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8/14/2019 Chemical Components in a Cigarette
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Chemical Components in a Cigarette
Nicotine
Nicotine is a powerful insecticide and poisonous for the nervous systems. Furthermore, there is enough
(50 mg) in four cigarettes to kill a man in just a few minutes if it were injected directly into the
bloodstream. Indeed, fatalities have occurred with children after they had swallowed cigarettes or
cigarette butts.
When diluted in smoke, nicotine reaches the brain in just seven seconds; it stimulates the brain cells
and then blocks the nervous impulse. This is where addiction to tobacco arises. Nicotine also causes
accelerated heart rate, but at the same time it leads to contracting and hardening of the arteries: the
heart pumps more but receives less blood. The result is twice as many coronary attacks. Nicotine thus
also increases the consumption of lipids (which is why it has a weight-loss effect) and induces temporary
hyperglycaemia (hence the appetite suppressing effect).
Carbon monoxide (CO)
This is the asphyxiating gas produced by cars, which makes up 1.5% of exhaust fumes. But smokers
inhaling cigarette smoke breathe in 3.2% carbon monoxide - and directly from the source.
Oxygen is mostly transported in blood by haemoglobin. When we smoke, however, the carbon monoxide
attaches itself to the haemoglobin 203 times more quickly than oxygen does, thereby displacing the
oxygen; this in turn asphyxiates( Impaired or impeded breathing) the organism. This causes the following
cardiovascular complaints: narrowing of the arteries, blood clots, arteritis, gangrene, heart attack,
etc. . . . but also a loss of reflexes and visual and mental problems. It takes between six and 24 hours
for the carbon monoxide to leave the blood system.
Irritants
These substances paralyse and then destroy the cilia of the bronchial tubes, responsible for filtering and
cleaning the lungs. They slow down respiratory output and irritate the mucus membranes, causing
coughs, infections and chronic bronchitis.
Tars
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As the cilia are blocked (see paragraph above), the tars in the cigarette smoke are deposited and collect
on the walls of the respiratory tract and the lungs, and cause them to turn black. So, just because a
smoker is not coughing, it doesn't mean that he or she is healthy! And this fact merely serves to pour
water on one of the most common and poorest excuses given by smokers. The carcinogenic action of
the tars is well known: they are responsible for 95% of lung cancers. It takes two days at least after
cessation of smoking for the cilia to start functioning properly again, albeit only gradually. By smoking
one packet of cigarettes every day, a smoker is pouring a cupful of these tars into his or her lungs every
year (225 grams on average)!
Chemistry of Tobacco Smoke
No less than 4000 irritating, suffocating, dissolving, inflammable, toxic, poisonous, carcinogenic gases
and substances and even radioactive compounds (nickel, polonium, plutonium, etc.) have been
identified in tobacco smoke. Some of these are listed hereafter: Benzopyrene, dibenzopyrene, benzene,
isoprene, toluene (hydorcarbons) ; naphthylamines; nickel, polonium, plutonium, arsenic, cadmium
(metallic constituents) ; carbon dioxide, methane, ammonia, nitric oxide, nitrogen dioxide, hydrogen
sulphide (gases); methyl alcohol, thanol, glycerol or glycerine, glycol (alcohols and esters);
acetaldehyde, acrolein, acetone (aldehydes and ketones); cyanhydric or prussic acid, carboxyl
derivatives (acids); chrysene, pyrrolidine, nicoteine, nicotinine, nicoteline, nornicotine, nitrosamines
(alkaloids or bases), cresol (phenols) etc.
Components in alcoholic beverages
1. Acetaldehyde,2. Methanol, 3. Acetone, 4. Ethyl formate,5. Ethanol,6. Ethyl acetate,7. n-propanol,8.
sec-butanol,9. Isobutanol,10. Active amyl alcohol,11. isoamyl alcohol, and 12. N-amyl alcohol.
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TypeRecepto
rFunction
PGI2 IP
vasodilation
inhibit platelet aggregation
bronchodilatationPGE2
EP1 bronchoconstriction
GI tract smooth muscle contraction
EP2
bronchodilatation
GI tract smooth muscle relaxation
vasodilatation
EP3 gastric acid secretion
http://en.wikipedia.org/wiki/Prostaglandin_receptorhttp://en.wikipedia.org/wiki/Prostaglandin_receptorhttp://en.wikipedia.org/wiki/Prostaglandin_I2http://en.wikipedia.org/wiki/Prostaglandin_I2http://en.wikipedia.org/wiki/Vasodilationhttp://en.wikipedia.org/wiki/Platelet_aggregationhttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/Prostaglandin_E2http://en.wikipedia.org/wiki/Prostaglandin_E2http://en.wikipedia.org/wiki/Bronchoconstrictionhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Vasodilatationhttp://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Prostaglandin_I2http://en.wikipedia.org/wiki/Vasodilationhttp://en.wikipedia.org/wiki/Platelet_aggregationhttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/Prostaglandin_E2http://en.wikipedia.org/wiki/Bronchoconstrictionhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Vasodilatationhttp://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Prostaglandin_receptorhttp://en.wikipedia.org/wiki/Prostaglandin_receptor8/14/2019 Chemical Components in a Cigarette
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gastricmucus secretion
uterus contraction (when pregnant)
GI tract smooth muscle contraction
lipolysis inhibition
autonomicneurotransmitters[8]
platelet response to their agonists [9][1] and
atherothrombosis in vivo [10] [2]
Unspecified
hyperalgesia[8]
pyrogenic
PGF2
FP uterus contraction
bronchoconstriction
Eg.nicotine
http://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Mucushttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Lipolysishttp://en.wikipedia.org/wiki/Autonomous_nshttp://en.wikipedia.org/wiki/Neurotransmittershttp://www.jci.org/articles/view/10881http://jem.rupress.org/cgi/content/full/204/2/311http://jem.rupress.org/cgi/content/full/204/2/311http://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Feverhttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/Bronchoconstrictionhttp://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Mucushttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Lipolysishttp://en.wikipedia.org/wiki/Autonomous_nshttp://en.wikipedia.org/wiki/Neurotransmittershttp://www.jci.org/articles/view/10881http://jem.rupress.org/cgi/content/full/204/2/311http://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Feverhttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/Bronchoconstriction