Benzimidazole derivativesR 0200 DOI: 10.1002/chin.201119121

A Direct, Regioselective Palladium-Catalyzed Synthesis of N-Substituted Benz-imidazoles and Imidazopyridines. — A sequential Pd-catalyzed amidation—Fe-me-diated reductive aminocyclization of o-chloronitro(het)arenes with aromatic or aliphat-ic amides provides an efficient access towards benzimidazole derivatives. A wide range of functional groups is tolerated, including ether, ester, cyano, halide or amino groups. The acid-labile acetal group, however, does not survive [cf. (IX)]. — (ALONSO, J.; HALLAND, N.; NAZARE*, M.; R'KYEK, O.; URMANN, M.; LINDENSCHMIDT, A.; Eur. J. Org. Chem. 2011, 2, 234-237, http://dx.doi.org/10.1002/ejoc.201001423 ; Sanofi-Aventis Dtschl. GmbH, D-65926 Frankfurt/M., Germany; Eng.) — Mischke

19- 121

ChemInform 2011, 42, issue 19 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim