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CyanationO 0273 Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Molecular

Oxygen or Hydrogen Peroxide and Sodium Cyanide: sp3 C—H Bond Activation and Carbon—Carbon Bond Formation. — Ruthenium-catalyzed oxidative cyana-tion of tertiary amines is conducted with molecular oxygen in the presence of sodium cyanide and acetic acid to give α-aminonitriles. The cyanation of tertiary amines is also accomplished with H2O2. The products can be converted into α-amino acids, diamines, and various heterocyclic compounds. — (MURAHASHI*, S.-I.; NAKAE, T.; TERAI, H.; KOMIYA, N.; J. Am. Chem. Soc. 130 (2008) 33, 11005-11012; Dep. Chem., Grad. Sch. Eng. Sci., Osaka Univ., Toyonaka, Osaka 560, Japan; Eng.) — S. Adam

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ChemInform 2008, 39, issue 51 © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim