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Reviews and Accounts ARKIVOC 2015 (i) 136-159
Page 136 ©ARKAT-USA, Inc.
Cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA) as solid
and heterogeneous catalysts in green organic synthesis: recent
advances
Rajesh H. Vekariya and Hitesh D. Patel*
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, Gujarat,
India
E-mail: [email protected]
DOI: http://dx.doi.org/10.3998/ark.5550190.p008.975
Abstract
The use of heterogeneous solid acid catalysts is important to the development of sustainable
chemical processes. To this end, cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA)
have been developed and used for a wide range of organic transformations, including the
synthesis of pharmaceutically important heterocyclic compounds. These heterogeneous catalysts
are easily recovered and reused several times without loss of their activity. In this review, we
mainly summarize applications of these catalysts in synthetic organic chemistry.
Keywords: Cellulose sulfuric acid (CSA), starch sulfuric acid (SSA), heterogeneous catalysts,
solid acid catalysts, organic synthesis, selectivity, green synthesis
Table of Contents
1. Introduction
2. Cellulose Sulfuric Acid (CSA)
2.1. Various organic transformations catalyzed by CSA
3. Starch Sulfuric Acid (SSA)
3.1. Various organic transformations catalyzed by SSA
4. Conclusions
5. Acknowledgements
6. References
1. Introduction
Synthetic organic chemistry generally involves the use of various solvents and catalysts, which
may be toxic, hazardous, corrosive and inflammable. These chemical processes highly influence
Reviews and Accounts ARKIVOC 2015 (i) 136-159
Page 137 ©ARKAT-USA, Inc.
of the environment. Recently, it has become a major issue at a global level. In view of the
seriousness of the chemical pollution, the uses of a wide range of these chemicals are being re-
examined, leading to a search for the design and development of environmentally friendly and
sustainable organic transformations for synthesis of various chemical compounds.
One of the ultimate goals for organic reactions is to reduce the use of harmful organic
solvents and use of heterogeneous catalysts instead of homogeneous catalysts, because of the
environment and economic regulations.1-4
Homogeneous catalysts such as H2SO4, HCl, HBr, HF,
CH3COOH and CF3COOH are frequently used in organic synthesis.5,6
However, these acid
catalysts are toxic, corrosive, harmful and difficult to handle. Furthermore, their disposal is a
headache for the chemical industry.7 In addition, under homogeneous conditions the catalysts are
difficult to recover and reuse.8 Not only the ecological profile, but also the economic profile is
improved, if recyclable heterogeneous catalysts and solvent free conditions can be used. For this
reason, over the last few years, enormous advances have been made to achieve environmentally
friendly chemical transformations using heterogeneous solid acid catalysts.9-17
Heterogeneous
solid acids have advantages over conventional homogeneous acid catalysts such as simplicity in
handling, decreased reactor and plant corrosion problems, and they can be easily recovered and
reused several times without loss of their efficiency.
In recent years, the direction of science and technology has been shifting more towards
eco-friendly, natural product resources and reusable catalysts. In this regard, biopolymers are
attractive candidates to explore for supported catalysis.18
Several interesting biopolymers have
been utilized as a support for catalytic applications, such as alginate,19
gelatin,20
starch21
and
chistosan22
derivatives.
Cellulose and starch are the most abundant natural polymers and have been widely
studied during the past several decades because they are biodegradable materials and a
renewable resource.23
Its unique properties make it an attractive alternative to conventional
organic or inorganic supports in catalytic applications. Therefore, many efforts have been made
by researchers constantly to introduce novel heterogeneous catalyzed organic transformation by
using cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA), which are more efficient,
economical and compatible with the environment. Also, these catalysts can be recovered and
reused several times without a decrease in activity. The present article is intended to review
briefly recent research progress concerning the synthesis of different organic compounds
catalyzed by CSA and SSA.
