Receptor binding activityX 0280 DOI: 10.1002/chin.201115205

The Identification of Novel Orally Active mGluR5 Antagonist GSK2210875. — The title antagonist (I) shows excellent bioavailability in rats and demonstrates excel-lent brain exposure. — (WATSON*, S.; et al.; Bioorg. Med. Chem. Lett. 20 (2010) 24, 7521-7524, http://dx.doi.org/10.1016/j.bmcl.2010.09.120 ; Neurosci. Cent. Excellence Drug Discovery, GlaxoSmithKline, New Front. Sci. Park, Harlow, Essex CM19 5AW, UK; Eng.) — K. Woydowski

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