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12/4/12
1
Dr. Sanjeeva Srivastava IIT Bombay
IIT Bombay Proteomics Course NPTEL
• Central Dogma
• DNA • RNA • Proteins
2
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IIT Bombay Proteomics Course NPTEL 3
DNA Genetic blueprint
RNA Molecular Photocopy
Proteins Building blocks
IIT Bombay Proteomics Course NPTEL 4
Prom
oter T
A T A
C A G
T A C
C G T
Q
Y
R
Message
Protein Sequence & Regula2on
Protein Structure
Protein/ Enzyme Structure
DNA Sequence
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IIT Bombay Proteomics Course NPTEL 15
Nucleoside= Base + Sugar
Nucleotide= Base + Sugar + Phosphate
Nucleic Acids = Nucleotide joined by phosphodiester
bonds
Phosphodiester bond
IIT Bombay Proteomics Course NPTEL 16
Bas
e
P
5’ 3’
Bas
e
P
5’ 3’
Bas
e
P
5’ 3’
Bas
e
P
5’ 3’
Bas
e
P
5’ 3’
Deoxyribose sugar
Nucleoside
Nucleotide
Phosphodiester bond
N-glycosidic linkage
3.4 Ao
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IIT Bombay Proteomics Course NPTEL 19
Parent DNA molecule
Replication
Conservative model
Dispersive model
Semi-conservative
model
Daughter DNA molecules
IIT Bombay Proteomics Course NPTEL 20
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IIT Bombay Proteomics Course NPTEL 23
IIT Bombay Proteomics Course NPTEL 24 Nucleotide
Nucleoside Base
Ribose sugar
P Base
Ribose sugar
Phosphate
Sugar phosphate backbone
Nitrogenous bases – Adenine/ Guanine/ Uracil/ Cytosine
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IIT Bombay Proteomics Course NPTEL 25
Messenger RNA (mRNA)
Transfer RNA (tRNA)
Ribosomal RNA (rRNA)
5‘UTR Start Stop Poly A tail Cap 3‘UTR Coding sequence
Large subunit
Small subunit
5’ 3’
Acceptor stem
TψC loop
Anticodon loop
D loop
Variable loop
IIT Bombay Proteomics Course NPTEL 26
Ribosome
Incoming aminoacyl-tRNAs
Amino acid
Movement of ribosome
Growing polypeptide chain
5’
3’
mRNA
Outgoing tRNAs
P site A site
Start codon
Stop codon
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IIT Bombay Proteomics Course NPTEL
• Central Dogma
• DNA • RNA • Proteins
27
IIT Bombay Proteomics Course NPTEL
• Berg J., Tmyoczko J. & Stryer L., Biochemitry fifth ed., W. H. Freeman & company, 2002. ISBN: 0716746840. • Lewin B., Gene VIII first ed., Pearson, 2003, ISBN: 0131239244. • Nelson D. & Cox M.,Lehninger, Principles of Biochemistry fourth ed., W. H. Freeman and company, 2004. ISBN: 023022699X. • Voet D. & Voet J., Biochemistry fourth ed., Wiley, 2000. ISBN: 047158651X.