CHEM 4630 BIOCHEMISTRY OF PROTEINShome.cc.umanitoba.ca/~joneil/4630/0-Intro-2016.pdf · 2016-01-05 · Higher-Throughput Protein Puriﬁcation PepTalk: The Protein Science Week is

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CHEM4630BIOCHEMISTRYOFPROTEINSThecourseoutlineisavailableat:h6p://home.cc.umanitoba.ca/~joneil/CHEM4630.Course.outline.htmSomethemesintheBiochemistryofProteins:1.  ProteinsareBIGorganicmolecules.Thephysical-chemicalproperKesoftheaminoacidsandthepep,debondexplain•  thephysical-chemicalproperKesofproteinswhichexplain•  theBIOLOGICALproperKesandfuncKonsofproteins.

2.Athemeofstructuralbiologyis:

DeterminesStructureFuncKon

TheannualnumberofmolecularstructuresdepositedintheBrookhavenProteinDataBankaregraphedtotheright.

h6p://www.rcsb.org/pdb/staKsKcs/contentGrowthChart.do?content=total&seqid=100

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3.AmajorareaofresearchishowproteinstructureexpressesfuncKonthroughproteindynamics.e.g.TheenzymeFoF1ATPsynthaseusesenergystoredinaprotongradienttosynthesizeATPfromADPandPi.TheconformaKonalchangethatreleasesATPisthespinningofacentral“rotor”relaKvetotherestoftheprotein.Intheabsenceofaprotongradienttheproteindynamicsis“stochas,c”(unpredictable)butinthepresenceofaprotongradientdirec@onalrotaKonoccursowingtoprotonaKonofachargedglutamicacidside-chain.

ThemoKonwasobserveddirectlybya6achingafluorescentacKnfilamenttotheprotein:h6ps://www.youtube.com/watch?v=QeHCAFKaWM8

ThefollowingmoviesoftheproteinmoKonarebasedoninterpolaKonofX-raydiffracKonstructuresusingflip-bookoranimaKontechniques:h6ps://www.youtube.com/watch?v=J8lhPt6V-yM4.TheoutstandingquesKonsinproteinchemistrycanbegleanedfromtheKtlesoftalksgivenatinternaKonalconferences.

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American Peptide Symposium

2015

1/4/16, 12:44 PMAPS 2015

Page 1 of 2http://aps2015.org/

Our Sponsors

Disney Discounts

Save time and money by purchasingDisney tickets at a discount throughour special Disney Microsite! Disneyis offering exclusive afternoon After2PM and After 4 PM tickets, as wellas a 10% savings on all multi-day,2+ day, tickets for attendees andguests. All Multi-day tickets includean additional complimentary "BonusVisit" admission.

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VISIT DISNEY!

Welcome to the American Peptide Society's 24th International

Symposium

Symposium Venue — Orlando, Florida

We extend to you a warm Orlando welcome to the 24th AmericanPeptide Symposium. A couple of years ago, we were asked toorganize the 24th Meeting of the American Peptide Society. Initially,

this seemed like a daunting task but we were keen to take on the challenge!This unique opportunity to host the peptide community for 6 days ofstimulating science was too hard to resist, despite the amount of work weneeded to invest in this project.

In our quest to understand the best possible mix of topics to appeal to thewidest audience from Academia to Industry, we found the answer: we wantedthe enabling aspects of peptide science to come through in the strongestpossible way. The meeting theme — Enabling Peptide Research from BasicScience to Drug Discovery — embraces the spirit of the scientific and socialprograms we have assembled for you.

Recently, the use of peptides as drugs has been increasing exponentially,especially in metabolic diseases and in exploring intracellular targets. A pre-Symposium, with a theme of peptides in metabolic diseases, is planned withan emphasis on basic pharmacology and peptide targets. This is followed bya number of regular scientific sessions, which focus on topics as diverse asmacrocycles, synthetic peptides, medicinal chemistry and peptidetherapeutics, all representing emerging peptide technologies.

The scientific program for 2015 opens with distinguished lecture by Dr.Richard A. Lerner (http://aps2015.org/program/lectures_opening.html) of TheScripps Research Institute followed by a social gathering at the Upper PoolDeck of the resort. The symposium will be concluded with a lecture by Dr.Jeffrey Friedman (http://aps2015.org/program/lectures_closing.html) of theRockefeller Institute, which will be followed by the closing banquet.

