Chemical Components in a Cigarette

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    Chemical Components in a Cigarette

    Nicotine

    Nicotine is a powerful insecticide and poisonous for the nervous systems. Furthermore, there is enough

    (50 mg) in four cigarettes to kill a man in just a few minutes if it were injected directly into the

    bloodstream. Indeed, fatalities have occurred with children after they had swallowed cigarettes or

    cigarette butts.

    When diluted in smoke, nicotine reaches the brain in just seven seconds; it stimulates the brain cells

    and then blocks the nervous impulse. This is where addiction to tobacco arises. Nicotine also causes

    accelerated heart rate, but at the same time it leads to contracting and hardening of the arteries: the

    heart pumps more but receives less blood. The result is twice as many coronary attacks. Nicotine thus

    also increases the consumption of lipids (which is why it has a weight-loss effect) and induces temporary

    hyperglycaemia (hence the appetite suppressing effect).

    Carbon monoxide (CO)

    This is the asphyxiating gas produced by cars, which makes up 1.5% of exhaust fumes. But smokers

    inhaling cigarette smoke breathe in 3.2% carbon monoxide - and directly from the source.

    Oxygen is mostly transported in blood by haemoglobin. When we smoke, however, the carbon monoxide

    attaches itself to the haemoglobin 203 times more quickly than oxygen does, thereby displacing the

    oxygen; this in turn asphyxiates( Impaired or impeded breathing) the organism. This causes the following

    cardiovascular complaints: narrowing of the arteries, blood clots, arteritis, gangrene, heart attack,

    etc. . . . but also a loss of reflexes and visual and mental problems. It takes between six and 24 hours

    for the carbon monoxide to leave the blood system.

    Irritants

    These substances paralyse and then destroy the cilia of the bronchial tubes, responsible for filtering and

    cleaning the lungs. They slow down respiratory output and irritate the mucus membranes, causing

    coughs, infections and chronic bronchitis.

    Tars

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    As the cilia are blocked (see paragraph above), the tars in the cigarette smoke are deposited and collect

    on the walls of the respiratory tract and the lungs, and cause them to turn black. So, just because a

    smoker is not coughing, it doesn't mean that he or she is healthy! And this fact merely serves to pour

    water on one of the most common and poorest excuses given by smokers. The carcinogenic action of

    the tars is well known: they are responsible for 95% of lung cancers. It takes two days at least after

    cessation of smoking for the cilia to start functioning properly again, albeit only gradually. By smoking

    one packet of cigarettes every day, a smoker is pouring a cupful of these tars into his or her lungs every

    year (225 grams on average)!

    Chemistry of Tobacco Smoke

    No less than 4000 irritating, suffocating, dissolving, inflammable, toxic, poisonous, carcinogenic gases

    and substances and even radioactive compounds (nickel, polonium, plutonium, etc.) have been

    identified in tobacco smoke. Some of these are listed hereafter: Benzopyrene, dibenzopyrene, benzene,

    isoprene, toluene (hydorcarbons) ; naphthylamines; nickel, polonium, plutonium, arsenic, cadmium

    (metallic constituents) ; carbon dioxide, methane, ammonia, nitric oxide, nitrogen dioxide, hydrogen

    sulphide (gases); methyl alcohol, thanol, glycerol or glycerine, glycol (alcohols and esters);

    acetaldehyde, acrolein, acetone (aldehydes and ketones); cyanhydric or prussic acid, carboxyl

    derivatives (acids); chrysene, pyrrolidine, nicoteine, nicotinine, nicoteline, nornicotine, nitrosamines

    (alkaloids or bases), cresol (phenols) etc.

    Components in alcoholic beverages

    1. Acetaldehyde,2. Methanol, 3. Acetone, 4. Ethyl formate,5. Ethanol,6. Ethyl acetate,7. n-propanol,8.

    sec-butanol,9. Isobutanol,10. Active amyl alcohol,11. isoamyl alcohol, and 12. N-amyl alcohol.

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    TypeRecepto

    rFunction

    PGI2 IP

    vasodilation

    inhibit platelet aggregation

    bronchodilatationPGE2

    EP1 bronchoconstriction

    GI tract smooth muscle contraction

    EP2

    bronchodilatation

    GI tract smooth muscle relaxation

    vasodilatation

    EP3 gastric acid secretion

    http://en.wikipedia.org/wiki/Prostaglandin_receptorhttp://en.wikipedia.org/wiki/Prostaglandin_receptorhttp://en.wikipedia.org/wiki/Prostaglandin_I2http://en.wikipedia.org/wiki/Prostaglandin_I2http://en.wikipedia.org/wiki/Vasodilationhttp://en.wikipedia.org/wiki/Platelet_aggregationhttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/Prostaglandin_E2http://en.wikipedia.org/wiki/Prostaglandin_E2http://en.wikipedia.org/wiki/Bronchoconstrictionhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Vasodilatationhttp://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Prostaglandin_I2http://en.wikipedia.org/wiki/Vasodilationhttp://en.wikipedia.org/wiki/Platelet_aggregationhttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/Prostaglandin_E2http://en.wikipedia.org/wiki/Bronchoconstrictionhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Bronchodilatationhttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Vasodilatationhttp://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Prostaglandin_receptorhttp://en.wikipedia.org/wiki/Prostaglandin_receptor
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    gastricmucus secretion

    uterus contraction (when pregnant)

    GI tract smooth muscle contraction

    lipolysis inhibition

    autonomicneurotransmitters[8]

    platelet response to their agonists [9][1] and

    atherothrombosis in vivo [10] [2]

    Unspecified

    hyperalgesia[8]

    pyrogenic

    PGF2

    FP uterus contraction

    bronchoconstriction

    Eg.nicotine

    http://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Mucushttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Lipolysishttp://en.wikipedia.org/wiki/Autonomous_nshttp://en.wikipedia.org/wiki/Neurotransmittershttp://www.jci.org/articles/view/10881http://jem.rupress.org/cgi/content/full/204/2/311http://jem.rupress.org/cgi/content/full/204/2/311http://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Feverhttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/Bronchoconstrictionhttp://en.wikipedia.org/wiki/Stomachhttp://en.wikipedia.org/wiki/Mucushttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/GI_tracthttp://en.wikipedia.org/wiki/Smooth_musclehttp://en.wikipedia.org/wiki/Lipolysishttp://en.wikipedia.org/wiki/Autonomous_nshttp://en.wikipedia.org/wiki/Neurotransmittershttp://www.jci.org/articles/view/10881http://jem.rupress.org/cgi/content/full/204/2/311http://en.wikipedia.org/wiki/Hyperalgesiahttp://en.wikipedia.org/wiki/Feverhttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Prostaglandin_F2alphahttp://en.wikipedia.org/wiki/Uterushttp://en.wikipedia.org/wiki/Bronchoconstriction