2. Cellulose Sulfuric Acid (CSA)
CSA was prepared according the following procedure: Take 5.00 g of cellulose in 20 ml of n-
hexane. The mixture is magnetically stirred and 1.00 g of chlorosulfonic acid (9 mmol) added
dropwise at 0 oC over 2 h. HCl gas is immediately evolved. After the addition is complete the
mixture is stirred for 2 h at room temperature. Then the mixture is filtered and the collected solid
washed with 30 ml of acetonitrile and dried at room temperature to afford 5.25 g of cellulose
Reviews and Accounts ARKIVOC 2015 (i) 136-159
Page 138 ©ARKAT-USA, Inc.
sulfuric acid as a white powder.33
CSA is non-explosive, non-hygroscopic and stable at room
temperature.
Organic transformations using CSA have many advantages such as a simple work-up
process, inexpensive catalyst, environmental friendly, excellent yield of the products with high
purity, shorter reaction times and solvent-free reaction conditions. The CSA is solid,
heterogeneous catalyst and after completion of organic transformation, it can be recovered and
reused several times without loss of its efficiency.
2.1. Various organic transformations catalyzed by CSA
Shaabani et al.24
have developed an efficient and environmentally friendly method for synthesis
of α-aminonitrile derivatives through the condensation reaction of amines, aldehydes and
trimethylsilylcyanide (TMSCN) by employing catalytic amount of cellulose sulfuric acid (CSA)
as a bio-supported catalyst at ambient temperature, which afforded excellent yield of the
products (Scheme 1). In order to optimize the reaction conditions, the authors have carried out
this reaction with various solvents, such as water, methanol, ethanol, acetonitrile (MeCN),
dichloromethane (DCM) and toluene. However, MeCN showed the best results in terms of the
yield of the products. Solvent free condition were also used for this reaction, but this did not give
the best results. Both aromatic and aliphatic aldehydes afforded excellent yields of the products.
In addition, acid sensitive aldehydes such as furfuraldehyde gave the aminocyano compound in
high yield. Short reaction times, the recyclability of the catalyst without loss of activity, simple
work-up process and use of non-hazardous, non-corrosive and inexpensive solid acid catalyst are
superior features of the protocol.
Scheme 1. Synthesis of α-amino nitrile derivatives catalyzed by CSA.
An efficient methodology for the synthesis of 4-aryl-1,4-dihydropyridines in excellent yield
under solvent-free condition through the three components condensation of various aldehydes,
ethyl acetoacetate and ammonium acetate (NH4OAc) at 100 oC, have been established by Murthy
et al.25
(Scheme 2). The authors have employed this reaction with various solvents such as
methanol, ethanol, acetonitrile, toluene, dioxane and tetrahydrofuran (THF). However, these
solvents were not efficient for this reaction as compared to solvent-free conditions in terms of the
yield of the products.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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Scheme 2. Synthesis of 4-aryl-1,4-dihydropyridines derivatives catalyzed by CSA.
Alinezhad and co-workers26
have discovered the solvent-free synthesis of bis-
indolylmethanes, bis-2-methylindolylmethanes, bis-1-methylindolylmethanes and 3,3′-
diindolyloxindole derivatives through the reaction of indoles with various aldehydes and ketones
in the presence of a catalytic amount of cellulose sulfuric acid, which afforded excellent yields of
the products (Scheme 3). This method is also highly chemoselective for aldehydes in the
presence of ketones. For comparative study various catalysts such as ZrOCl2.8H2O, AlPW12O40,
Amorphous zirconium titanium phosphate (15-ZTPA), NH4Cl, Zirconium tetrakis(dodecyl
sulfate) [Zr(DS)4], ZrCl4 and CSA were employed in this protocol. However, CSA was proven
the best catalyst for this transformation. Also, the reaction was preferably undertaken at ambient
temperature rather than high temperature. In addition, solvent-free condition showed better
results as comparable to the reaction in solvent like acetonitrile and water. Here, the variety of
aliphatic, aromatic and heterocyclic aldehydes and ketones underwent smoothly to the
corresponding bis-indolylmethanes in high in excellent yields.
NR''
R'''R R'
O
N
R
R'
N
R''
R''
R'''
R'''
NR
R'N
N
R R
R'
R'
HN
ONH
O
O
CSA (0.1 g)
r.t., grinding, 2-60 min.
