Charge:• Your task is to develop core ideas/projects for an $8-10M

($1.25-1.5M per year for 5 years) NIH Center proposal.

• Specifically, you should consider the following questions

Molecular Imaging• Group MembersPeter A. Dowben

Yuri L, Lyubchenko

Xiao Cheng Zeng

Ron Cerny

Stephen DiMagno

Michael Boska

Briefly describe the core projects your group would design for the Center. Please dream big.• We envision a comprehensive center that spans molecular biology,

target identification, whole cell studies, small animal, large animal, human imaging.

• Key new components of the facility include: centralized cell culture facility, an adjacent animal facility, cyclotron, preclinical PET/CT scanner, whole body MRI, small animal fluorescence scanner, imaging mass spectrometer.

• Magnetic and electric dipolar molecules with functionalities not only as MRI agents BUT also magnetocaloric and inductive heating and cooling; nanoimaging characterization of the MRI agents; imaging liqand-protected metal nanoparticles, PET, radiochemistry facility (cyclotron).

• “Donor’s Name” Institute for Translational Molecular Imaging

Identify the key faculty from from both campuses to involve in these projects. Include their strengths. (UNMC on next slide)• UNL Faculty StrengthsA. Gruverman ferroelectrics

Wai-Ning Mei (UNO) electronic structure theory

R. Sabirianov (UNO) electronic structure theory

L. Parkhurst, UNL Chemistry, fluoresence

D. Sellmyer, UNL Physics, metal nanoparticles synthesis

J. Shield, UNL Mech. Eng., nanoparticle characterization

Stephen DiMagno 18F Radiotracer synthesis

Chemistry (UNL)

Electrical Engineering (UNL)

Biomedical Engineering (UNL)

Identify the key faculty from from both campuses to involve in these projects. Include their strengths.

• UNMC Faculty StrengthsLiu, Yutong MRI applications, Image processing

Boska, Michael MRI applications

Sajja, Bala Image processing

Eppley Cancer Institute (UNMC) Molecular Biology/target ID

Neurosciences (UNMC) Moleuclar/histology/animal models

Cardiology (UNMC) Etc

Radiology (UNMC)

College of Pharmacy (UNMC)

Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects.Dana Farber Cancer Institute

U. Missouri Medical Center

Free University of Berlin (Institute for Inorganic Chemistry, Physical Chemistry, FU Medical Center)

University of Minnesota

List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested.

Thermo Fischer Scienticfic Health Care

GE Health Care

Sigma Aldrich

Epichem

Luna Nova

Cardinal Health

Siemens

Describe how you would link the Center to other campus resources.• MRI facilities

• Nanoimaging core facility, UNMC

• Nanoscience facility, UNL

• Mass Spectrometry facility, UNL