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OVERVIEW OF UNDERGRADUATE RESEARCH PROGRAMS CHEM2999 & CHEM3998

This booklet provides details of the CHEM2999 and CHEM3998 courses, in which students undertake an authentic short research project under the direction of a Chemistry academic member of staff taking advantage of UNSW's world-class researchers and research facilities. Student engage directly with academics and their research group, becoming involved with the group's regular activities such as group meetings, while learning important research and transferable graduate skills prized throughout academia, industry and business.

Both courses require a WAM of at least 65 and are offered in all three terms and in summer. Enrolment occurs every term.

CHEM2999 – Special Project in Chemistry

This course is most suitable for students in their second year with only first-year Chemistry background. It provides an early introduction to the university research environment. A particular focus of this course is communicating the complex research topic to a scientifically-literate non-expert audience.

CHEM3998 – Advanced Special Project in Chemistry

This course provides a more sophisticated introduction to the university research environment than CHEM2999 with a more complex project that utilises the skills and knowledge obtained by students in their early undergraduate degree. Students thus need to have completed at least 18 UoC of second year subjects OR 36 UoC of Level II Science or Engineering Courses to take this course.

These courses are designed to pave the way into Honours. However, you can most certainly undertake Honours without these courses.

For summer term research, students will need to find an appropriate academic who will be available for this period.

For each course a 1 hr fortnightly session is allocated but will be used as required for training, skills development, reflection and cohort building.

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Typical deadlines for Chem2999 and Chem3998

Term 1

Online form submitted by Wednesday Week 10 Term 3, the year preceding

Enrolments will occur on during the exam weeks of Term 3 or after the release of results depending on the WAM check

Term 2

Online form submitted by Wednesday Week 10 Term 1

Enrolments will occur on during the exam weeks of Term 1 or after the release of results depending on the WAM check

Term 3

Online form submitted by Wednesday Week 10 Term 2

Enrolments will occur on during the exam weeks of Term 2 or after the release of results depending on the WAM check

Summer Term

Online form submitted by Wednesday Week 10 Term 3

Enrolments will occur on during the exam weeks of Term 3 or after the release of results depending on the WAM check

ASSESSMENT

Both courses are pass/fail.

Both courses require attendance to an hourly weekly meet-up. This is a key component of the revised courses. It will enable students to build stronger supportive peer networks, discuss research careers and culture. It will provide an opportunity to practice short informal presentations to a non-specialist audience. Most importantly, these meetings will facilitate students in developing a high level of meta-cognition of the technical and transferable skills they are developing during their research placement, essential when applying for PhD positions and jobs in the future.

Both CHEM2999 and CHEM3998 requires the submission of a scanned copy of the laboratory notebook (or equivalent) and an excel spreadsheet (summarising activity) in Week 5 and Week 10 of each Term. Submission of a final report is required in Week 11 of each Term. Feedback is provided the week after each submission.

The two courses will be distinguished by the standard of research expertise that students must demonstrate to successfully pass this course, along with a different focus area in the final report: CHEM2999 students focus on contextualising their research while CHEM3998 students focus on identifying fruitful future directions of their research.

6

7

CHEM2999 & CHEM3998

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11

ON/OFF catalytic activities. One example are spiropyran molecules, which act as ‘photoacids’, being switched between stable acidic and non-acidic states using light stimulus. Photoacids based on spriopyran may be directly incorporated into molecular and supramolecular systems for applications in stimulus-responsible switching with applications ranging from synthetic catalysis to in-situ drug release. New photoacidic molecules are required which are suitable for building into larger structures and membranes, and the tuning their photoswitching properties will be studied using a combination of spectroscopic techniques.

Skills: organic synthesis, multidimensional NMR spectrometry, mass spectrometry

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(c) Novel ruthenium(II) complexes

Ruthenium(II) complexes are extremely useful complexes with applications ranging from energy storage and light harvesting, to catalysis and drug applications. This project will develop new types of chiral ruthenium(II) complexes which are responsive to their environments to allow these useful properties to be controlled by external stimuli (eg, temperature, chemical reagents, light, redox etc).

Skills: organic and inorganic synthesis, multidimensional NMR spectrometry, mass spectrometry, X-ray crystallography, cyclic voltammetry, X-ray crystallography, photophysical measurements

(d) Molecular rotors

(in collaboration with A/Prof. Jason Harper)

Being able to control motion at the molecular level is a fundamental challenge facing science. Nature uses controlled molecular motion, so called ‘molecular machines’ to control virtually every process in biology. So far, chemists use molecular machines to control nothing! This project involves the synthesis of molecular ‘rotors’ with a ‘propeller’ which can spin spontaneously when appropriate energy is supplied.

Skills: Organic synthesis, multidimensional NMR spectrometry

(e) …or other projects tailored to your interests!

1. Yang, J.; Bhadbhade, M.; Donald, W. A.; Iranmanesh, H.; Moore, E. G.; Yan, H.; Beves, J. E. Chem. Commun. 2015, 51, 4465-4468.

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13

breast cancer cell lines. The project will make use of new methods for oxygen tolerant polymer synthesis on microtitre plates that we have recently developed in order to prepare these libraries at low volume and high throughput.[2]

The project will involve the synthesis of several chain transfer agents required to generate the different polymer architectures, the synthesis of peptides for receptor binding, and subsequent polymerisation and polymer analysis by NMR, GPC and associated techniques. Screening of biological activity will be performed in collaboration with Dr Adam Gormley at Rutgers University in the USA, and there is the possibility of visiting his lab in the middle of the year to perform some of this work if you so choose.

(b) Stabilisation of glucose oxidase enzymes in nanocapsules (with Prof. Martina Stenzel)

Despite their extensive use in a range of synthetic, biosensing, and therapeutic applications, enzymes are often highly unstable to heat, pH, and the presence of organic solvents. However, several recent studies have shown that it is possible to protect enzymes against degredation by such environmental factors by encapsulating them within nanocapsules.[3,4]

We recently developed a new methodology for encapsulation of glucose oxidase (GOx) inside a type of nanoparticle known as a polyion complex (PIC) micelle. This gives excellent control over the structure of the nanoparticle, and allows us to crosslink the shell surrounding the enzyme to impart mechanical stability to the enzyme. In this project we will incorporate sugars such as trehalose, mannose, glucose and fructose, which have been shown to have a stabilising effect on enzymes,[3] into our enzyme nanoparticles and compare their effects on enzyme stability. This will be done by first polymerising the sugars into the polymer backbone and then assembling them into the core of the PIC micelle. Enzyme activity will be monitored after exposure to a range of solvent, thermal, and other environmental stresses.

The project will involve controlled polymer synthesis and self-assembly techniques to prepare the enzyme nanocapsules, characterisation by light scattering and electron microscopy, and the use of enzyme activity assays to measure their activity under a range of environmental stresses.

1) J. Lemke, S. von Karstedt, J. Zinngrebe and H. Walczak, Cell Death Differ., 2014, 21, 1350–64.

2) R. Chapman, A. J. Gormley, M. H. Stenzel and M. M. Stevens, Angew. Chemie Int. Ed., 2016, 128, 4576–4579; R. Chapman, A. J. Gormley, K. Herpoldt and M. M. Stevens, Macromolecules, 2014, 47, 8541–8547.

