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Chapter II. Mechanisms of Hormone Action. PS Wang/ 2004.05. Mechanism of Hormone Action. 1.Peptide hormones 2.Steroid hormones. PS Wang/ 2004.05. Three categories of second messengers. Cyclic nucleotides (cAMP; cGMP) Ca 2+ Phosphatidyl inositol. PS Wang/ 2004.05. - PowerPoint PPT Presentation
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1
Chapter II. Mechanisms of Hormone Action
PS Wang/ 2004.05
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Mechanism of Hormone Action
1. Peptide hormones2. Steroid hormones
PS Wang/ 2004.05
3
Three categories of second messengers
1. Cyclic nucleotides (cAMP; cGMP)2. Ca2+
3. Phosphatidyl inositol
PS Wang/ 2004.05
4Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1216
5Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1217
6
Hadley Endocrinology 1988 2nd ed #1968
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Hadley Endocrinology 1988 2nd ed #1969
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Hadley Endocrinology 1988 2nd ed #1970
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Hadley Endocrinology 1988 2nd ed #1971
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Greenspan & Forsham Basic & Clinical Endocrinology 1986 2nd ed #1204
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Greenspan & Forsham Basic & Clinical Endocrinology 1986 2nd ed #1205
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Greenspan & Forsham Basic & Clinical Endocrinology 1986 2nd ed #1206
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Inositol Triphosphate
a novel second messenger in cellular signal transduction
by Berridge, M. J., & Irvine, R. F. from Nature 312: 315-321, 1984.
PS Wang/ 2004.05
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Phospholipase C (PLC)
Calcium Release
Diacylglycerol (DG, DAG)
#1264
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McDonald Veterinary Endocrinology and Reproduction 1976 2nd ed #3
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Brook & Marshall: Essential Endocrinology 2001 4th ed, fig 2-20
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Brook & Marshall: Essential Endocrinology 2001 4th ed, fig 2-21
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Brook & Marshall: Essential Endocrinology 2001 4th ed, fig 2-22
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Prostaglandins (PG)Finding: 1934, by von Euler (Sweden), in human semenStructure: unsaturated fatty acid, 20 CCharacteristics: local hormone, 4 series (E, F, A, & B)Functions:PGE soluble in “ether”∵
PGE1: bronchial dilation; platelet aggregation PGE2: bronchial dilation; abortionPGF soluble in “phosphate” (“fosfat” in Swedish)∵
PGF2α: destruction of CL, induction of labor (late pregnancy) & abortion (early pregnancy)PGA1 vasodilation; diuresis; gastric secretionFunctional mechanisms:PG Ca2+ level muscle contraction or steroid synthesis orantagonizes cAMP action in a variety of tissues PS Wang/ 2004.05
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#202
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Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1232
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Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1233
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Discovery of Leukotrienes 1938 Feldbery & Kellaway
Cobra Venom Dog Lung Bronchoconstrictor Agent (= slow reacting substance,
SRS = leukotrienes) Whose effect lasted much longer than that of histamine
(= fast reacting substance)
1940 Brocklehurst Asthmatic Patients + Pollen Lung SRS (SRS-A, A = Anaphylaxis)
4000 X more powerful than histamine on stimulation of smooth muscle in the tracheobronchial tree
perfused
PS Wang/ 2004.05
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Tepperman Metabolic and Endocrine Physiology 1987 5th ed #1234