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Session: 2016-17
1
Schemes of Examinations
&
Syllabi
of
M. Pharmacy
for
Pharmacology
(2016-2017)
Ch. Bansi Lal University, Bhiwani
Session: 2016-17
2
Ch. Bansi Lal University, Bhiwani
Scheme of Examination for M. Pharmacy -Pharmacology
Semester-I Credits: 34 Marks: 750
Paper
Code
Subjects
Type
of
Course
Contact Hours Per Week Credits Examination Scheme Total
Theory Practical Total Theory Practical Total Internal
Assessment
Theory Practical
MPP-101 Modern Analytical
Techniques-I (MAT-I)
C.M.C 04 -- 04 04 -- 04 20 80 100
MPP-102 Pharmacology and
Therapeutics
C.C 04 -- 04 04 -- 04 20 80 100
MPP-103 Pharmacological
Techniques
C.C 04 -- 04 04 -- 04 20 80 100
MPP-104 Drug Discovery and
Toxicology
C.C 04 -- 04 04 -- 04 20 80 100
MPP-105 Biostatistics I.D.C 04 -- 04 04 -- 04 20 80 100
MPP-106 Practical (MAT-I) C.M.C - 06 (6X1) 06 -- 03 03 -- - 100 100
MPP-107 Practical Pharmacology
(MPP-102-104)
C.C - 18 (6X3) 18 -- 09 09 -- - 100 100
MPP-108 Seminar/ Journal Club C.C 03 -- 03 -- -- 01 -- -- -- 25
MPP-109 Self-study Paper C.C -- -- -- -- -- 01 -- -- -- 25
Total 23 24 47 20 12 34 100 400 200 750
Session: 2016-17
3
Scheme of Examination for M. Pharmacy -Pharmacology
Semester-II Credits: 34 Marks: 750
Paper
Code
Subjects
Type
of
Course
Contact Hours Per Week Credits Examination Scheme Total
Theory Practical Total Theory Practical Total Internal
Assessment
Theory Practical
MPP-201 Modern Analytical
Techniques-II (MAT-II) C.C 04 -- 04 04 -- 04 20 80 100
MPP-202 Clinical Pharmacology C.C 04 --- 04 04 04 20 80 100 MPP-203 Drug Designing and
Pharmacogenomics C.C 04 -- 04 04 -- 04 20 80 100
MPP-204 Molecular Pharmacology C.C 04 -- 04 04 -- 04 20 80 100 MPP-205 Advances in Pharmacology C.M.C 04 - 04 04 -- 04 20 80 - 100 MPP-206 Practical (MAT-II) C.C 06 (6X1) 06 -- 03 03 -- -- 100 100 MPP-207 Practical Pharmacology
(MPP-202-204) C.C -- 18 (6X3) 18 -- 09 09 -- -- 100 100
MPP-208 Seminar/ Journal
Club/Synopsis C.C 3 - 3 - - 01 - - 25
MPP-209 Self-Study Paper C.C - - - - - 01 - - - 25
Total 23 24 47 20 12 34 100 400 200 750
Session: 2016-17
4
Scheme of Examination for M. Pharmacy -Pharmacology 3
rd Semester Credits: 23 Marks: 225
PART-I (DISSERTATION WORK)
Paper
Code Subject
Contact
Hours
Credits
Examination Marks Max. Marks
Internal External
MPP-301 Pharmaceutical Entrepreneurship 04 04 20 80 100
MPP-302 Midterm Evaluation/Presentation/Viva voce -- -- -- 100 100
MPP-303 Journal Club (One Research Paper Per Student) 02 1 25 - 25
MPP-304 Research Work 36 18 - - -
Total 42 23 45 180 225
4th
Semester Credits: 23 Marks: 250
PART-II (DISSERTATION WORK)
Paper
Code
Subject Contact
Hours
Credits
Examination Marks Max. Marks
Internal External
MPP-401 Intellectual Property Rights 04 04 20 80 100
MPP-402 Journal Club (One Research Paper Per Student) 02 01 25 25
MPP-403 Research Work 36 18
MPP-404 Dissertation Evaluation by External Examiner - - - 100 100
MPP-405 Dissertation / Final Presentation & Viva voce - 50 50
Total 42 23 45 230 275
Duration- 02 years (04 semesters)
Total Marks- 2000
Total Credits- 114
Session: 2016-17
5
M. Pharmacy (Pharmacology)
Semester 1
MPP-101
Modern Analytical Techniques -I (MAT- I)
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
UV-Visible spectroscopy: Brief review of electromagnetic spectrum, UV-Visual range,
energy-wavelength colour relationships. Interaction of electro - magnetic radiation (UV-Vis)
and matter and its effects, Chromophores and their interaction with EMR, Woodward-Fieser
rule, Absorption spectra of organic compounds and complexes illustrating the phenomenon
and its utilization in qualitative and quantitative studies of drugs, Beer-Lambert‟s law, Shifts
and their interpretation (including solvent effects). Multi component analysis, derivative
spectroscopy.
Spectrofluorimerty: Fluorescence, Phosphorescence, Chemiluminescence-Theory,
instrumentation and applications. (9 Lectures)
UNIT-II
Infra-Red Spectroscopy: Nature of Infra-red radiation, Interaction of IR radiation with
organic molecules and effects on bonds, Molecular or infra-red spectra, Brief outline of
classical IR instrumentation and interpretation of spectra, including sample preparation for
spectroscopy, Qualitative interpretation of IR Spectra, Influence of substituents, ring size,
hydrogen bonding vibrational coupling and field effect on frequency, Quantitative methods,
FT-NIR and applications. Recent advances in IR Spectroscopy.
Raman spectroscopy- Principle, Instrumentation and applications.
Laser Spectroscopy: Introduction, principle, instrumentation and applications. (9 Lectures)
UNIT-III
Chromatographic Techniques: Introduction and classification.
High performance TLC – Principle, adsorbents, retention and separation parameters,
detection methods, quantitative and quantitative HPTLC.
Gas Chromatography: Introduction, Principles, Instrumentation, carrier gas, types of
columns, column selection- liquid stationary phases, column efficiency parameters, the Van
Deemter equation, Resolution, Derivatisation methods, Detectors. A critical comparison of
sensitivity, selectivity and field of applications of these detectors. Applications of GC in
Pharmaceutical sciences. (9 Lectures)
Session: 2016-17
6
Unit-IV
Liquid Chromatography: Instrumentation, columns, packing materials, column selection,
mobile phase selection, efficiency parameters, resolution and optimization of
chromatographic parameters. Detectors in HPLC: Comparison of sensitivity, selectivity and
field of applications of these detectors. Modes of HPLC-Ion pair, Ion-exchange, Size
exclusion, Supercritical, Chiral, Gel-permeation, Flash chromatography. Applications of
liquid chromatography. Ultra Performance Liquid Chromatography.
Emission Spectrometry (Atomic Absorption Spectrometry, Flame Photometry).
(9 Lectures)
Reference books:
1. Principles of Instrumental Analysis, 5th Ed., D.A. Skoog, F.J. Holler and T. A. Nieman.
2. "Spectrometric Identification of Organic Compounds" Silverstein, R.M., Bassler &
Morril 5th Ed., 1991.
3. Instrumental Methods of Analysis, H.H. Willard, L.L Merritt, J.A. Dean, F.A. Settle,
7th Ed.
4. Pharma Analysis, Modern Methods - (Ed) James W Munson Part-B, Vol. -2.
5. Drugs & Pharma, Sciences Series, Marcel Dekker Inc.
6. “Applications of absorption spectroscopy of organic compounds” by John R. Dyer.
7. “Contemporary practice of chromatography” by Poole, Colin F. and Sheila A. Schuette.
8. Ewing‟s Analytical Instrumentation Handbook, edited by Jack Cazes, CRC press.
9. “Practical HPLC method development” by L. R. Snyder Willey Interscience, Second
Ed.
10. Aldrich FT-IR Spectral Library.
11. “Pharmaceutical Analysis” by David C. Lee Blackwell Publisher.
Session: 2016-17
7
M. Pharmacy (Pharmacology)
Semester 1
MPP-106
Practical (MAT)
Maximum Marks: 100
Time: 06 hrs/week
1. Use of UV Vis spectrophotometer for analysis of Pharmacopoeial compounds and
their formulations.
2. Simultaneous estimation of multi component containing formulations by UV
spectrophotometry.
3. Effect of pH and solvent on UV spectrum of certain drugs.
4. Experiments on factors affecting the absorbance/fluorescence in UV spectroscopy/
Fluorimetry.
5. Interpretation of IR spectra
6. Experiments based on various chromatography techniques for separation of mixture
of compounds.
7. Any other practical based on aforementioned theory.
Reference books:
1. Principles of Instrumental Analysis, 5th Ed., D.A. Skoog, F.J. Holler and T. A.
Nieman.
2. "Spectrometric Identification of Organic Compounds" Silverstein, R.M., Bassler &
Morril 5th Ed., 1991.
3. Instrumental Methods of Analysis, H.H. Willard, L.L Merritt, J.A. Dean, F.A. Settle,
7th Ed.
4. Pharma Analysis, Modern Methods - (Ed) James W Munson Part-B, Vol. -2.
5. Drugs & Pharma, Sciences Series, Marcel Dekker Inc.
6. “Applications of absorption spectroscopy of organic compounds” by John R. Dyer.
7. “Contemporary practice of chromatography” by Poole, Colin F. and Sheila A.
Schuette.
8. Ewing‟s Analytical Instrumentation Handbook, edited by Jack Cazes, CRC press.
9. “Practical HPLC method development” by L. R. Snyder Willey Interscience, Second
Ed.
10. Aldrich FT-IR Spectral Library.
11. “Pharmaceutical Analysis” by David C. Lee Blackwell Publisher.
Session: 2016-17
8
M. Pharmacy (Pharmacology)
Semester 1
MPP-102
PHARMACOLOGY AND THERAPEUTICS
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Introduction to Pharmacology:
Pharmacokinetics: The dynamics of drug absorption, distribution and elimination with
special reference to factors affecting drug metabolism.
Pharmacodynamics: (Mechanisms of drug action and the relationship between drug
concentration and effect) Mechanisms of drug actions: Receptors, Structural and functional
families of receptors, Signal transduction through cytoplasmic second messengers, receptor
regulation, Classification of receptors, Methods of receptor characterization. Quantitation of
drug-receptor interactions and elicited effect. Autonomic Nervous System. (9 Lectures)
UNIT-II
Pathophysiology and Drug Therapy of Cardiovascular Disorders
Angina, arrhythmia, congestive heart failure, hyperlipoproteinemias andhypertension.
Drug Therapy of Endocrine Disorders
Disorders of thyroid gland, adrenal gland, diabetes mellitus, gonadal hormones and
contraceptives. (9 Lectures)
UNIT-III
Pathophysiology and Drug Therapy of Neurological and Psychiatric Disorders
Alzhiemer's disease, anxiety, depression, epilepsy, Huntington‟s disease, Parkinson's disease
and schizophrenia.
Pain and Inflammation
Drugs used in the treatment of osteoarthritis, gout and NSAIDs.
Pathophysiology and Drug Therapy of Gastrointestinal Disorders
Peptic ulcers, Helicobacter pylori and inflammatory bowel disease.
Pathophysiology and Drug Therapy of Respiratory Disorders
Asthma, tuberculosis COPD and Cough. (9 lectures)
Session: 2016-17
9
UNIT-IV
Chemotherapy of Microbial and Parasitic Diseases
Sulfonamides, quinolones, chloramphenicol, aminoglycosides, tetracyclines,penicillins,
cephalosporins, antiviral, antifungal, helminthiasis, malaria, leprosy,tuberculosis and
antineoplastic agents. Protozoal and Leishmania.
Multi-drug resistance, mechanism and drug resistant tuberculosis and malaria, antimicrobial
and anticancer. (9 Lectures)
Reading Material Recommended:
1. Brunton L.L., Lazo J.S. and Parker K.L., Eds. Goodman & Gilman‟s The
Pharmacological Basis ofTherapeutics. McGraw-Hill, New York. Latest Edition.
2. Katzung B.G. Basic and Clinical Pharmacology. Lange/McGraw-Hill Medical
Publications, NewYork. Latest Edition.
3. Kalant H. and Roschlan WHE. Principles of Medical Pharmacology. Oxford
University Press,New York. Latest Edition.
4. Rang H.P., Dale M.M. and Ritter J.M. Pharmacology. Churchill Livingstone,
New York. LatestEdition.
5. Sharma H.L. and Sharma K.K. Principles of Pharmacology. Paras Publisher,
Delhi. LatestEdition.
