow NIH (NIDDK)1985–1989 PhD
Dr. Mahesh Lakshman
Themis LazaridisProfessorCity College of New YorkDept of Chemistry and Biochemistry160 Convent AveNew York [email protected]://www.sci.ccny.cuny.edu/~themis/
Publications
Brice A., Lazaridis T. "Structure and Dynamics ofa Fusion Peptide Helical Hairpin on theMembrane Surface: Comparison of MolecularSimulations and NMR", J. Phys. Chem. B,118:4461-70 (2014)
Lazaridis T., Versace R. "The treatment ofsolvent in multiscale biophysical modeling", Isr.J. Chem., 54:1074-83 (2014)
Lazaridis T., Leveritt JM, PeBenito L. "Implicitmembrane treatment of buried charged groups.Application to peptide translocation across lipidbilayers", BBA Biomembranes, 1838:2149-59(2014)
Prieto L., He Y., Lazaridis T. "Protein arcs mayform stable pores in membranes", Biophys J,106:154-161 (2014)
Rahaman A., Lazaridis, T. "A thermodynamicapproach to alamethicin pore formation", BBABiomembranes 1838:98 (2014)
Research Interests
My research is in the area of Theoretical and Computational Biophysical Chemistry, which aims tounderstand how biological systems work in terms of the fundamental laws of Physics and Chemistry.Biomolecules, such as proteins and nucleic acids, have well defined conformations which often change inthe course of their function. Our goal is to understand the forces that operate within and betweenbiomolecules and develop quantitative mathematical models for their energy as a function ofconformation. Such models are useful in many ways, such as predicting the three-dimensional structurefrom sequence, characterizing conformational changes involved in biological function, or predicting thebinding affinity between two biomolecules.
The Lazaridis lab works inthe area of theoretical andcomputational Biophysics. Inthe past few years we haveworked on the interaction ofproteins with biologicalmembranes. We areespecially interested in theprocess of pore formation byantimicrobial peptides andother toxins.
1998- City College1992-1998 Postdoc, Harvard University1987-1992 PhD, University of Delaware
Dr. Themis Lazaridis
Jianbo LiuAssociate ProfessorQueens College and the Graduate Center of CUNYDepartment of Chemistry and Biochemistry65-30 Kissena Blvd.Queens, NY [email protected]://chem.qc.cuny.edu/~jliu/Liu_page/Liu_main.htm
PublicationsFangwei Liu, Wenchao Lu, Yigang Fang, and J.Liu*, "Evolution of oxidation dynamics of histidine:Non-reactivity in the gas phase, peroxides inhydrated clusters, and pH dependence insolution", Phys. Chem. Chem. Phys. 2014, 16,22179-22191.
J. Liu*, Steven D. Chambreau, and Ghanshyam L.Vaghjiani, "Dynamics simulations and statisticalmodeling of thermal decomposition of 1-ethyl-3-methylimidazolium dicyanamide and 1-ethyl-2,3-dimethylimidazolium dicyanamide", J. Phys. Chem.A., 2014, 118, 11133-11144.
Wenchao Lu, Fangwei Liu, Rifat Emre, and J. Liu*,"Collision dynamics of protonated N-acetylmethionine with singlet molecular oxygen (a1Dg):The influence of amide bond and ruling out thecomplex-mediated mechanism at low energies", J.Phys. Chem. B, 2014, 118, 3844-3852.
Rui Sun, Matthew R. Siebert, Lai Xu, Steven D.Chambreau*, Ghanshyan L. Vaghjiani, HansLischka, Jianbo Liu*, and William L. Hase*, "Directdynamics simulation of the activation anddissociation of 1,5-dinitrobiuret (HDNB)", J. Phys.Chem. A, 2014, 118, 2228-2236.Research Interests
Keywords: mass spectrometry, singlet oxygen, reaction dynamics/kinetics, spectroscopy
Our research focuses on using various instrumental analysis approaches (e.g., mass spectrometry, laser spectroscopy, and ion-molecule reactions) to probe biologically relevant processes in a spectrum of systems ranging from isolated biomolecules, through micelles and aerosols, to biomolecule solution. The experiments are complemented by extensive computational efforts including statistical modeling and dynamics simulations.
We are also active in discovering and developing new instrumentation methods and nanotechnologies.
Physical ChemistryAnalytical ChemistryComputational ChemistryNanomaterials
2013- current Associate Professor, Queens College2016-2013 Assistant Professor, Queens College1999-2000 Postdoc, Lawrence Berkeley Lab1997 Ph.D. (Physical Chemistry)
Dr. Jianbo Liu
Gustavo E. Lopez
ProfessorLehman College Department of Chemistry250 Bedford Park Blvd WestBronx, [email protected]
Publications (select)Effect of surface corrugation on low temperaturephases of adsorbed (p-H2)7 : A quantum path integralMonte Carlo study, Cruz, A., López, G.E. 2014, Phys.Lett. A, 378, 1375.
The gamma-butyrolactone receptors BulR1 andBulR2 of Streptomyces tsukubaensis: tacrolimus(FK506) and butyrolactone synthetases productioncontrol, Salehi-Najafabadi, Z.; Barreiro, C; Rodriguez-Garcia, A.; Cruz, A.; Lopez, G.E.; Marin, J.F. 2014Appl Microbiol Biotechnol, (DOI 10.1007/s00253-014-5595-9).
Quinoline-2-thiol Derivatives as Fluorescent Sensorsfor Metals, pH, and HNO, 2014, O’Connor, N.A.;Lopez, G.E.; Cruz, A., Curr. Chem. Lett. (DOI10.5267/j.ccl.2014.3.001).
Src activation by �-adrenoreceptors is a key switch fortumour metastasis, Armaiz-Pena, G.N.; Allen, J.K.;Cruz, Anthony; Villares, G.J.; Cruz, A.; Stone, R.L.;Nick, A.M.; Lin, Y.G.; Han, L.Y.; Mangala, L.S.;Villares, G.J.; Vivas-Mejias, P.; Rodriguez-Aguayo,C.; Nagaraja, A.S.; Gharpure, K.M.; Wu, Z.; English,R.D.; Soman, K.V.; Shazhad, M.M.K.; Zigler, M.;Deavers, M.T.; Zien, A.; Soldatos, T.G.; Jackson,D.B.; Wiktorowicz, J.E.; Torres-Lugo, M.; Young, T.;Geest, K.D.; Gallick, G.E.; Bar-Eli, M.; López-Berestein, G.; Cole, S.W.; López, G.E.; Lutgendorf,S.K.; Sood, A.K., 2013, Nature Comm., 4,doi:10.1038/ncomms2413.
Research Interests
Keywords: computational chemistry, path-integral Monte Carlo, molecular hydrogen, fluids, proton wires
Professor Gustavo Lopez is interested in developing computational techniques to describe varioussystems in computational phase. Specifically, quantum and classical Monte Carlo techniques are appliedto describe nanostructured systems, molecular hydrogen adsorbed on surface or trapped in fullerenes,and quantum liquids. Additionally, ab-initio techniques are used to describe molecular wires formed inhelical peptides, metal oxides, and semiconductors
Gustavo Lopez is a LehmanCollege computational andtheoretical chemist. Hespecializes in developing andapplying computationalmethods to describe system incondensed phase. Some ofthe system considered arequantum fluids, proton wires,molecular hydrogen trapped infullerenes, and biomolecularsystems.
2010-present Professor, Lehman College1994-2010 Professor, UPR-Mayaguez1993-1994 Assistant Professor, IU-PR1992-1994 Postdoc, U of Rhode Island1986-1992 PhD, UMASS-Amherst
Dr. Gustavo E. Lopez
Prof. Sharon LoverdeAssociate ProfessorCollege of Staten IslandStaten Island [email protected]"ps://sites.google.com/site/loverdelaboratory/
Publications1. "Molecular Mechanism for the Role of the H2A and H2B Histone Tails in Nucleosome ReposiDoning," Kaushik Chakraborty, Myungshim Kang, and Sharon M. Loverde, Journal of Physical Chemistry B, 122, 11827-11840 (2018). 2. "Molecular Dynamics SimulaDons of Supramolecular AnDcancer Nanotubes," Myungshim Kang, Kaushik Chakraborty, and Sharon M. Loverde, Journal of Chemical Informa6on and Modeling, 56, 1164-1168 (2018). 3. "NucleoDde State Effect on the ProtofilamentConformaDon of Tubulin Octamers," AnjelaManandhar, Myungshim Kang, Kaushik Chakraborty, and Sharon M. Loverde, Journal of Physical Chemistry B, 122, 6164-6178, (2018). 4. "Glassy Worm-Like Micelles in Solvent and Shear-Mediated Shape TransiDons," Kaushik Chakraborty, Kandaswamy Vijayan, Andre Brown, Dennis E. Discher, Sharon M. Loverde,SoG MaHer, 2018, DOI: 10.1039/C8SM00080H. 5."Isomeric Control of the Mechanical ProperDes of Supramolecular Filament Hydrogels," Yi-An Lin,Myungshim Kang, Wei-Chiang Chen,Yu-Chuan Ou, Andrew G. Cheetham, Pei-Hsun Wu, Denis Wirtz, Sharon M. Loverde and Honggang Cui, Biomaterials Science, 6, 216-224 (2018).
Research InterestsKeywords:
The Loverde laboratory utilizes all-atomistic and coarse-grained moleculardynamics simulations to investigate properties of soft and biological materials.We are also interested in characterizing the stability of macromolecularassemblies composed by proteins and/or nucleic acids.
Dr. Sharon Loverde is anAssociate Professor ofChemistry at College ofStaten Island. Herresearch group isinterested in the area ofsoft and biologicalmaterials.
2018- current Associate Professor, College of StaetnIsland2012-2018 Assistant Professor, College of StatenIsland2007-2012 NIH NRSA Postdoctoral Fellow, UPenn2001-2007 PhD, Materials Science and Engineering,Northwestern University
Dr. Sharon Loverde
Research Interests
Keywords: superhydrophobicity, wetting, polymer pen printing, photocatalysis, thermal interfaces
Using natural surfaces as inspiration, the Lyons group fabricates nanoscale materials with unique wetting,catalytic, thermal and/or optical properties. We are especially interested in developing a fundamentalunderstanding of reactions and properties at the solid-liquid-gas interface. We work closely with industrywith the goal of transitioning our inventions into industrially relevant innovations; active projects include:anti-reflective self-cleaning optically clear coatings to increase the energy efficiency of photovoltaic panelsand the isolation and study of single cells within nano/picoliter gel droplet arrays.
Dr. Alan LyonsAlan Lyons is Professor ofChemistry at the College ofStaten Island and GraduateCenter of CUNY. Hisresearch is focused on theeffect of topography andchemistry on the wetting,thermal, optical and catalyticproperties of surfaces.
Publications
Y. Zhao, Y. Liu, QF Xu, M. Barahman, A.M. Lyons, A Catalytic, Self-Cleaning Surface with Stable Superhydrophobic Properties: Printed PDMS Arrays Embedded with TiO2Nanoparticles, ACS Appl. Mater. Interfaces, 2015, 7 (4), pp 2632–2640.Z. Mao, M. Ganesh, M. Bucaro, I. Smolianski, R.A. Gross, A.M. Lyons, A High Throughput, High Resolution Enzymatic Lithography Process: Effect of Crystallite Size, Moisture and Enzyme Concentration, Biomacromolecules, 2014, 15 (12), 4627-4636.
D. Aebisher, D. Bartusik, Y. Liu, Y. Zhao, M. Barahman, Q.F. Xu, A.M. Lyons, A. Greer, Superhydrophobic Photosensitizers. Mechanistic Studies of 1O2 Generation in the Plastron and Solid/Liquid Droplet Interface, J. Am. Chem. Soc., 2013, 135, 18990–1899.
Q.F. Xu, B. Mondal, and A.M. Lyons, Fabricating Superhydrophobic Polymer Surfaces with Excellent Abrasion Resistance by a Simple Lamination Templating Method, ACS Appl. Mater. Interfaces, 2011, 3, 3508–3514.
R. Kempers, A.M. Lyons, A.J. Robinson, Modeling & Characterization of Metal Micro-Textured Thermal Interface Materials, ASME J. Heat Transfer, 2013, 136, 01130.
Dr. Alan M. LyonsProfessorCollege of Staten Island and Graduate Center CUNYRoom 62-2252800 Victory BoulevardStaten Island, NY [email protected]://csivc.csi.cuny.edu/Alan.Lyons/files/
2008- current Professor, Department of Chemistry,College of Staten Island & GraduateCenter CUNY.
1980-2008 Distinguished Member of TechnicalStaff, Manager & Group LeaderBell Laboratories, Murray Hill NJ
1981- 1987 PhD, MS, Polymer Chemistry NYU-Poly
Neepa MaitraProfessorHunter College and the Graduate Center, CUNY695 Park AvenueNew York NY [email protected]://www.hunter.cuny.edu/physics/faculty/maitra/home
Publications
N.T. Maitra, Charge Transfer in Time-DependentDensity Functional Theory, Journal of Physics:Condensed Matter, 2017, to appear.
N. T. Maitra, Perspective: Fundamental Aspectsof Time-Dependent Density Functional Theory,J. Chem. Phys. vol. 144, 220901 (2016).
E. Khosravi, A. Abedi, N. T. Maitra, The ExactPotential Driving the Electron Dynamics inEnhanced Ionization of H2
+, Phys. Rev. Lett. vol.115, 263002 (2015).
J. I. Fuks, K. Luo, E. D. Sandoval, N. T. Maitra,Time-Resolved Spectroscopy in Time-Dependent Density Functional Theory: An ExactCondition, Phys. Rev. Lett. vol. 114, 183002(2015).
F. Agostini, A. Abedi, Y. Suzuki, S. K. Min, N. T.Maitra, E. K. U. Gross, The Exact Forces onClassical Nuclei in Non-Adiabatic ChargeTransfer, J. Chem. Phys. vol. 142, 084303(2015).
Research Interests
Keywords: Electronic Structure and Dynamics, Time-Dependent Density Functional Theory(TDDFT), Non-Adiabatic DynamicsTDDFT is a method to describe electronic excitations and dynamics in atomic, molecular, chemicalsystems and solids. We focus on fundamental development: investigating properties of theexact functionals in order to guide the development of accurate approximations e.g. memory-dependence,in both the linear response regime and for dynamics in intense fields, impacting applications fromelectronic spectra to attosecond control and charge transfer. We also have several projects involvingthe exact-factorization approach to coupled electron-ion dynamics. This first-principles approach enablesus to define exact potentials that act on the electronic and nuclear subsystems, and is the correct startingpoint for building approximate mixed quantum-(semi)classical methods.
Neepa Maitra is atheoretical chemicalphysicist with researchinterests in densityfunctional theory, especiallyits time-dependent flavor,electronic excitations anddynamics and their couplingto ionic motion beyond theBorn-Oppenheimerapproximation.
2015 - current Professor (Hunter College and GC, CUNY)2009-14 Associate Professor (Hunter College and GC, CUNY)2004-14 Assistant Professor (Hunter College and GC, CUNY)1998-2003 Postdoc (UC Berkeley, Rutgers)1993-1998 PhD (Harvard)
Dr. Neepa Maitra
Prabodhika MallikaratchyAssociate ProfessorLehman College and the Graduate Center250 Bedford Park Blvd. West,Bronx, NY 10468Prabodhika.mallikaratchy@lehman.cuny.eduwww.mallikaratchylab.org
Selected Publications1.Federica Moccia,Chiara Platella, DomenicaMusumeci, Sana Batool, , Hasan Zumrut, JohnBradshaw, Prabodhika Mallikaratchy*, DanielaMontesarchio* “The role of G-quadruplex structuresof LIGS-generated aptamers R1. 2 and R1. 3 in IgMspecific recognition” : Int J Biol Macromol. 2019 ;133:839-849.2.S Lingala, LU Nordstrøm, PR Mallikaratchy“Synthesis of stable azide and alkyne functionalizedphosphoramidite nucleosides”: Tetrahedron Letters,2019; 60(3):211-213.
3.Sana Batool, Kimon V Argyropoulos, RoksanaAzad, Precious Okeoma, Hasan Zumrut, SanamBhandari, Rigzin Dekhang, Prabodhika Mallikaratchy*” Dimerization of an aptamer generated fromLigand-guided selection (LIGS) yields a high affinityscaffold against B-cells “Biochimica et BiophysicaActa (BBA)-General Subjects, 2019; 1863 (1), 232-240.4.Hasan Zümrüt, Naznin Ara, Maria Fraile, GeorgeMaio, Prabodhika Mallikaratchy “Ligand-guidedselection of target-specific aptamers: A screeningtechnology for identifying specific aptamersagainst cell-surface proteins”. Nucleic Acid Ther.2016 ;26(3):190-8.
For the current list of publications:www.https://scholar.google.com/citations?user=hCWxLbcAAAAJ&hl=en
Research Interests
Keywords: Nucleic Acid Aptamers (NAAs), Ligand-Guided Selection (LIGS), Nucleic Acid NanotechnologyLong-term goal oft this laboratory is to develop oligonucleotide aptamer based synthetic scaffolds for biological and biomedical applications. Therefore, our research program is aimed at generating new aptamers against biologically important cellular targets, and molecular engineering of multifunctional aptamer structures suitable for drug delivery, imaging and designer immunotherapeutic molecules.
Prabodhika Mallikaratchydevelops nucleic acid aptamersagainst cellular targets to probe cell-cell interactions, receptor-ligandsinteractions. Her research is highlyinterdisciplinary, which incorporateorganic chemistry, combinatorialscreening, structural biology,immunology and biochemistry.
2019- current Associate Professor2012-2019 Assistant Professor2008-2012 Research fellow, Memorial Sloan Kettering
cancer center2003-2008 PhD, University of Florida
Dr. Prabodhika Mallikaratchy
Hiroshi MatsuiProfessorHunter College695 Park Avenue,New York, NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Lou/Lou
Publications
Dielectric Response of High Explosives at THzFrequencies Calculated by Density FunctionalTheory, Lulu Huang, Andrew Shabaev, SamLambrakos, Noam Bernstein, Vern Jacobs, DanFinkenstadt, Lou Massa, Journal of MaterialsEngineering and Performance (2012) 21(7),1120-1132.
The Kernel Energy Method: Application toGraphene and Extended Aromatics, Lulu Huang,Hugo Bohorquez, Cherif F. Matta and LouMassa, IJQC, Vol. 111, 15, 4150-4157 (2011)
The Kernel Energy Method: Construction of 3 &4 tuple Kernels from a List of Double KernelInteractions, Lulu Huang, Lou Massa, Journal ofMolecular Structure: THEOCHEM, Vol. 962,issue 1-3, 72-79 (2010)
Calculation of Strong and Weak Interactions inTDA1 and RangDP52 by Kernel Energy Method,Huang, L.; Massa, L.; Karle, I.; Karle, J.Proceedings of the National Academy ofSciences, Vol. 106, No. 10, 3664-3669 (2009)
The Kernel Energy Method of QuantumMechanical Approximation carried to FourthOrder Terms, Huang, L.; Massa, L.; and Karle, J.PNAS, Vol. 105, No. 6, 1849-1854 (2008)
Research Interests
Keywords: differential equations, density matrices, density functional theory, Xraycrystallography, kernel energy method, information theory,
Applications of Quantum Mechanics to the electronic structure of atoms, molecules, and solids.
Postdoc: Brookhaven National LaboratoryPhD: Theoretical Molecular Physics, Georgetown University
Dr. Louis Massa
Hiroshi MatsuiProfessorHunter College /&Weill Medical College of Cornell University413 E. 69th StreetBelfer Research BuildingNew York, NY [email protected]/chemistry/faculty/Hiroshi/Hiroshil
Publications1. “Identification of novel nanovesicles and distinct exosome subsets via asymmetric-flow field flow study”, Zhang, H., Freitas, D., Kim, H.S., Fabijanic, K., Li, Z., Chen, H., Mark, M.T., Molina, H., Martin, A.B., Bojmar, L., Fang, J., Rampersaud, S., Hoshino, A., Matei, I., Kenific, C.M., Nakajima, M., Mutvei, A.P., Sansone, P., Buehring, W., Wang, H., Jimenez, J.P., Cohen-Gould, L., Paknejad, N., Brendel, M., Manova-Todorova, K., Magalhães, A., Ferreira, J.A., Osório, H., Silva, A.M., Massey, A., Cubillos-Ruiz, J.R., GallettI, G., Giannakakou, P., Cuervo, A.M., Blenis, J., Schwartz, R., Brady, M.S., Peinado, H., Bromberg, J., Matsui, H., Reis, C.A., & Lyden, D. Nature Cell Biol., 20, 332-343, (2018).
2. “The effect of cage shape on nanoparticle-based drug carriers: Anti-cancer drug release and efficacy via receptor blockade using dextran-coated iron oxide nanocages”, S. Rampersaud, J. Fang, Z. Wei, K.I. Fabijanic, S. Silver, T. Jaikaran, Y. Ruiz, M. Houssou, Z. Yin, S.P. Zheng, S. Mahajan, A. Hashimoto, A. Hoshino, D. Lyden, H. Matsui, Nano Lett., 16, 7357–7363 (2016).Research Interests
Keywords: Cancer Nanotechnology, Cancer Diagnostics/therapeutics, Lab-On-a-Chip, MedicalNanoparticles
Current interests of Matsui’s group are in the areas of 1) Nanopar4cle-based drug delviery andmedical imaging 2) Exosome engineering 3) T-cell-exosome-based immunotherapy 4) RNAdelivery for gene therapy/edi4ng 5) ultra-sound-based nanopar4cle medical treatment
Matsui is a Professor atHunter College and WeillMedical College of CornellUniversity. My researchareas are Cancerdiagnostics/ therapeutics,Bionanotechnology, Lab-On-a-Chip, andNanoparticle Synthesis forMedical Applications.
2001- current Current position1996-1999 Columbia University, Postdoc1992-1996 Purdue University, PhD1991-1992 Stanford University, MS
Dr. Hiroshi Matsui
Dr. Donna McGregor
Assistant ProfessorLehman College Department of Chemistry250 Bedford Park Blvd WestBronx, [email protected]
PublicationsD. McGregor, B.P. Burton-Pye, W.W. Lukens, andL.C. Francesconi, Insights into stabilization of the99TcVO core for synthesis of 99TcVO compounds. Eur.J. Inorg. Chem., 2014, 6, 1082-1089.
D. McGregor, W.V. Sweeney, P. Mills. The Design ofa Mercury Free Apparatus for teaching the Ideal GasLaw PV = nRT. J. Chem. Educ., 2012, 89 (4), pp 509–512
D. McGregor, B.P. Burton-Pye, I.M. Mbomekalle, P.A.Aparicio, S. Romo, X. Lopez, J.M. Poblet and L.C.Francesconi, 99Tc and Re Incorporated into MetalOxide Polyoxometalates: Oxidation State StabilityElucidated by Electrochemistry and Theory, Inorg.Chem., 2012, 51(16), 9017–9028.
B.P. Burton-Pye, I. Radivojevic, D. McGregor, I.M.Mbomekalle, W.W. Lukens and L.C. Francesconi,Photoreduction of 99Tc Pertechnetate by Nanometer-Sized Metal Oxides: New Strategies for Formationand Sequestration of Low-Valent Technetium, J. Am.Chem. Soc., 2011, 133(46), 18802-18815.
D. McGregor, B.P. Burton-Pye, R.C. Howell, I.M.Mbomekalle, W.W. Lukens, Jr., F. Bian, E. Mausolf,F. Poineau, K.R. Czerwinski, and L.C. Francesconi.Synthesis, Structure Elucidation and RedoxProperties of 99Tc Complexes of Lacunary WellsDawson Polyoxometalates: Insights into Molecular99Tc – Metal Oxide Interactions. Inorg. Chem., 2011,50 (5), 1670–1681Research Interests
Keywords: analytical, drug-design, inorganic, metal oxides, redox chemistry, radiochemistry, tri-peptides
Dr. McGregor is interested in 2 very different facets of Chemistry research.Chemical Education Pedagogy: Specifically, the development and study of how students learn chemistryin a flipped classroom using video lectures and active learning classroom activities.Using basic amino acids as building blocks for complex structures: Specifically the intelligent design ofshort peptide sequences that act as metal-chelating cores to model the binding of d-block metals inradiotherapuetic drug design and/or radioactive waste remediation. These systems also have the potentialto serve as interesting nanostructures due to their diverse chemical and physical properties.
Donna McGregor is anAnalytically trained InorganicChemist. Her primary researchinterests are in the fields ofChemical Education Pedagogyand the use of basic d and lAmino Acids as di and tri-peptide building blocks for theintelligent, systematic design ofmore complex metal-chelatingsystems and potentiallyinteresting nanostructures.
2015-Present Assistant Professor, Lehman College2013-2014 Distinguished Lecturer, Hunter College2009-2012 Doctoral Lecturer, Hunter College2004-2009 PhD, The Graduate Center, CUNY
Dr. Donna McGregor
Robert J. Messinger, Ph.D.Assistant ProfessorDepartment of Chemical EngineeringThe City College of New York140th St. and Convent Ave., ST-327New York, NY [email protected]://rmessinger.ccny.cuny.edu
Publications1. T.V. Huynh, R.J. Messinger, V. Sarou-Kanian, F. Fayon, R. Bouchet, M. Deschamps. “Restricted lithium ion dynamics in PEO-based block copolymer electrolytes measured by high-field nuclear magnetic resonance relaxation,” J. Chem. Phys., 2017, 147, 134902. 2. Z.J. Berkson, R.J. Messinger, K. Na, Y. Seo, R. Ryoo B.F. Chmelka, “Non-topotactictransformation of silicate nanolayers into mesostructured MFI zeolite frameworks during crystallization,” Angew. Chem. Int. Ed., 2017, 56, 5164-5169. 3. R.J. Messinger, M. Ménétrier, E. Salager. A. Boulineau, M. Duttine, D. Carlier, J.-M. AtebaMba, L. Croguennec, C. Masquelier, D. Massiot, M. Deschamps. “Revealing defects in crystalline lithium-ion battery electrodes by solid-state NMR: applications to LiVPO4F,” Chem. Mater. 2015, 27, 5212-5221. 4. R.J. Messinger, K. Na, Y. Seo, R. Ryoo, B.F. Chmelka, “Co-development of crystalline and mesoscopic order in mesostructured zeolite nanosheets,” Angew. Chem. Int. Ed., 2015, 54, 927-931. 5. R.J. Messinger, T.G. Marks, S.S. Gleiman, F. Milstein, B.F. Chmelka, “Molecular origins of macroscopic mechanical properties of elastomeric organosiloxane foams,” Macromolecules, 2015, 45, 4835-4849.
Research InterestsKeywords: Physical Chemistry, Materials Chemistry, Electrochemistry, Energy Materials, RechargeableBatteries, Solid-State NMR Spectroscopy, Transport Phenomena, Multi-Phase Fluids.
We study, design, and synthesize novel materials for energy applications, with a strategic emphasis onmeasuring, understanding, and controlling the molecular-scale phenomena that govern their macroscopicfunctions. We use advanced spectroscopic, diffraction, and electrochemical techniques, including novelmethods of nuclear magnetic resonance (NMR) spectroscopy. Advanced batterymaterials composed of low-cost, earth-abundant elements are of current interest,as well as multi-phase, complex fluids for energy applications.
Prof. Messinger studiesenergy materials with a focuson understanding andcontrolling properties up fromthe molecular level. Hisresearch lies at the interfaceof chemical engineering,materials science, physicalchemistry, & electrochemistry.Batteries & multi-phase fluidsare of current interest.
2017- current Assistant Professor, CUNY GraduateCenter Chemistry Doctoral Program
2015- current Assistant Professor, CCNY ChemicalEngineering & CUNY Energy Institute
2014-2015 Postdoctoral Fellow, CNRS-Grenoble &Grenoble Institute of Technology, France
2012-2014 European Union Marie Cure InternationalPostdoctoral Fellow, CNRS-Orléans, France
2006-2012 Ph.D., Chemical EngineeringUniversity of California, Santa Barbara
Dr. Robert J. Messinger
Dr. Aneta MieszawskaAssistant Professor, NanomedicineDepartment of ChemistryBrooklyn College2900 Bedford AvenueBrooklyn, New York [email protected]/web/academics/faculty
Publications
Mieszawska AJ, Kim Y, Gianella A, van Rooy I,Priem B, Labarre MP, Ozcan C, Cormode DP,Petrov A, Langer R, Farokhzad OC, Fayad ZA,Mulder WJ.; “Synthesis of polymer-lipidnanoparticles for image-guided delivery of dualmodality therapy” Biocojug Chem. 2013, PMID23957728.
Gianella A, Mieszawska AJ, Hoeben FJ,Janssen HM, Jarzyna PA, Cormode DP, CostaKD, Rao S, Farokhzad OC, Langer R, Fayad ZA,Mulder WJ. “Synthesis and in vitro evaluation ofa multifunctional and surface-switchablenanoemulsion platform.” Chem Commun. 2013PMID 23877789.
Mieszawska AJ, Mulder WJ, Fayad ZA,Cormode DP.; “Multifunctional gold nanoparticlesfor diagnosis and therapy of disease” Mol.Pharm. 2013, PMID 23360440.
Mieszawska AJ, Gianella A, Cormode DP, ZhaoY, Meijerink A, Langer R, Farokhzad OC, FayadZA, Mulder WJ.; “Engineering of lipid-coatedPLGA nanoparticles with a tunable payload ofdiagnostically active nanocrystals for medicalimaging” Chem. Commun. 2012, PMID22555311.
Research Interests
Keywords: second generation nanoparticles, theranostics, biodegradable polymers, nanocrystals
The Mieszawska group research focuses on nanotechnology and nanomedicine with specific interest indesigning and testing the nanoparticle systems for concurrent imaging and therapy of disease. Thesetheranostic nanoparticles are based on slow releasing biodegradable and biocompatible polymers, suchas PLGA or PLA, that encapsulate contrast agents and small drug molecules. The primary goal is to targetand deliver efficacious therapy directly to cancer cells. This interdisciplinary research involves activecollaboration with clinicians from Icahn School of Medicine at Mount Sinai.
Aneta Mieszawska is anAssistant Professor in theDepartment of Chemistry atBrooklyn College. Herresearch is focused onnanomedicine andapplication of nanoparticlebased systems for cancerdetection and treatment.
2013- current Assistant Professor, Brooklyn College2011-2013 Postdoctoral Fellow, Icahn School of
Medicine at Mount Sinai2007-2010 Postdoctoral Associate, Tufts University2002-2007 PhD University of Louisville
Dr. Aneta Mieszawska
Michael V. MirkinProfessor of ChemistryCUNY-Queens College65-30 Kissena BlvdFlushing, NY [email protected]://chem.qc.cuny.edu/~mirkinlab/mvm.html
Publications
Nanoelectrochemistry, ed. M.V. Mirkin and S.Amemiya, CRC Press, Boca Raton, FL, 2015
Scanning Electrochemical Microscopy, ed. A.J.Bard and M.V. Mirkin, CRC Press, Boca RatonFL, 2nd edition, 2012.
T. Sun, Y. Yu, B.J. Zacher and M.V. Mirkin,Scanning Electrochemical Microscopy ofIndividual Catalytic Nanoparticles, Angew.Chem. Int. Ed. 2014, 53, 14120 –14123 (VIParticle).
Y.X. Wang, T. Kakiuchi, Y. Yasui, and M.V.Mirkin, Kinetics of Ion Transfer at the IonicLiquid/Water Nanointerface, JACS, 2010, 132,16945-16952.
J. Velmurugan, D. Zhan, and M.V. Mirkin,Electrochemistry through Glass, Nature Chem.2010, 2, 498-502.
P. Sun and M.V. Mirkin, Electrochemistry ofindividual molecules in zeptoliter volumes, JACS,2008, 130, 8241-8250.
P. Sun, F.O. Laforge, T.P. Abeyweera, S.A.Rotenberg, J. Carpino, and M.V. Mirkin,Nanoelectrochemistry of mammalian cells,PNAS, 2008, 105, 443-448.Research Interests
Keywords: Electrochemistry/Physical/Analytical/Nano
We employ nanometer-sized electrochemical probes for molecular level characterization of chemicalprocesses and materials. A wide variety of phenomena are studied including charge-transfer reactions atthe solid/liquid and liquid/liquid interfaces, electrocatalysis, bioelectrochemistry, and electrochemicalimaging. The main focus is on obtaining quantitative physico-chemical information by combination ofexperiments with mathematical modeling and computer simulations. We also maintain active interest indevelopment of electrochemical techniques for analytical applications. These include carbon nanoprobes,amperometric nanosensors, and resistive-pulse sensors.
Michael V. Mirkin is aprofessor of chemistry atCUNY-Queens College. Hisresearch interests are in thefield of electrochemistry andinclude nano- and bio-electrochemistry, interfacialcharge-transfer reactions,electrocatalysis, andscanning electrochemicalmicroscopy (SECM).
1993 - current Professor of Chemistry1990-1993 Postdoc, University of Texas at Austin1982-1987 PhD in Electrochemistry, Kazakh State
University, USSR.
Dr. Michael V. Mirkin
David MootooProfessorHunter CollegeChemistry Department695 Park AvenueNew York NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Randy/Randy
Publications
Garg, H.; Francella, N.; Tony, K. A.; Augustin, L. A.; Fantini, J.; Barchi Jr, J. J.; Puri, A.; Mootoo; Blumenthal, R. Glycoside analogues of a-galactosylceramide, a novel class of small molecule inhibitors for HIV-1 entry. Antiviral Res. 2008 80, 54-61.
Hans, S. K.; Camara, F.; Martin-Montalvo, A.; Brautigan, D. L.; Heimark, D.; Larner, J.; Grindrod, S.; Brown, M.; Mootoo, D. R. Synthesis of the C-glycoside analog of b-galactosamine-(1->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Ca. Bioorg. Med. Chem. 2010, 18, 1103-1110.
Bachan, S.; Fantini, J.; Joshi, A.; Garg, H.; Mootoo, D. R. Synthesis, gp120 binding and anti-HIV activity of fatty acid esters of 1,1-linked disaccharides. Bioorg. Med. Chem. 2011, 19, 14803-14811.
Bachan, S.; Tony, K. A.; Kawamura, A.; Montenegro, D.; Joshi, A.; Garg, H.Synthesisand anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins. Bioorg. Med. Chem. 2013, 21, 6554-6564.
Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Altiti, A. S.; Mootoo, D. R. Application to the C-Glycoside of the immunostimulant KRN7000. Org. Lett, 2014, 16, 1466-1469.
Research Interests
Keywords:synthesis, glycomimetics, tumor targeting, immunostimulants
An broad area of current interest is the design and synthesis of molecules for interrogating anti-cancerpathways. Two strategies that center on targeting cytotoxic agents to tumors and glycolipids that boostthe immune system against cancer are being pursued. These projects entail the design and synthesis ofnovel small molecules and examination of their biological properties, in the context of specific diseasemechanisms.
Our research centerson the design,synthesis andapplication ofbiomechanisticprobes, and thedevelopment of newsyntheticmethodologies.
1989- current Professor1986-1989 Postdoc, Duke University1982-1986 Ph.D., University of Maryland
Dr. David R. Mootoo
Ryan P. MurelliAssociate ProfessorBrooklyn College2900 Bedford AvenueBrooklyn, [email protected]://userhome.brooklyn.cuny.edu/rpmurelli/
Publications
Bejcek, L. P.; Murelli, R. P. "Oxidopyrylium [5+2]Cycloaddition Chemistry: Historical Perspectiveand Recent Advances (2008-2018)"Tetrahedron, 2018, 74, 2501-21.
D'Erasmo, M. P.; Murelli, R. P. "Fluorous-PhaseApproach to α-Hydroxtropolone Synthesis" J.Org. Chem. 2018, 83, 1478-85.
Hirsch, D. R.; Schiavone, D. V.; Berkowitz, A. J.;Morrison, L. A.; Masaoka, T.; Wilson, J. A.;Lomonosova, E.; Zhao, H.; Patel, B. S.; Dalta, S.H.; Majidi, S. J.; Pal, R.; K.; Gallicchio, E.; Tang,L.; Tavis, J. E.; Le Grice, S. F. J.; Beutler, J. A.;Murelli, R. P. "Synthesis and BiologicalAssessment of 3,7-Dihydroxytropolones" Org.Biomol. Chem. 2018, 16, 62-9.
Fuhr, K. N.; Hirsch, D. R.; Murelli, R. P.;Brenner-Moyer, S. E. "Catalytic EnantioselectiveIntermolecular [5+2] Dipolar Cycloadditions of a3-Hydroxy-4-Pyrone-Derived OxidopyryliumYlide", Org. Lett., 2017, 19, 6356-9.
Research Interests
Keywords:Synthetic Organic Chemistry, Medicinal Chemistry, Chemical Biology.
Dr. Murelli and his groupdevelop and use tools ofsynthetic organic chemistryto meet challenges inmodern medicine. They areparticularly interested intropolones, which areunderexplored aromaticcompounds with a wealth ofpotential in biology andmedicine.
