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Triazole derivativesR 0280 DOI: 10.1002/chin.201128129
Isatin 1,2,3-Triazoles as Potent Inhibitors Against Caspase-3. — A variety of di-substituted 1,2,3-triazole derivatives are synthesized using the Huisgen cycloaddition reaction. Compounds (VIIId) and (IXa) are found to be the most potent inhibitors against caspase-3. — (JIANG*, Y.; HANSEN, T. V.; Bioorg. Med. Chem. Lett. 21 (2011) 6, 1626-1629, http://dx.doi.org/10.1016/j.bmcl.2011.01.110 ; Dep. Pharm. Chem., Sch. Pharm., Univ. Oslo, N-0316 Oslo, Norway; Eng.) — H. Toeppel
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ChemInform 2011, 42, issue 28 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim