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Changing the Mindset: How to Encourage Faculty to Think About Products and Understand Commercial Needs
Emily Loughran (UCLA), Satish Rao (Columbia), Sunita Rajdev (UCSF), Brian Shedd (LSU) & Ben Dibling (UPenn)
March 3rd, 2017
• “Traditional” Missions of Academic Institutions– Research– Education– Service
• Expanded Missions….– Economic Development– “Impact” on a global scale
• Faculty Focused on Core Activities– Teaching and mentoring – Securing funding – Publishing – Securing tenure
• Common Barriers to Faculty Engagement– Awareness– Ease of Working with the Technology Transfer
Office – Time Commitment
How Does Successful Commercialization Impact the Mission?
– Increased funding support for research programs– Exposure of trainees to the commercial sector– Development of new products and services with
societal impact– Local and national economic growth
Speaker Contact Information
Ben Dibling – [email protected] Loughran – [email protected]
Satish Rao – [email protected] Radjev – [email protected]
Brian Shedd - [email protected]
D6: Changing the MindsetHow to Encourage Faculty to Think about Products and Understand Commercial Needs
Sunita Rajdev, PhDAssociate Director, Licensing
ITA
CTSI
QB3QB3: Startup infrastructure; incubator space; seed investment
Clinical and Translational Sciences Institute: Catalyst Accelerator
ITA: Entrepreneurship Center, IP management & Licensing, Strategic Research Partnerships
UCSF Innovation Engine
CDHI
Center for Digital Health & Innovation
Some UCSF partnerships with translational focus:
• Industry Partnerships• GSK DPAc, Abbvie, Celgene, Daiichi-Sankyo, Pfizer CTI, MedImmune, Cisco, GE
• Non-Profit Partnerships• BioHub, Bluefield, Parker Institute of Cancer Immunotherapy
• UC-wide Collaborative Programs– UC CAI Program, UC Biomedical Research Acceleration, Integration &
Development (UC BRAID), UC Drug Discovery Consortium
CTSI Catalyst Program
REVIEW4 Panels: Rx, Dx,
Devices, D-Health; Review and feedback by panel of industry
experts; Identification of critical next steps
CONSULTATION
Mentoring by industry expert on
how best to achieve critical next steps
PITCH & AWARDS
Presentations; Awards of up to
$100K
INDUSTRY PARTNERSHIPS
Awards of up to $250K; larger collaborations
Catalyst - Unique Multi-Disciplinary Advisory Panel
• Leverages the biotechnology ecosystem of SF Bay area• Engages industry experts as reviewers and advisors on proposals• Panel consists of 200+ members, mainly volunteers• Experts provide customized input based on subject and project needs• New kind of private-public partnership
• Advisors from multiple sources with diverse expertise• Industry• Academia• Intellectual Property• Clinical/Regulatory
• Requirements:• 10 – 20 hours per year to review and consult
Therapeutics
Devices
Digital Health
Diagnostics
Thank [email protected]
Entrepreneurship support - Programs
Medical Device: Coulter-Columbia
Therapeutics: TrX Clean tech: Powerbridge NY
Media: The Combine
Entrepreneurship support - Other resources
Executives Advisors Network
Venture Capital outreachExecutives-in-Residence
CTV internal fund
Translational Fellows Program
Business Leads Capital Space
Outreach and Processes
Visiting faculty department meetings
Postdoc lunch and learns
Standardized startup-friendly licenses
Negotiated discounted and deferred rates for outside
counsel and insurance providers
Lectures and Events on campus
CTV instructed classes –Intellectual Property for
Entrepreneurs, Hacking for Energy
Researcher outreach Streamlined startup licensing Education
EducationResources Student Support
• Technology Commercialization
• Entrepreneurship for Engineers
• Intellectual Property Seminars
• IP Protection & Commercialization
• Grant Writing Assistance• NSF I-Corps• Funding: PoC,
Seed/Angel, VC
• Student Accelerator• Mentorship• Internships• Certificate Programs• Networking &
Collaboration
A focal point for innovation housed within the College of Engineering to deliver value in 3 key areas
LSU LIFT2 Fund“Leverage Innovation for Technology Transfer”
Created by LSU Board of Supervisors in January of 2014 to help across all the campuses of the LSU
system
Gateway to Innovation, Research and Entrepreneurship
Support Services for Entrepreneurs at UCLA Technology Development Group
Emily Loughran
Gateway to Innovation, Research and Entrepreneurship
Table of Contents
• Office Structure and Existing Programs
• Proof of Concept Fund
Gateway to Innovation, Research and Entrepreneurship
New Ventures was formed in 2012 as a dedicated team within TDG to assist external startup companies that license IP from UCLA
Office Organization
New Ventures
LicensingIndustry
SponsoredResearch
Assisting Licensees
Deal Flow
Gateway to Innovation, Research and Entrepreneurship
New Ventures aims to make UCLA startup companies more successful by focusing on three key areas
Goals Activities
• Source opportunities from faculty• Diligence startup potential• Find entrepreneurs• Connect to “Startup in a Box” services (vendors)
Venture Creation
Connections to Funding
Company Growth
• Market to angels / VCs• Host SBIR / STTR workshops• Identify and help prepare for business plan / pitch
competitions• Manage Proof of Concept fund
• Couple with talent / mentors• Provide pitch coaching services• Connect with core facilities and UCLA assets that could
add value
Gateway to Innovation, Research and Entrepreneurship
Startup in a Box connects startups to lawyers, banks, HR services, CROs and accounting services
Example Firms that Participate in the Program
Example Schools Represented in the SIAB Program
Gateway to Innovation, Research and Entrepreneurship
New Ventures hosts First Look LA, a showcase for our newest startups, with 9 other local institutions and universities
Example Companies from Past FLLA
Life Sciences Physical Sciences
Key Components
• 2 sessions of NSF I-Corps ZAP! training
• Pitch Coach brought in by New Ventures
• 10 minute pitches on June 28, 2017 at CNSI in front of entrepreneurs and investors
Gateway to Innovation, Research and Entrepreneurship
We meet with these groups on a quarterly basis as the Entrepreneurship Council to ensure we are working to
synergistically grow entrepreneurship at UCLA
TDG is the hub of entrepreneurship at UCLA, and we work closely with other entrepreneurial groups on campus
Gateway to Innovation, Research and Entrepreneurship
Table of Contents
• Office Structure and Existing Programs
• Proof of Concept Fund
Gateway to Innovation, Research and Entrepreneurship
With the support of UCLA Chancellor Gene Block, UCLA has seeded a proof of concept
fund with $1.7 M from state funds“With the funding being used to provide proof of concept funds, pay entrepreneurs in residence, and support outreach to attract private sector investment, I am confident that UCLA can continue developing the next generation of businesses and industries that will keep our state economically healthy and at the cutting edge of innovation”
- UCLA Chancellor Gene Block
Gateway to Innovation, Research and Entrepreneurship
Licensing Officers identified projects for proof of concept funding
Target Startup Opportunities
Outlicensing/ Entrepreneur
Spinout
Program Management
Proof of Concept Funding
1 2 3 4
• Licensing Officers (TTOs) presented their top technologies– The top technologies were selected for 10 min
presentations to an internal committee – Presentations assessed market, competition, use of
funds, timeline, and aided in establishing reasonable milestones
– Top pitches were presented to an industry-specific Advisory Committee (one for therapeutics and one for medical devices)
Gateway to Innovation, Research and Entrepreneurship
Therapeutics Advisory Panel
Alice Chen, PhDPrincipal at Accelerator Corp.
Melissa Fitzgerald, PhDHead of Strategic Research Partnership at Pfizer
Vijay Murthy, PhDPrinciple, Venture Investments at J&J Innovation
Kanad Das, PhDDirector, Business Development at Merck
Michael Martin, PhDSenior Investment Director at Takeda Ventures
Gateway to Innovation, Research and Entrepreneurship
Medical Device Advisory Panel
Anne Pianca, MS/MBADirector of R&D at Boston Scientific
Widya Mulyasasmita, PhDNew Ventures at J&J California Innovation Center
Javad SeyedzadehRegulatory & Quality Strategic Advisor, Neural Analytics
Jim DreherFounder / Managing Partner at Option3
Paul GrandCEO, MedTech Innovator
Kathryn WillybiroLead for Critical Care Discoveries, Edward Lifesciences
Gateway to Innovation, Research and Entrepreneurship
The funding will support projects that have concrete milestones
Target Startup Opportunities
Outlicensing/ Entrepreneur
Spinout
Program Management
Proof of Concept Funding
1 2 3 4
• Projects across the University will be considered as long as the intellectual property is owned by UCLA
• Precise funding amount will be tied to milestones and vary per project, but may range from $50 – 250 K
• Funding will be internally managed, with preference towards deploying capital to outside firms rather than labs
Gateway to Innovation, Research and Entrepreneurship
Novel Antimicrobial Therapeutics:membrane-disrupting drug-peptide
conjugates
Prof. Andrea KaskoBioengineering
Prof. Gerard WongBioengineering
TOBRAMYCIN
+
DESIGNED PEPTIDE
=
PENTOBRA
Problem: There is an urgent need for new classes of antimicrobial agentsSolution: Renovate existing antibiotics by conjugating a designed cell-disrupting peptide that is specific for the underlying antibiotic molecule
Gateway to Innovation, Research and Entrepreneurship
Multi-frequency Harmonic Acoustography for Tumor Border Detection
Problem: Surgeons must accurately determine tumor margins, often resulting in over or under resectionSolution: Ultrasound-based method that can determine tumor margins intraoperatively
Warren Grundfest, MDProfessor in Bioengineering,
EE, Surgery
Maie St. John, MD, Ph.DAssistant Professor-in-
Residence, Head and Neck SurgeryCo-Director, UCLA Head and Neck
Cancer Program
Gateway to Innovation, Research and Entrepreneurship
Funded Therapeutics ProjectsLead PIs Department Invention
Andrea Kasko GerardWong Bioengineering Novel Antimicrobial Therapeutics: membrane-
disrupting drug-peptide conjugates
William Lowry/ Heather Christofk/ Mike Jung
MCDB; Biological Chemistry; Chem/Biochem
Hair follicle stem cell activation and hair growth by metabolic regulatory
Ohyun Kwon/ Jau-Nian Chen
Chem/Biochem; MCDB
A Novel Target and Small Molecule for Treating Cardiac Fibrillation
Gateway to Innovation, Research and Entrepreneurship
Funded Medical Device ProjectsLead PIs Department Invention
Wentai Liu Bioengineering Bioelectronic medicine – Gastrointestinal Therapeutics for Alleviating Post-Op Ileus
Warren Grundfest / Maie St. John
Bioengineering; Electrical Engin. / Head and Neck Surgery
Multi-frequency Harmonic Acoustography for Tissue Identification and Border
Dejan Markovic / Itzhak Fried
Electrical Engineering / Neurosurgery
Wireless Implantable System to RestoreMemory
Gateway to Innovation, Research and Entrepreneurship
Entrepreneurs in Residence will be responsible for program management
Target Startup Opportunities
Outlicensing/ Entrepreneur
Spinout
Program Management
Proof of Concept Funding
1 2 3 4
• Entrepreneurs in Residence (EIRs) were sourced to manage each project
• New Ventures will manage the funding process, timelines, communication, and review process
• New Ventures will align with the EIRs, faculty, advisory committee, and TTO to establish appropriate milestones and use of money
• New Ventures will have regular meetings with EIRs, TTOs, and funded PIs
Gateway to Innovation, Research and Entrepreneurship
The most successful startups are those founded by a serial entrepreneur or a venture creation firm
Target Startup Opportunities
Outlicensing/ Entrepreneur
Spinout
Program Management
Proof of Concept Funding
1 2 3 4
• The goal of proof of concept funding is to 1) license the IP to an established company or 2) to a startup managed by a successful serial entrepreneur or venture creation firm
• Projects need to be advanced to the point of attracting promising licensees