3) A. Beloqui, S. Baur, V. Trouillet, A. Welle, J. Madsen, M. Bastmeyer, G. Delaittre; Small, 2016, 12, 1716–1722

4) E. M. Pelegri-O’Day, S. J. Paluck and H. D. Maynard, J. Am. Chem. Soc., 2017, 139, 1145-1154; R. J. Mancini, J. Lee and H. D. Maynard, J. Am. Chem. Soc., 2012, 134, 8474–9.

Preparation of single enzyme nanogels. Adapted from Beloqui et al [3]

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15

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16

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18

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FIELD ng (F10) w.edu.au

MISTRY

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20

Alternative Bridging Groups for Organometallic Polymers

The majority of alkyne-bridged organometallic polymers use linear aromatic spacer units, such as 1,4-diethynylbenzene, as the bridge between metal centres. Non-aromatic bridges such as 1,12-diethynyl-p-carborane (C6H12B10) have been described as “3D aromatic systems”. We are interested in the effect of aromatic bridges, as well as non-aromatic bridges such as 1,3-diethynylbenzene, on the chemical and electrochemical behaviour of organometallic polymers.

(b) The Organometallic Chemistry of Carbon Dioxide

Carbon dioxide reacts with many organometallic compounds to give products in which the CO2 is incorporated into the metal complex. A greater understanding of the ways in which CO2 binds and reacts with metal compounds may provide new ways to capture CO2 and utilise this wasted and environmentally dangerous compound.

Our previous work has focused on the stoichiometric insertion of CO2 into metal-hydride and metal-carbon bonds, to give metal formates and acetates, respectively. There have been many reports in the literature of catalytic activation of CO2 to yield formic acid (by hydrogenation), acrylates (by reaction of CO2 with ethylene), and carbonates (by reaction of CO2 with epoxides). We are interested in exploring the ability of novel iron(II) and ruthenium(II) complexes that we have prepared in the lab to catalytically activate CO2.

(c) The Chemistry of ‘CP3’ Complexes

We have recently developed a new type of polydentate ligand for transition metals, which binds to metal centres using three phosphorus donors and an anionic carbon donor. To date, we have only explored the chemistry of this ligand on ruthenium(II). We anticipate that this ligand will form complexes with a wide range of transition metals, and are particularly interested in investigating the synthesis and catalytic properties of new rhodium and iridium complexes.

Selected publications from the group:

1. L. D. Field, A. M. Magill, T. K. Shearer, S. J. Dalgarno, M. M. Bhadbhade, Eur. J. Inorg. Chem., 2011, 23, 3503-3510.

2. L. D. Field, P. M. Jurd, A. M. Magill, M. M. Bhadbhade, Organometallics, 2013, 32, 636-642.

3. O. R. Allen, L. D. Field, A. M. Magill, K. Q. Voung, M. M. Bhadbhade, S. J. Dalgarno, Organometallics, 2011, 30, 6433-6440.

4. L. D. Field N. Hazari, H. L. Li, Inorg. Chem., 2015, 54, 4768-4776.

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t-activated elecamatically impro

wish, S. Ciampi,atures”. Submi

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Cu for sensors.

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23

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24

magnetic nannanoporesarefit is the nolves develo

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derstanding compasses ed can changecluding bioory, there is exs, reaction ki

n organic rProf. Anna C

elow 100°C.ns in ionic liqof this projeed and to us

me. The proof these resud for studentnew methodsmore synthemising isolat

hydrocarbProf. Lawren

ant to be plareactivity of tems relative

nvolve synthenetic studies

25

STIC AND

how organicexamining he how a rea

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ng reaction p by focussin to get the re

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AL ORGAN

happen and al features ids. This kno

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olecular dyna

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RPER ng (F12) w.edu.au

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1. R. R. H574 & JChemPl

2. S. R. D

3. N. Kons

4. R. R. Het al., Phy2017, 15,

Catalysis us

ocyclic carbes are effectivject aims to r

ng any solveulk, electron the opportu systems; ths. The ultima

Solvent-sol(in collaborDr Leigh Ald

e previously nd the compuids and whlvents. This ple compounolvents for aements of ken to highlige a better unood solubilityes into ionic l

t examples of o

Hawker et al., OJ. Phys. Org. ClusChem 2017,

. George et al.,

standaras et al.

awker et al., Chys. Chem. Chem 5556; S. T. Kea

sing N-heter

enes, have sve for some relate structu

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ute interacration with Ddous, King’s

made use ofponents of any certain rea project aimsnds and simua given solutesolubility anght key solutnderstandingy giving us thliquids – and

our work in the a

Org. Biomol. ChChem. 2018, 31

82, 449; Butler

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., ChemistrySel

hem. Commun.m. Phys. 2018, aveney et al., J

rocyclic carb

ignificant roleprocesses b

ure and chemthis requires

toms). Alonge various ch

n vary from be able to ra

ctions in Dr Ron Haines College, &

f molecular dn ionic liquid;actions proces to extend tulations – whe. In order nd moleculae-solvent inte of what inte

he opportunit these could

above areas se

em. 2018, 16, 3, DOI: 10.1002r et al., J. Phys

Chem. 2015, 13

lect, 2017, 2, 71

. 2018, 54, 22920, 16558; W.

J. Phys. Chem.

26

benes: unde

es in organobut not for otmical propertis a series ofg with makinharacterisatiosimple screeationally cho

ionic liquies, UNSW; P

& Prof. Bill P

dynamics sim; this can be eed faster othis and to mhich ionic liquto do this b

ar dynamicseractions. Teractions arety to 'design' then be mad

ee:

3453, Org. Biom2/poc.3862; S. Ts. Org. Chem. 2

3, 9035 & 10745

18; M. H. Dunn

96 & J. Phys. OrE. S. Hart et al B. 2016, 120, 1

erstanding s

- and organohers; the origes of carbenf chosen car

ng the precuron techniqueening of cataose an NHC

ds: can wProf. Anna C

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model - both uid would be oth physical

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mol. Chem. 20T. Keaveney et018, 31, DOI: 1

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structure/act

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we design Croft, Univerrn Sydney U

understand inlain why ben

17, 15, 6433; Ct al., Pure Appl0.1002/poc.38

rom. Compd. 2

Chem. 2017, 82

8, 31, DOI: 10.1hem 2018, 53, 3PhysChem 201

ctivity relatio

alysis, howevs not well undtic efficacy, avary in one carbenes, thdertake evalgh to detailea given proce

better sorsity of Nott

University)

nteractions benzene is so s

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2016, 36, 897.

2, 7324.

1002/poc.3862;348 & Org. Biom16, 17, 3853.

onships3

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along with way only is project uation of

ed kinetic ess.

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m 2016, 81, 89, 745 & 700.

J. J. Black mol. Chem.

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To furthefor sevedynamicmolecula (b)

reorganialso pla

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elop and approcesses inThis enableserimental col but are not organic chean experime and chat abd, and you w

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28

affinities of sqxperiments.

Solvation Ml-known “var

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ondensed phs a longstandnal procedurd thermodyn2016, 120, uch as continolecules imf their compfor specific sfor simple or would like to

nd modern qedures for m

ty and basic

chemical me-heterocycliceffective cataour theoretica

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quantum mecmodelling solv

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ethods to moc carbenes. Talysts, and thal predictions

molecules. T

provides a frresult. Howevtions. Since t in developinulating solutiofor example:present, apption models t the most ficiency but their errors SN2) reactione the use of schanics andvation of ele

eterocyclic c(with NguyeA/ProHarpe

odel structurThe insights here are opps.

