2000 hydroxylamine derivatives

hydroxylamine derivatives (benzene compounds)Q 0110

26 - 081Synthesis of Optically Active N-Hydroxylamines by AsymmetricHydrogenation of Nitrones with Iridium Catalysts. — Asymmetrichydrogenation of nitrones (I) and (III) with iridium catalysts yields opticallyactive N-hydroxylamines (II) and (IV). The highest enantioselectivity is ob-tained by using the iridium catalyst system B). The effect of the solvent on theenantioselectivity is dramatic; THF shows the best results. When rutheniumcomplexes are used, no hydrogenation occurs whereas in the presence of rhodiumcatalysts no enantioselectivity is observed. — (MURAHASHI, SHUN-ICHI;TSUJI, TETUROU; ITO, SHUICHI; Chem. Commun. (Cambridge) (2000) 5,409-410; Dep. Chem., Grad. Sch. Eng. Sci., Osaka Univ., Toyonaka, Osaka560, Japan; EN)

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