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CHBE 594 Lect 6. The Case Statement. Building A Successful Proposal. Create Excitement. Describe The Work Well. Solid Research Plan. Qualified Investigator. The research plan and investigators qualifications are key pillars that support a proposal. Good research ideas are not enough - PowerPoint PPT Presentation
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CHBE 594 Lect 6The Case Statement
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Building A Successful Proposal
Solid
Rese
arch
Pla
n
Qu
alifi
ed
Investig
ato
r
Good Research Idea
Describe The Work Well
A good research idea is the
foundation of any successful proposalYou need an idea that satisfies the Heilmeier criteria and is fun to do
Good research ideas are not enoughYou need to be
qualified to do the work and have a good
research plan
The research plan and investigators qualifications are key pillars that
support a proposal
A compelling presentation is also
criticalYou need to describe
the work well and create excitement
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Topics For Today
Building the foundation for your proposal Making the case for funding Answering the Heilmeier
criteria What is the problem, why is it hard? How is it solved today? What is the new technical idea; why can we
succeed now? What is the impact if successful? How will the program be organized? How will intermediate results be generated? How will you measure progress? What will it cost Why should they fund you rather than
someone else?
Solid Research Plan
Qualified Investigator
Good Research Idea
Describe The Work Well
Solid Research Plan
Qualified Investigator
Good Research Idea
Describe The Work Well
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Solid Research Plan
Qualified Investigator
Good Research Idea
Describe The Work Well
Solid Research Plan
Qualified Investigator
Good Research Idea
Describe The Work Well
The Case Statement
Developing a case statement is an important preliminary step to developing a proposal
I use the case statement to make sure I have a good research idea so I do not waste time on a bad idea Case statement might not actually be
included in the proposal, but it outlines the key things you need to cover
Include it if you can I usually try to include all of the items
in the case statement in the executive summary
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The Case Statement
The case statement provides the pillars that you need to support the proposal. The Need: Demonstrating that the work will fulfill a
need Impact – the work needs to have a significant
impact Within Agency Funding Goals Uniqueness: Demonstrate that you can do
something no one else can do
Feasibility – need to demonstrate that the work can be done
Qualifications – need to demonstrate that you are qualified to do the work
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The Need
The first key part of the case statement is to establish the Need i.e. that you are working on a problem that really matters This should be a societal need e.g. helping to
improve human health, improving our economy, or making some other important contribution
Need statement must be simple enough that a college freshman can understand that the problem is important
It helps if you can cite some famous person, review article, or government report that says this is important. I have some of them posted on the course website.
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Impact
The next part of the work is to demonstrate that if your proposed work will be successful, your findings will have impact It is not good enough to be working on a
good problem. Your proposed work needs to make a difference to the problem
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Within Agency Funding Goals
This seems obvious, but if you send something to NIH and it does not have a goal of eventually improving human health or doing something else within the NIH charter, it will not get funded
Every proposal needs to be within an agencies funding goals or it will not be funded
Proposals need to explicitly show that they are within agency funding goals
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Uniqueness
Proposals also need to be unique to get funded You need to make the case that the agency should fund
you not someone else Agencies get more good proposals than they can
fund If someone is well known for an area, the agency will
not usually fund someone else You will usually not get funding to continue your PhD
Agencies would rather fund your research advisor instead
Also it is not good for your career – the other person has a lead; you will never catch up
On the other hand if you use the skills from your PhD on a new problem, you stand a high chance of funding
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Feasibility
Lastly, you need to demonstrate that the work is feasible in order to get funding
Methods to demonstrate feasibility Reputation of PI in area Publications in similar areas
Preliminary data Realistic work plan
You must demonstrate feasibility to get funded
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Qualifications
You also need to demonstrate that you are qualified to do the work
Methods to establish qualifications Knowledge of literature in area Publication record in area Degrees, postdocs
Preliminary data
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If I Can Make A Case, I have A Good Foundation For A Proposal
Solid
Rese
arch
Pla
n
Qu
alifi
ed
Investig
ato
r
Good Research Idea
Describe The Work Well
Example From One Of My Proposals
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The aim of this proposal is to use Magnetic resonance imaging (MRI) and X-ray computed tomography (CT) to develop better models for water transport within the flow channels in
proton exchange membrane (PEM) fuel cells. According to recent reviews, water management remains a critical unsolved problem in fuel cell design [1-4]. Flooding (i.e filling the cathode gas channel or gas diffusion layer so no air can get to the cathode) is still an issue[4] and that leads to unstable performance and long term cell degradation. Water drops get stuck in the flow channels [5-7]. That leads to freeze damage[5, 6]. There are several models of the water motion, but in a 2005 review, Ma et al [8] noted “... at the
moment, most fuel cell models do not have experimental data, particularly detailed measurement data to validate the models and model predictions ... This situation continues to limit the fuel cell modeling activity”. Additionally, in his Keynote address, Djilali [9] commented that a key factor holding back fuel cell technology was “limited data for.. transport parameters and lack of in situ data for (model) validation”.
First show problem is important
Notice the use of review papers to stress importance
Impact
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Figure 1 shows an MRI image of one of the drops in an operating fuel cell. These water drops have not been considered in the current
generation of fuel cell models. At present there are no equations for the motion of water drops at the
conditions and geometries in a typical fuel cell. Yet, until we understand the drop motions, we are never going to be able to adequately model water transport PEM fuel cells.
