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Chapter 14
Hallucinogenic Drugs
MescalinePeyote cactus
PsilocybinPsilocybe mushrooms
psilocybin psilocin
LSD
Pharmacology of Hallucinogenic Drugs
LSD Trip (psychological effects)1. Onset
2. Plateau
3. Peak
4. Come-down
Pharmacology of Hallucinogenic Drugs
Physiological effects• Activate sympathetic nervous system
– Dilated pupils– Heart rate increase– Blood pressure increase– Body temperature increase
• Dizziness • Nausea and vomiting
Pharmacology of Hallucinogenic Drugs
Most hallucinogens are 5-HT receptor agonists
If you use a 5-HT receptor antagonists together with a hallunicongen, illusions and hallucinations disappear
Pharmacology of Hallucinogenic Drugs
Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue
Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue
Problems with hallucinogenic drugs
• “Bad Trip”
• Flashbacks
• Psychotic breakdown
Pharmacology of Hallucinogenic Drugs
http://www.antidrug.health.am/img/haluc.jpg
PCP
Dissociative Anesthetics
Ketamine crystals
Dissociative Anesthetics
PCPSelf-administration of PCP into the nucleus accumbens shell by rats
KetamineKetamine administration produces a dose-dependent increase in psychotic-like symptoms