Unlike previous events, two workshops will be conducted at this meeting: (1)workshop on peptide Chemistry Manufacturing and Controls (CMC) andregulatory challenges; and (2) workshop on career development, job searchstrategy and interview preparation. The lectures from awards winners,including the Merrifield, Vincent du Vigneaud, Makineni, and GoodmanAwards are spread out over the six days of the symposium.

Ved Srivastava, Ph.D.(mailto:[email protected]=Message%20from%20APS%20Website)GlaxoSmithKline, Symposium Co-Chair

Andrei Yudin, Ph.D.(mailto:[email protected]?Subject=Message%20from%20APS%20Website),University of Toronto, SymposiumCo-Chair

!

!

read more +(http://aps2015.orlandomeetinginfo.com/)

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JOIN US FOR THE 24TH APS SYMPOSIUM

AMERICAN PEPTIDE SYMPOSIUM

JUNE 20-25 2015

ORLANDO, FLORIDA

.

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Scientific Topics

Poster and Oral Presentations will Cover the Following Topics:

Symposium Sessions topics

Peptides in Metabolic DiseaseSynthetic methodsMacrocyclesPeptide biomaterialsBioactive peptidesPeptide structure and functionProteomics and EpigeneticPeptide catalysisCell Penetrating PeptidesPeptide medicinal chemistryMetabolism - ADMEPeptide therapeuticsPeptides in the clinicPeptide formulation and deliveryEmerging Peptide TechnologiesImmunotherapy

Stay Connected

Contact Us

Email: [email protected] (mailto:[email protected])

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.PepTalk

2016

1/4/16, 12:34 PMPeptalk - The Protein Science Week

Page 1 of 2http://www.chi-peptalk.com/

Recombinant Protein Therapeutics

Enhancing Antibody Binding and Specificity

Membrane Proteins

Emerging Technologies for AntibodyDiscovery and Engineering

Next-Generation Cancer Immunotherapies

Antibody-Drug Conjugates

Bispecific Antibody Therapeutics

Optimizing Biologics FormulationDevelopment

Lyophilization and Emerging DryingTechnologies

Protein Aggregation and EmergingAnalytical Tools

Engineering Genes, Vectors, Constructs andClones

Recombinant Protein Expression

Membrane Proteins

CHO Cell Culture

Applying Expression Platforms

Characterization of Biotherapeutics

Detection and Characterization ofParticulates and Impurities

Extractables and Leachables

Single-Use Technologies and ContinuousProcessing

Protein Purification and Recovery

Membrane Proteins

Higher-Throughput Protein Purification

PepTalk: The Protein Science Week is one of the largestgatherings of protein science researchers in the world. It offers anarray of education, innovation and networking programs, andprovides many opportunities to scientists.

PepTalk is an annual gathering where industry experts from aroundthe world convene to share case studies, unpublished data,breakthroughs and solutions that support and enhance research,and to gain new perspectives on the evolution of biologics.

Event Features Include:

Network with over 1200 attendees from over 30 countriesHear unpublished data and case studies from industry leadersCreate your own agenda – Premium Package allows access toall conferences for one price!Showcase your research by presenting a scientific posterParticipate in the popular BuzZ Session Roundtable DiscussionsView over 150 scientific postersBuild your own schedule using the event mobile appVisit over 100 companies in the exhibit hallTake advantage of student fellowships available for gradstudents and Ph.D. candidates

Download 2016 Brochure

Download Conference At A Glance

Premier Sponsors:

View All Sponsors

View Media Partners

View 2016 Participant list

#PTK16Agenda Sponsor/Exhibitor Downloads Travel CD/DVD Posters Press Register

<><>

.Annual World

Protein and Peptide Conference

2016

1/4/16, 12:32 PMBIT's 9th Annual World Protein & Peptide Conference

Page 1 of 4http://www.bitcongress.com/pepcon2016/ScientificProgram.asp

Scientific Program

BIT’s 9th

Annnual World Protein & Peptide Conference -2016Theme: Translation, Health and Happiness

Time: April 25-28, 2016Venue: International Conference Center, Dalian, China

Scientific Program

KeynoteForum Symposium 1 Symposium 2 Symposium 3 Symposium 4 Symposium 5 Symposium 6 YIF

Keynote Forum of PepCon-2016

Day 1: Afternoon, Tuesday, April 26, 2016

13:30-16:35

Moderator: Dr. Matthew He, Assistant Dean, Full Professor, Nova Southeastern University, USA

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International Union for

Biochemistry and Molecular Biology

2015

1/4/16, 12:37 PMIUBMB 2015 | SBBq - Confirmed Speakers

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Confirmed SpeakersKeynote Lecturers (confirmed):

Bruce Alberts, University of California, San Francisco, USAGünther Meister, University of Regensburg, GermanyJohann Deisenhofer, University of Texas Southwestern Medical Center, USAJose Onuchic, Rice University, USAKurt Wüthrich, The Scripps Research Institute, USAMartin Chalfie, Columbia University, USATom Steitz, Howard Hughes Medical Institue, USASalvador Moncada, The University of Manchester, UK

Symposia Speakers (confirmed):

Abel Santamaria, Universidad Autonoma Del Mexico, MXAdi Kimchi, Weizmann Institute of Science, IsraelAkihiko Nakano, University of Tokyo, JapanAlejandro Buschiazzo, Institut Pasteur de Montevideo, UruguayAlexandra Newton, University of California, San Diego, USAAmira Klip, University of Toronto, Ontario, CanadaAnamaria Camargo Aranha, Instituto Ludwig, BrazilAndrea Thompson Da Poian, Universidade Federal do Rio de Janeiro, BrazilAndrea Cristina Paula Lima, Universidad de Chile, ChileAndy Weyrich, University of Utah, USAAnthony J. Kettle, University of Otago, New ZealandBeatriz Alvarez, Universidad de La Republica, UruguayBonnie Wallace, Instiute of Structural and Molecular Biology, Birkbeck College, University of London, UKBianca Zingales, Universidade de São Paulo, BrazilByron Caughney, NIH-NIAID, USABruce Alberts, University of California, San Francisco, USACarol Prives, Columbia University, USACelso Caruzo Neves, Universidade do Rio de Janeiro, BrazilChunlin Long, College of Life and Environmental Sciences, Minzu University of China, ChinaClaudio J. Soto, University of Texas, USADario S. Zamboni, Faculdade de Medicina, USP-RP, BrazilDavid Carling, Imperial College of London, UKDebora Foguel, Universidade do Rio de Janeiro, BrazilDeborah Kurrasch, University of Alberta, CanadaDeborah Schechtman, Universidade de São Paulo, BrazilDiogo Onofre de Souza, Universidade Federal do Rio Grande do Sul, BrazilDmitry Korzhnev, University of Connecticut Health Center, USAEhud Gazit, Tel Aviv University, IsraelEduardo Galembeck, Universidade Estadual de Campinas, BrazilEfstathios S. Gonos, National Hellenic Research Foundation, GreeceElena N. Elpidina, M.V. Lomonosov Moscow State University, MoscowEric Lam, Rutgers, the State University of New Jersey, USAEnrico Gratton, University of California – Irvine, USAEtelvino J.H. Bechara, Universidade de São Paulo, BrazilFabio C.L. Almeida, Universidade Federal do Rio de Janeiro, BrazilFernanda de Felice, Universidade Federal do Rio de Janeiro, BrazilFernando Goldbaum, Fundación Instituto Leloir, ArgentinaFrancisco Ambrósio, Universidade de Coimbra, PortugalFrancisco José BARRANTES, University of Argentina-CONICETFrancisco Laurindo, Universidade de São Paulo, BrazilFred Robert Tabita, The Ohio State University, USA

The Event

1/4/16, 2:48 PMCSHL Meetings

Page 1 of 2https://meetings.cshl.edu/meetingshome.aspx

All Cancer Cell/Mol Bio 'Omics Neuro Genetics Immun/Infect

Meetings & Conferences

Meeting Name Meeting Dates Abstracts Due

Systems Biology: Global Regulation of Gene Expression Tue Mar 15 - Sat Mar 19 2016 Fri Jan 8 2016

Evolutionary Biology of Caenorhabditis & Other Nematodes Wed Mar 30 - Sat Apr 2 2016 Fri Jan 15 2016

Neuronal Circuits Wed Apr 6 - Sat Apr 9 2016 Fri Jan 22 2016

The PARP Family & ADP-ribosylation Wed Apr 13 - Sat Apr 16 2016 Fri Jan 29 2016

Protein Homeostasis in Health & Disease Mon Apr 18 - Fri Apr 22 2016 Fri Jan 29 2016

Gene Expression & Signaling in the Immune System Tue Apr 26 - Sat Apr 30 2016 Fri Feb 5 2016

Nuclear Organization & Function Tue May 3 - Sat May 7 2016 Fri Feb 12 2016

The Biology of Genomes Tue May 10 - Sat May 14 2016 Fri Feb 19 2016

The Cell Cycle Tue May 17 - Sat May 21 2016 Fri Feb 26 2016

Retroviruses Mon May 23 - Sat May 28 2016 Fri Mar 4 2016

81st Cold Spring Harbor Symposium: Targeting Cancer Wed Jun 1 - Mon Jun 6 2016 Fri Mar 11 2016

Glia in Health & Disease Thu Jul 21 - Mon Jul 25 2016 Fri May 6 2016

Genome Engineering: The CRISPR/Cas Revolution Wed Aug 17 - Sat Aug 20 2016 Fri May 27 2016

Regulatory & Non-Coding RNAs Tue Aug 23 - Sat Aug 27 2016 Fri Jun 3 2016

The PI3K-mTOR-PTEN Network in Health & Disease Tue Aug 30 - Sat Sep 3 2016 Fri Jun 10 2016

Translational Control Tue Sep 6 - Sat Sep 10 2016 Fri Jun 17 2016

Epigenetics & Chromatin Tue Sep 13 - Sat Sep 17 2016 Fri Jun 24 2016

Home Meetings Courses

Cold Spring Harbor Symposium

2016

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.

1/4/16, 2:48 PMCSHL Meetings

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Epigenetics & Chromatin Tue Sep 13 - Sat Sep 17 2016 Fri Jun 24 2016

Axon Guidance, Synapse Formation & Regeneration Tue Sep 20 - Sat Sep 24 2016 Fri Jul 1 2016

Mechanisms of Aging Mon Sep 26 - Fri Sep 30 2016 Mon Jul 25 2016

Germ Cells Tue Oct 4 - Sat Oct 8 2016 Fri Jul 15 2016

Thirty Years of HIV/AIDS Research: The Science & Beyond Wed Oct 12 - Sat Oct 15 2016 Thu Sep 1 2016

Biological Data Science Tue Oct 25 - Sat Oct 29 2016 Fri Aug 12 2016

Neurodegenerative Diseases: Biology & Therapeutics Wed Nov 30 - Sat Dec 3 2016 Fri Sep 16 2016

Blood Brain Barrier Wed Dec 7 - Sat Dec 10 2016 Fri Sep 23 2016

Cold Spring Harbor LaboratoryMeetings & Courses Program

PO Box 100, 1 Bungtown RoadCold Spring Harbor, NY 11724-2213

Phone (516) 367-8346Fax: (516) 367-8845

[email protected]

1/4/16, 12:25 PMThe Protein Society: The home for the international protein science community

Page 1 of 3http://www.proteinsociety.org/meetings/symposium/

JOIN EMAIL LIST | MEMBERS ACCESS PROTEIN SCIENCE HERE:

