Chapter 5 Anatomy, Physiology and Pathophysiology

Chapter 5Chapter 5

Anatomy, Physiology and Pathophysiology

National EMS Education Standard Competencies National EMS Education Standard Competencies

Anatomy and Physiology

Integrates complex knowledge of the anatomy and physiology of the airway, respiratory, and circulatory systems to the practice of EMS

Pathophysiology

Applies comprehensive knowledge of the pathophysiology of respiration and perfusion to patient assessment and management

IntroductionIntroduction

• Anatomy refers to structure and components of human body– Gross anatomy: visible to naked eye

– Microscopic anatomy: visible through microscope

• Physiology examines body functions

• Pathophysiology studies body functions in an abnormal state

Topographic AnatomyTopographic Anatomy

• Planes and Lines

• Terms of Direction

• Terms of Movement

• Positions and Postures

The Integumentary System (Skin): Anatomy

The Integumentary System (Skin): Anatomy

• Germinal layer of epidermis produces new skin cells

• Dermis contains sweat glands, sebaceous glands, hair follicles, blood vessels, specialized nerve endings

• Mucous Membranes

The Integumentary System (Skin): Physiology

The Integumentary System (Skin): Physiology

• Functions– Protect the body in the environment

– Regulate body temperature

– Transmit information from environment to brain

The Skeletal System: AnatomyThe Skeletal System: Anatomy

• Skeleton gives us our recognizable human form, protects vital internal organs.

• Bones

• Tendons—connect muscles to bones

• Ligaments—connect bone to bone

• Cartilage—cushions between bones– Lubricated by joint fluid (synovial fluid)

Overview of Bones (2 of 2)Overview of Bones (2 of 2)

Components of a long bone (humerus)

The Skeletal System: Physiology

The Skeletal System: Physiology

• Bones protect internal organs.

• Together with muscles, bones enable movement.

• Bone stores minerals.– Particularly calcium

• Bone plays role in forming blood cells and platelets.

The Skeleton The Skeleton

• Axial

• Appendicular

• Joints

The Musculoskeletal System: Anatomy

The Musculoskeletal System: Anatomy

• Three types of muscle:– Cardiac

• Found only in the heart

• Specially adapted

– Skeletal

– Smooth• Involuntary

• In blood vessels, intestines

The Musculoskeletal System: Physiology

The Musculoskeletal System: Physiology

• Contraction and relaxation make movement possible.

• A by-product of movement is heat.

• Muscles protect structures under them.– For example, intestines are protected by rectus

abdominus muscles.

The Musculoskeletal System: Anatomy (4 of 4)

The Musculoskeletal System: Anatomy (4 of 4)

The Respiratory System: Anatomy

The Respiratory System: Anatomy

• Nose

• Mouth

• Throat

• Larynx

• Trachea

• Bronchi

• Bronchioles

• Lungs

• Diaphragm

• Muscles of chest wall

• Accessory muscles of breathing

The Respiratory System: Physiology

The Respiratory System: Physiology

• Respiration– Exchanges gases

• Ventilation– Process of moving

air in and out of lungs

• Breathing control– Medulla

– Pons

– Chemoreceptors

– Carboxic drive

– Hypoxic drive

Acid-Base Regulation Acid-Base Regulation

• pH ranges from 0 (most acidic) to 14 (most basic).

• Normal pH of the human body is 7.35 to 7.45.

• Buffer systems are defenses against acid-base changes in the body.

Acid-Base RegulationAcid-Base Regulation

• Hydrogen ions combine with bicarbonate ions to form carbonic acid

• Carbonic acid breaks down into carbon dioxide and water

• As hydrogen ions are liberated in the body, they combine with bicarbonate ions (action of the buffer system) to resist pH changes in blood

• H+ binds to HCO3- to form H2CO3


• The body attempts to maintain a ratio of HCO3:H2CO3 of 20:1

• As carbonic acid is manufactured by the buffer system it breaks down into carbon dioxide and water

• H2CO3 produces CO2 and H2O


• The respiratory system is responsible for maintaining appropriate levels of carbon dioxide in blood

• As Carbon dioxide is generated, chemoreceptors send messages to the control centers of the brain

• Control centers respond by elevating the respiratory rate


• The kidneys are responsible for secreting excess hydrogen ions or excess bicarbonate ions in urine in order to maintain appropriate acid-base balance

• If blood is acidic, the kidneys secrete hydrogen ions

• If blood is alkaline, the kidneys secrete bicarbonate ions

• Urine production is a relatively slow process

Acid-Base AbnormalitiesAcid-Base Abnormalities

• Metabolic – Acidosis occurs when the body liberates more

hydrogen ions than the kidneys excrete

– Alkalosis occurs when the body absorbs more bicarbonate than is eliminated by the kidneys

• Respiratory– Acidosis occurs when the body fails to eliminate

carbon dioxide

– Alkalosis occurs when the body releases too much carbon dioxide

Interpreting Blood GasesInterpreting Blood Gases

• Acidosis = pH < 7.35– Respiratory

• pCO2 > 45; If compensated, HCO3- > 26 mg/dl

– Metabolic• HCO3- is < 22 mg/dl, pCO2 is normal

• Alkalosis = pH > 7.45– Metabolic

• pCO2 < 35 and HCO3- is low

– Respiratory• HCO3- > 26 mg/dl, pCO2 is normal

Ventilation (1 of 2) Ventilation (1 of 2)

• Tidal volume—air moved in a single breath

• Inspiratory reserve volume—deepest breath you can take after normal breath

• Expiratory reserve volume—maximum amount of air you can forcibly breathe out after normal breath

Ventilation (2 of 2) Ventilation (2 of 2)

• Vital capacity—amount of air moved with maximum inspiration and expiration

Characteristics of Normal Breathing

Characteristics of Normal Breathing

• Normal rate and depth (tidal volume)

• Regular rhythm (pattern of inhalation and exhalation)

• Good audible breath sounds on both sides of chest

• Regular rise and fall movement on both sides of chest

• Movement of abdomen

Compromised Breathing Patterns in Adults

Compromised Breathing Patterns in Adults

• Labored breathing

• Minute alveolar ventilation < 4200 ml

• Muscle retractions (clavicles, ribs)

• Pale or cyanotic (blue) skin

• Cool, damp (clammy) skin

• Tripod position

The Circulatory System: Anatomy

The Circulatory System: Anatomy

• Heart– Location

– Chambers, valves, accessory structures

– Heartwall and Pericardium

• Blood vessels– Types

– Circulatory pathways

• Blood

Heart SoundsHeart Sounds

• Created by contraction and relaxation of heart and flow of blood

• Heard during auscultation with stethoscope

• Normal heart sound: “lub-DUB”

• S1 and S2 are normal sounds, S3 and S4 are often not– Also abnormal: murmurs, bruits, clicks, snaps

The Electrical Conduction System

The Electrical Conduction System

• Electrical stimulus controls mechanical pumping action.

• Conduction system components:– Sinoatrial (SA) node

– Atrioventricular (AV) node

– Bundle of His

– Right and left bundle branches

– Purkinje fibers

Regulation of Heart FunctionRegulation of Heart Function

• Autonomic nervous system, endocrine hormones, and heart tissue, control:– Rate of contraction (chronotropic state)

– Rate of electrical conduction (dromotropic state)

– Strength of contraction (inotropic state)

• Baroreceptors respond to changes in pressure.

• Chemoreceptors sense changes in chemical composition of blood.

The Cardiac Cycle The Cardiac Cycle

• Process that creates the pumping of the heart– Systole

– Diastole

• Pulse pressure

• Afterload

• Stroke volume

• Cardiac output = stroke volume × heart rate

Blood Composition Blood Composition

• Plasma

• Red blood cells– Hemoglobin

– Surface Antigens

• White blood cells (leukocytes) – Fight infection

• Granulocytes (neutrophils, eosinophils, basophils)

• Agranulocytes (monocytes, lymphocytes)

• Platelets

The Circulatory System: Physiology (1 of 2)

The Circulatory System: Physiology (1 of 2)

• Pulse is created by blood pumping out of left ventricle into major arteries.

• Blood pressure is pressure blood exerts against artery walls.– Sphygmomanometer measures high/low points.

• Systemic vascular resistance is how dilated or constricted the blood vessels are.

The Circulatory System: Physiology

The Circulatory System: Physiology

• Average adult has about 5 L of blood– Infants 300 mL,

children 2 to 3 L

• Central and peripheral pulses

• BP = CO X SVR

The Lymphatic System The Lymphatic System

• Absorb fat from digestive tract, maintain fluid balance, and fight infection

• Transports lymph

• Lymph nodes interspersed along course of lymph vessels

• Lymph vessels absorb excess fluid and return it to the central venous circulation

Cellular Transport Mechanisms Cellular Transport Mechanisms

• Cell membrane is selectively permeable.

• Allows differences in concentrations inside and outside cell


• Diffusion– Movement of solutes from an area of high

concentration to an area of low concentration to produce an even distribution of particles in the space available

• Depends on:– Permeability of membrane

– Concentration gradient


• Osmosis– Movement of a solvent from an area of low

solute concentration to one of high concentration

• Osmotic pressure

• Facilitated diffusion

• Active transport

Body Fluid BalanceBody Fluid Balance

• Body fluid is divided into:– Intracellular fluid

(ICF)– Extracellular fluid

• Intravascular fluid (plasma)

• Interstitial fluid

• Fluid balance maintains homeostasis

• Regulated by– Antidiuretic

hormone from pituitary gland

– Thirst

• Fluid imbalance can be life-threatening

The Nervous System: Anatomy and Physiology

The Nervous System: Anatomy and Physiology

• Components

• Central nervous system

• Peripheral nervous system

The Central Nervous System The Central Nervous System

• Brain

• Spinal Cord

• Meninges

The Peripheral Nervous System

The Peripheral Nervous System

• Divisions– Somatic nervous system

– Autonomic nervous system has two parts:• Sympathetic nervous system

• Parasympathetic nervous system

• Sensory and Motor Nerves

• Cranial and Spinal Nerves

The Endocrine System: Anatomy and Physiology (1 of 2)


• Made up of glands located throughout body

• Glands– Remove, concentrate, or alter materials from

blood

– Secrete them back into body

• Glands secrete proteins called hormones.– Regulate mood, growth and development,

metabolism, sexual development, much else



The Pituitary Gland and the Hypothalamus

The Pituitary Gland and the Hypothalamus

• Pituitary gland is called “master gland.”– Its secretions control those of other endocrine

glands.

– Secretes growth hormone, thyroid-stimulating hormone, adrenocorticotropin hormone, gonadotropic hormones, ADH, oxytocin

• Hypothalamus is main link between endocrine system and nervous system.

The Thyroid GlandThe Thyroid Gland

• Large gland at base of neck

• Manufactures and secretes hormones that have role in growth, development, metabolism

• Secretes calcitonin– Helps maintain normal calcium levels in blood

• Parathyroid glands – Located in thyroid– Secrete parathyroid hormone

The PancreasThe Pancreas

• Organ of both the endocrine system and digestive system

• Produces insulin and glucagon

• Insulin causes uptake and metabolism of sugar, fatty acids, amino acids.

• Glucagon stimulates breakdown of glycogen to glucose.– Also stimulates liver and kidneys to produce

glucose

The Adrenal GlandsThe Adrenal Glands

• Located on top of each kidney

• Secrete:– Sex hormones

– Hormones vital in maintaining water and salt balance

– Adrenaline (mediates “fight-of-flight” response)

– Epinephrine and norepinephrine

The Reproductive Glands and Hormones

The Reproductive Glands and Hormones

• Gonads are ovaries in women and testes in men.

• Major female hormones– Estrogen– Progesterone– Human chorionic

gonadotropin (hCG)

• Ovaries produce estrogen and progesterone.

• Developing fetus manufactures hCG

• Testosterone is produced by testes.– And to smaller

extent by adrenal glands and ovaries

The Digestive System: Anatomy

The Digestive System: Anatomy

The Digestive System: Physiology (1 of 2)

The Digestive System: Physiology (1 of 2)

• In succession, different secretions (primarily enzymes) are added to food by:– Salivary glands

– Stomach

– Liver

– Pancreas

– Small intestine

• Converts food into basic sugars, fatty acids, amino acids

• These products cross wall of intestine and travel through portal vein to liver

• Liver further processes and stores or transports to heart

• Circulatory system then nourishes all cells

The Digestive System: Physiology

The Digestive System: Physiology

The Urinary System: Anatomy and Physiology (1 of 2)


• Controls discharge of waste filtered from blood by kidneys

• Functions– Controls fluid balance in body

– Filters and eliminates wastes

– Controls pH balance



• Components– Kidneys

– Ureters

– Urinary bladder

– Urethra

• This example shows the male urinary system.

The Genital System: Anatomy and Physiology

The Genital System: Anatomy and Physiology

• Controls reproductive processes by which life is created

• Male genitalia lie outside pelvic cavity.– Except for prostate gland and seminal vesicles

• Female genitalia lie inside pelvic cavity.– Except for clitoris and labia

The Male Reproductive System and Organs

The Male Reproductive System and Organs

• Testicles, epididymis, vasa deferentia, penis

• Functions– Reproduction

– Production of sex hormones

– Penis is also part of urinary system

The Female Reproductive System and Organs

The Female Reproductive System and Organs

• Ovaries, fallopian tubes, uterus, cervix, vagina

• Functions– Reproduction

– Production of sex hormones

Life Support Chain (1 of 2)Life Support Chain (1 of 2)

• Body’s cells require:– Oxygen

• Brought by respiratory and circulatory systems

– Nutrients• Food broken down by digestive system into

glucose

• Brought by circulatory system

– Removal of wastes• Removed by circulatory system

Life Support Chain (2 of 2)Life Support Chain (2 of 2)

• Aerobic metabolism uses oxygen.– Only possibility for some cells (eg, heart, brain)

• Anaerobic metabolism does not use oxygen.– Most cells can operate without oxygen for 1 to 3

minutes.

– Lactic acid is a by-product.• Converted back to useful energy source once

oxygen becomes available

Pathophysiology (1 of 4)Pathophysiology (1 of 4)

• Study of functional changes that occur when body reacts to disease

• Airway patency– Can be impaired by blocked airway

– Muscles of breathing can be impaired.

– Decreased level of consciousness can impair ventilation.


• Respiratory compromise– Can be caused by decrease of oxygen in air

– Fluid in alveoli can prevent gas exchange.

– Cells will move to anaerobic metabolism.

– Body can adapt to mild, gradual compromise.

– Severe or prolonged compromise can cause death.


• Shock– Condition in which perfusion is inadequate to

organs and tissue

– Hypovolemic shock results from lack of blood volume (as from trauma).

– Cardiogenic shock results from heart inefficiencies.

– Distributive shock results from issues regarding dilation and constriction of blood vessels.


• Alteration of cellular metabolism– In strenuous exercise, demand for glucose

exceeds supply.

– Body burns fats and turns them into glucose.

– This process is inefficient, but body can sustain for a while.

– If there are breathing or perfusion problems, however, process can cause damage or death.

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Chapter 5 Anatomy, Physiology and Pathophysiology