R, R' = H, alkyl, aryl, hetero arylR'', R''' = H, Me
(2 mmol)
73-98 %
(1 mmol)
r.t., grinding,10-120 min.
R, R' = H, Me(2 mmol)
85-88 %
(1 mmol)
CSA (0.1 g)
Scheme 3. Synthesis of bis-indolylmethane derivatives catalyzed by CSA.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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A mild, simple and efficient protocol for the diazotization and iodination of various aromatic
amines has been developed by Nemati et al.27
employing sodium nitrite and potassium iodide in
the presence of cellulose sulfuric acid under solvent-free conditions at room temperature
(Scheme 4). In addition, both electron-withdrawing groups and electron-donating groups
containing aryl amines were smoothly converted into the corresponding aryl iodides in excellent
yields. In comparison with conventional diazotization procedures, acidic effluent is not produced
with this protocol, which makes it more "green" and environmentally friendly. In conventional
synthesis,28
the reaction is usually carried out with sodium nitrite at low temperature in two
steps: diazotization of the aryl amine in hydrochloric or sulfuric acid and then reaction with
iodine or KI sometimes in the presence of copper salts. The CSA protocol has advantages over
the classical process in the use of mild reaction conditions, avoidance of corrosive acids and
toxic solvents, and short reaction times.
Scheme 4. Diazotization and iodination catalyzed by CSA.
A simple procedure for the synthesis of 6-chloro-8-substituted-9H-purine derivatives
involving the one-pot condensation of 6-chloropyrimidine-4,5-diamine and various aldehydes in
the presence of catalytic cellulose sulfuric acid (CSA) under solvent-free conditions at room
temperature has been disclosed by Maddila and co-authors29
(Scheme 5). The reaction did not
proceed in the absence of CSA. Lesser amounts of catalyst produced a lower yield of the
products, 0.045 g of CSA gave the best yield.
Scheme 5. Synthesis of 6-chloro-8-substituted-9H-purine derivatives catalyzed by CSA.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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An efficient protocol for the synthesis of aryl-14H-dibenzo[a.j]xanthene derivatives from the
β-naphthol and corresponding aromatic aldehydes was developed by Madhav and co-workers,30
in the presence of catalytic amount of cellulose sulfuric acid (CSA) under solvent-free condition
at 100 oC to afford excellent yield of the products (Scheme 6). There was no significant change
in the yield of the products, when the reaction was carried out at 120 oC instead of 110
oC, but at
100 oC the yield of the products becomes lower. Various catalysts such as p-toluenesulfonic acid
(p-TSA), sulfuric acid in acetic acid and silica sulfuric acid (SSA) were employed in this reaction
for comparative study, but they were not efficient as compared to CSA. By this protocol 4-oxo-
4H-chromene-3-carbaldehyde and 6-nitro-4-oxo-4H-chromene-3-carbaldehyde could be
efficiently converted into corresponding aryl-14H-dibenzo[a.j]xanthene derivatives. A
significant improvement in the rate of the reaction and the yields of the products was observed,
when the reactions were carried out using CSA as compared with the classical acidic catalysts
such as acetic acid-sulfuric acid31
and p-toluenesulfonic acid (p-TSA)32
. In addition, after
completion of the reaction, the CSA could be recovered and reused several times while the
conventional catalysts could not be recovered.
Scheme 6. Synthesis of aryl-14H-dibenzo[a.j]xanthene derivatives catalyzed by CSA.
Safari et al.33
have established an eco-friendly method for the synthesis of 1,4-
dihydropyridines in excellent yields via the one-pot condensation of 1,3-diphenyl-2-propen-1-
one derivatives, ethyl acetoacetate and ammonium acetate utilizing catalytic amount of cellulose
sulfuric acid (CSA) in water under reflux condition (Scheme 7). Only 0.02 g of CSA was enough
for this transformation. To optimize the reaction condition authors have carried out this reaction
with different amount of CSA and they have noted that when the amount of CSA was increased
from 0.02 to 0.05, the yield of the products was significantly increased with the reduction in the
reaction time. For comparative study authors have carried out this reaction with various solvents
such as ethanol, methanol, isopropanol, tertiary-butanol, tetrahydrofuran (THF) and acetonitrile
(ACN), but they are not efficient as in water.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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Scheme 7. Synthesis of 1,4-dihydropyridines derivatives catalyzed by CSA.