This would even be stronger if I could find someone from industry who said they need to understand the drops
Uniqueness
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Key to the work will be the application of MRI and CT imaging to examine the motion of water drops in an operating fuel cell for the first time. MRI has provided the first high resolution, three dimensional high resolution pictures of the water motion in fuel
cells[7, 10, 13-21]. We have access to a 14.7 Tesla MRI machine; one of only 7 in the world. This
gives us the capability of taking higher resolution pictures than anyone else. We also have also done the first CT images of water motion in operating fuel cells. That allows us for example to determine whether the water drop touches the gas diffusion layer at the top of the flow channel and provide details of the drop shape. In previous work, we have
Within Agency Goals
Water management is a call out on both the NSF and the DOE website Topic within agency goals
Masel has $4,000,000/yr of other funding NSF & DOE have a goal of funding
scientists who need help Funding Masel not within agency goals
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Lets Go Back To List Of Why Proposals Are Turned Down
Class I: Problem (58 percent} The problem is of insufficient importance or is
unlikely to produce any new or useful information.
The proposed research is based on a hypothesis that rests on insufficient evidence, is doubtful, or is unsound.
The problem is more complex than the investigator appears to realize.
The problem has only local significance, or is one of production or control, or otherwise fails to fall sufficiently clearly within the general field of the agency.
The problem is scientifically premature and warrants, at most, only a pilot study.
The research as proposed is overly involved, with too many elements under simultaneous investigation.
The description of the nature of the research and of its significance leaves the proposal nebulous and diffuse and without clear research aim.
Source: Ernest M. Allen “Why Are Research Grant Applications Disapproved?” 132, 960 1532-1534.
One often gets comments like this even when
the work is important
because it is not interesting to the reviewer.
I try to cite some source (review article, national
academy or government
report) that says it is important to
head off this criticism
Examples Of Ideas That Are Not Sufficiently Important To Attract
Funding Developing a new technique/molecule because it is cool
Research needs to answer real questions New techniques to answer important questions or provide
capabilities that people care about are great New techniques that are new without answering questions
or providing capabilities that someone cares about will not be funded
Study something abstractly interesting but of no practical value
There are too many practical problems to solve and too little research money. You need to focus on something that matters to society
Work problems that might be important, but no data is available to show that it is important
Making more precise measurements of the effects of variables when the precision is not needed for a practical application
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Examples Of Important But Unfundable Ideas
Work on an important problem where you do not make the importance clear in the proposal
Exploratory studies (i.e. studies that explore a series of variables, and will then use the results to infer a hypothesis) Studying the effects of variables on some
important performance measure is fundable Ideas not supported by preliminary data
or calculations
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Next: Consider The Examples From Lecture 4; Can I Make A Case For
Funding? The Masel group synthesized a
number of MOF’s with novel properties Particle size control Water stability
Can I write a successful NIH proposal to use these MOFs for the following?
Drug delivery? (JACS paper) MRI contrast agents? (JACS paper) Adsorbents for separations
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MRI Contrast Agents
Is there a need? Google search identified 4 existing agents
A few lawsuits, but mostly success Search NIH SBIR
No mention of MRI contrast agents Search NIH Roadmap http://nihroadmap.nih.gov/
No mention of a need for better MRI contrast agents Intracellular contrast agents needed however
Literature search Many articles by chemists citing their new contrast
agent None by physicians
Review article by radiologist – many agents in trials but no major problems with existing agents
Need doubtful – not a good proposal
Is there a need? Google search identified 4 existing agents
A few lawsuits, but mostly success Search NIH SBIR
No mention of MRI contrast agents Search NIH Roadmap http://nihroadmap.nih.gov/
No mention of a need for better MRI contrast agents Intracellular contrast agents needed however
Literature search Many articles by chemists citing their new contrast
agent None by physicians
Review article by radiologist – many agents in trials but no major problems with existing agents
Need doubtful – not a good proposal
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Drug Delivery?
NIH SBIR mentions several cases of drug delivery Drug delivery for the treatment of alcoholism,
drug addiction, mental disorders Maintenance of drug levels for extended
periods of time to alleviate compliance problems.
Targeted drug delivery using ultrasound drug packets that fall apart under
ultrasound for cancer Drug delivery for eyes Drug delivery across blood-brain barrier for
stroke
Need for better drug delivery clear
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Would New Materials For Drug Delivery Have Impact
NIH says yes Needs
Molecules that protect drugs in stomach and release in intestines (lowering nausea)
Molecules that hold molecules and release when in a tumor
Probably needs a peptide or sugar shell Molecules whose release can be targeted
externally For example release in ultrasound
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Within Agency goals, unique?
NIH has a study section (BMBI) that considers new materials for drug delivery see http://www.csr.nih.gov/Roster_proto/sectionI.asp GDD studies drug delivery itself
UIUC materials unique (only water stable large pore mofs)
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Feasibility
Methods to demonstrate feasibility Reputation of PI in area Publications in similar areas Preliminary data Realistic work plan
I have none of these for human health – unlikely to get funded
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How Could I Get Funded?
Collaborate with someone who is an expert on drug delivery or cancer treatment
Take preliminary data
The combination of preliminary data and collaboration with a recognized expert would make a strong case for funding Still need to provide a realistic research
plan & write a compelling proposal
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Do Not Forget The Heilmeier Criteria
What is the problem, why is it hard? How is it solved today? What is the new technical idea; why can
we succeed now? What is the impact if successful? How will the program be organized? How will intermediate results be
generated? How will you measure progress? What will it cost Why should they fund you rather than
someone else?Adapted From Gio Wiederhold, Stanford
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Summary
A good idea forms the foundation for a successful proposal
Assess the idea by making the case for funding including The Need Impact Within Agency Funding Goals Uniqueness Feasibility
Preliminary data Research plan
Solid Research Plan
Qualified Investigator
Good Research Idea
Describe The Work Well
Solid Research Plan
Qualified Investigator
Good Research Idea
Describe The Work Well
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Questions?