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Fused pyridine derivativesR 0450 DOI: 10.1002/chin.201019142

Novel Hybrids from Lamellarin D and Combretastatin A 4 as Cytotoxic Agents. — An N-ylide-mediated pyrrole formation strategy involving dihydroisoquinoline hy-drochlorides (IV) and phenacyl bromides (V) is adopted to synthesize novel hybrids such as (VI). (VI) exhibit anti-proliferative activity in vitro against five human cancer cell lines. Hybrids closely resembling structure features of lamellarin D show potent activities. Hybrid (VIe) having isopropoxy groups at positions 8 and 14 and OH groups at positions 20 and 21 reveals the most effective activity against all five cell lines. — (SHEN, L.; YANG, X.; YANG, B.; HE, Q.; HU*, Y.; Eur. J. Med. Chem. 45 (2010) 1, 11-18; Joint Lab. Med. Chem., Sch. Pharm. Sci., Zhejiang Univ., Hangzhou 310058, Peop. Rep. China; Eng.) — H. Hoennerscheid

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ChemInform 2010, 41, issue 19 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim