1. ChallengesforBiomedicalScientists asEntrepreneurs AnAdventurousTour StanleyChang,MD.,Ph.D. CEO,MedigenBiotech 1

2. My Footprints in Medigen Biotech Corp. MedigenBiotechCorp.(2000~2008) StrategicalliancewithProgen ATaiwanbasedr&D Biotech Pharmaceuticals,Australia, Asingleprojectcompanyinitially 2000 SeedsmoneyuptoUSD20M Focusonclinical BroughtPI88fromFDAINDtoPII developmentofnovel EstablishedNATplatform therapiesforcancersand InitiatedbusinessinChina liverdiseases Expandingdevelopmentpipeline EstablishNucleicAcidTest MedigenBiotechCorp.(2009~) (NAT)Platformasthe2nd SecurerevenuefromNATbusiness corebusinessin2005 Establishproductsportfolio OutlicensephaseIIIproject SuccessfullycompletedFDAs PI88HCCPhaseIItrialin Strengthenfinancialposition 2006 IPO 2

3. Major Biomedical Achievements (1900~2004) Controlofreportableendemiccontagiousdiseases Inventionofmicroscopeanddiscoveryofmicroorganisms Findingofpenicillinandotherantibiotics Eliminationoftraditionalcontagiousdiseases Advancesinmedical/surgicaltechnologies Newtreatmentsforchronicandsystemicdiseases Anesthesia,aseptictechniquesandkeyholesurgery Organtransplantationsandartificialorgans Computerassistedmedicalimagingtechnologies Reproductiveandlifecloningtechnologies Testtubebabies Cloningoflives 3

4. The Dream of Biomedical Scientists WhatIhaveinmyprofession Innovation Newconcepts Newdiscoveries Visions Newtechnologies () WhatIcandotohelphumanlives Abetterqualityoflife Translation Ahealthierlivingbody () Ahappierhumanlife Theultimategoalsofabiomedicalscientist Ethics Agreatscientisttocontributetomankind () Thebonusofscientificachievements,ifsuccessful Reputation Application Financialrewards () 4

5. The Character of Biotechnology R&Dbasedinnovationsandimprovements IPandknowhowdependent Capitalintensiveinvestment Globalcompetitions Inherentlyrisky Potentiallyhighrewards Winnertakesall 5

6. Biotech Stories- Good and Bad GenentechBiotech InsulinandHerceptin AcquiredbyRocheatUS$41B AmgenBiotech Erythropoietin(EPO) NorthfieldLaboratories,Inc.(1985~2009) US$41.5/share(2/29/00),US$0.17/share(6/1/09) Bloodsubstitute(incurredloss:USD220M) TargetedGeneticsCorp.(1992~2009) US$280/share(1/31/00),US$0.23/share(6/1/09) Genetherapy(incurredloss:USD322M) Nanogen Inc.(1993~2009) US$101/share(2/29/00),US$0.04/share(6/1/09) DiagnostickitsforCVdiseases(incurredloss:USD400M) 6

7. Prerequisites for Biomedical Business Yourself Solidbiosciencebackground Generalsocialawarenessandskill Fundamentalbusinessknowledge Basicmanagerialexperience Thereadinessforchallenges Thecouragetoacceptfailure Beyondyourself Corecompetence Businessmodel/plan Corporatestrategies Funding Humanresource Riskmanagement 7

8. Chapter 1 Build Basic Human Character C commitment H honesty A accountability R respect A attitude C courage T trust E ethicsandintegrity R responsibility 8

9. Chapter 2 Build Entrepreneurship Vision Tenacity Determinant Execution Curiosity Courage Creativity Character Communicability Conviction Charisma Common Sense Competence Crisis Management 9

10. Chapter 3 Make a Healthy Start-up Proprietaryandcuttingedge Doableandprofitable Products/pipeline Strategies Deepandcommitted Pocket Thoroughandcomprehensive Competentandreliable Patents Team 10

11. Chapter 4 Find a Balance in Yourself Biomedicalprofessionalsare mosttalent,faraboveaverage usuallyinnovativeandcreativeinmedical/lifescience generallykindandoptimistic,butmaybenavesometimes honestandstraightforwardincommunicationandrelationships relativelypoorinmanagement,humanskillsandfinance Businessmenare evenmoretalentthantheaveragemedicalprofessionals veryinnovativeingettingotherpeoplesmoneyintotheirpockets commonlyopportunisticandcunning rarelydecent,andalwayshavepersonalagendas profitdriven,practicalandsometimesbloody borntobebusinessmen 11

12. Chapter 5 Do Things Right Experience=Time+Money Stayfocused,focusedandfocused Dontcountonasingleexpert,countonateam Goodprojectscomewithaprice;therearenofreemeals Alwaysrefertofactsandevidence;doeverythingbythebook Wheninhesitation,followthelogic,notyourwhim Whenindoubt,choosenottoinvest/involve DaretosayNO,savingmoneyismorecrucialthansavingface Poweryouprojectwithpassionandsufficientresource Atthefirstsignofaninjury,stopthebleedingimmediately Rewardthosewhodeserved,notthosewhoyouliked Staycalmandpatient,Romeisnotbuiltinaday Dontbefrustrated,evenbigpharma makemistakes 12

13. Roadmaps of Biotech Business 13

14. Are You Ready ? EssentialAbilitiestoLearnandBuildintheschool Scientificreasoningandlogicthinkingability Masteringprofessionalknowledgeandskills Goodcommandofnativeandforeignlanguages Roundnessinpersonalcharactersandhumanities Skillsofcommunication,expressionandteamwork Multidisciplinaryknowledgeandexpertise Abilitytodeliverandtoexecute Lifelonglearning ~Chancesareonlyforthosewhoarereadytotake~ 14

15. Suggested Reading GoodtoGreat byJimCollins Level5Leadership FirstWhoThenWhat ConfronttheBrutalFacts TheHedgehogConcept ACultureofDiscipline TechnologyAccelerators ThinkBIGActSmall byJasonJennings BlueOceanStrategy byW.ChanKimandReneeMauborgne -- -- 15

16. Tips from the Experienced Top10mistakesbiotechsmake ByStephenFerruolo,JD. Partner,BusinessLawDepartmentatGoodwinProcter Commoncausesofbiotechfailure NotthinkingstrategicallyaboutIP Notunderstandingthetargetmarket Notraisingenoughmoney Nothavingaregulatorystrategy NotlisteningtotheFDA Designingtrialspoorly Notproperlypoweringtrials Relyingheavilyonthirdparties,especiallyCROs Notbeingreadyforsuccess Notknowingwhentopartner 16

17. ~ Innovations for a Better Life ~ 17