Chemistry 250: Reactivity 1 - College of Saint Benedict ... · Chemistry 250: Reactivity 1 Spring 2013 Tentative Even Day Class Schedule Resources • Workbook: Principles of Reactivity

Chemistry 250: Reactivity 1

Spring 2013 Tentative Even Day Class Schedule

Resources • Workbook: Principles of Reactivity 1

Available in the CSB Bookstore

• Text: Choose one or more of the following options: 1. Chemistry 250 Custom Book -- shrink-wrapped with 2 passcodes

(strongly recommended) § Note answers are available for organic in-chapter problems and

biochem end of chapter problems within your text § Note answers for the inorganic chapters and some organic (end of

chapter problems) are available on the NMR Moodle page

2. Online Text (Structure & Reactivity, Part III, available at: ( http://employees.csbsju.edu/cschaller/ROBI1.htm )

OR if desired a softcover copy of online textbook: (http://academicpub.sharedbook.com/serve/ac/acapub/student_product_page.html?slug=1344449420_58_488)

• Online homework passcodes: (ONLY if you didn’t buy text with

passcodes)

o Two Passcodes: 1) Hornback & 2) Garrett & Grisham: (http://www.cengage.com/owl/)

OWL with Cengage 24 months Instant Access Code for Garrett/Grisham's Biochemistry, 5th Ed ISBN-10: 1-133-35236-7 ISBN-13: 978-1-133-35236-5 $113.00 OWL (24 months) Instant Access Code for Organic Chemistry, 1st Edition ISBN-10: 0-495-05102-0 ISBN-13: 978-0-495-05102-2 $74.00

o There may be students from Fall 2012 Chem 251 with extras that will sell

at a discount.

Getting Started on OWL Chemistry 250

There are 2 separate online passcodes you will need to use, so you will need to go through the following procedure twice. On the web, go to: http://owl.cengage.com In the box labeled Instructor/Student Login, click on: Organic Or Biochemistry Go through the books and choose: Organic Chemistry, 2nd Ed; Hornback Or Biochemistry, 5th Ed; Garrett&Grisham Go through the list of schools and choose: College of Saint Benedict - Saint Joseph, Minnesota Select: Student registration Select: Chemistry 250 Spring 2013 with Instructor Name

Make sure you select the correct section! Choose your own loginid and password and enter the access code you bought with your book Two Notes:

These passcodes will be good for all next year (DON”T throw them away!) and you will have to re-register each semester. We will begin using the organic passcode in January and the biochemistry passcode in March – Keep them in a safe place!

Anionic Nucleophilic Additions to Carbonyls Tuesday, January 15, Day 2

Overview • First-Day Overview of Class Structure

o Roster o Syllabus and Course Outline

• Group work and Pedagogical Theory • Assign Groups

In class: Nu Additions

• Introduction to Anionic Nucleophilic Additions to Carbonyls o Mechanism, Workbook: 3-9 o Acetylides, Cyanides and Grignards, Workbook: 10-12

Note Upcoming Deadline:

• OWL Review Packet 1: Due Jan 23 Ch 1: Chemical Bonding Ch 2: Organic Structures and Electrostatics Ch 3: MO Ch 4: Acid-Base Ionic Radii Resonance Structures

• OWL Review Packet 2: Due Feb 12 Ch 7: Stereochemistry Ch 16: Aromaticity

Chapter 5/12: Nomenclature: OWL 5bdghi, 12bd

• MLK Extra Credit: Percy Julian (Due Thursday, Jan 23)

Tuesday, January 15 6:30-8:00 pm Faculty Tutorial, O’Connells

Percy Julian Extra Credit Assignment

(10 points) Extra Credit Assignment: Percy Julian

1) Watch PBS Nova movie, “Forgotten Genius”

on-line: http://www.pbs.org/wgbh/nova/julian/program.html

2) After watching the movie, follow at least one related interactive link at the

bottom of the PBS Julian website.

3) Write a response to the movie and website (2-3 pages):

a. Summary of Percy Julian’s scientific achievements

b. Mention of the obstacles that Percy Julian faced

c. Discussion of the link that you followed

d. Brief Conclusion with a personal response regarding something that you

learned

4) Due Tuesday, January 22nd.

Thursday, January 17, Day 4 Preparation: Nu Additions

• Read: o Reactivity 1 text: Chapter 18. Additions to the Carbonyl Group

§ 18.1 General Mechanisms o Structure & Reactivity online text: CO1-CO4, CO6 o Reactivity 1 text: Chapter 18. Additions to the Carbonyl Group

§ 18.2 Addition of Hydride § 18.4 Addition of HCN § 18.5 Preparation and Properties of Organometallic

Nucleophiles § 18.6 Addition of Organometallic Nucleophiles

o Structure & Reactivity online text: CO7-CO8, CO16 • Suggested Practice Problems:

o Reactivity 1: 18.1, 18.2, 18.6, 18.8, 18.9, 18.10 § NOTE: Answers are found in NMR Moodle Site

o Structure and Reactivity: CO1.1-1.3, CO2.1-2.2, CO3.1-3.3, CO4.1, CO6.1-6.2

§ NOTE: Answers are found in CO22 • Homework due:

o Introduction to OWL: How to Complete and Submit Assignments

o OWL: 18a (Tutor, Carbonyl Reactions) o Passport: Practice problems

• Structure and Reactivity: CO1.1, CO5.1, CO8.1

In class: Nu Additions • Anionic Nucleophiles

o Hydrides, Workbook: 13-14 o MO of Nucleophilic Addition, Workbook, 15-16 o Chiral Hydrides, Workbook: 17-18 o Practice, Workbook: 19-22 o Sample Notecards, Workbook: 23

Thermodynamics Monday, January 21, Day 6

Preparation: Thermodynamics of Reactions • Read:

o Reactivity 1 text: § Chapter 6.2 Two Keys to Stability of TM Complexes

o Structure & Reactivity online text: TD1-TD3 • Suggested Practice Problems:

o Structure & Reactivity, Part III: TD 1.1, 2.1, 3.1, 3.2, 3.3 NOTE: Answers are found in TD7

• Homework due: o Group Assignment: Bio Hydrides, Roadmap Practice, Workbook:

19-21 o Passport: Bring Notecards of new reactions, Workbook: 22 o OWL: 18b, 18c, 18d

In class: Thermodynamics

• Enthalpy, Workbook: 35-36 • BDE, Workbook: 37-38 • Reaction Diagrams, Workbook: 43-44 • Enthalpy of Reactions, Workbook: 45 • PSA#1

Wednesday, January 23, Day 2 Preparation: Thermodynamics of Reactions

• Read: o Structure & Reactivity online text: TD1-TD3

• Suggested Practice Problems: o Structure & Reactivity, Part III: TD 1.1, 2.1, 3.1, 3.2, 3.3

NOTE: Answers are found in TD7 • Homework due:

o Group Assignment: Bond Energy, Workbook: 41-42 o OWL: Review Packet #1 o MLK day Extra Credit: Percy Julian

In class: Thermodynamics

• Entropy, Workbook: 46-52 • Free Energy, Workbook: 53-56


Reversible Nucleophilic Additions to Carbonyls Friday, January 25, Day 4

Preparation: Nu Additions • Read:

o Structure & Reactivity online text: TD5, CO5, CO6 CO10-CO13 o Organometallic HyperText:

§ Microscopic Reversibility • Suggested Practice Problems:

o Reactivity 1: CO7.1-7.4, CO6.1-6.2, CO8.1-8.6 § NOTE: Answers are found in CO22

• Homework due: o Group Homework, Organic Nomenclature: Workbook: 31-33 o OWL: Introduction to Thermodynamics


• Reversibility, Workbook: 61-66 Tuesday, January 29, Day 6


o Reactivity 1 text: Chapter 18. Additions to the Carbonyl Group § 18.8 Addition of Nitrogen Nucleophiles

o Structure & Reactivity online text: CO14-CO15, SC8, SC11 • Suggested Practice Problems:

o Reactivity 1: 18.3, 18.16-18.24 § NOTE: Answers are found in NMR Moodle Site

• Homework due: o OWL: 18g (Acetal Tutor), Microscopic Reversibility


• Nitrogen Neutral Protic Nucleophiles, Workbook: 67-71 • Oxygen Neutral Protic Nucleophiles, Workbook: 72-74 • PSA#2