2017- current Associate Professor, Brooklyn College2010- 20017 Assistant Professor, Brooklyn College2007-2010 Postdoctoral Associate, Yale University2002-207 PhD Studies, Boston College
Dr. Ryan Murelli
Daniele MusumeciAssistant ProfessorYork College-Chemistry Department94-20 Guy R. Brewer Blvd., Room 3F01KNY 11451Jamaica [email protected]/portal_college/dmusumeci
Publications
S. Ruan, D. Musumeci, et al. Surface TransportMechanisms in Molecular Glasses Probed by theExposure of Nano-particles, The Journal ofChemical Physics, 2017, 146, 203324.
D. Musumeci, M. Hasebe, et al. Crystallization ofOrganic Glasses: How Does Liquid FlowDamage Surface Crystal Growth?, CrystalGrowth & Design, 2016, 12, 2931-2936.
M. Hasebe, D. Musumeci, et al. Fast SurfaceCrystallization of Molecular Glasses: Creation ofDepletion Zones by Surface Diffusion andCrystallization Flux, Journal of PhysicalChemistry B, 2015, 119, 3304-3311.
I. J. Vitorica-Yrezabal, S. Libri, et al.Coordination Polymer Flexibility Leads andEnables a Crystalline Solid-Vapour Reaction: AMulti-technique Mechanistic Study, Chemistry- AEuropean Journal, 2015, 21, 8799-8811.
M. Hasebe, D. Musumeci, et al. Fast SurfaceCrystal Growth on Molecular Glasses and ItsTermination by the Onset of Fluidity, Journal ofPhysical Chemistry B, 2014, 118, 7638-7646.
Research Interests
Keywords: pharmaceutical materials, crystallization, glasses, solubility.
The research in the laboratory of Daniele Musumeci centers around the investigation of crystallizationprocesses of pharmaceutical compounds from solution and from the amorphous state. Dr. Musumeciinterests include organic solid-state chemistry, crystal engineering, characterization of amorphous andcrystalline materials, high-resolution microscopy, and the development of strategies to improve solubility ofpoorly water soluble oral drugs.
Dr. Musumeci is apharmaceutical scientist withexpertise in materials science,solid-state chemistry, physicalpharmacy, and crystallizationprocesses of pharmaceuticalcompounds. His researchfocus on the mechanisticunderstanding of crystallizationprocesses and the developmentof strategies to improve the oralsolubility of drugs.
2013- current Assistant Professor at York College2011-2013 Postdoc at UW-Madison2009-2011 Postdoc at NYU2006-2009 Ph.D. at Sheffield University, UK
Dr. Daniele Musumeci
Naphtali O�ConnorAssistant ProfessorLehman College, CUNY250 Bedford Park BlvdWest Bronx, NY [email protected]/academics/chemistry/prof-oconnor.php
Publications
O�Connor, N.A.; Abugharbieh, A.; Buabeng, E.;Yasmeen, F.; Mathew, S.; Samaroo, D.; Cheng,H. �The Crosslinking of Polysaccharides withPolyamines and Dextran-PolyallylamineAntibacterial Hydrogels� Int. J. Biol. Macromol.(2015) 72, 88-93.
Samaroo, D.; Perez, E.; Aggarwal, A.; Wills, A.;O � Connor, N.A. � Strategies for DeliveringPorphyrinoid-based Photosensitizers inTherapeutic Applications� Therapeutic Delivery(2014), 5(7), 859-872.
Solomon, M.R.; O�Connor, N.A.; Paik, D.C.;Turro, N.J. � Nitroalcohol Induced HydrogelFormation in Amine-Functionalized Polymers.� J.Appl. Polym. Sci. (2010), 117(2), 1193-1196.
O'Connor, N.A.; Stevens, N.; Samaroo, D.;Solomon, M.R.; Martí, A.A.; Dyer, J.;Vishwasrao, H.; Akins, D.L.; Kandel, E.R.; Turro,N.J. � A covalently linked phenanthridine-ruthenium(II) complex as a RNA probe.� Chem.Comm. (2009), 2640-2642.
Stevens, N.; O'Connor, N.A.; Vishwasrao, H.;Samaroo, D.; Kandel, E.R.; Akins, D.L.; Drain,Charles M.; Turro, N.J. � Two color RNAintercalating probe for cell imaging applications.�J. Am. Chem. Soc. (2008) 130, 7206-7207.Research Interests
Keywords: biomaterials, hydrogels, polymers
My current research focus is the development of materials for biomedical applications. We recentlydeveloped a method for preparing polysaccharide-polyamine crosslinked hydrogels. We are currentlyexploring their application as anti-microbial and wound healing materials.We are also working on the development of curcumin based biomaterialsas antibacterial agents and cancer therapeutics.
Naphtali has a variedresearch background thatreflects his wide researchinterests. His researchranges from developingbiomaterials to designingmolecular probes.
2008- current Current position2007-2008 Postdoc/Columbia University2000-2006 PhD/University of California, Irvine
Dr. Naphtali O�Connor
Associate ProfessorQueens College, and the Ph.D. Program inChemistry and Biochemistry, The Graduate Center ofthe City University of New York65-30 Kissena Blvd.Queen, NY - 11367Email. [email protected]://chem.qc.cuny.edu/~skumar/
Selected PublicationsWardman JH et al. �Identification of a small-molecule ligand that activates theneuropeptide receptor GPR171 andincreases food intake� Sci Signal. 2016,9(430):ra55.
Blazekovic F et al. "HLA-DR peptideoccupancy can be regulated with a widevariety of small molecules. Hum VaccinImmunother. 2016, 12(3):593-8
Dibyendu Dana et al. "Development of ahighly potent, selective, and cell-activeInhibitor of cysteine cathepsin L-A hybriddesign approach" ChemicalCommunications (Camb) 2014,50(74):10875-8
Hsin-Pin Ho, et al. �Studies on QuantitativePhosphopeptide Analysis by MALDI MassSpectrometry Without Label,Chromatography or Calibration Curves�Rapid Communications in MassSpectrometry 2014, 28(24):2681-9
Ivone Gomes et al. "GPR171 is aHypothalamic G Protein-Coupled Receptorfor BigLEN, a Neuropeptide involved inFeeding� Proceedings of the NationalAcademy of Sciences (PNAS) USA, 2013,110(40), 16211–16216
Tirtha K. Da et al. �Centrosomal KinaseNek2 Cooperates With Oncogenic PathwaysTo Promote Metastasis� Oncogenesis,2013, 2, e69; doi:10.1038/oncsis.2013.34
Research Interests: Chemical Biology of ProteinPhosphorylation and Proteolysis
Keywords: Cysteine Cathepsins, Protein Kinases, andTyrosine PhosphatasesDescription of research activities and strategy. Theresearch in Kumar�s laboratory spans at the interface ofchemistry and biology, and is broadly focused on discovery ofunknown enzyme function using chemical biologyapproaches. The current project includes the development ofsmall molecule probes for protein kinases, protein tyrosinephosphatases, and cysteine proteases and utilizing them tounderstand the enzyme function in both normal and diseasedhuman physiology. For more information, please visit thewebsite.
2014- current Associate Professor2007-2014 Assistant Professor2002-2007 Postdoc, Albert Einstein College of Medicine1996-2002 PhD, Wesleyan University
Dr. Sanjai Kumar Pathak
Ralf M. Peetz, PhDAssoc. Prof.CUNY/ Staten Island and Graduate Center2800 Victory BoulevardBuilding 6S-227Staten Island, NY [email protected]://www.csi.cuny.edu/departments/chemistry
PublicationsSengupta, Arijit; Doshi, Ami; Jaekle, Frieder; Peetz,Ralf M., Journal of Polymer Science Part A (2015),accepted
Zhilin, Denis M.; Peetz, Ralf M., Journal of ChemicalEducation (2014), 91(1), 119-122
Sengupta, Arijit; Ghosh, Sutapa; Peetz, RalfM., Synthetic Metals (2010), 160(17-18), 2037-2040
Burrows, Hugh D.; Narwark, Oliver; Peetz, Ralf;Thorn-Csanyi, Emma; Monkman, Andrew P.;Hamblett, Ian; Navaratnam, Suppiah, Photochemical& Photobiological Sciences (2010), 9(7), 942-948.
Mukherjee, Narayan; Peetz, Ralf M.,Macromolecules (2008), 41(18), 6677-6685
Research Interests
Keywords: Functional Materials, Conjugated Polymers, Donor Acceptor Systems
We are currently interested in the controlled synthesis of donor-acceptor macromolecules for potential usein organic polymer photovoltaics. Some candidates featuring promising electronic properties andabsorbing over a broad range of wavelengths are currently scheduled to be tested in prototypephotovoltaic cells.
Ralf Peetz is interested infunctional materials thatcould be of use in meetingfuture energy needs.
2003- current CSI and Graduate Center2000-2003 Postdoc, University of Akron, Institute
of Polymer Science1997-2000 PhD, University of Hamburg,
Germany
Dr. Ralf M. Peetz
Sébastien PogetAssistant ProfessorCollege of Staten Island, CUNYDepartment of Chemistry2800 Victory Blvd.Staten Island, NY [email protected]/faculty/POGET_SEBASTIEN.html
PublicationsP. Anand, A. Grigoryan, M. H. Bhuiyan, B.Ueberheide, V. Russell, J. Quinoñez, P. Moy, B.T. Chait, S. F. Poget, M. Holford: Sample limitedcharacterization of a novel disulfide-rich venompeptide toxin from terebrid marine snail Terebravariegata. PLoS ONE 2014, 9, e94122.
S. F. Poget, M. E. Girvin: Solution NMR ofmembrane proteins in bilayer mimics: Small isbeautiful, but sometimes bigger is better.Biochim. Biophys. Acta 2007, 1768, 3098-106.
S. F. Poget, S. M. Cahill, M. E. Girvin: Isotropicbicelles stabilize the functional form of a smallmultidrug-resistance pump for NMR structuralstudies. J. Am. Chem. Soc. 2007, 129 2432-2433.
Research InterestsKeywords: Solution-state NMR, membrane protein structural biology, ion channels, toxins,electrophysiology, biophysics
The Poget lab is interested in the structural and functional study of membrane proteins through solution-state NMR and other biophysical methods. Our studies focus on better understanding the interactions ofanimal peptide toxins with their target ion channel domains as tools for an improved understanding of ionchannel function and starting point for drug development. To carry out these studies at the cutting edge ofstructural biology, we are also involved in the development of new and improved methods for membraneprotein studies, including development of more powerful membrane mimetics such as bicelles and optimizedNMR methods.
Dr. Poget is interested inmembrane protein structureand function, with aparticular emphasis on theinteractions between ionchannel domains andanimal peptide toxins.
2009- current Assistant Professor, College of Staten Island, CUNY
2003-2009 Postdoc, Albert Einstein College of Medicine, NY
2001-2003 Postdoc, Rockefeller University, NY1997-2001 PhD, University of Cambridge, UK
Dr. Sébastien Poget
Adam A. Profit, Ph.D.Associate ProfessorYork College94-20 Guy R. Brewer BlvdJamaica, NY [email protected]/portal_college/aprofit
Publications
Profit, A. A., Vedad, J. Saleh, M., and Desamero,R.Z.B. �Aromaticity and Amyloid Formation:Effect of p-Electron Distribution and ArylSubstituent Geometry on the Self-Assembly ofPeptides Derived from hIAPP22-29� ArchBiochem Biophys 2015, 567, 46-58.
Profit, A. A., Felsen, V., Chinwong, J., Mojica, E-R., and Desamero, R.Z.B. �Evidence of p-stacking Interactions in the Self-assembly ofhIAPP22-29� PROTEINS: Structure, Function andBioinformatics 2013, 81, 690-703.
Research Interests
Keywords: Amyloid, protein kinases, peptides, peptoids, enzymology, solid phase synthesis
The abnormal formation of protein aggregates, or amyloid deposits, is the hallmark of Alzheimer�s disease as wellas type 2 diabetes. My laboratory is investigating the molecular interactions that occur between key proteins thatcontribute to the formation of amyloid in these diseases. Through a more detailed understanding of how theseproteins self-assembly to form aggregates, we hope to design and develop small molecule and peptide mimeticinhibitors which may serve as potential therapeutic agents.
We are also developing compounds that inhibit the activity of key enzymes (kinases) which can cause tissues togrow out of control and develop into tumors. To accomplish this we are synthesizing molecules that exploit theunique molecular recognition motifs found in these enzymes to more effectively deliver inhibitory species to theactive site.
Protein-ligand interactions isthe unifying theme of myresearch interests. Inparticular, the design,synthesis and application ofbiologically relevant probemolecules to study andelucidate protein-protein andprotein-ligand interactionsinvolved in amyloid diseasesand cancer.
2014- current Associate Professor of Chemistry2004-2014 Assistant Professor of Chemistry2000-2004 Merck Research Laboratories1997-2000 Postdoc - Albert Einstein College of Medicine1997 PhD - Stony Brook University
Dr. Adam A. Profit
Krishnaswami Raja, Ph.D.Associate ProfessorCollege of Staten IslandDepartment of Chemistry2800 Victory BoulevardStaten Island, New York [email protected]://www.csi.cuny.edu/faculty/RAJA_KRISHNASWAMI.html
Publications�Curcumin-derived green plasticizers forPoly(vinyl) chloride.� Saltos, J., Shi, W.;Mancuso, A, Park, T.; Averick, N.; Sun, C.; Fata,J. E.;. Punia, K.; Raja, K. S.* RSC Adv., 2014, 4(97), 54725 – 54728.
Raja, K.S. Editorial: Green Anti-Cancer Agentsand Ayur-Biotechnology: A smart approachtowards improving R&D productivity. AnticancerAgents in Med Chem 2013 Dec;13(10):1467-8.
Raja, K.S.; Banerjee, P.; Lamoreaux, W.; Shi,W.; Auerbach, A.;“Novel Curcumin andTetrahydrocurcumin derivatives” US patentnumber 8487139
Dolai, S. ; Shi, W.; and Raja, K.S.“Synthesis ofDrug/Dye-Incorporated Polymer–ProteinHybrids” Methods in Molecular BiologyBioconjugation Protocols : Strategies and Vol751, 29-42, 2011.
Raja, K.S., Dolai, S. ; Shi, W.; Wang, Q.Bionanoparticles as nanoscaffolds for chemicalmanipulation”. Encyclopedia of Nanoscience andNanotechnology, Marcel Dekker, 2009, SecondEdition.
Research Interests
Keywords: Origin of life, stigmergy scaffolds, 3D Cell culture, Ayurbiotecnology, Virus Chemistry,Bioconjugation, Green drug development, Polymer-protein hybrids
The Raja group is interested in creating programmable scaffolds for probing the origins of multi-cellularlife, synthesis of well defined polymer-bionanoparticle/targeting protein hybrids and green drug discoveryand development based on Ayurveda. The research spans the areas of small molecule and polymersynthesis, bioconjugation chemistry and bioengineering.
Krishnaswami Raja isCollege of Staten IslandChemistry faculty working inthe area ofBionanotechnology, Originof life research and greendrug discovery anddevelopment.
2012- current Associate Professor2005-2012 Assistant Professor, College of Staten
Island2000-2004 Skaggs Post Doctoral Fellow TSRI 1999 Indian Institute of Science
Dr. Krishnaswami Raja
Name: Varattur D. ReddyPosition : ProfessorAffiliation: Kingsborough Community CollegeAddress: 2001 Oriental Blvd
Manhattan Beach, Brooklyn, NY [email protected] [email protected]
Publications
Reddy, V. D., Greener Organic Chemistry Experiments: A Miniscale and MicroscaleApproach 3rd Edi2on, John Wiley & Sons, 2015.
Reddy, V. D. Organometallic AnB-cancer Complexes�. U.S. Pat. 2012/032507 and Int. Pat. WO 2012/138988 A2.
Reddy, V. D.; Dayal, D.; Szalda, D.J. Cosenza, S.C.; Reddy, M.V.R. � Synthesis, structures, and anBcancer acBvity of novel Organometallic ruthenium-maltolcomplexes�. J. Organomet. Chem, 2012, 700, 180.
Reddy, V. D.; Dayal, D.; Cosenza, S.C.; Reddy. M.V. R.; Pearl. Jr., W.C.; Adams, R.D. �Glycalruthenium carbonyl clusters: Synthesis, characterizaBon, and anBcancer acBvity,�J.Organomet. Chem, 2009, 694, 959.
Reddy, V. D. �Synthesis, characterizaBon, and reacBvity of a novel ruthenium carbonyl cluster containing tri-O-benzyl-D-glucal as a chiral carbohydrate ligand,� J. Organomet.Chem, 2006, 691, 27.
Research Interests
Synthesis of organic and organometallic compounds as anticancer and anti-Alzheimer's diseaseagents. Organic synthesis involves total synthesis of natural and unnatural products andmodified carbohydrates. Organometallic chemistry involves synthesis of novel organometalliccatalysts, efficient methodologies for the synthesis of biologically active molecules,bioorganometallics, and drug delivery systems. Research facilities at Kingsborough are 400MHz NMR Facility, IR, GC, and HPLC.
Our group research focuses on thefollowing areas: Synthesis oforganic and organometalliccompounds as anticancer and anti-Alzheimer�s disease agents, andcatalysis.
2001- current Kingsborough Community College-CUNY1993-2001 Schering Plough Pharmaceutical Company
currently Merck and American HealthFoundation
1990-1993 Hunter College and Queens College1990 Ph.D. Indian Institute of Technology, Mumbai
Dr. Varattur Reddy
CUNY by the Sea
Susan A. RotenbergPosition: ProfessorAffiliation: Queens CollegeDepartment of Chemistry & Biochemistry65-30 Kissena BoulevardFlushing, NY [email protected]://rotenberglab.com/(website under construction)
Publications
X. Zhao, and S.A. Rotenberg. �Phosphorylationof Cdc42 effector protein-4 (CEP4) by proteinkinase C promotes motility of human breastcells.� J. Biol. Chem. 2014, 289:25844-25854.
S. De, A. Tsimounis, X. Chen, and S.A.Rotenberg. "Phosphorylation of a-tubulin byprotein kinase C stimulates microtubuledynamics in human breast cells." Cytoskeleton2014, 71: 257-272.
X. Chen, X. Zhao, T. P. Abeyweera, and S. A.Rotenberg. �Analysis of substrates of proteinkinase C isoforms in human breast cells by thetraceable kinase method.� Biochemistry 2012,51: 7087-7097.
X. Chen and S.A. Rotenberg. �Phospho-MARCKS drives motility of mouse melanomacells.� Cell. Signal. 2010, 22: 1097-1103.
T.P. Abeyweera, X. Chen, and S. A. Rotenberg.�Phosphorylation of a6-tubulin by protein kinaseCa activates motility of human breast cells.� J.Biol. Chem. 2009, 284: 17648-17656.
Research Interests
Keywords:Enzyme inhibitors; protein structure and function relationships; cell signaling pathways
Prof. Rotenberg
1990 - current Professor1985 - 1990 Postdoctoral - Rockefeller University,
Columbia University1980 - 1985 Ph.D. – Brown University
Dr. Susan A. Rotenberg
Kevin Ryan, Ph.D.Associate Professor, Biochemistry DivisionDepartment of Chemistry and BiochemistryThe City College of New YorkMR-1337, 160 Convent Ave.New York [email protected]://www.sci.ccny.cuny.edu/~kr107/index2/index.html
Publications
Liu, M. T.; Nagre, N. N.; Ryan, K., Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3' cleavage reaction. Bioorganic & Medicinal Chemistry 2014, 22 (2), 834-41;
Li, Y.; Peterlin, Z.; et al., Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry. ACS Chemical Biology 2014;
Lama, L.; Seidl, C. I.; Ryan, K., New insights into the promoterless transcription of DNA coligo templates by RNA polymerase III. Transcription 2014, 5 (1);
Seidl, C. I.; Lama, L.; Ryan, K., Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells. Nucleic Acids Research 2013, 41 (4), 2552-64;
Kurland, M. D.; Newcomer, M. B.; et al., Discrimination of saturated aldehydes by the rat I7 olfactory receptor. Biochemistry 2010, 49 (30), 6302-4.
Research Interests
Keywords: molecular recognition, olfaction, RNA, micro RNA, RNA interference, RNA polymeraseIII, chemical biology, transcription
In the RNA area, we study the use of chemically synthesized transcription templates as potentialinformation-bearing molecules for producing small therapeutic RNA in human cells. A second RNA area isthe biochemistry of RNA processing reactions that occur during the biogenesis of messenger RNA inhuman cells. In the olfaction area, we use pharmacology, organic synthesis and chemical biology to probethe biochemistry of the sense of smell.
Dr. Ryan’s lab applieschemical concepts tobiological problems in twomain areas, RNA andolfactory molecularrecognition.
2009- current Associate Professor2003-2008 Assistant Professor1996-2003 Postdoc, Columbia University (Chemistry
and Biology Depts.) 1996 Ph.D., University of Rochester
Dr. Kevin Ryan
Matthew Y. SfeirAssociate ProfessorPhotonics InitiativeAdvanced Science Research Center85 St. Nicholas TerraceNew York NY, [email protected]://sfeirlab.ws.gc.cuny.edu/
PublicationsA. Pun, A. Asapoordarvish, E. Kumarasamy, M.Tayebjee, D. Niesner, D. McCamey, S. Sanders,L. Campos, M. Y. Sfeir, Ultrafast IntramolecularSinglet Fission to Persistent Multiexcitons byMolecular Design, Nature Chemistry, (2019).J. Hu, K. Xu, L. Shen, Q. Wu, G. He, J-Y. Wang,J. Pei, J. Xia, M. Y. Sfeir, New insights into thedesign of conjugated polymers for intramolecularsinglet fission, Nature Comm., 9, 2999 (2018).M. Tayebjee, S. Sanders, E. Kumarasamy, L.Campos, M. Y. Sfeir, D. McCamey, Quintetmultiexciton dynamics in singlet fission, NaturePhysics, 13, 182 – 188 (2017).K. Appavoo, X. Liu, V. Menon, M. Y. Sfeir,Excitonic Lasing in Solution-ProcessedSubwavelength Nanosphere Assemblies, NanoLetters, 16, 2004 – 2010 (2016).E. Busby, J. Xia, J. Low, R. Song, J. Miller, X-Y.Zhu, L. Campos, M. Y. Sfeir, A design strategyfor intramolecular singlet fission mediated bycharge-transfer states in donor–acceptor organicmaterials, Nature Materials, 14, 426-433 (2015).K. Appavoo, M. Liu, C. Black, M. Y. Sfeir,Quantifying Bulk and Surface RecombinationProcesses in Nanostructured Water SplittingPhotocatalysts via In Situ UltrafastSpectroscopy, Nano Letters, 15 1076 (2015).
Research InterestsKeywords: Ultrafast optics, nanophotonics, charge and spin dynamics, energy, optoelectronics
Charge and Spin Correlations in Organic Materials: Discovery of novel multi-excitonic and correlatedelectron phenomena in organic semiconductors and conductors.Nanostructured Energy Conversion Devices: Fabricating energy conversion devices, including solarcells, disordered lasers, and photoelectrochemical cells from nanomaterials and assemblies.Next Generation Ultrafast Spectroscopy Methods: Developing high speed, imaging, and in situcapabilities for ultrafast spectroscopy using next generation sources and detectors.
Dr. Sfeir’s research usesbroadband ultrafast andoptoelectronic techniques toidentify novel electronicproperties in molecular andnano-materials. His groupinvestigates their use innovel devices architectures,including for light harvestingand photonics applications.
2019-current Associate Professor, CUNY ASRC &The Graduate Center
2009-2019 Scientist, Center for Functional NanomaterialsBrookhaven National Laboratory
2005-2009 Postdoc, Condensed Matter Physics andMaterials Science, Brookhaven National Lab
2000-2005 PhD, Chemical Physics, Columbia University
Dr Matthew Sfeir
Chwen-Yang ShewProfessorCollege of Staten IslandDepartment of Chemistry2800 Victory BoulevardStaten Island, NY [email protected]/faculty/SHEW_CHWEN_YANG.html
PublicationsS. Oda, Y. Kubo, C.-Y. Shew, K. Yoshikawa,Fluctuations induced transition of localization ofgranular objects caused by degrees of crowding,Physica D (2016) in press.
C.-Y. Shew, and K. Yoshikawa, �A toy model fornucleus-sized crowding confinement �J. Phys.:Condens. Matter 27 064118 (2015)
E. Sánchez-Díaz, C.-Y. Shew, X. Li, B. Wu, G. S.Smith and W.-R. Chen, “Phase Behavior Under aNoncentrosymmetric Interaction: Shifted-Charge Colloids Investigated by Monte CarloSimulation,� J. Phys. Chem. B, 118, 6963–6971(2014)
C.-Y. Shew, K. Kondo and K. Yoshikawa, �Rigidityof a spherical capsule switches the localizationof encapsulated particles between inner andperipheral regions under crowding condition:Simple model on cellular architecture,� J. Chem.Phys. 140, 024907 (2014).
C.-Y. Shew and K. Yoshikawa, �Abstracting theessence of the confinement effect on crowdingmicrospheres: Mean-field theory and numericalsimulation,� Chem. Phys. Lett. 590, 196-200(2013).
Research Interests
Keywords: Statistical Mechanics, Thermodynamics, Liquid State Theory and Computer Simulation
Our group develops model, theory and simulaaon to elucidate the structure of colloids,polymeric materials, confined and crowded cells, and self-assembled nanoparacles.
Research Area: TheoreticalPhysical Chemistry inStructure of CondensedMatters, Macromolecules,and Biological Cells
2011- current Professor, CSI2005-2010 Associate Professor, CSI1999-2004 Assistant Professor, CSI1995-1998 Postdoc. UW-Madison2000-2005 PhD, CUNY
Dr. Chwen-Yang Shew
Jennifer A. ShustermanAssistant ProfessorHunter CollegeDepartment of Chemistry695 Park AveNew York NY [email protected]/chemistry/faculty/Shusterman
Publications
J.A. Shusterman, N.D. Scielzo, K.J. Thomas, E.B.Norman, S.E. Lapi, C.S. Loveless, N.J. Peters, J.D.Robertson, D.A. Shaughnessy, A.P. Tonchev, “TheSurprisingly Large Neutron Capture Cross-Sectionof 88Zr”, Nature, 2019, 565.
E.C. Uribe, H.E. Mason, J.A. Shusterman, andW.W. Lukens, “Organic Layer Formation andSorption of U(VI) on AcetamideDiethylphosphonate-Functionalized MesoporousSilica", Dalton Trans., 2017, 46.
E.C. Uribe, H.E. Mason, J. A. Shusterman, A.Bruchet, and H. Nitsche, “Probing the interaction ofU(VI) with phosphonate-functionalized mesoporoussilica using solid-state NMR spectroscopy", DaltonTrans., 2016, 45.
J.A. Shusterman, H.E. Mason, J. Bowers, A.Bruchet, E.C. Uribe, A.B. Kersting, and H. Nitsche,“Development and Testing of DiglycolamideFunctionalized Mesoporous Silica for Soprtion ofTrivalent Actinides and Lanthanides“, ACS Appl.Mater. Interfaces, 2015, 7.
J. Shusterman, H. Mason, A. Bruchet, M. Zavarin,A.B. Kersting, and H. Nitsche, “Analysis of TrivalentCation Complexation to Functionalized MesoporousSilica using Solid-State NMR Spectroscopy“,Dalton Trans., 2014, 43.
Research Interests
Keywords: Radiochemistry, Actinides, Nuclear Chemistry, Nuclear Fuel Cycle, Nuclear Forensics,Isotope Production
The research in the Shusterman lab is focused on the investigation of isotope production pathways,materials for heavy metal separations, and radiochemical measurements of nuclear reaction properties forapplication to the nuclear fuel cycle, medicine, forensics, and fundamental nuclear science.
Dr. Shusterman is aradiochemist with interestsin separations developmentfor the nuclear fuel cycleand forensics, and isotopeproduction
2018- current Assistant Professor, Hunter College2016-2018 Postdoc., Lawrence Livermore
National Laboratory2010-2015 PhD; University of California, Berkeley
Dr. Jennifer Shusterman
Yolanda A. SmallAssistant ProfessorDepartment of ChemistryCUNY York College and The Graduate Center94 - 20 Guy R. Brewer Blvd,Jamaica, NY [email protected]/portal_college/small-yolanda-1
PublicationsSmall, Y. A. “Bridging Thermodynamic andKinetic Processes in Electrochemically RelevantCalculated Pourbaix Diagrams” J. Nat. Sci..,2016, 3(2), 2334-2951.
Small, Y. A.; et. al. “Proton Management as aDesign Principle for Hydrogenase-InspiredCatalysts” Ener. and Env. Sci. 2011, 4, 3008-3020.
Small, Y. A., et. al. “Photocatalytic WaterOxidation Process at the GaN (101bar0) – WaterInterface” J. Phys. Chem. C, 2010, 114(32),13695–13704.
Research Interests
Keywords:
Two main computational methods are applied to answer questions about the molecular interactions ofcatalysts and semiconductors: (1) Quantum Mechanical/Molecular Mechanical (QM/MM) modeling andsimulations and (2) electronic structure methods using Gaussian-based Density Functional Theory (DFT).
Dr. Small’s research is atthe interface of biology,chemistry and condensedmatter physics where sheapplies computationaltechniques to addressquestions ranging fromreactions in enzymes toreactions at theaqueous/semiconductorinterface.
2010- current Assistant Professor – York College CUNY2007-2010 Postdoc – Brookhaven National Lab2001-2007 Ph.D. – The Pennsylvania State University
Dr. Yolanda Small
Ruth E. StarkDistinguished ProfessorCity College Dept. of Chemistry and BiochemistryCUNY Institute for Macromolecular AssembliesCCNY CDI 1302, 85 St. Nicholas TerraceNew York, NY [email protected]://www.sci.ccny.cuny.edu/resgroup
Publications
W. Huang, O. Serra, K. Dastmalchi, L. Jin, L.Yang, R.E. Stark, Comprehensive MS and Solid-state NMR metabolomic profiling revealsmolecular variations in native periderms fromfour Solanum tuberosum potato cultivars, J.Agric. Food Chem., 2017, 65, 2258-2274.
L.Q. Jin,* Q. Cai,* W. Huang, K. Dastmalchi, J.Rigau, M. Molinas, M. Figueras, O. Serra, R.E.Stark, Potato native and wound periderms aredifferently affected by down-regulation of FHT, aPotato Feruloyl Transferase, Phytochemistry,2018, 147, 30-48.
Q. Wang,* S. Rizk,* C. Bernard, M.P. Lai, D.Kam, J. Storch, R.E. Stark, Protocols and pitfallsof obtaining fatty acid-binding proteins forbiophysical studies of ligand-protein and protein-protein interactions, Biochem. Biophys. Rep.,2017, 10, 318-324.
E. Camacho, C. Chrissian, R.J.B. Cordero, L.Liporagi-Lopes, R.E. Stark, A. Casadevall, N-acetylglucosamine supplementation affectsCryptococcus neoformans cell wall compositionand melanin architecture, Microbiology, 2018,163, 1540-1556.
Research Interests
Keywords: molecular biophysics, biopolymers, bioanalytical chemistry, solid- and solution-state NMR
The Stark Laboratory uses structural biology and biophysical approaches to study plant protective polymers, lipid metabolism, and potentially pathogenic melanized fungal cells. Study of the molecular and mesoscopic architectures underlying the integrity of cuticles in natural and engineered potatoes and tomatoes is undertaken using solid- and solution-state nuclear magnetic resonance (NMR), mass spectrometry, and atomic force microscopy. Ligand recognition and peroxisome proliferator-activated receptor interactions of fatty acid-binding proteins are under investigation by solution-state NMR and fluorescence spectroscopy. The molecular structure and development of melanin pigments within fungal cells are probed using (bio)chemical synthesis and solid-state NMR.
Dr. Stark’s biophysicsresearch program focuseson the molecular structureand interactions ofprotective plant bio-polymers, fatty acid-bindingproteins that mediate painand obesity, and melaninpigments associated withhuman fungal infections.
2007 - current CUNY Dist. Prof., CCNY1985 - 2007 Assoc.-Dist. Prof., Coll. of Staten Island1979 - 1985 Asst. Prof., Amherst College1977 - 1979 Postdoctoral Fellow, M.I.T.1977 PhD, Physical Chemistry, UC San Diego
Dr. Ruth E. Stark
Maria C. TamargoProfessor and Former Executive OfficerThe City College of New YorkDepartment of Chemistry160 Convent AvenueNew York NY [email protected]://www.ccny.cuny.edu/profiles/maria-tamargohttps://www.idealscrest.org
Publications
V. Deligiannakis, S. Dhomkar, M. S. Claro, I. L. Kuskovsky, M. C. Tamargo, Interface Modification in Type-II ZnCdSe/Zn(Cd)Te QDs for High Efficiency Intermediate Band Solar Cells, J. Crystal Growth 512, 203-207 (2019).
M. S. Claro, I. Levy, A. Gangopadhyay, D. J. Smith, M. C. Tamargo, Self-assembled Bismuth Selenide (Bi2Se3) quantum dots grown by molecular beam epitaxy, Scientific Reports 9, 3370 (2019).
I. Levy, T. A. Garcia, S. Shafique and M. C. Tamargo, Reduced twinning and surface roughness of Bi2Se3 and Bi2Te3
layers grown by molecular beam epitaxy on sapphire substrates, J. Vac. Sci. Technol. B 36, 02D107-1 (2018).
Y. Kaya, A. Ravikumar, G. Chen, M. C. Tamargo, A. Shen, and C. Gmachl, Two-band ZnCdSe/ZnCdMgSe quantum well infrared photodetector, AIP Adv. 8, 075105 (2018)
T. A. Garcia, V. Deligiannakis, C. Forrester, I. Levy and M. C. Tamargo, Bi2Se3 van der Waals Virtual Substrates for II–VI Heterostructures, phys. status solidi b 254, 1700275 (2017).
Research Interests
Keywords: Molecular Beam Epitaxy, compound semiconductors, II-VI semiconductors, photonicdevices, nanomaterials, topological insulators.
Materials growth, properties and applications of semiconductor multi-layered structures grown by molecular beam epitaxy (MBE). Areas of research activity include III-V compounds, strained-layer and short-period superlattices, surface and interface chemistry, visible light emitters, optoelectronic devices, wide bandgap II-VI compounds, II-VI/III-V heteroepitaxy, low dimensional nanostructures, selective area epitaxy, intersubband devices, quantum cascade lasers, VECSELs, topological insulators.
Maria C. Tamargo isProfessor of Chemistry atthe City College of NewYork. Her research is insemiconductor materialsand nanostructures design,growth by epitaxial growthtechniques, characterizationmethods, and applications.
1993 - present The City College of New York andThe Graduate Center - CUNY
1984-1992 Bellcore1978-1984 AT&T Bell Labs1972-1978 PhD (Johns Hopkins University)1968-1972 BS (University of Puerto Rico)
Dr. Maria C. Tamargo
Ming Tang, PhDAssistant ProfessorDepartment of Chemistry2800 Victory BlvdCollege of Staten IslandStaten Island, NY [email protected]://www.csi.cuny.edu/campus-directory/ming-tang
Publications
D. Lam, J. Zhuang, L. Cohen, B. Arshava, F.Naider, M. Tang “Effects of chelator lipids,paramagnetic metal ions and trehalose onliposomes by solid-state NMR”, Solid State Nucl.Magn. Reson. 2018, 94, 1-6.
M. Tang, K. Mao, S. Li, J. Zhuang, K. Diallo,“Paramagnetic Effects on NMR Spectra ofIsotropic Bicelles with Headgroup ModifiedChelator Lipids and Metal Ions”, Phys. Chem.Chem. Phys. 2016, 18, 15524-15527.
M. Tang, G. Comellas, C. M. Rienstra,“Advanced Solid-State NMR Approaches forStructure Determination of Membrane Proteinsand Amyloid Fibrils”, Acc. Chem. Res. 2013, 46,2080-2088.
M. Tang, A. E. Nesbitt, L. J. Sperling, D. A.Berthold, C. D. Schwieters, R. B. Gennis, C. M.Rienstra, “Structure of the Disulfide BondGenerating Membrane Protein DsbB in the LipidBilayer”, J. Mol. Biol. 2013, 425, 1670-1682.
M. Tang, L. J. Sperling, D. A. Berthold, A. E.Nesbitt, R. B. Gennis, C. M. Rienstra, “Solid-State NMR Study of the Charge-TransferComplex between Ubiquinone-8 and DisulfideBond Generating Membrane Protein DsbB”, J.Am. Chem. Soc. 2011, 133, 4359-4366.Research Interests
Keywords: Membrane proteins, ion channels, amyloidogenic proteins, Phosphoinositide, solid-state NMR, protein aggregates, paramagnetic relaxation enhancement.The elucidation of structure-function relationships of membrane proteins will contribute tremendously toour understanding of how proteins interact with lipids and/or cofactors to operate. In turn, thesefundamental discoveries will translate into novel biomaterials and rationally designed therapeutic agents,since roughly 60% of all current drug targets are membrane proteins, yet structures of membrane proteinsremain scant relative to their soluble counterparts. We have successfully developed solid-state NMRmethods to tackle the challenges of membrane proteins and protein aggregates. Hence, we will be able toobtain detailed atomistic models from the structural information to describe the fundamental principles ofhow the membrane influence protein functions and vice versa.
Ming Tang is an assistantprofessor in the chemistry andbiochemistry programs at CUNY.His long-term research endeavoris to investigate the function-modulating interactions betweenproteins and membranecomponents by solvingstructures of membrane-associated protein complexesand aggregates by NMRspectroscopy.
2013- current Assistant Professor, College of StatenIsland, CUNY
2008-2013 Postdoc, University of Illinois at Urbana-Champaign
2003-2008 PhD, Chemistry, Iowa State University
Dr. Ming Tang
Micha TomkiewiczProfessorBrooklyn College of CUNYDept. of Physics, Brooklyn CollegeBrooklyn, NY [email protected]://academic.brooklyn.cuny.edu/physics/micha/
Publications
Research Interests
Keywords: Climate Change, Physics of Sustainability, Energy.
Environmental issues, science and society, photoelectrochemistry, electrochemistry, physics and chemistry of solid-liquid interfaces, morphology and transport properties of composite media, solar energy conversion and storage, photovoltaic devices, batteries .Strategy: Students will learn how to do energy audits and carbon footprints on a variety of scales. Students will do longitudal studies on the various components of the global efforts to change energy sources from reliance on fossil fuels toalternative energy sources.
2015- current Professor of physics and Chemistry,Brooklyn College, CUNY
1973 - 1976 IBM Thomas J. Watson1971 – 1973 UC-Berkeley1969 PhD - Hebrew University - Jerusalem
Dr. Micha TomkiewiczMicha Tomkiewicz is a professor of physics and chemistry at Brooklyn College and the school for Graduate Studies of the City University of New York. He served as founding-director of the Environmental Studies Program and the Electrochemistry Institute at Brooklyn College; was divisional editor, Journal of the Electrochemical Society (1981-91); chairman, Energy and Technology Division, the Electrochemical Society (1991-93); and member, International Organizing Committee of the conferences on Photochemical Conversion and Storage of Solar Energy (1989-92).
Weekly blog on climate change at: http://climatechangefork.blog.brooklyn.edu/
Lori Scarlatos, Micha Tomkiewicz, Ryan Courtney; “Using an Agent-Based Modeling Simulation and Game to Teach Socio-Scientific Topics”, Interaction Design & Architecture Journal – IxD&A, N. 19, Winter 2013/2014, pp. 77 – 90.
Yevgenie Ostrovskiy, Michael Cheng and MichaTomkiewicz, “Intensive and Extensive Parametrization of Energy Use and Income in US States and in Global Urban Environments”, The International Journal of Climate Change: Impacts and Responses Volume 4, Issue 4, pp.95-107.(2013)
Micha Tomkiewicz and Lori Scarlatos, “Bottom-up Mitigation of Global Climate Change”, the International Journal of Climate Change: Impacts and Responses Volume 4, Issue 1, pp.37-48 (2013)
Micha Tomkiewicz; “Climate Change: The Fork at the End of Now”; Momentum Press (2011).
Mariana TorrenteAssistant ProfessorDepartment of Chemistry2900 Bedford AvenueIngersoll Hall Extension 343/345Brooklyn [email protected]
Publications
Torrente, M.P., L.M. Castellano, and J. Shorter.Suramin inhibits Hsp104 ATPase and disaggregaseactivity. PLoS ONE. 9(10): e110115. (2014)
Torrente, M.P., and J. Shorter. The metazoanprotein disaggregase and amyloid depolymerasesystem: Hsp110, Hsp70, Hsp40, and small heatshock proteins. Prion. 7(6): 457-463. (2013)Torrente, M.P, Gelenberg, A.J., and Vrana, K.V.Boosting serotonin in the brain: is it time to revampthe treatment of depression? J Psychopharmacol.26(5), 629-35. (2012)
Torrente, M.P., Zee, B.M.; Young, N.L.; Baliban,R.C; Leroy, G.; Floudas, C.A.; Hake, S.B.; GarciaB.A., Proteomic Interrogation of Human Chromatin.PLoS One, 6, (9), e24747. (2011)
Plazas-Mayorca, M.D. and Vrana, K.E. Proteomicinvestigation of epigenetics in neuropsychiatricdisorders: A missing link between genetics andbehavior? Journal of Proteome Research, 10 (1),58-65. (2011)
Research Interests
Keywords:We seek to understand the role of epigenetic mechanisms and protein folding in the etiology ofneurodegenerative and neuropsychiatric disease. The central hypothesis of our research is thatposttranslational modification (PTM) of histones and protein misfolding play a key role in linking geneticpredisposition to cellular toxicity in neurodegenerative disease. Epigenetics and protein aggregation mayreveal alternative mechanisms behind the occurrence of disease, serving as the missing link betweengenetic and environmental factors.
Dr. Torrente is interested inthe molecular mechanismsunderlying neurodegenerativeand psychiatric disease.
2015- current Assistant Professor, Brooklyn College; NIH Career Transition Award Fellow2012-2015 IRACDA PENN-PORT Postdoctoral Fellow, University of Pennsylvania2010-2012 NIH NRSA Postdoctoral Fellow, Penn State University College of Medicine2010 Ph.D. in Chemistry, Princeton University
Dr. Mariana Torrente
Dr. Rein UlijnDirector of NanoscienceEinstein Professor of Chemistry, Hunter CollegeAdvanced Science Research Center85 St Nicolas TerraceNew York NY, [email protected]/Nanoscience/
PublicationsC.G. Pappas, R. Shafi, I.R. Sasselli, H. Siccardi, T.Wang, V. Narang, R. Abzalimov, N. Wijerathneand R.V. Ulijn, Dynamic Peptide Libraries for theDiscovery of Supramolecular Nanomaterials, Nat.Nanotechnol., 2016, 11, 960.
Lampel, Scott A. McPhee, H.-A. Park, G.G. Scott, S.Humagain, D.R. Hekstra, B. Yoo, P.W.J.M. Frederix,T.-D. Li, R.R. Abzalimov, S.G. Greenbaum, T.Tuttle,C. Hu, C.J. Bettinger and R.V. Ulijn, PolymericPeptide Pigments with Sequence-encodedProperties, Science, 2017, 356, 1064.
C. Zhang, R. Shafi, A. Lampel, D. MacPherson, C.Pappas, V. Narang, T. Wang, C. Madarelli and R.V.Ulijn, Switchable Hydrolase Based on ReversibleFormation of Supramolecular Catalytic Site Using aSelf-Assembling Peptide, Angew. Chem. Int. Ed.,2017, 56, 14511.
M. Kumar, N.L. Ing, V. Narang, N. Wijerathne, A.I.Hochbaum and R.V. Ulijn, Amino Acid-EncodedBiocatalytic Self-Assembly Enables the Formation ofTransient Conducting Nanostructures, Nat. Chem.,2018, 10, 696-703.
J. Son, D. Kalafatovic, M. Kumar, B. Yoo, M.A.Cornejo, M. Contel, and R.V. Ulijn, CustomizingMorphology, Size, and Response Kinetics of MatrixMetalloproteinase-Responsive Nanostructures bySystematic Peptide Design, ACS Nano., 2019, 13,1555-1562.
Research Interests
Keywords: molecular systems, bionanotechnology, hydrogels, peptides, biocatalysis, adaptive materials
The Ulijn group are interested in the development of materials and systems that mimic biology’s adaptiveproperties but are much simpler. These materials (including gels, emulsions, structured surfaces andnanotubes) have potential applications in health care, cosmetics, lifestyle products, food science. Theseapplications are sought in active collaboration with researchers and companies across the globe. The approachis cross-disciplinary and covers the entire range from fundamental understanding to eventual applications andsocietal benefit.
Rein Ulijn is foundingdirector of the nanoscienceinitiative at the AdvancedScience Research Centre atCUNY and Professor ofNanochemistry at HunterCollege. His research isfocused on minimalisticmolecular materials andadaptive systems that areinspired by biology.
2014- Current Director of Nanoscience, ASRC2008-2014 Professor of Nanochemistry, University
of Strathclyde, Glasgow, UK2003-2008 Associate Prof., U. of Manchester, UK2001-2003 Postdoc. University of Edinburgh, UK1998-2001 PhD University of Strathclyde, UK1992-1998 MSc Wageningen University, NL.
Dr. Rein Ulijn
Michele VittadelloAssociate Professor of Chemistry and Env. ScienceMedgar Evers College of CUNY1638 Bedford AvenueBrooklyn NY [email protected]
Publications
Bertasi, F. et al. Electrolytes for SecondaryMagnesium Batteries Based on Chloroaluminate Ionic Liquids. ChemSusChem, 2015, 8, 3096-3076.
Negro, E. et al. The influence of the cationicform and degree of hydration on the structure of NafionTM. Solid State Ionics2013, 252, 84-92.
Harrold, J. W. Jr et al. Functional Interfacingof Rhodospirillum rubrum Chromatorphoresto a Conducting Support for Capture and Conversion of Solar Energy. J. Phys. Chem. B 2013, 117,11249-11259.
Vittadello, M. et al. Iodide-ConductingPolymer Electrolytes based on Poly-Ethylene Glycol and MgI2: Synthesis and Structural Characterization. Electrochimica Acta 2011, 57, 112-122.
Di Noto, V. et al. Broadband dielectric and conductivity spectroscopy of Li-ionconducting 3D-HION-APEs based on PEG400, Zr and Al Nodes. ElectrochimicaActa 2011, 57, 192-200.
Research Interests
Keywords: Energy Nanotechnology and Materials, Biohybrid Photosynthetic/MitochondrialSystems, Polymer Electrolytes, Lithium/Magnesium Batteries, Supercapacitors, Fuel Cells,Photovoltaic Devices, Bionanotechnology, Environmental Elemental Analysis, Radioremediation.
Investigation of fundamental physical-chemical properties of nanomaterials, materials and biomaterials with potential applications in the field of energy storage/generation and biotechnology; Design and assembly of new devices; High quality publications and patents.
Dr. Vittadello’s research is focused on the areas of nanotechnology and materials science, inorganic and physical chemistry
2015- current Associate Professor2008-2015 Assistant Professor2005-2008 Postdoc (Rutgers University)2003-2005 Postdoc (Hunter College)2000-2003 PhD (University of Padua)
Dr. Michele Vittadello
Chen WangAssistant ProfessorDepartment of Chemistry, Queens College65-30 Kenssina Blvd.120B Remsen HallNew York [email protected]://www.wanglabcuny.net
Publications
1. C. Wang, E. A. Weiss. Accelerating FRETbetween Near-Infrared-Emitting Quantum DotsUsing a Molecular J-aggregates as an ExcitonBridge. Nano Lett., 2017, 17 (9), 56662. C. Wang, M. S. Kodaimati, G. C. Schatz, andE. A. Weiss. The Photoluminescence SpectralProfiles of Water-Soluble Aggregates of PbSQuantum Dots Assembled through ReversibleMetal Coordination. Chem. Comm., 2017, 53(12), 19813. C. Wang, E. A. Weiss, Sub-nanosecondResonance Energy Transfer in the Near-Infraredwithin Self-Assembled Conjugates of PbSQuantum Dots and Cyanine Dye J-Aggregates.J. Am. Chem. Soc., 2016, 138 (30), 95574. C. Wang, M. Angelella, S. J. Doyle, L. A.Lytwak, P. J. Rossky, B. J. Holliday, and M. J.Tauber. Resonance Raman Spectroscopy of theT1 Triplet Excited State of Oligothiophenes. J.Phys. Chem. Lett., 2015, 6 (18), 35215. C. Wang, M. J. Tauber. High-Yield SingletFission in a Zeaxanthin Aggregate Observed byPicosecond Resonance Raman Spectroscopy. J.Am. Chem. Soc., 2010, 132, 13988
Research Interests
Keywords: ultrafast optical spectroscopy, exciton dynamics, nanomaterials, quantum dot
The aim of our research is to achieve systematic control of the behavior of excitons within thesuperstructures of quantum dots and organic molecules that are developed in our lab. We employ time-resolved optical spectroscopy to investigate the evolution of excitonic states in these novel nanostructures.The knowledge we learn can direct rational designs of materials for applications including optoelectronicdevices, photocatalysis, and biomedical sensors.
As experimental physicalchemists, we assemblesemiconductor nanocrystalsand molecules to createnovel materials, andinvestigate photophysical/photochemical properties ofthese materials using time-resolved optical laserspectroscopy
2018 - current Assistant Professor, Queens College2015 - 2018 Postdoc, Northwestern University2008 - 2014 PhD, University of California, San Diego
Dr. Chen Wang
Nan-Loh YangProfessor of ChemistryCollege of Staten Island2800 Victory BoulevardStaten Island, NY [email protected]
PublicationsAshish Punia, Edward He, Kevin Lee, Probal Banerjee, and Nan-Loh Yang, Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity. Chem. Commun., 2014, 50, 7071.
Monica Apostol ;Tatsiana Mironava ;Nan-Loh Yang; Nadine Pernodet Miriam H Rafailovich. Cell sheet patterning using photo-cleavable polymers. Cell sheet patterning using photo-cleavable polymers. Polymer Journal . 2011; 43(8):723-
Chong Cheng and Nan-Loh Yang” Well-Defined Diblock Macromonomer with a Norbornene Group at Block Junction: Anionic Living Linking Synthesis and Ring-Opening Metathesis Polymerization” Macromolecules, 2010, 43 (7), pp 3153–3155
Kai Su, Nurxat Nuraje, Lingzhi Zhang, I-Wei Chu, Hiroshi Matsui, and Nan-Loh Yang.“ First Preparations and Characterization of Conductive Polymer Crystalline Nanoneedles” Macromol. Symposia, Special Issue: Polymers at Frontiers of Science and Technology (2009), 279(1), 1-6.
Su, Nurxat Nuraje, and Nan-Loh Yang*„An Open-Bench Method for the Preparation of BaTiO3, SrTiO3 and BaxSr1-xTiO3 nanocrystals at 80 oC”,ACS Langmuir,,(2007),23,11369-11371
Research Interests
Keywords: Nanoeletronics, Superbugs killers, Photopolymers Novel Polyacetals,Supercapacitor Fast Switch, Amphiphilic Polyelectrolytes, Micelles
Professor Yang’s research group is involved in developing amphiphilic non-hemolytic andantibacterial nanoparticle based structural tuningwith optimizing hydrophobic – hydrophilic moleculartopography. The nanoelectronics research exploits the characteristic ofmicell reactors and interfacial polymerization.
Nan-Loh Yang is a Professorof Chemistry at College ofStaten Island.. His researchareas include: antimicrobialpolymer nanoparticle;polymers with well-definedstructure;and materials fornanoelectronics - giantdielectric constant element,fast cionductance switch, 4-stage memory and roomtemperature magnetoelectriccoupling.
Current Professor of Chemistry, CUNY-CSI1969-1970 Postdoc, Mount Sinai School of Medicine1969 PhD Polymer Chemistry NYU-Poly
Dr. Nan –Loh Yang
Barbara ZajcProfessorThe City College of New YorkDepartment of Chemistry160 Convent AvenueNew York [email protected]://www.ccny.cuny.edu/profiles/Barbara-Zajc.cfm
Publications
Wei, W.; Khangarot, R. K.; Stahl, L.; Veresmortean,C.; Pradhan, P.; Yang, L.; Zajc, B.: GeneratingStereodiversity: Diastereoselective Fluorination andHighly Diastereoselective Epimerization of �-AminoAcid Building Blocks, Org. Lett. 2018, 20, in press.DOI: 10.1021/acs.orglett.8b01358.
Banerjee, S.; Sinha, S.; Pradhan, P.; Caruso, A.;Liebowitz, D.; Parrish, D.; Rossi, M.; Zajc, B.:Regiospecifically Fluorinated Polycyclic AromaticHydrocarbons via Julia-Kocienski Olefination andOxidative Photocyclization. Effect of Fluorine AtomSubstitution on Molecular Shape, J. Org. Chem. 2016,81, 3983–3993. Editor-Selected Featured ArticleFeatured on the Front Cover of Issue 10
Kumar, R.; Singh, G.; Todaro, L. J.; Yang, L.; Zajc, B.:E- or Z-Selective Synthesis of 4-Fluorovinyl-1,2,3-triazoles with Fluorinated Second-GenerationTriazole-Substituted Julia-Kocienski Reagents, Org.Biomol. Chem. 2015, 13, 1536–1549 .
Singh, G.; Kumar, R.; Swett, J.; Zajc, B.: ModularSynthesis of N-Vinyl Benzotriazoles, Org. Lett. 2013,15, 4086-4089.
Mandal, S. K.; Ghosh, A. K.; Kumar, R.; Zajc, B.:Expedient Synthesis of a-Substituted Fluoroethenes,Org. Biomol. Chem. 2012, 10, 3164-3167Featured on the Front Cover of Issue 16Research Interests
Keywords: Fluoroorganic chemistry, Biomolecules, Chemical Carcinogenesis
Fluoroorganics are highly important in diverse areas, but introduction of fluorine remains challenging. Ourresearch is focused in two main directions. One involves development of methods for regiospecificintroduction of fluorine atom into organic molecules. Here, we are developing and expanding a toolbox ofnovel reagents for the synthesis of variously functionalized vinyl fluorides, as also various novel fluorinatedsynthetic building blocks. Another area of research involves the use of fluorine as probe in structureactivity studies in the area of chemical carcinogenesis. Specifically fluorinated polycyclic aromatichydrocarbons, their metabolites and their DNA conjugates are synthesized as probes to understandingcellular events after metabolism and DNA binding. We are currentlyinvestigating the use of the new hydrocarbons for development ofnovel materials.
Zajc is anorganic/bioorganicchemist working in areasof (a) fluoroorganicchemistry, (b) chemicalcarcinogenesis, and (c)synthetic methodology.
2013 Professor2003 Associate Professor (CCNY)2001 Assistant Professor (Substitute, CCNY)1999 Associate Professor (U of Ljubljana)1993 Assistant Professor (Docent, U of Ljubljana)1991 Fogarty Fellow NIH (NIDDK)1989 PhD
Dr. Barbara Zajc
Guoqi ZhangAssistant ProfessorDepartment of SciencesJohn Jay College of Criminal Justice524 W 59th Street, 10019New York NYEmail: [email protected]://www.jjay.cuny.edu/faculty/guoqi-zhang
PublicationsZ. Yin, G. Zhang, S. Zheng, T. Phoenix, J. C.Fettinger, “Assembling mono-, di- and tri-nuclearcoordination complexes with a ditopic analogueof 2,2':6',2''-terpyridine: syntheses, structuresand catalytic studies”, RSC Advances, 2015, 5,36156-36166.
G. Zhang, G. Proni, S. Zhao, Ed C. Constable,C. E. Housecroft, J. A. Zampese, M. Neuburger,“Chiral tetranuclear and dinuclear copper(II)complexes for TEMPO-mediated aerobicoxidation of alcohols: are four metal centresbetter than two?”, Dalton Trans. 2014, 43,12313-12320
G. Zhang, K. V. Vasudevan, B. L. Scott, S. K.Hanson, “Understanding the mechanisms ofcobalt-catalyzed hydrogenation anddehydrogenation reactions”, J. Am. Chem. Soc.2013, 135, 8668-8681.
G. Zhang, S. K. Hanson, “Cobalt-catalyzedtransfer hydrogenation of C=O and C=N bonds”,Chem. Commun. 2013, 49, 10151-10153.
G. Zhang, B. L. Scott, S. K. Hanson, “Mild andhomogeneous cobalt-catalyzed hydrogenation ofC=C, C=O, and C=N bonds”, Angew. Chem. Int.Ed. 2012, 51, 12102-12106.
Research InterestsKeywords: Inorganic/Organometallic Catalysis, Energy Conversion; Forensic Chemistry
Description of research activities and strategy:Our research concerns over the design and synthesis of novel non-precious metal complexes and theirapplications in energy-related catalysis, supramolecular chemistry, anticancer drugs and forensic science.
Prof. Zhang is an inorganicchemist who has broadresearch interests ininorganic/organometalicchemistry, non-preciousmetal catalysis and forensicchemistry, with a focus onthe synthesis of novelorganic-inorganic functionalmaterials.
2013- current Assistant Professor2006-2013 Postdoc Los Alamos National Lab and
Uni. Basel2001-2006 Ph.D., Institute of Chemistry, CAS
Dr. Guoqi Zhang
Shengping ZhengAssistant ProfessorHunter College695 Park AvenueNew York, NY [email protected]://www.hunter.cuny.edu/chemistry/faculty/Shengping/Shengping
PublicationsYin, Z.; Zhang, J.; Wu, J.; Green, R.; Li, S.; Zheng, S. “Synthesis of o-Chlorophenols via an Unexpected Nucleophilic Chlorination of Quinone Monoketals Mediated by N, N’-Dimethylhydrazine Dihydrochloride” Org. Biomol. Chem. 2014, 12, 2854-2858.
Yin, Z.; Zhang, J.; Wu, J.; Liu, C.; Sioson, K.; Devany, M.; Hu, C.; Zheng, S. “Double Hetero-Michael Addition of N-Substituted Hydroxylamines to Quinone Monoketals: Synthesis of Bridged Isoxazolidines” Org. Lett.2013, 15, 3534-3537.
Zhang, J.; Wu, J.; Yin, Z.; Zeng, H.; Khanna, K.; Hu, C.; Zheng, S. “An Expedient Stereoselectiveand Chemoselective Synthesis of Bicyclic Oxazolidinones from Quinols and Isocyanates” Org. Biomol. Chem. 2013, 11, 2939-2942.
Zhang, J.; Yin, Z.; Leonard, P.; Wu, J.; Sioson, K.; Liu, C.; Lapo, R.; Zheng, S. “A Variation of Fischer Indolization Involving Condensation of Quinone Monoketals and Aliphatic Hydrazines” Angew. Chem. Int. Ed., 2013, 52, 1753-1757.
Research InterestsKeywords: Organic Synthesis, Anticancer, Antiviral, Heterocycles, Natural Products
1.New methodologies in heterocycle synthesis
2.Total synthesis of bioactive natural products
Our group focuses on thesynthesis of bioactiveheterocycles and their SARstudies.
2008- current Assistant Professor, Hunter College2005-2008 Postdoc, Columbia University2000-2005 PhD, Columbia University
Dr. Shengping Zheng
Shuiqin ZhouProfessor of ChemistryCollege of Staten Island2800 Victory BoulevardStaten Island, NY [email protected]
PublicationsH. Wang, Y. Sun, J. Yi, J. Fu, J. Di, A. del C.Alonso, S. Zhou. Fluorescent porous carbonnanocapsules for two-photon imaging, NIR/pHdual-responsive drug carrier, and photothermaltherapy. Biomaterials, 2015, 53, 117-126.
H. Wang, J. Yi, S. Mukherjee, P. Banerjee, S.Zhou. Magnetic/NIR-thermally responsive hybridnanogels for optical temperature sensing, tumorcell imaging and triggered drug release. Nanoscale,2014, 6, 13001–13011.
H. Wang, A. Mararenko, G. Cao, Z. Gai, K. Hong,P. Banerjee, S. Zhou, Multifunctional 1D magneticand fluorescent nanoparticle chains for enhancedMRI, fluorescent cell imaging, and combinedphotothermal/chemotherapy, ACS Appl. Mater.Interfaces 2014, 6, 15309–15317.
H. Wang, Z. Wei, H. Matsui, S. Zhou, One-potsynthesis of Fe3O4@Carbon quantum dots hybridnanoflowers for highly active and recyclable visible-light driven photocatalyst. J. Mater. Chem. A, 2014,2, 15740-15745.
Y. Li, S. Zhou. Facile one-pot synthesis of organicdye-complexed microgels for optical detection ofglucose at physiological pH. Chem. Commun.2013, 49, 5553-5555.Research Interests
Keywords: responsive polymers, hybrid nanogels, nanoparticles, carbon dots, assembly,biosensing, drug delivery, cell imaging, environmental remediation
The Zhou group is interested in the development of (1) glucose-responsive hybrid nanoparticles (NPs) forglucose sensing and self-regulated insulin delivery; (2) multifunctional nanomaterials from the combinationof optically active NPs with responsive polymers for sensing, imaging, and therapy; and (3) compositenanomaterials from the complex assembly of carbon-based NPs,inorganic NPs, and other amphiphilies in the confinement of(bio)polymers and colloids for sensing, catalysis, and environmentalremediation
Shuiqin Zhou is a Professor ofChemistry at CUNY College ofStaten Island. Her research isfocused on responsive polymer-nanoparticle (including carbondots) hybrid nanogels, inorganic-carbon composite nanoparticles,and complex assembly ofnanoparticles for sensing,imaging, drug delivery, andenvironmental remediation.
2008- current Professor of Chemistry, CUNY-CSI2002-2007 Associate Prof. of Chemistry, CUNY-CSI2000-2002 Senior Chemist, Dow Chemical Company1996-2000 Postdoc, SUNY at Stony Brook1993-1996 PhD, Chinese University of Hong Kong 1988-1991 MSc, Xiamen University, China1984-1988 BSc, Xiamen University, China
Dr. Shuiqin Zhou