A GLOBAL COMMUNITY OFRESEARCHERS DEDICATED TO THEUNDERSTANDING OF PROTEINS

2016 SYMPOSIUM

THE 30TH ANNIVERSARY SYMPOSIUM OFTHE PROTEIN SOCIETY

Baltimore, Maryland USA | July 16-19, 2016 | Hyatt Regency Baltimore

Topics

Birth, Life, & Death of Proteins

Protein Evolution & Design

Protein Folding & Misfolding

Emerging Methods for Protein Research

Membrane Protein Folding & Function

Proteins on the Move

Applied Protein Research

Dynamic Modulation of Protein Function

Interface Between Proteins & Nucleic Acids

Interdisciplinary Approaches to Protein Science

2016 Program Planning Committee

Brenda Schulman, St. Jude Children’s Research Hospital

Andreas Plückthun, University of Zurich

Ralf Langen, University of Southern California

Nieng Yan, Tsinghua University

2016 Confirmed Speakers

Anna Marie Pyle, Yale UniversityAndrzej Joachimiak, University of ChicagoBeili Wu, The Scripps Research InstituteBil Clemons, California Institute of TechnologyCliff Brangwynne, Princeton UniversityDan Tawfik, Weizmann Institute of ScienceDavid Eisenberg, University of California, LosAngelesEmmanuelle Charpentier, Molecular InfectionMedicine Sweden

AWARDS CRITERIA

ABOUT MEETINGS MEMBERSHIP AWARDS THE JOURNAL RESOURCES GET INVOLVED

30th Anniversary Symposium of The

Protein Society 2016

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1/4/16, 12:27 PMGordon Research Conferences - Meeting List: 2016

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Gordon Research Conferences

Meeting List: 2016

The following meetings are currently scheduled for 2016. The meeting list can be sorted by conference name, type (GRC orGRS), date, or location, by clicking on the corresponding column heading. The list can also be narrowed down in differentways by selecting one of the tabs below. Click on a meeting name to view more details, including the current program (ifavailable).

All Meetings By Category By Site By Date By Keyword By Discipline

Display only New Meetings Hide meetings that have taken place

Display only Gordon Research Seminars

Displaying: 325 of 325 Total Meetings

Type Conference Name Dates Conference Site

Advanced Health InformaticsThe Use of Big Data in Health Related Research

Jul 17-22 The ChineseUniversity of HongKong

Advanced Materials for Sustainable Infrastructure DevelopmentThe Science and Technology of Sustainable Concrete

Jul 31 - Aug 5 The Hong KongUniversity ofScience andTechnology

Alcohol & the Nervous SystemBreakthroughs in Alcohol Neuroscience Research at the Level ofMolecules, Cells, Synapses, and Behavior

Feb 7-12 Hotel Galvez

AngiotensinAngiotensin: From Cell Biology and Signaling Networks to NovelPhysiological Paradigms and Therapeutics

Feb 21-26 RenaissanceTuscany Il Ciocco

Angiotensin (GRS)The Renin Angiotensin System in Health and Disease: LatestAdvances and New Technologies

Feb 20-21 RenaissanceTuscany Il Ciocco

Antibody Biology & Engineering Mar 20-25 Hotel Galvez


2016

Diffrac@onMethodsinStructuralBiology(GRS)ProteinFuncKoninTimeandSpace:InsightsfromDiffracKonExperiments

IntrinsicallyDisorderedProteinsDisorderedProteins:FromMechanismstoTherapeuKcOpportuniKes

LipoproteinMetabolismLipidandLipoproteinMetabolisminChronicDiseasePathogenesisandTreatment

MembraneTransportProteinsMembraneTransporters:TranslaKngMoleculestoMedicine

Phosphoryla@on&G-ProteinMediatedSignalingNetworksNewDruggableTargetsUnderlyingStructuralandSpaKalAspectsofSignalinginMetabolic,Inflammatory,andOtherStress-RelatedDiseasePathways

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ProteinFoldingDynamicsFolding:TheLandscapesofNaturalandSyntheKcLife

ProteinProcessing,Trafficking&Secre@onSecretoryandEndocyKcPathwaysinHealthandDisease

ProteinTransportAcrossCellMembranesProteinTransportAcrossCellMembranes:Mechanism,Structure,andRegulaKon

Enzymes,Coenzymes&MetabolicPathwaysAdvancesinEnzymologyfromDeterminingEnzymeFuncKontotheInterplayofLargeEnzymeSystems

IntermediateFilaments(GRS)BreakingBarriersinIntermediateFilamentBiology:FromStructuretoMechanismsandTargetsinHumanDiseases

IonChannelsMolecularBasisforElectricalSignalingintheNervousSystemandBeyond

LigandRecogni@on&MolecularGa@ngMolecularBasisofLigandRecogniKonandGaKnginTransmembraneSignalingandTransport