A simple and efficient protocol has been discovered by Mofakham and co-workers34
for the
synthesis of 3,4-dihydroquinoxalin-2-amine, 4H-1,4-benzothiazin-2-amine and 1,6-dihydro-
pyrazine-2,3-dicarbonitrile derivatives by utilizing various of amines, isocyanides and carbonyl
compounds in the presence of catalytic amount of cellulose sulfuric acid (CSA) in ethanol at
room temperature (Scheme 8). Various solvents such as water, dichloromethane (DCM),
chloroform, acetonitrile (ACN), benzene, tetrahydrofuran (THF), methanol and ethanol were
examined in the synthesis of synthesis of 2-(2-bromophenyl)-N-cyclohexyl-2-
(phenylamino)acetamide, by authors for optimization of the reaction condition, but only ethanol
and methanol gave excellent results compare to others. In addition, catalysts such as TsOH.H2O,
Scheme 8. Synthesis of 3,4-dihydroquinoxalin-2-amine and 4H-1,4-benzothiazin-2-amine.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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HCl, silica sulfuric acid (SCA) and xanthane sulfuric acid (XSA) were employed in same
reaction, but they were not efficient as like CSA. Here, 1,6-dihydropyrazine-2,3-dicarbonitriles
were efficiently synthesized by this protocol using 2,3-diaminomaleonitrile, isocyanides and
carbonyl compounds in the presence of catalytic amount of cellulose sulfuric acid (CSA) in
ethanol at room temperature, which afforded excellent yield of the products (Scheme 9).
Scheme 9. Synthesis of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives catalyzed by CSA.
Rajack et al.35
have described an environmentally friendly procedure for the synthesis of 3,4-
dihydropyrimidin-2(1H)-ones/-thiones via Biginelli condensation in the presence of cellulose
sulfuric acid (CSA) in water at 100 oC to afford good yield of the products (Scheme 9). In this
care, 0.04 g CSA gave poor results as compared to 0.05 g of CSA. Various organic solvents such
as ethanol, methanol, acetonitrile, dioxane and toluene showed poor results as compared to water
in terms of the yield of the product. In addition, N-dihydro pyrimidinonedecahydroacridine-1,8-
dione derivatives have been synthesized in excellent yield through the Hantzsch type
condensation of 5-ethoxycarbonyl-4-(4-aminophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-
one, dimedone and aromatic aldehydes in acetonitrile under reflux conditions (Scheme 10). To
optimize the reaction condition, the authors have carried out various catalysts such as Dowex,
silica sulfuric acid (SSA), Amberlyst-15 and p-TSA in both Biginelli as well as for Hantzsch
type condensation reaction. However, all these catalysts did not show better results as compared
to CSA. Various 3,4-dihydropyridinones and acridine derivatives were efficiently synthesized
demonstrating wide synthetic utility of this method.
An environment friendly protocol for the synthesis of N-substituted pyrroles through the one-
pot condensation reaction of 2,5-hexandione with amines and diamines in the presence of
catalytic amount of cellulose sulfuric acid (CSA) at room temperature under solvent-free
conditions have been demonstrated by Rahmatpour36
(Scheme 11). Short reaction times and high
product yields make this method a highly useful synthetic protocol. To optimize reaction
conditions the author carried out this reaction with various solvents such as dichloromethane
(DCM), chloroform, carbon tetrachloride and acetonitrile, however the use of these solvents gave
less efficient results than the solvent-free conditions. There was an observed significant
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improvement in the rate of the reaction and the yields of the products, when the reactions were
carried out using CSA as compared with the classical acidic catalysts such as hydrochloric
acid,37
sulfuric acid,38
and p-toluenesulfonic acid (p-TSA).39
In addition, after completion of the
reaction, the CSA could be recovered and reused several times while the conventional catalysts
could not be recovered.
