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2001 anthracene derivatives
anthracene derivativesQ 1080
35 - 11010-Phenylbutyryl-substituted Anthracenones as Inhibitors of Ker-atinocyte Growth and LTB4 Biosynthesis. — Twelve compoundsof type (III), (V), (VII), and (IX) are prepared and tested as inhibitors ofleukotriene B4 (LTB4) biosynthesis. Compounds (III) and (IX) show inhibitoryactivity against LTB4 biosynthesis. Their anti-proliferative activity is compa-rable to that of the known antipsoriatic anthralin. — (MUELLER, KLAUS;BREU, KLAUS; REINDL, HANS; Eur. J. Med. Chem. 36 (2001) 2, 179-184;Inst. Pharm. Chem., Westfael. Wilhelms-Univ., D-48149 Muenster, Germany;EN)
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