Center for Biological PhysicsLori Goldner, Jenny Ross

Adrian Parsegian

Direct measurement of intermolecular forces

to build a physics of molecular organization

Watching single molecules move through channels

Theory of intermolecular forces organizing soft materials, colloids and large bio-molecules

exploded virus and intact virus

Bacteriophage T2 Kleinschmidt et al. (1962)

DNA spooled inside a virusA. Evilevitch, (2006).

Viral DNA is under pressure that can drive infection:

QuickTime™ and a decompressor

are needed to see this picture.

QuickTime™ and a decompressor

are needed to see this picture.

Equation of State: Osmotic pressure vs. DNA density, function of salt, temperature, etc.

Building a physics of forces and energies for nanometer-to-micrometer - size particles

Unified equation of state for flexible polymers: Osmotic pressures of many sizes and concentrations fit with ONE parameter.

Joel Cohen (Univ Pacific), Rudi Podgornik (Slovenia)

To be part-time @UMass

25 µm

1 cm

_+

2 nm

70 µm

E(mV)

I(pA)

100 µm

10 ms

pA

Detection

10 ms

pA

Current through channel

0

Sergey Bezrukov, Philip Gurnev

Building an apparatus in Hasbrouck next month

Transport through single ionic channels Current detection of single-molecule transit

Theory of intermolecular forces

(electrostatics, electrodynamics, solvation, steric) example of single-walled carbon nanotubes

Rick Rajter, Rudi Podgornik, Roger French, Wai-Yim Ching, AP

Connection between dielectric spectra

and van der Waalstorques/forces.

Under study

DNA, Lipids (cell membranes), Proteins

Xiangyun Qiu, Rudi Podgornik, to be working @UMass

Jason DeRouchey, Don Rau, et al. at NIH (where I used to work)

Thanks