Scheme 10. Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones and decahydroacridine-
1,8-dione derivatives catalyzed by CSA.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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Scheme 11. Synthesis of N-substituted pyrroles catalyzed by CSA.
Shaabani et al.40
has developed a synthesis of quinoline derivatives via Friedlander
condensation reaction of 2-aminoarylketone with an activated CH-acid such as cyclic or acyclic
β-diketones or cyclic ketones in the presence of catalytic amount of cellulose sulfuric acid (CSA)
and starch sulfuric acid (SSA) in excellent yields within a short period of time under solvent-free
conditions at 100 oC (Scheme 12). Here, the efficiency of CSA and SSA towards this reaction
Scheme 12. Synthesis of quinoline derivatives catalyzed by CSA.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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Scheme 13. Synthesis of quinoxaline derivatives catalyzed by CSA.
A new and green method has been discovered by Liu et al.43
for the synthesis of 5-
hydroxymethylfurfural (HMF) and 5-ethoxymethylfurfural (EMF) from fructose using cellulose
sulfuric acid (CSA) as a bio-degradable catalyst (Scheme 14). Here, HMF was obtained in high
yield (93.6%) in dimethylsulfoxide (DMSO) for 45 min. While, EMF was obtained in an
excellent yield (84.4%) by the etherification of HMF under the same reaction conditions. In
addition, EMF could be also synthesized in good yield (72.5%) directly from the fructose
through one-pot reaction, which included that the dehydration of fructose into HMF, followed by
etherification of HMF into EMF.
CSA (50 mg),DMSO (3 mL)
(1 mmol)
100 oC, 45 min.OH
CH2OH
HO
HO
OHOH2C OOHC
OH
HMF
93.6 %
CSA (50 mg),Ethanol (5 mL)
OOHC
O
100 oC
EMF
CSA(50mg),
Ethanol (5mL)
100 oC
Method A: 84.4 %
Method B: 72.5 %
Method A
Method
B
Scheme 14. Synthesis of HMF and EMF catalyzed by CSA.
Shaabani and co-workers44
have also developed a high yielding synthesis of imidazoazine
derivatives through the one-pot three-component condensation reaction of aldehydes, 2-
aminoazine and isocyanides in the presence of catalytic amount of cellulose sulfuric acid (CSA),
as an effective bio-supported catalyst in methanol at room temperature (Scheme 15). The results
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showed that the efficiency and the yield of the product in methanol were higher than those
obtained in other solvents like water, ethanol, dichloromethane, toluene, acetonitrile and solvent-
free condition. This reaction was also carried out in the presence of various acids such as
Amberlyst-21, Montmorillonite-K10, CSA, HCl, H2SO4, acetic acid and AlCl3. However the best
yield was obtained with CSA.
Scheme 15. Synthesis of imidazoazine derivatives catalyzed by CSA.
Shaterian and co-workers45
have disclosed that the primary, secondary and tertiary alcohols
as well as phenols and naphthols were effectively converted into their corresponding
trimethylsilyl ethers in excellent yield by using with hexamethyldisilazane (HMDS) in the
presence of catalytic amount of cellulose sulfuric acid (CSA) at room temperature with short
reaction times (Scheme 16).
Scheme 16. Silylation of alcohols and phenols catalyzed by CSA.
Nemati et al.46
have developed a green and mild protocol for the diazotization and azidation
of various aromatic amines by using sodium nitrite and sodium azide respectively in the presence
of catalytic amount of CSA at room temperature, which afforded excellent yield of the products
(Scheme 17). In addition, the wide range of arylamines containing electron-withdrawing groups
and electron-releasing groups were efficiently converted into the corresponding aryl azides with
excellent yields make this protocol environmentally friendly. There was an observed significant
improvement in the rate of the reaction and the yields of the products, with this protocol as
compared to the classical synthetic method of aryl azides.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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Scheme 17. Diazotization and azidation by using CSA.
