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ChemInform 2012, 43, issue 33 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Pyridine derivatives R 0380 DOI: 10.1002/chin.201233162 Furanyl Cyclic Amines: A Diastereoselective Synthesis of 2,6-syn-Disubstituted Piperidines under Thermodynamic Control. — Treatment of furanyl substituted 1,5-tosylamino alcohols with TosOH under thermodynamic control allows highly diastereoselective access to 2,6-syn-substituted piperidines. — (O'BRIEN*, M.; LEACH, A.; ARMSTRONG, R. J.; CHONG, K.; SHERIDAN, R.; Org. Biomol. Chem. 10 (2012) 12, 2392-2394, http://dx.doi.org/10.1039/c2ob07008a ; Univ. Chem. Lab., Cambridge Univ., Cambridge CB2 1EW, UK; Eng.) — Jannicke 33- 162

ChemInform Abstract: Furanyl Cyclic Amines: A Diastereoselective Synthesis of 2,6-syn-Disubstituted Piperidines under Thermodynamic Control

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Page 1: ChemInform Abstract: Furanyl Cyclic Amines: A Diastereoselective Synthesis of 2,6-syn-Disubstituted Piperidines under Thermodynamic Control

Pyridine derivativesR 0380 DOI: 10.1002/chin.201233162

Furanyl Cyclic Amines: A Diastereoselective Synthesis of 2,6-syn-Disubstituted Piperidines under Thermodynamic Control. — Treatment of furanyl substituted 1,5-tosylamino alcohols with TosOH under thermodynamic control allows highly dia-stereoselective access to 2,6-syn-substituted piperidines. — (O'BRIEN*, M.; LEACH, A.; ARMSTRONG, R. J.; CHONG, K.; SHERIDAN, R.; Org. Biomol. Chem. 10 (2012) 12, 2392-2394, http://dx.doi.org/10.1039/c2ob07008a ; Univ. Chem. Lab., Cambridge Univ., Cambridge CB2 1EW, UK; Eng.) — Jannicke

33- 162

ChemInform 2012, 43, issue 33 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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