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Oxazine derivativesR 0595 Tandem Ring-Opening/Closing Reactions of N-Ts Aziridines and Aryl Propargyl

Alcohols Promoted by t-BuOK. — N-Protected aziridines react with aryl propargyl alcohols by ring-opening followed by ring closure to afford dihydroxazine derivatives. Additional ionic hydrogenation produces morpholine derivatives as cis-isomers or dia-stereomeric mixture. — (WANG, L.; LIU, Q.-B.; WANG, D.-S.; LI, X.; HAN, X.-W.; XIAO, W.-J.; ZHOU*, Y.-G.; Org. Lett. 11 (2009) 5, 1119-1122; State Key Lab. Catal., Dalian Inst. Chem. Phys., Dalian 116023, Peop. Rep. China; Eng.) —R. Simon

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