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C-C bond formationO 0282 DOI: 10.1002/chin.201107062

A Palladium/Copper Bimetallic Catalytic System: Dramatic Improvement for Suzuki—Miyaura-Type Direct C—H Arylation of Azoles with Arylboronic Acids. — Palladium/copper bimetallic-catalyzed Suzuki—Miyaura-type coupling is disclosed for direct C—H arylation of azoles, instead of azole halides or pseudohalides, with aryl-boronic acids. The catalytic system not only allows the C-arylation of a broader spec-trum of azoles under relatively mild conditions, but is also applied to the direct synthe-sis of 3-arylated indolizines from indolizines such as (IVf). — (LIU, B.; QIN, X.; LI, K.; LI, X.; GUO, Q.; LAN, J.; YOU*, J.; Chem. Eur. J. 16 (2010) 39, 11836-11839, http://dx.doi.org/10.1002/chem.201001338 ; Key Lab. Green Chem. Technol., Sichuan Univ., Chengdu, Sichuan 610064, Peop. Rep. China; Eng.) — Bartels

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ChemInform 2011, 42, issue 07 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim