Barbituric acid derivativesR 0530 DOI: 10.1002/chin.201139157

Thermal Solvent-Free Synthesis of Novel Pyrazolyl Chalcones and Pyrazolines as Potential Antimicrobial Agents. — Simple thermal heating under neat conditions gives access to new chalcones (III) which are then converted to the corresponding py-razolines (IV) in a solvent-free reaction. All synthesized compounds are tested for their antibacterial and antifungal activity. Derivative (IIIa) shows promising antibacterial potency nearly to the activity of the standard antibiotics ciprofloxacin, griseofulvin and fluconazole. — (SIDDIQUI*, Z. N.; MUSTHAFA, T. N. M.; AHMAD, A.; KHAN, A. U.; Bioorg. Med. Chem. Lett. 21 (2011) 10, 2860-2865, http://dx.doi.org/10.1016/j.bmcl.2011.03.080 ; Dep. Chem., Aligarh Muslim Univ., Aligarh 202 002, India; Eng.) — H. Haber

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