This work

amework ver, such much of

ng robust on phase J. Phys.

proximate that treat

popular they are are very ns. In this statistical QM/MM ementary

carbenes Dr. Vinh en and

of Jason er)

re-activity provided ortunities

Fluocan conf

In thbioafluor

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orine is a sma have a drformation, anhe Hunter gactive molecrinated molec

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Fine-tuningpeptides are riety of diseae two major d-to-tail cyclise shapes of cproject, we aproblems. Ted amino a blocks.

rators: Prof Mky Avery

Next-genera proteases a

ce-specific mcycles of seV, and thus we are des

s. The key s at very p distribution o

rators: A/Prof

FL

all atom that ramatic impand binding affroup, we are

cules. We cocules that we

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the shapes promising leases includinlimitations ofsation is oftencyclic peptideare using flu

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Maria Kavalla

ation enzymare enzymes manner. Aspaeveral diseas they are psigning a neis to incorpo

precise locatof the activat

f Renate Grif

LUORINE

packs a big act on molefinity for protee harnessingollaborate ee create.

search areas

of cyclic peead compoung cancer anf cyclic peptidn inefficient; es to optimisuorine chemi

to synthesh are valua

aris, A/Prof S

me inhibitorsthat cleave o

artic proteaseses includingotential drugw class of aorate fluorinetions, in ordted intermedi

ffith, Dr Junm

29

IN MEDIC

punch. Whenecular propeein targets. g such effec

extensively to

s within the

eptides nds for the nd malaria. des: (i) their (ii) it is difficu

se their targeistry to solvesise stereosable shape-c

Shelli McAlpi

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der to mimiciate of peptid

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nic moleculesetabolic stab

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th, Dr Eddy P

NTER ng (F12) w.edu.au

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s, fluorine bility, 3D

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Pasquier,

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e/hypnotic ac-rape” drug.of GHB’s

e’s conformamany differenwe are creatrable activity

rator: Prof Ma

Molecular Vunprecedenis a commo

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ult for tumouwith a slowe

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e above projexperimental totection assa

novel treatmcause of deatoptions are pproach. We natural hypoitude-chambeage-control mel understans hypoxia res

ole Jones, A/

undesirableyrate (GHB)nds to neuro previously b

ments incluunately howctivity, which We believeeffects can ational flexibnt neurotransting conform while editing

ary Collins, D

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A and weld thr cells to repr developme

aham Ball, A

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ment for stroth and disabiextremely li

e’re developoxia protectiver-in-a-pill”), mode after a nding of thesponse.

/Prof Renate

e activity out is a molec

otransmitter rbeen prescribding alcoho

wever, GHB has led to ite that the be attribut

bility, which asmitter recepationally-rest

g out the und

Dr Junming H

ting new mo

hat kills 1 in cipal treatme the resistanrugs. We are

he two strandpair. This wilnt of drug res

A/Prof Larry W

hers within thther techniquase peptide s

30

oke ility in Austraimited. We

ping drugs tve mechanis which will stroke. The e proteins t

Griffith

t of illegal dcule with a receptors in bed to treat olism and also has ts abuse as bewildering ted to the allows it to

ptors. In this tricted fluorin

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rugs

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t will stick to

the Western tatic cancer,

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laser spectrcover new chtribute to inte

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oaming” reactnough energyforming unexs and to exp

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31

LASER PR

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molecular ed products the MW, g to harmful ng of either rpenes) or toluenes) is eral projects

mospheric spo form H2O acted radicals

her a typicad react it witd using laserstructure of t

mospheric pro

on fuels andaking radicalt gain or lod and probed

32

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tion with Chrins (CFCs) anoducts, but wck: they abso

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r centuries. Tand the pathwored to have

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ombustion (C

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unsaturated across a -b

measured in e.g. -pinenadducted or aine where thwill provide tunds.

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and tissues iation of diff

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33

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synthetic ent. Much between

pography) influence

elopment. ome (e.g.

synthetic ques.

ne glycol) 1; Mater.

ppropriate

tures disulfides h acceptor

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tructures witengineering. ition (Fig. 2;idics will be ere formulatio3D bulk poly

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microenviroation. We mils and were a

e micro-tumoigure 4; Natue believed toof suffering in

model sysutic developmof students g spatiotemp

es. redith N. Silberstein, Amr

man, Douglas Zhang, And

Junmin Lee, N. Ashwin B.

r A. Abdeen, Kathryn L. W

h well-defineWe are exp Advanced Memployed to

ons for transly(ethylene gly

tive hydroge

ract with mpathologica

matrix presin the labor

osite magnetod across thedy temporal amic reversi where stiffe 2016). Thesagnets, whic

oject involvesnds (e.g. H-n the hydror therapeutic

umours for c

ellular “plastietastasis is onment thaicroengineereable to uncovrs in orchest

ure Materials be the root n cancer. Oustems into ment on patieincluding: neporal uptake

r A. Abdeen, Sang Yup K

drew M. Smith, Jeffrey S.

Bharadwaj, Randy H. Ew

Wycislo, Timothy M. Fan,

ed segregateploring the eMaterials 20 establish graation to a 3D

ycol) hydroge

els to drive c

matrices thatal processesentation. Hatory has poactive mate

e full spectrurelationship

bility, we disening guides se materials

ch will broades: 1) the inve-bonding in gel framewo

c developmen

cancer nano

city” has lea conseque

at promote ed small pover an intrigutrating the ac 2016). This cause of rec

ur vision for thautonomous

ent derived cew hydrogel of nanopart

im, and Kristopher A. Kili

Moore, and Kristopher A

woldt, and Kristopher A. K

and Kristopher A. Kilian,

34

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cell and tiss

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en the use ofestigation of

polysacchaork, and 3)nt.

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ed us to caence of dyn intravasatiopulations ofuing role for gctivation of a is importantcurrence andhe future of ts tissue-mimcells. We havchemistry anticles, integra

ian, Mechanochemical fu

A. Kilian, Rapid 3D extrus

Kilian, Magnetoactive hyd

, Interfacial geometry dict

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sue engineer

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ologically releatrix interacttical time pe

ecification (Fapted to muf this techniqustiffening anrides), 2) c) establishin

development

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nctionalization of disulfide

ion of synthetic tumor mic

rogels for temporal modu

tates cancer cell tumorige

potential to brogel materia

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ring

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an be evant tions.

eriods ig. 3; ltiple hydrogue to virtually

nd softening covalent tethg a 3D ma

t (w/ Prof. M

e we believections in theasation andcells across

the perimetem cell (CSCese CSC-like

s, the primaryhe integrationtectures, foew directionsn techniquestiple differen

e linked hydrogels, Mater

croenvironments, Advanc

ulation of stem cell activity

enicity, Nature Materials,

Fig. iron Hea

be transformaals of tissuedles in the ps. We aim ton extruded h

gel systems, y any laboratin hydrogel

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M.

e e d s

er C) e y n

or s s, nt

rials Horizons, 2016, 3, 44

ced Materials, 2015, 27 (3

ty, Advanced Healthcare

2016, 15, 856-862.

3. Cancer cell particles in a h

alth. Mater., 201

Fig. 4. Incurvaturethe activstem-likeMater., 2

ational to e-mimetic polymers, o develop hydrogels

and use tory. New materials on oxide e tumour

47-451

37), 5512-5517

Materials, 2016, 5

adherent to hydrogel (Adv. 16)

nterfacial e will guide ation of a

e state (Nat. 2016)

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. (a) Theoreson between nd. Upon discnic chloroalum in the formatio

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Tarascon J.-M. Building b

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reality of post-lithium-ion

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inger Science & Business

51, 652–657 (2008).

batteries with high energ

um batteries. Adv. Mater.

able batteries. J. Am. Ch

g of li–s rechargeable bat

36

ed rechargeascale energy

cific capacity es. (c) Electr reduced to itated by the a

minium comple

tion with Prof

ng high-peral specific crmation of so In this projlates sulphurattery cycling

s Media, 2008.

gy densities. Nat. Rev. Ma

28, 7564–7579 (2016).

hem. Soc. 139, 6635–664

tteries. Adv. Mater. 25, 65

able AI-ion bay storage app

of Li-ion anrochemical res semiquinon

asymmetric cleex.

f. Do Kyung

rformance bapacity.6 Ho

oluble polysuject, we willr within the e

g process.

ater. 1, 16013 (2016).

3 (2017).

547-6553 (2013).

atteries couldplications.

d Al-ion battedox of quinoe state. Followeavage of dia

Kim at KAIST

attery candiowever, it ha

lphides3, whl design a 1electrode, in

d provide a p

teries. (b) Baone-based mwed by interaluminium hex

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ND SYNTHEShibitors

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timicrobial di Prof. David

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sensing comodel the real structures ion strategy oposal will inimicrobial ac

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biotics used well-defined tcts. Howevea single rece

an be develoto design nSMAMP) mim disrupt thf the bacteria

37

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of novel biological hierarchy. e organicalso their t of their ads. The hemistry,

need to ojects are

asR. This t of drug of novel

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38

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POUNDS THUNSW)

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Educatospecificateachingdifficultiebased re Are youdifferenyou:

(a)

As part oexpandintested laconcepts

You will following

(b)

Technologreatly entertainalready developilearning

ors have proally in chemisg to provide aes students esearch.

u interested nce on the w

Effects of th

of the excitinng on similaaboratory skis by complet

have the opg research qu

Do students Are studentsDoes this asIs the blende

Developmen

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ning way to lexist [5] bu

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gressed signstry [1-3], hoan outstandilearning che

in doing resway we edu

hreshold/ma

ng new chanar changes lls. In this noting hurdle ta

pportunity to uestions that

study differes more effectssessment med (online an

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possibilities crease efficially boring o

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39

the past 50 is still muchnal experiencounter using

emical eductudents? Th

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year chemiste award-win

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shold assessng and applybetter unders

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of where teaiencies in teor repetitive cd into the cu-based appsved in some

LT: 9385

years in unh to discoverce at UNSW

g modern tec

cation? Do yhe following

ry a novel asning undergs must show o receive a p

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nderstanding r, develop an. We hope tochnologies b

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KIM LAlton Buildinlapere@unsw

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how studennd implemeno address thbacked by e

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40

(c) Have your own idea(s)?

If you have your own idea for a project that aligns with our philosophy then we would like to hear from you. Get in contact with me and we can discuss your project idea(s).

References

1. M. M. Cooper and R. L. Stowe, “Chemistry Education Research—From Personal Empiricism to Evidence, Theory, and Informed Practice,” Chem. Rev., vol. 118, no. 12, pp. 6053–6087, 2018.

2. N. Reid, “A scientific approach to the teaching of chemistry. What do we know about how students learn in the sciences, and how can we make our teaching match this to maximise performance?,” Chem. Educ. Res. Pract, vol. 9, no. 1, pp. 51–59, 2008.

3. V. Talanquer and J. Pollard, “Let’s teach how we think instead of what we know,” Chem. Educ. Res. Pract., vol. 11, no. 2, pp. 74–83, 2010.

4. M. K. Seery, “Harnessing technology in chemistry education,” New Directions in the Teaching of Physical Sciences, vol. 0, no. 9, pp. 77–86, 2013.

5. “New app a game changer for chemistry education - RMIT University.” [Online]. Available: https://www.rmit.edu.au/news/all-news/2017/jun/new-app-a-game-changer-for-chemistry-education. [Accessed: 21-Aug-2018].

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would learn how to synthesize molecules, and multiple techniques including how to run reactions in solution and on solid phase. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.

(c) Developing prodrugs: a general approach for building cell permeable drug molecules

This project will involve the synthesis of prodrugs that can enter cells and where masking groups are cleaved in cell lysate revealing the active molecule. The approach for this project will involve the incorporation of masking polar side chains with methyl groups, which are easily removed upon cell entry via enzymes. Prodrugs will also incorporate N-methyls on the backbone amide bonds and D-amino acids, both modifications disrupt intramolecular hydrogen bonds within a macrocycle and change the orientation of the side chains in such a way as to improve cell permeability. The prodrug molecules will also include asparagines, where these side chain amides increase transport across the cell membrane. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.

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mediate the phosphorylation. This work originated from earlier work on the synthesis of a natural product. Variolin B is a member of a unique class of marine alkaloids isolated from an extremely rare Antarctic sponge. It is no longer available from its natural source. The Morris group have devised a synthesis of variolin B that has restored access to the material and allowed further biological studies to be carried out. From this work it has been established that variolin B is a potent kinase inhibitor and represents an important scaffold for the development of kinase inhibitors. A range of analogs have been developed that are more selective inhibitors of certain kinases, as well as have better properties (such as solubility).

Our recent publication (ACS Chem. Biol., 2017, 12, 825) describes how we have developed a new class of kinases inhibitor that selectively inhibits the kinase SRPK1 and has led to the identification of a series of molecules that are currently being developed as a treatment for aged macular degeneration, in collaboration with Exonate.

The Morris group is focused on developing selective inhibitors of the various RNA slicing kinases (the CLKs, DYRKs and SRPKs), with appropriate drug-like properties so they can be used as chemical probes to help understand the role these important kinases have on biological systems. A combination of synthesis and structure-based drug design is used to do this work, with students able to use Schrodinger and Cresset software to aid their design work.

(c) Developing the AAL(S) Scaffold for Therapeutic Applications (collaborations with Assoc Prof Nigel Turner (SOMS), Prof Alaina Ammitt (UTS), Dr Nikki Verrills/Dr Matt Dun (Newcastle)

Ceramide synthase (CerS) and protein phosphatase 2A (PP2A) are two enzymes that play a critical role in the regulation of multiple cellular signalling processes. The malfunctioning of these two enzymes has been found to have implications in diseases such as cancer, diabetes, asthma and neurological diseases including Alzheimer’s disease and stroke. Little is known about the biological mechanism of these enzymes and in particular, how they cause such diseases. To gain insight into these biological processes, the CerS and PP2A binders, FTY720 and AAL(S), will be used to explore the binding site of both enzymes and allow the identification of chemical probes which can be used to develop an understanding of the biological mechanisms of these complex diseases.

Development of the AAL(S) scaffold will allow for analog production which along with key biological testing will provide key information towards revealing the biochemical pathways and proteins involved regulating both enzymes at a molecular level. With Prof Ammitt, work is focused on using these molecules for the development of therapeutics for the treatment of asthma, whereas with Asoc Prof Turner we are developing molecules to elucidate the role of CerS in fat metabolism (see Turner et al, Nature Communications, 2018, 9: 3165 | DOI: 10.1038/s41467-018-05613-7)

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53

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55

compound family. Due to the donating ability of the two nitrogen atoms, the exocyclic C-C double bond is very electron-rich and strongly polarized. This interesting feature of NHOs offers multinucleophilic reactivity over the ketene aminal frameworks.[6] Due to the strong nucleophilicity of the -carbon, NHOs can act as strong Lewis/Bronsted bases.[7-9] This project will focus on synthesizing a family of NHOs, estimating their basicity and applying them as organocatalysts to promote environmentally friendly chemical processes. Students are encouraged to discuss with Vinh in person about this project.

(c) Project NTV3 - Tropylium-Based Host-Guest (collaboration with A/Prof Pall Thordarson) This project will explore the potential of tropylium-bearing systems in host-guest chemistry in collaboration with A/ProfPall Thordarson’s group. The electron-deficient nature of tropylium moiety makes it particularly attractive for the bindingand sensing of small and medium-sized biologically importantanions such as chloride, phosphate and carbonates. Wepropose the synthesis of tropylium-based macrocycles (see figure) as the starting point for this project, which will representa new platform in supramolecular chemistry. Please also see Thordarson’s Honours projects for more details.

References [1] D. J. M. Lyons, R. D. Crocker, M. Blümel, T. V. Nguyen,* Angew. Chem. Int. Ed. 2017, 56, 1466-1484. http://dx.doi.org/10.1002/anie.201605979

[2] T. V. Nguyen,* A. Bekensir, Org. Lett. 2014, 16, 1720-1723. http://dx.doi.org/10.1021/ol5003972 [3] T. V. Nguyen,* M. Hall, Tetrahedron Lett. 2014, 55, 6895-6898. http://dx.doi.org/10.1016/j.tetlet.2014.10.100 [4] T. V. Nguyen,* D. J. M. Lyons, Chem. Commun. 2015, 51, 3131-3134. http://dx.doi.org/10.1039/C4CC09539A

[5] Demelza J. M. Lyons, Reece D. Crocker, Dieter Enders, Thanh V. Nguyen,* Green Chem. 2017, in press (DOI = 10.1039/C7GC01519D). http://dx.doi.org/10.1039/C7GC01519D

[6] R. D. Crocker, T. V. Nguyen,* Chem. Eur. J. 2016, 22, 2208-2213. http://dx.doi.org/10.1002/chem.201503575

[7] M. Blümel, J.-M. Noy, D. Enders, M. H. Stenzel, T. V. Nguyen,* Org. Lett. 2016, 18, 2208-2211.

http://dx.doi.org/10.1021/acs.orglett.6b00835

[8] M. Blümel, R. D. Crocker, J. B. Harper, D.Enders, T. V. Nguyen,* Chem. Commun. 2016, 52, 7958-7961.

http://dx.doi.org/10.1039/c6cc03771b

[9] Ugur Kaya, Uyen P. N. Tran, Dieter Enders, Junming Ho, Thanh V. Nguyen,* Org. Lett. 2017, 19, 1398–1401. http://dx.doi.org/10.1021/acs.orglett.7b00306

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ubiquitous of glyphosa factor affecmetalloenzy

a Zn2+-cl activity beinerties. A c binding propproject.

ocalized on th, carboxylatecombinatoriasate and AM

obility MS

mplexation pr

interests di

nate linkers

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different cules like em ideal

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herbicide te. Metal cting the

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roperties.

irectly.

We are modificatranslatio(a) Devehard tis

Repairinchallengsignificanegativeis to decustom-dare varioceramic high-temimpossib

(b) Nano

Cardiovaglobally.ability ofengineeregeneracardiomytissue emechanstimulateregion.

(c) Synt

Unlike oquantummetallic oxidativeDNA, caThey offhaving n

interested ination techniquon. elopment ofsue defects

ng large bonege and sunt socio-e

ely affect quaevelop a 3Ddesign synthous 3D prin scaffolds.

mperature sinble for incorp

ocomposite

ascular disea In case of mf damaged hring offers ation, by yocytes. Thengineered pical strengthe formation

thesis of por

other inorganm dots, mag

nanoparticlee lesions, dealcium phospfer several anon-toxic deg

n design, syues for tissue

f a technolos without usi

e defects remboptimal ou

economic ality of life. T

D printing prhetic bone gting techniquHowever, th

ntering after poration of bio

cardiac pat

ases are themyocardial inheart tissue is

promising combinin

e aim of this patch that prh, and bioacof new vasc

rous calcium

nic nanocarrnetic nanopa

es that increaecrease cell

phates are theadvantages ogradation pro

BIOMAREGE

ynthesis and e engineerin

ogy for 3D ping sintering

mains a majoutcomes carepercussionhe aim of thocess to fab

graft. Currenues for fabrihese scaffolprinting that omolecules s

tches for tre

e leading caufarction, the s severely lim

strategies g biomateproject is to ovides optimctivity for ceculature, and

m phosphate

iers such asarticles, silicase mutation viability ande safest cateover other naoducts, excel

60

ATERIALSENERATIO

characterisag and regen

printing of pg; ink optim

r surgical an have ns and is project bricate a tly, there ication of lds need makes it such as grow

eatment of m

use of death regenerationmited. Tissue

for cardiacerials and fabrication a

mal structureells that cand facilitate o

e nanopartic

s carbon naca nanoparticn frequency, d induce daegory of biomanoparticles llent biocomp

Level 7, H

S DESIGNON (with S

ation of biomerative medi

porous bioaisation

wth factors an

myocardial in

h n e c d a , n oxygen and n

cles for drug

notubes, cles and produce mage to

materials. such as patibility,

DR. IMAHilmer Build

E: iman.ro

N FOR SKEScientia Pro

materials andcine with an

ctive ceram

nd drugs.

nfarction

nutrient trans

g delivery ap

AN ROOding (E10), oohani@unsw

ELETAL Tof. Justin G

d developing emphasis o

mics for trea

sfer to the d

pplications

OHANI Rm735 w.edu.au

TISSUE Gooding)

g surface on clinical

tment of

damaged

in vivo acalcium in the fnanomeof poros

(d) Fabcomposantimicr

Bioactiveand regebond to bioactivein termsquite chsintered aim of composiinto 3D c

(e) Devenginee

There isIdeally, tsimilar tointerconattachmevascularMoreoveoxygen producinporous cdoes nostrong p

(f) Bioacas a cue

Incorporfor direcengineecalcium enhanceany groosteoart

and in vitro sphosphate n

field that hadicine. The aity to be able

brication ansition melrobial prope

e glasses haenerate osse host bone ae glasses has of numberhallenging to without crysthis project

ition that hasconstructs w

veloping a ering.

s a current nthe structure o that of trabnected poreent, proliferisation ander, porous sttransfer that

ng porous mconstructs mot resemble torous scaffo

ctive ion dee for stem ce

ration of therct stimulationring strategiphosphate

e chondrogenowth factor thritis.

tability, and nanoparticlesas impeded aim of this pre to uptake su

nd in vitrolt-derived erties.

ave been useeous defectsand stimulateave been lagr of commer design a gstallisation but is to fabrs antimicrobiaithout or min

facile tech

need for bett of the synth

becular bone,es. This is eration, and formation tructure facilt are key fa

materials suchade by suchthe trabeculalds that mimi

elivery by caell differenti

rapeutic ionsn of cells is ies. The aimnanoparticle

nic differentir and a p

pH depende in porous anthe applicat

roject is to syubstantial am

characteribioactive

ed in the clins due to theie new bone ging behind rcial productglass composut also remaicate a newal property aimal crystallis

hnique to f

ter bone graetic graft sho, highly porouessential fo

d migratio of new litates nutrie

actors for heh as polyme methods sh

ar bone. Theics the trabec

alcium phosiation.

into the struan attractivem of this ses doped wation of stem

possible tre

61

ent solubility. nd non-agglotion of this ynthesis calcmounts of bio

isation of glasses

nical practiceir unique abgrowth. How other biocerts worldwidesition that c

ains bioactivew bioactive and can be fosation.

fabricate h

aft substituteould be us with or cell n for tissue.

ent and ealth cell meer sponge mhow either lowe aim of projecular structur

phate nano

ucture of bioe approach fstudy is to with specific m cells withoatment me

Despite all oomerated formcategory ofium phospha

omolecules.

novel with

e to fill ility to wever, ramics e. It is an be e. The

glass ormed

ighly porou

s to regener

etabolism. Tethod, robocw mechanicaect is to estare of bone at

particles

materials for tissue fabricate ions to out using thod for

of these advam has been a materials i

ate nanoparti

us ceramic

rate disease

There are vacasting or exal strength orablish a facile complex ana

antages, synan ongoing cn drug delivcles with hig

cs for bone

ed or damag

ariety of metxtrusion prinr a pore struce method toatomical sha

nthesis of challenge very and h degree

e tissue

ed bone.

thods for ting. The cture that produce

apes.

My reseapplicatirenewabdetection

(a)

Light froBut, to gneglect tthe bandefficiencreached harnessewavelen

Recentlyorganic concentrrange of

(b)

One stracollectorSuch syluminesc

When liisotropictowards reabsorproles of reduce improvebe possorientatio

earch group ons ranging

ble energy. On schemes, v

Photochem

om the sun generate a pthat part of thd gap. Such

cy of solar ce 25%). Photed to congth light, inc

y, we havepolymer andrate the absof nanostructu

New Materia

ategy to slasr. However, ystems are cence solar c

ght falls oncally. About solar cells ption effects.f absorption

reabsoments have sible by cleon of transit

M

investigatesg from studyOur principavacuum cham

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reaches us photovoltagehe spectrum a strategy lells to abouttochemical unvert long reasing the p

applied Pd dye-sensitorption of lighured architect

als for Lumi

sh the cost ousually such expensive concentrator

n a slab of 75% of this on the edg. We will cou and emissiorption. been shown ever design ion dipole m

MOLECULA

s how moleying radicals al tools are fmbers and m

version for Im

as a contine in a solar c with photon imits the ene 33% (UNSW

upconversionwavelength

photocurrent

UC to amoized solar ceht and increatures incorpo

nescence S

of solar enerh systems re

and cumb is promising

material co light is trapge of the suple fluoresceon, and Further

by us to of the

moments.

62

Level 5,

AR SPEC

ecules intera and ions ofemtosecond

mass spectrom

mproved So

uous spectrcell, we usu energies beergy conversW Si cells hn (PUC) canh into sho of the device

orphous silicells. But, effase upconveorating biomim

Solar Concen

rgy is to useely on geombersome, an way to do th

ontaining fluopped in the slab. Until nent dyes to

PROF, Science a

T: 04 39 3

TROSCOP

act with lighof astrophysid and nanosmeters.

olar Energy C

um. ually elow sion ave be

orter e.

con, ficiencies arersion efficienmetic light ha

ntration (wit

e a small aremetric concennd cannot chis using pas

orophores, lslab by tota

now, such slight-absorbi

. TIMOTnd Enginee86 109 E: sc

PY AND S

ht, and the cal and atm

second laser

Conversion

e still too lowncies, we arearvesting ma

th A/Prof. Pa

ea of solar cntration of suconcentratedsive molecul

ight is absoal internal resystems havng nanomate

THY SCHering Buildchmidtim@g

SOLAR EN

consequencmospheric intrs, with soph

w for applicae currently exaterials.

all Thordars

cell and a launlight usingd diffuse ligles.

orbed but reeflection, anve been plaerials to sep

HMIDT ing (E8) mail.com

NERGY

ces, with terest, to histicated

ation. To xploring a

on)

rge solar g mirrors. ght. The

e-emitted d guided

agued by arate the

63

(c) Laser Spectroscopy of Isolated Radicals and Ions (with Prof. Scott Kable)

The new Molecular Photonics Laboratory houses sophisticated lasers and equipment with which we can discover new transient chemical species of importance in the gas phase chemistries of our atmosphere and the interstellar medium.

Atmospheric Radicals

One of the greatest scientific challenges of our time is to understand the complex chemistry of the atmosphere. Plants and human activity are responsible for >1000 Tg (1012 kg) of volatile organic compounds being emitted into the atmosphere each year. These molecules are processed into less volatile compounds which then find their way into secondary organic aerosols, which are a major natural impactor on public health and climate. In this project, we will develop laser-based spectroscopic methods to detect and characterize intermediates formed on the way from the plant to the aerosol particle.

Interstellar Molecules and Ions

As stars die, they eject complex organic molecules into the interstellar medium, where they live out millennia before being incorporated into new stars and planetary systems. These organic molecules are the seeds of life, but, as yet, we do not know the chemical make up of the interstellar medium from which planetary systems are formed.

Using a star as a lamp, we can peer into this medium using telescopes by observing molecular absorption spectra. However, despite there being hundreds of nibbles taken out of the visible stellar spectra of stars occluded by diffuse clouds, only a few molecules have been unambiguously detected by their visible spectra. The unidentified features are known as the diffuse interstellar bands, and are the longest standing mystery in astrophysical spectroscopy.

In this project, we will develop techniques to capture the spectra of isolated, never-seen-before aromatic cations which the leading candidates for carrying the DIBs, and (hopefully) solve this long standing problem.

(d) Advanced Spectroscopy for Complex Functional Materials (with Dr Dane McCamey, School of Physics)

Complex functional materials are employed in a range of applications, the development of which is motivated by the future technological needs of society. Organic solar cells, organic light emitting diodes and organic electronics all employ materials characterized by a complex relationship between morphology and function which can only be elucidated by advanced spectroscopic techniques.

Combining lasers and magnetic resonance, we will develop and apply new advanced spectroscopic techniques to complex functional materials, revealing the dynamical behaviour of charge carriers and excited states.

We their

We and elec

Our solid

It would

(a)

Lithium-their limvehicles particulaand celectrolyreliable sodium-for largerenewabon one test their

Positive

These elimitationsulfates and battto dram

Electroly

Sodium-temperaconducti

chemically tur physical prouse a combi neutron d

ctrochemical goal is to fud oxide fuel c

d be great to

Towards the

ion batteriesmitations hav

and energyar sodium-ionharacterising

yte materials.and affo

ion battery te-scale energble power soof the followr component

electrode ma

electrodes prns for lithium will be synthtery performa

matically imp

ytes

-ion conductatures (>300ion at room t

une the atomoperties suchnation of tec

diffraction (aand impedanlly characteri

cells, and the

o work with H

e next gene

s are ubiquitoe restricted

y storage of n batteries, g new e. We will wor

ordable rooto provide sgy storage frources. Stud

wing parts of in idealized

aterials

rovide the so-ion batterieshesized and ance. We areprove perform

ing ceramics0C). This pemperature.

S

mic arrangemh as energy shniques to ch

at the Austnce analysis,ise materials

en characteris

Honours stu

ration of bat

ous in our dwide-scale renewable eby developilectrode ark to develop

om-temperatuufficient powom intermitte

dents will wof a battery abatteries.

ource of the s. Here, new characterizee working tomance.

s or glassy-cproject works

64

T

OLID STA

ment (crystal storage capaharacterise otralian Sync and electron

s, place themse how they

udents on th

tteries: Sod

daily lives, e.use in appli

energy. This ing

and p a ure wer ent ork and

sodium-ionsw sodium-coned to determowards scaff

ceramics ares towards m

D

T: 9385 4714

ATE AND

structure) ofacity, ionic coour materialschrotron ann microscopy

m into real-wowork in these

he following

ium-ion batt

g. mobile phications requproject will t

s and represntaining trans

mine the relatfolding layer

e known to making mate

R. NEERDa

4 E: neeraj.sh

MATERIA

f solid state nductivity or , including bud ANSTO),y. orld devices se devices.

projects:

teries

hones and lauiring highertarget new b

sent the largsition metal otionship betwred electrod

be excellenterials with s

RAJ SHAlton Buildinharma@unsw

ALS CHEM

materials to thermal exput not limited solid stat

such as batte

aptop compur power, e.gbattery chem

gest cost anoxides, phospween crystal de materials

t electrolytessufficient so

ARMA ng (F12) w.edu.au

MISTRY

enhance ansion.

d to X-ray te NMR,

eries and

uters, but g. electric istries, in

d energy phates or structure

s in order

s at high odium-ion

Negative

Negativeused fornegativewe will b

(b)

The majfor billiontear on b(e.g. in material costs. Innegativedue to groups o(e.g. –Ctypically voids anstates. Ssynthesicontrollavoids of in order to produ

(c) phase e

Safety isadvantagthe ionicespecialapproximconductipreventito the cproject lcharacteto study will shed

(d)

Dependidesigned

e electrode m

e electrodes r lithium-ion

e electrodes be enable the

Tuning neg

ority of matens of dollars both moving optics, coat that neithern order to ae thermal exp

transverse or cooperativCN- or WO6

feature larnd cations wiSo why not s tool? In t

ably insert L the NTE mato tune the cce ZTE mate

Improving sevolution

s an importages to the hc conductivitly under am

mately 1000ivity of the eng further de

crystal structuithium-ion an

erized. Impor the formatio

d light on the

Other proje

ing on your d. Please co

materials

are the leas batteries shand underst

e next genera

ative therma

erials expand per year in parts (e.g. intings, electror expands n

achieve this, pansion (NTEvibrations o

ve rotations 6). These mrge crystalloth variable ouse a battethis project Li and Na iterials, via a

cooperative rerials.

solid-state e

ant aspect ohighly flammaties of solid-

mbient condit0C as the electrolyte. Ievelopment aures adoptednd oxide-ion rtantly, variabon (from star formation pr

cts

interests, onsult with Ne

st investigatehow poor petanding their ation of devic

al expansion

d during heatmaintenancen aircraft gasonics). If a znor contracts the oppositE) is a propeof atom of units

materials ographic xidation

ery as a we will nto the battery, otations

electrolytes

f high poweable liquid e-state compotions. At the

operating tn both examand use of thd by the eleconducting mble temperatrting reagentsrocesses and

ther solid steeraj for furth

65

ed componenerformance limitations tces.

n to produce

ting via therme, re-manufas turbines), azero thermals upon heatite extreme oerty exhibited

by underst

r batteries. Uelectrolytes thounds are g

e other extretemperatures

mples, electrhese technoloectrolytes anmaterials wilture time-ress) of these iod optimal con

tate projectsher details.

nt in a sodiumin sodium-io

towards reve

e zero therm

mal expansiocture and re

and componel expansion ing, this couof materials d by a small

anding thei

Using a solidhat are comgenerally loweme, solid os are esseolyte ionic cogies. The io

nd how they l be synthes

solved neutroonic conduct

nditions requi

, e.g. makin

m-ion batteryon batteries. ersible sodium

mal expansio

on and this pplacement co

ents that are (ZTE) mate

uld dramaticaare considegroup of ma

r formation

d-state electmercially ava

wer than thexide fuels cntially deter

conductivity ionic conducti

evolve with ized and the

on powder ditors under vared for synth

ng new supe

y and the com By developm insertion/e

on materials

process is resosts due to w designed to

erial can be ally reduce ered in this aterials predo

characteris

trolyte has sailable. Unfoe liquid councells often oprmined by tis a critical ivity is direct temperature

eir ionic condiffraction willaried conditiohesis.

erconductors

mpounds ping new extraction

s

sponsible wear and be static made, a industrial project -

ominantly

stics and

significant ortunately nterparts, perate at the ionic hurdle in ly related e. In this ductivities be used ons. This

, can be

The druginclu– thedete

In oprepdisc

It would

(a)

time withstudying

(b)

Carbohyscientificcommunsignal trTo improof a ligathe recotowards

DiffereABC t

delivery of dg delivery hauding polymee core holds

ermines the inur group, we

paration to teuss their dru

d be great to

Imitating vir

h microscopg cell uptake

Drug carrier

ydrates havec communitynication evenransmission aove the distrnd (e.g. carbognition of m the improv

ent nanoparttriblock terpo

NANOPA

drugs can beave typically ers. In our gro the drug, manteraction wie work on difesting these pg delivery pr

o work with H

ruses with p

y techniques

rs inspired b

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nts, includingand infectionribution of drbohydrate anmalignant ce

ved treatmen

ticles prepareolymers

SC

ARTICLES

e improved by sizes belowoup, we syntainly anti-canth cells. fferent aspecparticles on croblems.

Honours stu

polymers: Le

Mnsswbqngndk

s such as A

by nature: N

a hot topic fo to the myria: cellular rec

n by pathogeugs in a biol

nd peptide taells), could nt of cancer

ed from

66

CIENTIALevel 7,

AND TAI

y packaging w 100 nm athesize varioncer drugs, w

cts starting frcancer cell li

udents on th

earning from

Most drug cnanoparticlessuccessful nstructures. Ewith its wormbioactive groquick entry. nanoparticlesgain more nanoparticlesdifferent softkey parame

AFM to evalu

Nanoparticle

for research ad number ocognition, inflens displayedlogical syste

argeted therabe an impor and other

A PROF. , Science a

T: 9385 4

LORED P

the drug intond can be pus polymers

while the she

rom organic sines. We hav

he following

m the succes

carriers descs. Interestnano-objectsExample is thm-like morphoups that allo In this pros that will si

understands into cells,tness as we ter. The stuate the prop

es with suga

within the f biological lammation, d by them. m, the use

apeutics for ortant step diseases.

