2000 thiadiazine derivatives

thiadiazine derivativesR 0660

08 - 191Chlorophenylmethyl Benzothiadiazine Dioxides Derivatives: PotentHuman Cytomegalovirus Inhibitors. — Compounds of type (III), (V),(VI), (IX), and (X) are prepared by known methods (no yields given). Thecompounds are tested for their inhibition of human cytomegalovirus (HCMV).The data show that the benzyl- or chlorophenyl-substituted compounds aremore efficient than the benzyloxymethyl-substituted compounds. Compound(X) is also tested for its antiviral activity against three HCMV-clinical isolatesand shows an effective antiviral inhibition in all three cases. — (MARTINEZ,ANA; GIL, CARMEN; PEREZ, CONCEPCION; CASTRO, ANA; PRIETO,COLUMBIANA; OTERO, JOAQUIN; Bioorg. Med. Chem. Lett. 9 (1999) 21,3133-3136; Inst. Quim. Med., CSIC, E-28006 Madrid, Spain; EN)

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