6. Shargel L., Mutnick A.H., Souney P.F. and Swanson L.N. Comprehensive
Pharmacy Review.Wolters Kluwer Health / Lippincott William & Wilkins, New
Delhi. Latest Edition.
7. Dipiro J.T., Talbert R.L., Yee G.C., Matzke G.R., Wells B.G. and Posey L.M.,
Eds.Pharmacotherapy: A Pathophysiologic Approach. McGraw-Hill, New York.
Latest Edition.
8. Gudman & Gillman
Session: 2016-17
10
M. Pharmacy (Pharmacology)
Semester 1
MPP-103
PHARMACOLOGICAL TECHNIQUES
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Development and Scope of Experimental Pharmacology: CPCSEA guidelines to conduct experiments on animals, Animal house: Design and
facilities to maintain the animals, Common laboratory animals, breeding methods,
anesthesia& euthanasia of experimental animals, different routes of drug administration.
Alternatives to Animal Screening
Cell lines and other in-vitro techniques (ELISA, PCR techniques). (9 Lectures)
UNIT-II
Biological assays
Bioassay, various types of bioassays, advantages and limitations of bioassays with suitable
examples
Immunoassays: General principles and procedures of immunoassays. Immunoassay for
digoxin and insulin
Genetically Modified Animals as Tools of Experimental Pharmacology Transgenic animals and their applications in drug discovery, techniques involved in
transgenic technology and gene knockout, gene knockdown and gene silencing animals.
(9 Lectures)
UNIT-III
Experimental Techniques Employed in the Screening of Drugs Belonging to Following
Categories-I Antipsychotics, antianxiety agents, nootropics, antidepressants, antiparkinsonianagents,
antiepileptics, analgesics and anti-inflammatory agents.
Antidiabetic and antiobesity drugs. (9 Lectures)
UNIT-IV
Experimental Techniques Employed in the Screening of Drugs Belonging to Following
Categories-II Antianginals, antiarrhythmics, antiatherosclerotics, antihypertensive agents and drugs for
myocardial infarction.
Antiulcer, antimalarial and anthelmintic agents.
Hepatoprotectives and renoprotectants.
Evaluation of antioxidant profile (Biochemical estimation). (9 Lecture)
Session: 2016-17
11
Books Recommended:
1. Remington’s Pharmaceutical Sciences 20th edn.
2. Bartfai T. and Lee G.V. Drug Discovery. Elsevier, New York. Latest Edition.
3. Huang Z. Drug Discovery Research. Wiley Inter Science, USA. Latest Edition.
4. Evans R.P., Drug and Biological Development. Springer, USA. Latest Edition.
5. Ricky N.G. Drugs from Discover to Development. Wiley-Blackwell, USA.
Latest Edition.
6. Evaluation of drug activities: Pharmacometrics by D R Laurence and A L
Bacharach Vol1 and 2 Academic Press, London, U.K., 1964.
7. Drug Discovery and Evaluation Pharmacological Assay by Vogel H G and
Vogel W H (Springer publication)
8. Kulkarni S.K. Handbook of Experimental Pharmacology. Vallabh Prakashan,
New Delhi. Latest Edition.
9. Modern drug research- Paths to better and safe drugs (Medicinal Chemistry vol
9) by Y C Martin, E. Kutter and V. Austel
10. Modern Methods of Drug Discovery by Hillisch, A and Hilgenfeld, R
11. David R. Gross, Animal Models in Cardiovascular Research, 2nd
edition,
Kluwer Academic Publishers, London, U.K., 1994.
Session: 2016-17
12
M. Pharmacy (Pharmacology)
Semester 1
MPP-104
DRUG DISCOVERY AND TOXICOLOGY
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Introduction to Drug Discovery: History of drug discovery, sources of drugs (plants, animals, microorganisms, drugs from
organic synthesis), existing drugs as a source of new drug, lead identification and
optimization.
Preclinical Studies and Drug Development
Stages of drug discovery, phase zero, pre-clinical and safety evaluation, acute, sub-acute,
chronicstudies, in-vivo and in-vitro studies (behavioral, biochemical, neurochemical
models)and special studies including carcinogenicity, mutagenicity, teratogenicity.
(9 Lectures)
UNIT-II
Novel Drug Targets for Drug Discovery: Exploration and investigation of therapeutic drug targets as enzymes, receptors, genes,
platelets and matrix metalloproteases for drug design. (9 Lectures)
UNIT-III
Toxicology:
Concept, development and scope of toxicology, behavioural and neurotoxicity, teratology,
endotoxin, pesticides, cardiac, hepatic, renal and pulmonary toxicity. Industrial,
environmental and forensic toxicology, clinical toxicology, principles andmanagement of
different types of poisoning, toxicity reactions, Reproductive toxicology assessment,
relationship between maternal and developmental toxicity, target organ toxicity like kidney,
liver, cardiac and endocrine toxicity, OECD guidelines, Principle of GLP. (9 Lectures)
UNIT-IV
Immunotherapy: Introduction to immune system, cellular and humoral immunity,
complement, antigen-antibody interactions, immunity to bacteria, virus, protozoa, and fungi,
immunomodulators and immunosuppressants and their use in autoimmune disorders,
principles and development of vaccines against different diseases. (9 Lectures)
Session: 2016-17
13
Books Recommended:
1. Bartfai T and Lee GV. Drug Discovery. Elsevier, New York. Latest Edition.
2. Huang Z. Drug Discovery Research. Wiley Inter Science, USA. Latest Edition.
3. Evans RP, Drug and Biological Development. Springer, USA. Latest Edition.
4. Ricky NG. Drugs from Discover to Development. Wiley-Blackwell, USA.
5. Ballantyne B, Marrs T and Turner P. General and Applied Toxicology. Macmillan
Press Ltd., London. Latest Edition.
6. Practical approaches in toxicity studies by Poole and Leslie
7. Alternatives to animals in toxicity testing. Scientific American 26: (1989), 16-22.
8. Goldsby RA, Kindt TJ and Osborne BA. Kuby‟s Immunology. WH Freeman Book,
New York. Latest Edition.
9. Klaasen KCD and Amdur MA. Casarett&Doul's Toxicology. Mcmillan Press Ltd.,
London. Latest Edition.
10. Kulkarni S.K. Handbook of Experimental Pharmacology. Vallabh Prakashan, New
Delhi. Latest Edition.
Session: 2016-17
14
M. Pharmacy (Pharmacology)
Semester 1
MPP-105
BIOSTATISTICS
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
Unit I
Probability and Descriptive Statistics Scientific notation: significant digits, rounding off,
scientific notation, Error analysis; Counting and Probability: Addition rules; Permutations;
Combinations; Inclusion-exclusion rule; Sampling with and without replacement;
Conditional probability: Bayes‟ theorem; Independence; Descriptive statistics and Random
variables; Measures of central tendency: mean, median, mode; Expectation; Measures of
spread: range, percentile, standard deviation; Higher moments: kurtosis, skew, Displaying
data: Histograms, stemand-leaf plots, box plots, frequency distributions; Discrete random
variables: Bernoulli, Binomial, Poisson; Geometric distributions; Continuous random
variables: Normal; Exponential distributions; Standard normal distribution. (9 Lectures)
Unit II
Inferential statistics and one sample hypothesis testing Samples and populations: Random,
stratified and cluster sampling; Single- and Double-blind experiments; Point and interval
estimates; Sampling distributions: t, chi-square, F distributions; Hypothesis testing: null and
alternative hypotheses, decision criteria, critical values, type I and type II errors, Meaning of
statistical significance; Power of a test; One sample hypothesis testing: Normally distributed
data: z, t and chi-square tests; Binomial proportion testing. (9 Lectures)
Unit III
Multi-sample and nonparametric hypothesis testing two sample hypothesis testing;
Nonparametric methods: signed rank test, rank sum test; Kruskal-Wallis test; Analysis of
variance:One-way ANOVA (9 Lectures)
Unit IV
Curve fitting Regression and correlation: simple linear regression; Least squares method;
Analysis of enzyme kinetic data; Michaelis-Menten; Lineweaver-Burk and the direct linear
plot; Logistic Regression; Polynomial curve fitting.
Design of Experiments Single factor experiments; Randomized block design; Lackett-
Burman Design; Comparison of k treatment means; Factorial designs; Blocking and
confounding; Response surface methodology. (9 Lectures)
Session: 2016-17
15
Texts/References
1. Bernard Rosner, Fundamentals of Biostatistics, 5th Edition, Thomson Brooks/Cole,
2000.
2. Richard A. Johnson, Probability and Statistics for Engineers, 6th Edition, Prentice
Hall, 2000.
3. Morris H. DeGroot, Mark J. Schervish, Probability and Statistics, 3rd Rev. Edition,
Addison-Wesley, 2002.
4. E. Kreyszig, Advanced Engineering Mathematics, 9th Edition, John Wiley, 2006.
Session: 2016-17
16
M. Pharmacy (Pharmacology)
Semester 1
MPP-107
PRACTICAL PHARMACOLOGY
Maximum Marks: 100
Time: 18 hrs
1. Principles of Experimental Pharmacology:
a) Experimental animals in pharmacological research
b) Care, use and housing of experimental animals, CPCSEA guidelines
c) Standard techniques used in experimental animals
d) Euthanasia, anaesthetics and analgesics used in experimental animals
2. Qualitative study of agonists and antagonists on isolated muscle preparations like
fundus strip, uterus, tracheal chain, vas deferens, anococcygeus muscle, ileal
preparations
3. ED50, pA2, pD2, value determinations of agonists and antagonists on isolated muscle
preparations like fundus strip, uterus, tracheal chain, vas deferens, anococcygeus
muscle, ileal preparations
4. Bio-assays of Autonomic drugs and Autacoids and other practicals pertaining to the
theory syllabus.
5. Bioassay of Ach by interpolation, matching and bracketing methods
6. Bioassay of Ach by 3-point and 4-point methods.
7. Bioassay of histamine by 4-point or 3-point methods.
8. Bioassay of oxytocin by 3- or 4-point methods.
9. Bioassay of d-tubocurarine by cumulative method.
10. Bioassay of 5-HT by 3- or 4- point methods.
11. To study the myelosuppressive effects of anticancer agent
12. To study the effect of prokinetic agents on gastric emptying
13. Immunoassays through Elisa.
Preclinical Screening:
1. General techniques involved in experimental Pharmacology.
Screening of drugs, with appropriate statistical tests, for the following activities:
2. Analgesic by hot plate, tail flick, tail dip and writhing methods.
3. Anti-inflammatory drugs by rat paw edema method and cotton pallet granuloma
4. Antipyretics by yeast induced pyrexia in rats.
5. Antiepileptic drugs by MES & PTZ models.
6. Local anaesthetics drugs by infiltration, nerve plexus and surface anaesthesia methods.
7. To study the effect of hepatic microsomal enzyme induction and inhibition by recording
the duration of pentobarbital sleeping time
8. To study the apomorphine-induced compulsive behaviour (stereotype) in mice.
9. To study the antianxiety effect of drugs in mice using elevated plus-maze apparatus, Y
maze, Audiogenic chamber and Hebb‟s rectangular maze
10. To study the phenothiazine-induced catatonia in rats.
11. To study the anti-secretory and ulcer-protective effect of drugs in pylorus ligated rats.
12. Myelosuppressive activity of a drug through determination of hematological parameters
in rats.
Session: 2016-17
17
Toxicity studies:
1. Problem solving exercises on acute toxicity test to find out LD50 of a drug.
2. Brine-shrimp lethality bioassays
3. Drug Mutagenicity study using Mice bone-marrow chromosomal aberration test
4. Drug Mutagenicity study using Mice bone-marrow micronucleus test.
5. Histopathology of organs.
Books Recommended:
1. Remington’s Pharmaceutical Sciences 20th edn.
2. Bartfai T. and Lee G.V. Drug Discovery. Elsevier, New York. Latest Edition.
3. Huang Z. Drug Discovery Research. Wiley Inter Science, USA. Latest Edition.
4. Evans R.P., Drug and Biological Development. Springer, USA. Latest Edition.
5. Ricky N.G. Drugs from Discover to Development. Wiley-Blackwell, USA. Latest
Edition.
6. Evaluation of drug activities: Pharmacometrics by D R Laurence and A L Bacharach
Vol1 and 2 Academic Press, London, U.K., 1964.
7. Drug Discovery and Evaluation Pharmacological Assay by Vogel H G and Vogel W
H (Springer publication)
8. Kulkarni S.K. Handbook of Experimental Pharmacology. Vallabh Prakashan, New
Delhi. Latest Edition.
9. Modern drug research- Paths to better and safe drugs (Medicinal Chemistry vol 9) by
Y C Martin, E. Kutter and V. Austel
10. Modern Methods of Drug Discovery by Hillisch, A and Hilgenfeld, R
11. David R. Gross, Animal Models in Cardiovascular Research, 2nd
edition, Kluwer
Academic Publishers, London, U.K., 1994.
Session: 2016-17
18
M. Pharmacy (Pharmacology)
Semester 2
MPP-201
Modern Analytical Techniques-II (MAT-II)
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Nuclear Magnetic Resonance Spectroscopy: Fundamental principles of NMR (Magnetic
Properties of nuclei, applied field and precession, absorption and transition frequency).
Chemical shift concept, Isotopic nuclei, Reference standards, proton magnetic spectra, their
characteristics, presentation, terms used in describing spectra and their interpretation (signal
no., position, intensity), Brief outline of instrumental arrangements and some practical
details, Signal multiplicity phenomena in high resolution PMR, Spin-spin coupling,
Application of Signal Splitting and coupling constant data to interpretation of spectra,
Decoupling and shift reagent methods. Quantitative NMR. Brief outline of principles of 13C
NMR. Introduction to 2-D NMR Techniques. Applications of NMR technique in
Pharmaceutical sciences. (9 Lectures)
UNIT-II
Mass Spectrometry: Basic principles and brief outline of instrumentation. Ion formation
and types, molecularion, meta stable ions, fragmentation processes, Fragmentation patterns
and fragment characteristics in relation to parent structure and functional groups, Relative
abundances of isotopes and their contribution to characteristic peaks, Mass spectrum, its
characteristics, presentation and interpretation, Chemical ionisation mass spectrometry, ESI,
Ion-trap,. FAB mass spectroscopy. Applications of mass spectrometry. (9 Lectures)
Unit-III
X-Ray Diffraction Methods: Elementary crystallography, X-Ray diffraction, Bragg‟s law,
X-Ray powder diffraction, X-Ray powder diffractometer- interpretation of data.
Thermal Analysis: Principles and applications of thermogravimetric analysis (TGA),
Differential thermal analysis (DTA) and Differential scanning Calorimetry (DSC).
(9 Lectures)
Unit-IV
Electrophoresis: Principle, techniques, instrumentation including detection strategies and
applications
Hyphenated techniques: Brief introduction (LC-MS, GC-MS, GC-IR, LC-NMR and GC-
NMR) and applications.
Radioimmunoassay Assay and ELISA: Principle, instrumentation and applications.(9
Lectures)
Session: 2016-17
19
Reference books:
1. Principles of Instrumental Analysis, 5th Ed., D.A. Skoog, F.J. Holler and T. A.
Nieman.
2. "Spectrometric Identification of Organic Compounds" Silverstein, R.M.,
Bassler&Morril 5th Ed., 1991.
3. Instrumental Methods of Analysis, H.H. Willard, L.L Merritt, J.A. Dean, F.A. Settle,
7th Ed.
4. Pharma Analysis, Modern Methods - (Ed) James W Munson Part-B, Vol -2.
5. Drugs &Pharma, Sciences Series, Marcel Dekker Inc.
6. “Applications of absorption spectroscopy of organic compounds” by John R. Dyer.
7. “Contemporary practice of chromatography” by Poole, Colin F. and Sheila A. Schuette.
8. Ewing‟s Analytical Instrumentation Handbook, edited by Jack Cazes, CRC press.
9. “Practical HPLC method development” by L. R. Snyder Willey Interscience, Second
Ed.
10. Aldrich FT-IR Spectral Library.
11. “Pharmaceutical Analysis” by David C. Lee Blackwell Publisher.
Session: 2016-17
20
M. Pharmacy (Pharmacology)
Semester 2
MPP-206
Practical (MAT-II)
Maximum Marks: 100
Time: 06 hrs/week
1. Interpretation of NMR and Mass spectra.
2. Experiments Based on flame photometry.
3. Any other practical based on aforementioned theory.
Reference books:
1. Principles of Instrumental Analysis, 5th Ed., D.A. Skoog, F.J. Holler and T. A.
Nieman.
2. "Spectrometric Identification of Organic Compounds" Silverstein, R.M., Bassler &
Morril 5th Ed., 1991.
3. Instrumental Methods of Analysis, H.H. Willard, L.L Merritt, J.A. Dean, F.A. Settle,
7th Ed.
4. Pharma Analysis, Modern Methods - (Ed) James W Munson Part-B, Vol -2.
5. Drugs & Pharma, Sciences Series, Marcel Dekker Inc.
6. “Applications of absorption spectroscopy of organic compounds” by John R. Dyer.
7. “Contemporary practice of chromatography” by Poole, Colin F. and Sheila A.
Schuette.
8. Ewing‟s Analytical Instrumentation Handbook, edited by Jack Cazes, CRC press.
9. “Practical HPLC method development” by L. R. Snyder Willey Interscience, Second
Ed.
10. Aldrich FT-IR Spectral Library.
11. “Pharmaceutical Analysis” by David C. Lee Blackwell Publisher.
Session: 2016-17
21
M. Pharmacy (Pharmacology)
Semester2
MPP-202
CLINICAL PHARMACOLOGY
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Principles and advancements in the following topics:
Introduction to Clinical Pharmacology
Definition, scope and development of clinical pharmacology, role of pharmacist in
healthcare system, prescription monitoring and national drug policy,
pharmacoepidemiology, pharmacovigilance, patient counselling, medication errors and drug
information systems, BA/BE studies.
Concepts of Pharmaceutical Care and its Implementation
Plan, components and challenges, communication and behavioural skills in clinical
pharmacology practice. (9 Lectures)
UNIT-II
Drug Therapy in Specialized Patient Populations
Neonates: Special childhood diseases and their management, national immunization
programmes, relevant paediatric management issues as dosages adjustment,
pharmacokinetics and compliance.
Geriatrics: Pharmaceutical care plan based on age related physiological and
pharmacokinetic/pharmacodynamic changes, compliance related issues.
Pregnancy and Lactation: Guidelines and principles of drug therapy during pregnancy and
lactation. Management of hypertension, diabetes, epilepsy etc. during pregnancy. (9 Lecture)
UNIT-III
Clinical Trials:
a) GCP, ICH & ICMR guidelines to conduct clinical trials
b) Requirements of clinical trials, Helsinki declaration, ethical and legal issues
inclinical trials.
c) Design (placebo, multicentre clinical trials, randomization, blinding) and different
phases of clinical trials (Phase 1 to 4), principles of controlled clinical trials.
d) Protocol designing, CRF, patient informed consent, patient enrolment, inclusion and
exclusion criteria, withdrawals and drop out, run-in period.
e) Clinical trial team, monitoring of clinical trial, report preparation, deviations
inclinical trials.
f) Clinical data management and publishing research studies.
g) Orphan drugs
Session: 2016-17
22
h) Institutional Ethics Committee (IEC), DSMB/IRB
i) Compensation in clinical trial (9 Lectures)
UNIT-IV
Adverse Drug Reactions
Incidence, importance, surveillance and their monitoring, WHO ADR reporting programmes
in India and drug interactions.
Pharmacoeconomics: Cost and outcomes research and its potential applications in health
and medicine, types of cost like marginal cost, average costs, medical and nonmedical costs,
direct and indirect costs. Pharmacoeconomic studies: Costminimization, cost-benefit, cost-
effectiveness and Cost-utility analysis.
Telemedicine History and advances in telemedicine, benefits and limitations of telemedicine. (9 Lectures)
Books Recommended:
1. Dhillon S., Kostrzewski, A., Clinical Pharmacokinetics, Pharmaceutical Press,
London.
2. Dipiro, J., Spruill, W., Wade, W., Blouin, R., Pruemer, J., Concepts in clinical
pharmacokinetics, American society of health-system pharmacists, Inc.
3. Burton, M., Shaw, L., Schentag, J., Evans, W., Applied pharmacokinetics &
pharmacodynamics, Lippincott Williams & Wilkins, Philadelphia
4. Kimki C., Hui, Duffull B., Stephen, Simulation for the designing clinical trials by
Marcel Dekker Inc., New York.
5. Tom Walley, Alan Haycox and Angela Boland, Pharmacoeconomics, Elsevier.
6. Bootman JL, Townsend RJ, McGhan WF, Principles of Pharmacoeconomics, Harvey
Whitney Books Company, Cincinnati, OH
7. Bryan Ballantyne, Timothy Marrs, Paul Turner. General and Applied Toxicology by
Stockton press.
8. Methods of clinical trials by Alan Spreit and Simon.
9. Clinical Pharmacology by P N Bennet and Brown
10. The Oxford textbook of Clinical Pharmacology and drug therapy by D.G. Graham-
Smith and J.K.Aronson.
Session: 2016-17
23
M. Pharmacy (Pharmacology)
Semester 2
MPP-203
DRUG DESIGNING AND PHARMACOGENOMICS Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
NOTE: In all nine questions will be set, two from each unit and one compulsory
question of short answer type covering all the units. Students are required to attempt
one compulsory question and four other questions selecting at least one from each unit.
All questions are of equal marks.
Theory
UNIT I
In-Silico Tools/Software, general ideas of drug designing, 2D and 3D QASR, concept of a
pharmacophore and pharmacophore based searches of ligand databases. Concepts of
COMFA. Methods for simulated docking (9 Lectures)
UNIT II
Drug response to patients, Structural influence in the Drug response. Efficacy and
metabolism of drugs. Drug metabolism pathways and adverse drug reactions. Detoxification
and poisoning and Drug discovery and approval. Metabolic changes of drugsand related
organic compounds - Ayurgenomics - Genomics and Modern Medicine. Pharmacogenomics
and Pharmacognosy. (9 Lectures)
UNIT III
Concepts of Pharmacogenetics, Pharmacogenomics- Introduction, basic concepts
aboutgenetic diseases.Personalized medicine- introduction and importance. The genetics
oftherapeutic targets and gene-based targets. Pharmacogenomics necessity in drugdesigning.
Polymorphisms-Introduction, types and importance in Drug targets.Prediction ofstructural
changes among sequences by the influence of polymorphisms. Genetic analysisof human
variation, Microsatellite for studying genetic variation. (9 Lectures)
UNIT IV Tools for pharmacogenomics analysis. Pharmacokinetics (PK), Pharmacodynamics (PD).
Process in Structural Pharmacogenomics- Target Structure optimization, Validation, lead
identification, ADME prediction, synthesis, assays and Clinical trials. (9 Lectures)
SUGGESTED READINGS:
1. Rapley R and Harbron S. Molecular analysis and Genome discovery.John Willey &
Sons, Ltd. 2004.
2. Falconer DS, Mackay TFC, Introduction to Quantitative Genetics.4th Edition.
3. Daniel A. Brazeau, PhD, and Gayle A. Brazeau.A Required Course in Human
Genomics, Pharmacogenomics and Bioinformatics.
4. Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA,
Feldman MW Science, Vol 298 (5602), 2381-2385, 2002.
Session: 2016-17
24
5. Anderson JL, Horne BD, Stevens SL, et al. for the Couma-Gen
Investigators.Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing
in PatientsInitiating Oral Anticoagulation.Circulation.2007,116, 2563
Session: 2016-17
25
M. Pharmacy (Pharmacology)
Semester 2
MPP-204
MOLECULAR PHARMACOLOGY
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Molecular Biology DNA and genome, basic double helix structure, flow of genetic information, molecular basis
of transcription and protein synthesis.
Receptor Interactions
Role of cyclic nucleotides, phosphoinositides, arachidonic acid, calcium and nitric oxide in
cellular signalling.Pharmacology of toll-like receptors. (9 Lectures)
UNIT-II
Recombinant DNA Technology Tools of recombinant DNA, restriction endonucleases, other enzymes, plasmid,
bacteriophage, cosmid, vectors, c-DNA, genomic library, gene isolation, cloning,
expression, DNA sequencing, oligonucleotide synthesis, southern and northern
hybridization, fluorescence in-situ hybridization, restriction fragment length polymorphism,
PCR, DNA fingerprinting and their applications for diagnosis of disease, site-directed
mutagenesis and gene silencing, Vaccines. (9 Lectures)
UNIT-III
Principles of Gene Therapy
Gene transfer technologies, clinical applications of gene therapy, different targets of gene
therapy, gene-based personalized drug therapy, antisensetechnology.
Stem Cell Introduction to stem cells- Embryonic Stem Cells, Adult stem cells, Molecular basis
pluripotentency and its application, Stem cell niches, Stem cell renewal, Cell cycles
regulators in stem cells. Epigenetic mechanism of cellular memory, Germ line stem cells,
Stem cells and cloning, nuclear cloning and Epigenetic reprogramming; Growth Factors and
Signal Cascades BMP, Nodal, Wnt, Notch and Retenoid signalling during
gastrulation.Biology and its implications in modern medicine. (9 Lectures)
Session: 2016-17
26
UNIT-IV
Pharmacology of endothelins, nitric oxide, purines, peptides and cytokines, their agonists
and antagonists. Pharmacogenetics, Biotechnology derived products and their regulatory
requirements
Functional Genomics and Proteomics: Analysis of microarray data; Protein and peptide
microarray based technology; PCR-directed protein in situ arrays; structural proteomics
(9 Lectures)
Reading Material Recommended:
1. Lodish H., Baltimore D., Berk A., Zipursky SL., Matsundaira P. and Darnell J.
Molecular CellBiology. W.H. Freeman & Company, New York. Latest Edition.
2. Brown T.A. Gene cloning and DNA analysis. Blackwell Science, USA. Latest
Edition.
3. Alberts B., Bray D., Lewis J., Raff M. Roberts K. and Watsaon J.D., Eds. Molecular
Biology of theCell. Garland Publishers, New York. Latest Edition.
4. Muller R.F. and Youngh ID., Eds. Emmery's Elements of Medical Genetics.
ChurchillLivingstone, New York. Latest Edition.
Session: 2016-17
27
M. Pharmacy (Pharmacology)
Semester 2
MPP-205
ADVANCES IN PHARMACOLOGY
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Receptor Pharmacology
Classification and structure of receptors: Dopamine receptors, serotonin receptors,
endothelin receptors, GABA-benzodiazepine receptors, excitatory amino acid receptors,
sigma receptors, adenosine and cannabinoids, PCR and G-Protein Receptor.
Cytokines Classification, cytokines receptors, chemokine receptors and their role in CNS
and CVS disorders.
NanomedicinePrinciple, applications, nanodevices and nanoparticles in medicine.
(9 Lectures)
UNIT-II
Neurotrophins Nerve growth factor, brain derived neurotrophic factor, neurotrophin 3 & 4,neurotrophin
receptors and their involvement in depression and neurodegenerativedisorders.
Neurotransporters Plasma membrane neurotransmitter transporters (Na+/Cl- dependent
neurotransmitter transporters, Na+/K+ dependent glutamate transporters), vesicular
neurotransmitter transporters (monoamine transporters and acetylcholine transporters.
Apoptosis Necrosis, apotototic cell death cascade, implications in inflammation and
asthma,beta cell apoptosis in diabetes. (9 Lectures)
UNIT-III
ProbioticsPre and probiotics, mechanism of action, therapeutic applications, ethical issues
&safety considerations.
Therapeutic potential of purinergicsignaling and xanthine oxidase inhibitors in
diversepathological conditions.
Mitochondrial dysfunction linked neurological diseases, mitochondrial mediated celldeath in
diabetes. (9 Lectures)
UNIT-IV
Newer antibiotics and chemotherapeutic agents, biochemical mechanisms of multidrug
resistance in chemotherapy, strategies to reverse MDR. Endothelium derived vascular
substances (NO, endothelins) and their modulators,pharmacology of atrial peptides, reactive
oxygen intermediates, antioxidants and theirtherapeutic implications.
Pharmacology of leptin and its receptors, β3 adrenoceptor and antiobesity drugs.
(9 Lectures)
Session: 2016-17
28
Reading Material Recommended:
1. Annual Reviews of Pharmacology and Toxicology.
2. Pharmacological Reviews.
3. Trends in Pharmacological Sciences.
4. Trends in Neurosciences.
5. Journal of Pharmacology and Experimental Therapeutics.
Session: 2016-17
29
M. Pharmacy (Pharmacology)
Semester 2
MPP-207
PRACTICAL PHARMACOLOGY
Maximum Marks: 100
Time: 18hrs
1. Phytochemical investigation of some herbs
a) Extraction and fractionation of some herbs.
b) Preliminary chemical investigation of some extracts
c) Chromatographic evaluation of extracts.
d) Separation and characterisation of selected molecules through
HPLC/HPTLC/GC-MS.
e) Chemical characterisation of some known drug through UV and IR
2. To generate Pharmacokinetic parameters to a drug based on hypothetical
model/methods.
3. Problem solving exercises on calculation of doses (maintenance and loading etc.) in
different cases.
4. Determination of Plasma concentration of drugs using HPLC.
5. Exercises on evidence-based medicine: SOAP to hypothetical/real cases. (Minimum
of 12)
6. Clinical Chemistry through determination of Fasting Blood Sugar, Lipid profile,
Liver function test, urea and Creatine.
7. To biologically identify the poisons/drugs present in the biological fluids/solutions
based on the leads obtain from the case histories
8. Some in vitro enzyme based bioassays (5-LO, AchE inhibition)
9. To demonstrate alpha action of a drug
10. To demonstrate beta action of a drug
11. To demonstrate muscarinic action of a drug
12. To demonstrate nicotinic action of drug
13. To demonstrate 5 HT action of a drug.
14. Antioxidant activity of Super oxide dismutase (SOD), Catalase, Reduced glutathione.
15. To assess competitive antagonism between Ach and d-tubocurarine, through pA2
value on rectus muscle.
16. To assess the influence of Physostigmine and d-tubocurarine on DRC of
acetylcholine.
17. Plasmid DNA Extraction
18. Restriction Enzyme Digestion.
19. Ligation of Digested DNA
20. Transformation of Bacterial Cells
21. Genomic DNA Extraction
22. PCR amplification
23. Polyacrylamide Gel Electrophoresis
24. Western Blotting.
Session: 2016-17
30
Books Recommended:
1. Bartfai T and Lee GV. Drug Discovery. Elsevier, New York. Latest Edition.
2. Huang Z. Drug Discovery Research. Wiley Inter Science, USA. Latest Edition.
3. Evans RP, Drug and Biological Development. Springer, USA. Latest Edition.
4. Ricky NG. Drugs from Discover to Development. Wiley-Blackwell, USA.
5. Ballantyne B, Marrs T and Turner P. General and Applied Toxicology. Macmillan
Press Ltd., London. Latest Edition.
8. Practical approaches in toxicity studies by Poole and Leslie
9. Alternatives to animals in toxicity testing. Scientific American 26: (1989), 16-22.
11. Goldsby RA, Kindt TJ and Osborne BA. Kuby‟s Immunology. WH Freeman Book,
New York. Latest Edition.
12. Klaasen KCD and Amdur MA. Casarett&Doul's Toxicology. Mcmillan Press Ltd.,
London. Latest Edition.
13. Kulkarni S.K. Handbook of Experimental Pharmacology. Vallabh Prakashan, New
Delhi. Latest Edition.
14. Clinical Pharmacy and Therapeutics by Roger Walker and Clive Edward 3rd
edition
15. Davidson‟s Principles and Practice of Medicine 18th
edition
16. Text Book of Therapeutics, Drug and Disease Management by Herfindal E T and
Gourley D R 6th
edition.
17. Avery‟s Drug Treatment.
18. Basic and Clinical Pharmacology by B G Katzung 7th
edition.
19. Annual Reviews of Pharmacology and Toxicology.
20. Pharmacological Reviews.
21. Trends in Pharmacological Sciences.
22. Trends in Neurosciences.
23. Journal of Pharmacology and Experimental Therapeutics.
Session: 2016-17
31
M. Pharmacy (Pharmacology)
Semester 3
MPP-301
PHARMACEUTICAL ENTREPRENEURSHIP
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Accounting and Finance
Taking decision on starting a venture; Assessment of feasibility of a given venture/new
venture; Approach a bank for a loan; Sources of financial assistance; Making a business
proposal/Plan for seeking loans from financial institution and Banks; Funds from bank for
capital expenditure and for working; Statutory and legal requirements for starting a
company/venture; Budget planning and cash flow management; Basics in accounting
practices: concepts of balance sheet, P&L account, and double entry bookkeeping;
Estimation of income, expenditure, profit, income tax etc.
UNIT-II
Marketing
Assessment of market demand for potential product(s) of interest; Market conditions,
segments; Prediction of market changes; Identifying needs of customers including gaps in
the market, packaging the product; Market linkages, branding issues; Developing
distribution channels; Pricing/Policies/Competition; Promotion/ Advertising; Services
Marketing
UNIT-III
Negotiations/Strategy With financiers, bankers etc.; With government/law enforcement authorities; With
companies/Institutions for technology transfer; Dispute resolution skills; External
environment/changes; Crisis/ Avoiding/Managing; Broader vision–Global thinking
Information Technology How to use IT for business administration; Use of IT in improving business performance;
Available software for better financial management; E-business setup, management.
UNIT-IV
Human Resource Development (HRD) Leadership skills; Managerial skills; Organization structure, pros & cons of different
structures; Team building, teamwork; Appraisal; Rewards in small scale set up.
Fundamentals of Entrepreneurship Support mechanism for entrepreneurship in India
Session: 2016-17
32
Role of knowledge centre and R&D Knowledge centres like universities and research institutions; Role of technology and
upgradation; Assessment of scale of development of Technology; Managing Technology
Transfer; Regulations for transfer of foreign technologies; Technology transfer agencies.
Case Study 1. Candidates should be made to start a „mock paper company‟, systematically
following all the procedures.
• The market analysis developed by them will be used to choose the product or
services. SEMESTER - IV 25 M.Sc (General Biotechnology)
• A product or service is created in paper and positioned in the market. As a product
or services available only in paper to be sold in the market through the existing links.
At this juncture, the pricing of the product or the service needs to be finalized,
linking the distribution system until the product or services reaches the end
consumer.
• Candidates who have developed such product or service could present the same as a
project work to the Panel of Experts, including representatives from industry sector.
If the presented product or service is found to have real potential, the candidates
would be exposed to the next level of actual implementation of the project.
2. Go to any venture capital website (like sequoiacap.com) and prepare a proposal for
funding from
SUGGESTED READINGS:
1. Dynamics of Entrepreneurial Development & Management, Vasant Desai –
Himalaya Publishing House
2. Entrepreneurship Development –Poornima M. Charantimath – Small Business
Enterprises – Pearson Education – 2006 (2 & 4)
3. Entrepreneurship Development – S. S. Khanka – S. Chand & Co
Session: 2016-17
33
M. Pharmacy (Pharmacology)
Semester 4
MPP-401
INTELLECTUAL PROPERTY RIGHTS
Maximum Marks: 100
Theory Examination: 80
Internal Assessment: 20
Time: 3 hrs
Note: There shall be nine questions in all. Question no. 1 shall be compulsory,
consisting of eight short answer type questions covering the entire syllabus. Two
questions will be asked from each unit. Student will have to attempt one question from
each unit. Each question shall carry equal marks.
UNIT-I
Intellectual Property Rights
Concepts and fundamentals: The emergence and growth of the concepts regarding
intellectual property (IP), intellectual property protection (IPP) and intellectual property
rights (IPR); economic importance, copyright, trademarks; role of IP in pharmaceutical
industry; global ramifications and financial implications.
Ethical issues in IPR/IPP (9 Lectures)
UNIT-II
Trade Related Aspects of Intellectual Property Rights
Intellectual property and international trade, concept behind WTO, WIPO, GATT, TRIPs,
TRIMS and GATS, status in India and other developing countries. (9 Lectures)
UNIT-III
Indian Patent Act. 1970 and its amendments: WTO and modifications under TRIPS, filing of
a patent application, precautions before patenting-disclosures/non-disclosures, publication-
article/thesis, prior art search – published patents search, internet search, patent sites,
specialized service search requests, costs, patent application forms and guidelines, fee
structure, time frames, jurisdiction aspects. (9 Lectures)
UNIT-IV
Technology Development/Transfer Commercialization Related Aspects Technology
development: Types of patent applications provisional, non-provisional, PCT and
convention patent applications, international patenting requirement procedures and costs.
Patent infringement: Meaning, scope, litigation, drug related patents infringements, case
studies and examples, patenting by research students. (9 Lectures)
Session: 2016-17
34
Reading Material Recommended
1. Treece DJ. Managing Intellectual Capital: Organizational, Strategic and Policy
Dimension. Oxford University Press, England. Latest Edition.
2. Wadedhra BL. Law Relating to Patents, Trademarks, Copyright Design and Geographical
Indications. Universal Law Publishing, New Delhi. Latest Edition.
3. Bansal P. IPR Handbook for Pharma Students and Researchers, Pharma Book Syndicate,
Hyderabad. Latest Edition.
4. Copyright Protection in India [website: http:copyright.gov.in].
5. Information on Orange Book [website: www.fda.gov/cder/ob/default.htm].