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Amide formationO 0325 DOI: 10.1002/chin.201019044

Anhydrous Hydration of Nitriles to Amides Using Aldoximes as the Water Source. — Various nitriles are converted to amides under neutral and anhydrous conditions. Sensitive functional and protecting groups are tolerated and no racemization is ob-served. — (LEE, J.; KIM, M.; CHANG*, S.; LEE, H.-Y.; Org. Lett. 11 (2009) 24, 5598-5601; Dep. Chem., Korea Adv. Inst. Sci. Technol., Daejeon 305-701, S. Korea; Eng.) — R. Simon

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ChemInform 2010, 41, issue 19 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim