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Pyridine derivativesR 0380 Triazole Oxytocin Antagonists: Identification of Aryl Ether Replacements for a

Biaryl Substituent. — Putative overlap of known oxytocin antagonists is used to iden-tify aryl ether left-hand side substituents as replacements for biaryl substituents. Com-pound (VIII), exhibiting significantly improved aqueous solubility, is a selective and potent oxytocin antagonist and represents one of the most ligand efficient oxytocin antagonists. — (BROWN*, A.; BROWN, L.; BROWN, T. B.; CALABRESE, A.; ELLIS, D.; PUHALO, N.; SMITH, C. R.; WALLACE, O.; WATSON, L.; Bioorg. Med. Chem. Lett. 18 (2008) 19, 5242-5244; Dep. Chem., Pfizer Global Res. Dev., Sandwich, Kent CT13 9NJ, UK; Eng.) — H. Hoennerscheid

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