MARTInd Enginee4656 E: m.s

OLYMERS

o nanoparticprepared usi to create corll makes the

synthesis to ve meeting w

projects:

ss of viruses

cribed in litetingly, natu, viruses, h

he by now wehology. In adow fast recogoject, we wilmulate the sding of th we will ma have found

udent will theperties of the

ar antennae

Uptake of sugar poly

INA STEering Buildstenzel@unsw

S FOR CATREAT

cles. Nanopaing various re-shell nano particles so

polymer nanwith clinicians

es

erature are ure’s own ave often eell-known Ebddition, virus

gnition of the ll prepare eshape of vir

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ENZEL ing (E8) w.edu.au

ANCER TMENT

rticles for materials oparticles luble and

noparticle s and we

spherical highly elongated bola virus ses carry host and elongated ruses. To of these rticles of

ould be a nd some le before

es with ncer

Synthesare prepactive pothese na

c)

NanoparThey cacells in influencecellular growing Howevetumour tumorigecolleaguKilian hacancer ssurfacesphenotyuptake differencto target

(d) Collabor

When blmicellesaggregasharp tHowevestructurenanoparaffect thare excunderstaproject ycan evemathemhttp://ain

is of glycopopared either olymers. The

anoparticles i

Interaction

rticles are quan be used an efficient

e of shape, uptake. Th

various immr, these cellwhere canc

enicity, mixedue in the scas developedstem cells ans of different pe. Incubatioof nanopartces in interact cancer stem

Learning mration with Dr

lock copolym, it is wide

ate has a cortransition ber, we do noe is and howrticle. Thesehe biological cellent tools and why diffeyou would spen spend a datical mo

nse.edu.au/g

olymers has by direct RA

ese nanoparinteract with

of nanopart

uickly taken as vehicle toway. A lot

size and ohis knowledgmortal cances do not reser cells mayd in with cachool of ched a model thand cells of en geometries on of these icles by varction of nano

m cells or me

more about r Chris Garve

mers self-assely assumedre-shell strucetween bothot know whaw much watee propertiesactivity. Smathat provid

erent nanopapend some tiday at the Aodelling. Srad_students

been one ofAFT polymerrticles will bebiological me

icles with ca

up by canceo deliver druis known abther paramege was gaier cells in tsemble cell fy display enncer stem cemistry, A/Pat allows us nhanced tumsuch as coilsmodels with

rious phenotoparticles andtastatic cells

the structuey from ANS

semble into d that the cture with a h phases. at the real er is in the s however all angle neue more inforticles behavme at ANST

Australian SyStudents s2/honours_s

67

f our core acrization of ge loaded withedia such as

ancer stem

er cells. ugs into bout the eters on ined by the lab. found in nhanced cells. My Prof Kris to grow

morigenicity os and stars r

h nanoparticltypes simultd help us ide.

re of nanopTO

utron scatterormation. Onve differently TO and learnynchrotron inare eligibscholarships

ctivities over lycomonomeh anti-cancer proteins

cells Collabo

on an engineresulting in tes allows us

taneously. Tentify what ty

particles –

ring (SANS) nce we und and why som and apply th

n Melbourne.ble to .

the last few ers or by posr drugs and

oration with A

eered surfaceumour tissues to evaluate

This can helypes of nano

Scattering

and small aderstand theme of them dhe technique Prerequisiteapply for

years. The st-functionaliwe like to le

A/Prof Kris K

e. Cells are ge with a steme the rate olp us evaluaoparticles are

analysis at

angle X-ray se structure, do not perfore. If time pere is some inr a sc

polymers zation of

earn how

Kilian

grown on m-cell-like of cellular ating the e suitable

ANSTO

scattering we also

m. In this mits, you nterest in holarship

My groumajor chtechniqustudies ifrom simprocesse It would

(a)

Over theapproaccoordinaorderingrange of

Sorting another

This resfaced infacile stoexcellentuning theffectiveshown h

Quantum

Magneticrole to ppretty usfascinatiunderstawhen disingle cembeddideal maquantum

up focuses onhallenges fa

ues that incluis the notion

mple inter-moes in order to

d be great to

Metal organ

e last 20 yehes that hav

ation compou and immenf molecular g

and storing

search projecn industry - orage of gaset host materheir propertiee gas-selectihere.

m phenomen

c materials hplay in quantseful at secung therefor

and the behamensionalitychains (1D) ed into a no

aterials in whm confinemen

n making anacing us todaude X-ray an of hierarchicolecular inteo deliver new

o work with H

nic framewo

ears, inorganve reinvigoraunds or MOFse composituests, openi

molecules -

ct is specificeffective sepeous fuels surials for smaes MOFs canve membran

na in magneti

have revolutioum computinuring notes tre that weaviour of sucy is constrain or sheets on-magnetic ich to study t

nt.

MAT

d understanday: energy, nd neutron scal emergen

eractions; wew materials di

Honours stu

rks (MOFs):

nic chemistryated the subFs. These toional flexibiling up many

how to sele

cally targetedparations of uch as H2. Hall moleculesn become efnes such as

ic materials

onised the wng; they haveto the fridge e still do ch materials, ned. MOFs (2D) of m matrix, mathe effects of

68

TERIALS

ding new mawater and scattering in tt properties

e aim for a isplaying nov

udents on th

coordinatio

ry has takenbject – one aopologically bty, along witpotential app

ect for one m

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way in which e also been door. It is not fully

especially can have

metal ions king them f magnetic

A/PL

T: 938

CHEMIST

aterials that asustainabilitytruly multi-diand complexgreater und

vel properties

he following

on chemistry

n on board area showingbeautiful matth structural plications.

molecule ove

al challengestreams an

s MOFs makH4 or H2. Bge vessels oelecting MO

we store anda navigation

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Spin-wavusin

PROF. JLevel 1, Da85 4672 E: j

TRY AT TH

are often focy. We makesciplinary proxity - the worerstanding os.

projects:

y of the 21st

a number og particular terials displayrigidity; they

er

s d e y

or F

d use informnal aid for ce

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ve spectrum ng inelastic n

JOHN STlton Buildinj.stride@unsw

HE NANOS

cused on some use of a rojects. Key rld around usof these fund

t century

of new concepromise is py intimate lo are ideal ho

mation and haenturies and

the

of a frustrateneutron scatt

TRIDE ng (F12) w.edu.au

SCALE

me of the range of to these s derives damental

epts and polymeric ng range osts for a

ave a key are even

eory

ed magnet tering

(b)

Solid stastructureorder givplay imparomaticapproximdimensiointeractiosystemscomputa

Inter-mo

IdentifiedinteractioproblemsystemsThis wormodellinof our ev

Donor-A

The inteactive chand lightinvestigaknown tomaterialsenablingrange oftremendapplicati(OLEDs)moleculehighly instacking

(c)

Other pspectrospossible

Order and d

ate materialses; however ves way to dportant roles cs, are omating to onality direcons and or

s to studyational simula

olecular hydro

d by Linus Pons, the bass to study wh

s, making userk is highly co

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69

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n terms of te transitions we world of phviour of mole

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also ideal enable to ry stable.

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71

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hanges aroumpound. Themore ‘exotic’ synthesisingmbination ofus to go on a

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oviding high ain research flearning, so

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controlling thelifetimes, i.e.

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wski, Adam D. Martin, Albility in the three-dimensiwski, Adam D. Martin an 140, 2869-2874.

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ours Project

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ails.

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pramolecular systems, CAtwood, Jonathan W. Steust 2017, 28-35. M. Sagnella, Maria Kava

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75

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