Muscle&MolecularMotorsMotorMechanismsfromSingleMoleculestoCellularFuncKon

NotchSignalinginDevelopment,Regenera@on&DiseaseNotchSignaling:PhenotypestoMolecularMechanisms

NOXFamilyNADPHOxidasesNOXMolecularInsightsLeadingtoTranslaKon

Pep@des,Chemistry&BiologyofCrossingBarriersbyPepKdeScienceforHealthandWellness

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Thiol-BasedRedoxRegula@on&Signaling(GRS)RedoxBiologyinDiseasesofAging:FundamentalMechanismsandTherapeuKcPotenKal

ThreeDimensionalElectronMicroscopyAdvancingandReshapingStructuralBiologywithElectronCryo-Microscopy

1/4/16, 12:28 PMGordon Research Conferences - 2016 Meeting - Protein Folding Dynamics

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Meeting Details

Protein Folding DynamicsGordon Research Conference

Folding: The Landscapes of Natural and Synthetic Life

Dates

January 10-15, 2016

Location

Hotel GalvezGalveston, TX

Organizers

Chair: Peter G. Wolynes

Vice Chair: Benjamin Schuler

Application Deadline

The application deadline for this meeting was December 13, 2015. You may still submit an application, which may beconsidered by the conference chair if there is still room available.

Meeting Description

The protein folding problem has long been regarded as a fundamental mystery blocking our understanding of how the geneticinformation locked in DNA is transformed into a dynamic living organism. In the last decades, however, a basic understandingof the folding process has been achieved. The keys to this progress include borrowing theoretical ideas about energylandscapes from condensed matter physics and physical chemistry, employing powerful computer simulation techniques andbringing to bear new experimental tools such as single molecule methods and ultrafast spectroscopy, as well as elaboratingthe classical kinetic techniques of biophysical chemistry while exploiting the capabilities of protein engineering. Thus manycommunities from physics, chemistry and biology have merged to form the discipline of protein folding dynamics. Many of thefundamental issues about how proteins fold remain under intense investigation. New frontiers include understanding thediversity and basic time scales of folding larger proteins building on what has been learned in small model systems. Also wecan now enquire how folding behavior has evolved in natural history, using huge quantities of genomic data. Folding is nowknown to be an emergent property. Recognizing this, to test our understanding, the community is now also exploring whetherfolding can be instantiated in completely novel designed systems, so-called "foldamers". Folding is not just a preliminary stepto biological function but is intimately involved in functional processes such as allosteric change and molecular recognition.Furthermore the evolution of these capabilities has shown its mark on protein folding dynamics, an area of great fermentbringing together a new group of biologists. The misfolding of some proteins seems central to the progress of many diseasessuch as Alzheimer's and here the new tools of the folding community are bringing new insights. Finally we now can askwhether the hard won paradigms of protein folding dynamics gleaned from studying small globular proteins can be applied tomembrane protein folding in which other biological actors are implicated as chaperones. Also can folding concepts be applied

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to studying how the very largest structures in the cell are organized, such as chromosomes? Sessions covering both newdevelopments in the basic areas as well as applications of folding dynamics to more complex biology are planned.

Contributors

Meeting Program

Sunday

4:00 pm - 8:00 pm Arrival and Check-in

6:00 pm Dinner

7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff

7:40 pm - 9:30 pm Keynote Session: The Atomistic Basis of Folding Energy Landscapes

Discussion Leader: Angel Garcia (Los Alamos National Laboratory, USA)

7:40 pm - 8:25 pm Robert Best (National Institutes of Health, USA)"Molecular Origins of Internal Friction in Protein Folding Dynamics"

8:25 pm - 8:35 pm Discussion

8:35 pm - 9:20 pm Klaus Schulten (University of Illinois, USA)"What Can Be Learnt from the Molecular Dynamics View of Protein Translocation, Folding andAggregation?"


