2001 indole derivatives, isoindole derivatives

indole derivatives, isoindole derivativesR 0140

18 - 097Heterocyclic Substituted Anthralin Derivatives as Inhibitors ofKeratinocyte Growth and Inducers of Differentiation. — A numberof heterocyclic substituted derivatives [cf. (III), (V)] of antipsoriatic anthralinare synthesized and evaluated for their biological activity. Indole analogue(IIIa) shows potent antiproliferative activity combined with the ability to inducekeratinocyte differentiation. — (MUELLER, KLAUS; REINDL, HANS;BREU, KLAUS; Bioorg. Med. Chem. Lett. 11 (2001) 1, 47-50; Inst. Pharm.Chem., Westfael. Wilhelms-Univ., D-48149 Muenster, Germany; EN)

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