Thursday, January 31, Day 2 Preparation: Nu Additions

• Read: o Structure & Reactivity online text: TD6

• Suggested Practice Problems: o Structure & Reactivity, Part III: TD 5.1, 5.2, 5.3, 5.4

§ NOTE: Answers are found in TD7 o Structure and Reactivity: CO5.1, CO10.1-10.2, CO11.1, CO13.1-

13.2 § NOTE: Answers are found in CO23

• Homework due: o Group Homework: practice problems

§ Reactivity 1 text: 18.16, 18.17, 18.21, 18.22, 18.24 o Passport: Finish all mechanisms for 67-74 o OWL: 18f, 18g, 18h, 18j


• Thermodynamics of Reversible Rxns, Workbook: 76-80 • Practice, Workbook: 81-86

Coordination Compounds Monday, February 4, Day 4

Preparation: Ligand Binding • Read:

o Reactivity 1 text: § Chapter 2.3 Modern View of CC compounds § Chapter 2.4 An Introduction to Nomenclature § Chapter 6.2 Two Keys to Stability of TM Complexes

o Structure & Reactivity online text: CC1-CC7 o Organometallic Reader: Simplifying OM Complexes

§ Part I § Part II § Part III

o Organometallic Hypertext: § Denticity § Electron Counting

• Suggested Practice Problems: o Structure & Reactivity, Part III: CC 3.1-3.7, 4.1-4.8, 6.1-6.9 o NOTE: Answers are found in CC11

• Homework due: o Group Homework, Workbook: 84-86 o Individual Homework on Nomenclature: Workbook: 91-92 o OWL: Review Packet 2 Due (Stereochemistry and Organic

Nomenclature) In class: Ligand Binding

• Hapticity, Workbook: 102-103 • Hard-Soft Acid-Base Workbook: 105-108 • Practice Workbook: 109-115

Wednesday, February 6, Day 6 Preparation: Ligand Binding

• Suggested Practice Problems: o Structure & Reactivity, Part III: CC 7.1-7.5 o NOTE: Answers are found in CC11

• Homework due: o Group Homework: Review CCmpds: Workbook: 93-101 o OWL: Electron Counts on Coordination Compounds, d

electrons, Geometry of Coordination Compounds, Inorganic Nomenclature, Hard-Soft Acid Base

o Passport on Fuel Cells, Workbook: 119 § How Fuel Cells Work § Fuel Cells Explained

In class: LIgand Binding

• Metal Organic Frameworks, Workbook: 120-132

Tuesday, February 5 6:30-8:00 pm Faculty Tutorial, O’Connells

Ligand Field Theory Friday, February 8, Day 2

Preparation: • Read:

o Reactivity 1 text: Chapter 4.1-4.2: Bonding Theories for Coordination Cmpds, p 57-69

o Structure & Reactivity online text: CC8-CC9 o Organometallic Reader:

§ Ligand Field Theory • Suggested Practice Problems:

o Reactivity 1: Ch 2—#25-28 § Note: Answers available (NMR Moodle site)

• Homework due: o Group Homework: Workbook: 132-134 o Individual Passport, MO Review: Workbook: 135-137

In class: Crystal Field Theory

• d orbital shapes and ligand field theory, Workbook, 138-141 • Feb PSA

Tuesday, February 12, Day 4


o Reactivity 1 text: Chapter 4: Bonding Theories for Coordination Cmpds

o Structure & Reactivity online text: CC8-CC9 • Suggested Practice Problems:

o Reactivity 1: Ch 4—#9, 11, 15, 21, 25, 27, 37, 43 § Note: Answers available (NMR Moodle site)

• Homework due: o None

In class: Ligand Field Theory

• Field Splitting, Workbook, 142-144 • Metal Ion Effects, Workbook, 145-146 • Ligand Effects, Workbook, 147-153


Thursday, February 14, Day 6

Preparation: Ligand Field Theory • Read:

o Reactivity 1 text: Chapter 4.3 (p 69-86) o Structure & Reactivity online text: CC8-CC10

• Suggested Practice Problems: o Reactivity 1: Ch 4—# Ch 4, # 31, 39, 47

§ Note: Answers available (NMR Moodle site) • Homework due:

o Individual Passport: LFT Summary, Workbook: 154 o OWL: Octahedral Spin, Metal Ion Effects, Spectrochemical 1

and 2

In class: Ligand Field Theory • Splitting for non-octahedral, Workbook 155-162 • PSA#3

Monday, February 18, Day 2

Preparation: Ligand Field Theory • Read:

o UCDavis ChemWiki CFT Summary § CFT Summary § Note: This site has problems with answers

o Reactivity 1 text: Chapter 4.3 (p. 129-131) • Suggested Practice Problems:

o Structure & Reactivity, Part III: CC 8.1-8.4, 9.1-9.6, 10.1-10.3 § NOTE: Answers are found in CC11

o Reactivity 1: Ch 4—# Ch 4, # 53, 55, 57 § Note: Answers available (NMR Moodle site)

• Homework due: o Group Homework: Square Planar Fun, p 163-164

In class: Ligand Field Theory

• Lability Workbook, 165-169 • Magnetism, Workbook, 170-174 • UV, Workbook, 175-178 • Applications, Workbook, 184-201

Introduction to Catalysis

Wednesday, February 20, Day 4

Preparation: Catalysis • Read:

o Structure & Reactivity online text: RK8

o Catalysis and Reaction Energetics • Suggested Practice Problems:

o Structure & Reactivity, Part III: • Homework due:

o Group Homework: Magnetism, 170-174 o OWL: Ligand Exchange, Magnetic Properties, Magnetic

Moments

In class: Catalysis • Catalysis, Workbook: 206-217 • PSA#4

Tuesday, February 19 No Faculty Tutorial

Thursday February 21-24th

LONG WEEKEND

Carbonyl Binding and Migratory Insertion Tuesday, February 26, Day 6


o Structure & Reactivity online text: MI1, MI2, MI3 o Organometallic Reader:

§ Carbon Monoxide o Organometallic HyperText:

§ Insertion Reactions • Suggested Practice Problems:

o Structure & Reactivity, Part III: TD 6.1, 6.2, 6.3, 6.4, 6.5 § NOTE: Answers are found in TD7

o Structure and Reactivity: CO15.1-15.8 § NOTE: Answers are found in CO23

• Homework due: o Individual Passport, Catalysis Summary: Workbook: 218 o Group Homework: LAD, Workbook: 220-221


• Carbonyl Binding and Migratory Insertion, Workbook: 226-231 • PSA#5


Thursday, February 28, Day 2 Preparation: Nu Additions

• Read: o Structure & Reactivity online text: MI4, MI5 o Organometallic Insertion Reactions

§ Insertions o Organometallic HyperText:

§ β-hydride Elimination • Suggested Problems:

o Structure & Reactivity, Part III: MI1-MI5 § NOTE: Answers are found in MI6

• Homework due: o Group Homework, Application Problems: Workbook: 232-233


• 1,2-Insertion and β-elimination, Workbook: 233-238

Nucleophilic Additions to Carbonyls: Part 4 Monday, March 4, Day 4


o Reactivity 1 text: Chapter 18. Additions to the Carbonyl Group § 18.7 Wittig Reactions

o Structure & Reactivity online text: CO18 • Suggested Problems:

o Structure & Reactivity, Part III: MI1-MI5 § NOTE: Answers are found in MI6

• Homework due: o Passport: Insertions and Eliminations, MI5.1, 5.2, 5.3, 5.4 o Group Homework, Instructor Assigned: Workbook: 237-242 o OWL: 18e (Wittig Tutor), Migratory Insertion


• Sulfur and Phosporus Ylides, Aldols, Workbook: 248-250 Wednesday, March 6, Day 6


o Reactivity 1 text: Chapter 20: Enolates and Other Carbon Nucleophiles

§ 20.1 Enols and Enolates § 20.5 Aldol Condensations

o Structure & Reactivity online text: CO9 • Suggested Practice Problems:

o Reactivity 1: Wittigs § Wittigs: 18.12, 18.13, 18.14, 18.15 § NOTE: Answers are found on NMR Moodle site


• Homework due: o Individual Homework, Enolates: Workbook, 252-255


• Applications of Ylides/Enolates to Synthesis, Workbook: 251, 256-266

Tuesday, March 5 6:30-8:00 pm Faculty Tutorial, O’Connells

Nucleophilic Substitutions Friday, March 8, Day 2

Preparation: Nu Substitutions • Prepare Notecards on Carbonyl Addition Reactions • Read

o Reactivity 1: Chapter 19. Nucleophilic Additions to Acid Derivatives

§ 19.1 General Mechanism § 19.2 Preparation of Acyl Chlorides § 19.3 Preparation of Anhydrides § 19.4 Preparation of Esters § 19.5 Preparation of Carboxylic Acids

o Structure & Reactivity online text: CX1-CX4 • Suggested Practice Problems:

o Reactivity 1: Wittigs § Aldols: 20.2, 20.9, 20.10 § NOTE: Answers are found on NMR Moodle site


• Homework due: o Group Homework: Do either of these sets of practice problems

§ Reactivity 1 text: 18.5, 20.9 o Individual Homework, Callystatin, Workbook, 266 o OWL: 20a, 20f, 20g

In class: Nu Substitutions

• Ski Slope, Workbook: 271-272 • March PSA

Tuesday, March 12, Day 4 Preparation: Nu Substitutions

• Read o Reactivity 1: Chapter 19. Nucleophilic Additions to Acid

Derivatives § 19.7 Reaction with Hydride Nucleophiles § 19.8 Reduction of Acid Derivatives to Aldehydes § 19.9 Reaction with Organometallic Reagents § 20.7 Haloform Reactions


o Reactivity 1: 19.2-19.16 § NOTE: Answers are found on NMR Moodle site

o Structure and Reactivity: CX1.1, CX2.1-2.2, CX3.1-3.3, CX4.1-4.5 § NOTE: Answers are found in CX9

• Homework due: o Passport Homework: Workbook, 273 as notecards o OWL: 19a, 19b (Tutors)


• Substitutions, Workbook: 274-279 **Register for OWL, Garrett and Grisham, 5th Ed. Biochemistry Review Packet due March 21

(BIG assignment, LOTS of points – PLAN Ahead)


Thursday, March 14, Day 6 Preparation: Nu Substitutions

• Read: o Reactivity 1: Chapter 19. Nucleophilic Substitutions to Acid

Derivatives § 20.6 Ester Condensations § 19.11 Derivatives of Sulfur and Phosphorus Acids


o Prepare Notecards on Carbonyl Substitution Reactions o Reactivity 1: 19.17-19.24

§ NOTE: Answers are found on NMR Moodle site o Structure and Reactivity: CX5.1-5.7, CX6.1-6.10

§ NOTE: Answers are found in CX9 • Homework due:

o Group Homework: Workbook, Weinreb Amides, 295-296 o OWL: 19c, 19d, 19e, 19f, 19g o OWL: 20h (Tutor)


• Claisens, Sulfonates, Phosphonates, Workbook: 280-287 • PSA#5

Conjugate Additions

Monday, March 18, Day 2 Preparation: Nu Substitutions

• Read: o Reactivity 1: Chapter 20: Enolates

§ Ch 18.10 Conjugate Addition to Carbonyls § Ch 20.10 Michael Additions and Robinson Annulations

o Structure and Reactivity: CO19 Conjugate Addition • Suggested Practice Problems:

o Reactivity 1: 19.25, 20.14-20.18 § NOTE: Answers are found on NMR Moodle site

o Structure and Reactivity: CX7.1, 7.2a, § NOTE: Answers are found in CX9

• Homework due: o OWL: 20i, 20j

In class: Conjugate Additions

• Conjugate Additions, Workbook: 302-305 Wednesday, March 20, Day 4


o Reactivity 1: Chapter 20: Enolates and Carbon Nucleophiles § Ch 20.10 Michael Additions and Robinson Annulations § Ch 20.11 Synthesis

• Suggested Practice Problems: o Reactivity 1: 18.25, 18.26, 20.25-20.28

§ NOTE: Answers are found on NMR Moodle site o Structure and Reactivity: CO19.1-19.5


o Group Homework: Helminthosporal Workbook, 306 o OWL: 20k, 20l (preview of enamines), 18j, 18k, 18m

In class: Conjugate Additions

• Robinson Annulations/Stork Enamines, Workbook: 307-310


Enzyme Catalysis Friday, March 22, Day 6

Preparation: Enzymes • Register for new OWL course using your second passcode.

o Campbell and Farrell, Biochemistry • Read:

o Reactivity 1 text: Chapter 13: Enzymes – Kinetics and Specifity § 13.1 Characteristic Features § 13.4 Inhibition of Enzymes § 13.6 Enzyme Specificity § 13.7 Are all enzymes Proteins? § 13.8 Enzyme Design

o Reactivity 1 text: Chapter 14: Mechanisms of Enzyme Action o Enzyme Catalysis Interactive Concepts Chapter 6

• Homework due: o Group Homework, Hinesol: Workbook, 313 o Passport, Catalysis Review: Workbook, 318-319 o G&G OWL: Biochem Review Packet

In class: Enzyme Catalysis

• Enzymatic Catalysis/Transition State Analogs, Workbook: 320-325 • PSA#6

EASTER Break

Metals in Enzyme Catalysis Wednesday April 3, Day 2

Preparation: Enzymes • Read:

o Reactivity 1 text: Chapter 6.5 Bioinorganic Applications o Chem. Rev., Bioinorganic Enzymology, Vol. 96(7), 1996, pp

2239–2314

• Suggested Practice Problems: o Reactivity 1: Mechanisms of Enzyme Actions

§ 14.1, 14.2, 14.7, 14.12-14.18 § NOTE: Answers are found on NMR Moodle site

• Homework due: o Group Homework: Workbook, HIV Protease, 330-333 o G&G OWL: 13.1, 13.6, 14.3, 14.6, 14SAS

In class: Metals in Biochemical Catalysis

• Bioinorganic, Workbook: 334-344

Tuesday, April 2 No Faculty Tutorial, O’Connells

Biochemical Pathways: Reactions, Thermodynamics and Regulation

Friday, April 5, Day 4

Preparation: Pathways • Read:

o Structure & Reactivity online text: MP1-MP3 o Reactivity 1 text: Chapter 18. Glycolysis

§ Except 18.7 and 18.8 o Glycolysis Biosynthesis Interactive Concepts Chapter 15

• Homework due: o Group Homework: Workbook, 343-344 o G&G OWL: Ch15, Special Focus on Hemoglobin

In class: Glycolysis

• Glycolysis: A Mechanistic Approach, Workbook: 353-361 • April PSA

Tuesday, April 9, Day 6


o Reactivity 1 text: Chapter 19. TCA cycle (Kreb’s Cycle) § Except 19.6, 19.7 and 19.9

o TCA Cycle Biosynthesis Interactive Concepts Chapter 16 • Suggested Practice Problems:

o Reactivity 1: 18.5, 18.9, 18.20, 18.21 § NOTE: Answers are found on NMR Moodle Site

• Homework due: o Passport: pages from the Glycolysis section (TBA in class) o G&G OWL: Glycolysis 18.1, 18.3, 18.4

In class: TCA Cycle

• TCA or Kreb’s Cycle: Mechanistic Approach, Workbook: 362-367

Tuesday, April 9 6:30-8:00 pm Faculty Tutorial, O’Connells

Thursday, April 11, Day 2 Preparation: Pathways

• Read: o Reactivity 1 text: Chapter 17. Metabolism – An Overview

§ Except 17.4 and 17.5 o Glycolysis Biosynthesis Interactive Concepts Chapter 14

• Suggested Practice Problems: o Reactivity 1: 19.2, 19.4, 19.9, 19.14, 19.15

§ NOTE: Answers are found on NMR Moodle site • Homework due:

o Passport: page from TCA Cycle section (TBA in class) o Passport: Thermodynamics Review, Workbook, 374 o G&G OWL: TCA Cycle 19.1, 19.3, 19.4, SAS

In class: Glycolysis

• Thermodynamic Control, Workbook: 375-382 • Standard Free Energy Changes, Workbook, 387-390 • PSA#7

Monday, April 15, Day 4


o Reactivity 1 text: Chapter 15. Enzyme Regulation o Structure & Reactivity online text: MP4

• Suggested Practice Problems: o Reactivity 1: 17.4, 17.6, 17.9, 17.14,17.15, 18.1, 18.11, 18.13,

18.14, 18.15 § NOTE: Answers are found on NMR Moodle site

• Homework due: o Group Homework: Cumulative Problem, Workbook, 383-386 o G&G OWL: 3.1, 3.5, 3.6, 3.Self-Assessment (Thermodynamics

of Biological Systems) 18.Self-Assessment (Thermodynamics of Glycolysis)

o G&G OWL: Gluconeogenesis 22.1

In class: Regulation of Pathways

• Allosteric Enzyme Regulation, Workbook: 395-398 • Covalent Modification of Enzymes: Workbook: 401-408

Wednesday, April 17, Day 6 Preparation: Pathways

• Read: o Covalent Modification: Phosphorylation

• Suggested Practice Problems: o Reactivity 1: 15.16, 15.18, 15.20, 17.8, 19.3

§ NOTE: Answers are found on NMR Moodle site • Homework due:

o Group Homework, Workbook, Instructor Choice, 399-400,412-416

In class: Pathways • Fatty Acid Biosynthesis: Mechanistic, Workbook: 422-428

Tuesday, April 16 6:30-8:00 pm Faculty Tutorial, O’Connells

Friday, April 19, Day 2


o Fatty Acid Biosynthesis Interactive Concepts Chapter 18 o Structure & Reactivity online text: MP5

• Homework due: o Passport: Workbook, 429 o Group Homework: Workbook, 412-414 o G&G OWL: 15 Enzyme Regulation 15.1, 15.2, 15.3, 15.5, SAS

In class: Pathways

• Fatty Acid Biosynthesis: Regulation, Workbook: 430-434 • β-Oxidation, Workbook: 435-438 • PSA#8

Tuesday, April 23, Day 4 Preparation: Pathways

• Read: o Fatty Acid Biosynthesis Interactive Concepts Chapter 18 o Structure & Reactivity online text: MP5

• Suggested Practice Problems: • Homework due:

o G&G OWL: Lipid Biosynthesis 24.1, 24.2 o G&G OWL: Common Catabolic Pathway 27.1

In class: Pathways

• Ketogenesis, Workbook: 439-442 • Diabetes, Workbook: 448-451

Tuesday, April 23 No Faculty Tutorial, O’Connells

Wednesday, April 24 Scholarship and Creativity Day

Chemistry and Biochemistry Senior Presentations A list of titles, times and locations will be announced

Extra Credit Option Attend one Chemistry or Biochemistry Senior Presentation Write a 1 paragraph summary Due April 26th

**Look Ahead

Practice Final Exam, Hornback OWL 90 Multiple Choice questions due May 7

Polymers

Friday, April 26, Day 6 Preparation: Polymers

• Read: o Frank Harris, J. Chem. Ed., 1981, 58(11), 837-843. o Case Western Virtual Textbook

• Homework due: o OWL: 23 Lipid Catabolism (23.2, 23.3, Self-Assessment) o Extra Credit: Summary of a Senior Presentation

In class: Pathways

• Polymer Architecture, Workbook, 456-461 • Polymer Properties, Handout

Tuesday, April 30, Day 2

Preparation: Polymers • Homework due:

o Group Homework, Workbook: 462 o Hornback OWL: 24. Nylon Formation Tutor

In class: Polymers

• Polymer Synthesis, Workbook, 463-466 • PSA#19

Tuesday, April 30 6:30-8:00 pm LAST Tutorial, O’Connells

Thursday, May 2, Day 4 Preparation: Polymers

• Read: o Protein Biosynthesis Interactive Concepts Chapter 12

• Suggested Problems: o Structure and Reactivity: CX8.1-8.5


o Passport: Transcription Review, 467-469 o Hornback OWL: Polymers

In class: Pathways

• Protein Biosynthesis, Workbook, 470-479 Monday, May 6, Day 6

Preparation: Polymers • Homework due:

o G&G OWL: Protein Synthesis o OWL: Multiple Choice Practice Final Exam

In class: Applications

• Applications, TBA • May PSA

Tuesday, May 7: Study Day Final Exam: 8-10 am on Friday, May 9

Documents

Chemistry 250: Reactivity 1 - College of Saint Benedict ... · Chemistry 250: Reactivity 1 Spring 2013 Tentative Even Day Class Schedule Resources • Workbook: Principles of Reactivity