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Multi-membered N-heterocyclesR 0690 DOI: 10.1002/chin.201004180

Olefinic-Amide and Olefinic-Lactam Cyclizations. — The reaction with titanium ethylidene, generated in situ, leads to aromatic and nonaromatic bicyclic N-heterocy-cles. The cyclization product of (XII) is unstable and thus isolated as (XIV) or (XV). In some cases, small amounts of non-cyclized products are isolated as well [cf. (IX), (XVIII)]. — (ZHOU, J.; RAINIER*, J. D.; Org. Lett. 11 (2009) 16, 3774-3776; Dep. Chem., Univ. Utah, Salt Lake City, UT 84112, USA; Eng.) — R. Steudel

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