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Cervical Cancer
HIV genome
Virion
HPV life cycle
HPV infection
Cancers and HPV
HPV cancers
Cervical cancer
HPV carcinogenesis
Cellular proteins
HPV pathways
HPV infection time line
HPV infection
Pap screening
Primary prevention
Virus like particles
Three vaccines
Timeline of HPV Association
Precursor Lesions
Efficacy of HPV Vaccine
Gardasil-9
Clinical Trial Evidence
What the HPV Vaccines Don’t Do They don’t prevent infection or disease caused by
most of the other HPV types that cause 30% of
cervical cancer not caused by HPV16/18.
They don’t induce regression of established HPV
infections or prevent progression of HPV-induced
lesions.
7 Years after vaccination
Protection from Initial Infection
HPC vaccine
Safety record
Vaccine effectiveness
Vaccination
CIN1 reduction
Effectiveness
Cervical cancer prevention
Worldwide HPV vaccine
uptake
US girls vaccination rate
Increasing Uptake, Particularly
in Low Resource Settings
One dose efficacy of Cervarix
Cervarix after 4 years
One dose clinical trials
Single dose efficacy trial
HPV vaccines
Immune mediators of protection
Antibody responses to VLPs
Persistence of antibodies
B cells recognize dense
repetitive protein arrays
Repetitive antigen display
Virus like particles
Durable serum Abs
Antibody response
HPV achilles heal
Cervix Ab response
Murine model
Basement membrane
Antibody titers and protection
Passive transfer
Keratinocyte transfer
Gardasil sera protection
Conclusions
Collaborators