Monday

7:30 am - 8:30 am Breakfast

8:30 am Group Photo

9:00 am - 12:30 pm The Rights and Wrongs of Folding

Discussion Leader: Jose Onuchic (Rice University, USA)

9:00 am - 9:45 am Sheena Radford (University of Leeds, United Kingdom)"Stopping the Amyloid Cascade: New Molecular Insights and Some New Opportunities"

9:45 am - 10:00 am Discussion

10:00 am - 10:30 am Coffee Break

10:30 am - 11:15 am Paul Whitford (Northeastern University, USA)"The Role of Disorder in Biomolecular Assemblies"




11:30 am - 12:15 pm Susan Marqusee (University of California, Berkeley, USA)"Touring the Landscape: The View Depends on How You Look"


12:30 pm Lunch

1:30 pm - 4:00 pm Free Time

4:00 pm - 6:00 pm Poster Session

6:00 pm Dinner

7:30 pm - 9:30 pm Fast Folding

Discussion Leader: Martin Gruebele (University of Illinois at Urbana-Champaign, USA)

7:30 pm - 8:15 pm Gerhard Hummer (Max Planck Institute of Biophysics, Germany)"Fast Folding: Mechanisms from Simulations"


8:30 pm - 9:15 pm Victor Munoz (University of California, Merced, USA)"Gradual Disorder of Fast Folding Proteins Monitored at Atomic Resolution"


Tuesday


9:00 am - 12:30 pm Folding the Chromosome

Discussion Leader: Bin Zhang (Rice University, USA)

9:00 am - 9:45 am Andrew Belmont (University of Illinois, USA)"Boundary Conditions for Chromosome Folding Models from Direct Visualization of Native andReconstituted Chromosomes"



10:30 am - 11:15 am Erez Lieberman Aiden (Baylor College of Medicine, USA)"How the Genome Folds: Now Inside the Loop"


11:30 am - 12:15 pm Masaki Sasai (Nagoya University, Japan)"Fluctuating Three-Dimensional Genome Architecture and Gene Regulation"


12:30 pm Lunch



6:00 pm Dinner

7:30 pm - 9:30 pm Towards Synthetic Life: The World of Foldamers

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Discussion Leader: Jeffrey Hartgerink (Rice University, USA)

7:30 pm - 8:15 pm Samuel Gellman (University of Wisconsin-Madison, USA)"Higher Order Structure in Peptidic Foldamers"


8:30 pm - 9:15 pm Ivan Huc (Université de Bordeaux / CNRS, France)"Designing Foldamers with Predictable Structures"


Wednesday


9:00 am - 12:30 pm Folding One Molecule at a Time

Discussion Leader: William Eaton (National Institute of Diabetes and Digestive and KidneyDiseases, NIH, USA)

9:00 am - 9:45 am Jane Clarke (University of Cambridge, United Kingdom)"Folding Proteins On and Off the Ribosome"



10:30 am - 11:15 am Ashok Deniz (The Scripps Research Institute, USA)"Single-Molecule Folding Biophysics of Disordered Proteins"


11:30 am - 12:15 pm Michael Woodside (University of Alberta, Canada)"Observing Transition Paths in the Folding of Proteins and Nucleic Acids with Single-Molecule ForceSpectroscopy"


12:30 pm Lunch



6:00 pm Dinner

7:00 pm - 7:30 pm Business Meeting

Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site andScheduling Preferences; Election of the Next Vice Chair

7:30 pm - 9:30 pm Folding Membrane Proteins

Discussion Leader: Daniel Otzen (Aarhus University, Denmark)

7:30 pm - 8:15 pm Paula Booth (King's College London, United Kingdom)"Helical Membrane Proteins and Lipid Bilayer Mechanics"


8:30 pm - 9:15 pm James Bowie (University of California, Los Angeles, USA)



"Folding Membrane Proteins One at a Time"


Thursday


9:00 am - 12:30 pm Misfolding Landscapes

Discussion Leader: Yaakov Levy (Weizmann Institute of Science, Israel)

9:00 am - 9:45 am Tuomas Knowles (University of Cambridge, United Kingdom)"Kinetics of Protein Aggregations"



10:30 am - 11:15 am Pernilla Wittung-Stafshede (Chalmers University of Technology, Sweden)"In Vitro Protein Cross-Reactivity: Links Between Parkinson's, Bacteria and Diabetes?"


11:30 am - 12:15 pm Martin Zanni (University of Wisconsin-Madison, USA)"Humans but Not Rats? Cats but Not Dogs? A Study into the Molecular Mechanism of Type 2Diabetes Using 2D IR Spectroscopy"


12:30 pm Lunch



6:00 pm Dinner

7:30 pm - 9:30 pm Frustration and the Evolution of the Folding Landscape

Discussion Leader: Elizabeth Komives (University of California, San Diego, USA)

7:30 pm - 8:15 pm Faruck Morcos (University of Texas at Dallas, USA)"Investigating Co-Evolutionary Landscapes of Interaction Specificity in Signaling Proteins"


8:30 pm - 9:15 pm Diego Ferreiro (University of Buenos Aires, Argentina)"Frustration and the Energy Landscapes of Repeat- Proteins"


Friday


9:00 am Departure

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1/4/16, 12:40 PMHome - Miami Winter Symposium 2016

Page 1 of 6http://www.miamiwintersymposium.com/

Miami 2016 Winter SymposiumInflammation

January 24—27, 2016 | Hyatt Regency Miami, USA

Latest News:There is still time to register for the Miami 2016 Winter Symposium - hurry register here!

WARNING - SCAM ALERT: Exhibitor Housing Services (EHS) Read more here!

Sessions

Acute Inflammation

Cardiovascular and Metabolic Inflammation

Neuroinflammation

Cancer and Inflammation

Resolution of Inflammation

Inflammation has remained during evolution for a good reason: it helps combating pathogens, opposingtissue injury, and healing wounds. However, in some scenarios, inflammation cannot resolve and exertsdetrimental effects on human health. The list of tissues and systems adversely affected by inflammation

Elsevier Conferences

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2016

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continues to lengthen and includes the nervous system, the vasculature, metabolism, and tumors.

This Symposium leads off with a session on acute inflammation and its resolution or development into chronicinflammation. Subsequent sessions focus on the impact of inflammation on cardiovascular metabolism,nervous system, and cancer. A final session is centered on the pharmacological control of inflammationresolution.

Other conferences are focused on a single inflammatory condition (one tissue, one organ): at variance withthis, this Symposium program brings together experts that will discuss side by side different typesof inflammation with different technical approaches and competences.

This Symposium will be therefore of interest to a wide range of scientists: immunologists, neuroscientists,those working on diseases including diabetes, cancer, autoimmunity, neurological disorders, stroke andatherosclerosis.

Many biotechnology and pharmaceutical companies are developing therapies to interfere withproinflammatory cytokines and their receptors and/or with cytokine signaling pathways. Some speakers fromthese companies will be present to describe how basic science can develop into translational results.

Miami 2017 Winter Symposium

Sunday 22nd – Wednesday 25th January 2017

Diabetes: Today’s Research – Tomorrow’s Therapies

Conference Speakers

David Artis, USA

Glen Barber, USA

Ajay Chawla, USA

Vishwa Dixit, USA

Christopher Glass, USA

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5.Proteomics:Thestudyofglobalproteinexpressionpa6ernsthatdefinecellsinspecificbiologicalstates.-omeisanounsuffixfromtheLaKnomameaningmass.Itmayinvolvethestudyofalltheproteinsinanorganelle,cell,Kssue,ororganism.Itmayincludeotheraspectsofproteinanalysisincludingstructure,dynamics,locaKon,acKvity,funcKon,drugbinding,interacKons,regulaKonetc.6.GenomeSequencinghasdiscoveredthemolecularbasisofthemorethan1000humangeneKcdiseases.e.g.CysKcFibrosis,MuscularDystrophy,Parkinson’sDisease,Toure6e’sSyndrome……..

Whatabouttheproteinswhicharetheproductsofthosegenes?Tounderstandthediseasesandcurethemrequiresadetailedunderstandingoftheproteinsandtheirstructures.ThemostspectacularadvancetodatehasbeenthedevelopmentofAspproteaseinhibitorsusefulinsuppressingHIV-1.Thedrugsweredesignedusingthe3DstructureofAspprotease.7.Howdoproteinsfoldintotheirbiologically-acKve3Dstructures?Herearesomeexamplesofproteinfoldingdiseases:

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Documents

CHEM 4630 BIOCHEMISTRY OF PROTEINShome.cc.umanitoba.ca/~joneil/4630/0-Intro-2016.pdf · 2016-01-05 · Higher-Throughput Protein Puriﬁcation PepTalk: The Protein Science Week is