A green and environmentally friendly method for the synthesis of 1-oxohexahydroxanthene
derivatives in higher yields was developed by Karma and co-workers47
using ortho-hydroxy
benzaldehydes and substituted 1,3-hexanediones in the presence of a catalytic amount of CSA at
room temperature (Scheme 18). The best results were obtained using 0.08 g of catalyst, while
with lower amounts, or in the absence of a catalyst, lower yields of the products resulted. For
comparison, the authors carried out this reaction with various catalysts such as methanesulfonic
acid, silica sulfuric acid and sulfuric acid in acetic acid. However, in such cases the yield of the
products was very low compared to CSA.
CSA (0.08 g)
(1 mmol)95-96 %
R' = H, Me(2 mmol)
CHO
OHr.t., grinding, 20-30 min.
O
OR'R'
OR'
R'
OO
OH
R' R'
CSA (0.08 g)
(1 mmol)87-96 %
R = H, Cl, OMe, Br,
NO2, diCl, diBr
R' = H, Me
(2 mmol)
CHOH
OH
RRr.t., grinding, 20-30 min.
O
OR'R'
OR'
R'
O OOH
R' R'
Scheme 18. Synthesis of 1-oxo-hexahydroxanthene derivatives catalyzed by CSA.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
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Kuarm et al.48
have described an efficient and environment friendly process for the synthesis
of quinoxaline derivatives through the condensation reaction of the 2,1,3-benzothiadiazole-4,5-
diamine and 3-(α-bromoacetyl)-coumarins in the presence of cellulose sulfuric acid (CSA) by
grinding in a mortar and pestle at room temperature in excellent yields with high purity (Scheme
19). Various catalysts such as silica sulfuric acid, methanesulfonic acid and sulfuric acid in acetic
acid were also employed in this reaction for comparison study; however those are not so efficient
as CSA.
Scheme 19. Synthesis of quinoxaline derivatives catalyzed by CSA.
Reddy et al.49
have discovered one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
by utilizing various aldehydes, β-ketoesters and urea/thiourea in the presence of cellulose
sulfuric acid (CSA) in ethanol under reflux conditions to afford excellent yield (Scheme 20).
Various solvents such as ethanol, methanol, dichloromethane, acetonitrile and toluene were also
employed in this reaction for comparative study, among those ethanol shows better efficiency in
terms of the yield of the product.
Scheme 20. Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones catalyzed by CSA.
Oskooie and co-workers50
have discovered an efficient protocol for the synthesis of β-
acetamido ketone derivatives in high yield through the one-pot, four-component condensation of
benzaldehyde, dimedone, acetyl chloride and acetonitrile in the presence of cellulose sulfuric
acid (CSA) in acetonitrile under reflux condition (Scheme 21. Here, the synthesis of N-[(4,4-
dimethyl-2,6-dioxocyclohexyl)phenyl)methyl]acetamide was selected as the model reaction. To
investigate the effect of catalyst amount on the yield of the reaction the authors have carried out
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model reaction with different amount of catalyst. The results show that the optimum amount of
catalyst was 0.01 g. The model reaction was performed in the presence of the same amounts of
various catalysts such as silica sulfuric acid (SSA), p-toluenesulfonic acid (p-TSA), sulfamic
acid, SbCl3 and various heteropoly acids, but they didn’t work efficiently as like CSA.
Scheme 21. Synthesis of β-acetamido ketone derivatives catalyzed by CSA.
An efficient and green protocol for the synthesis of 2-substituted benzimidazoles has been
discovered by Kuarm and co-workers51
via condensation of 2,1,3-benzothiadiazole-4,5-diamine
with different aldehydes in the presence of the catalytic amount of the cellulose sulfuric acid
(CSA) under solvent-free conditions by grinding in a mortar and pestle at room temperature
(Scheme 22). The efficiency of the cellulose sulfuric acid compared to various sulfur analog
acidic catalysts such as silica sulfuric acid (SSA), p-Toluenesulfonic acid (p-TSA) and sulfuric
acid in acetic acid were also examined. However, cellulose sulfuric acid is more efficient and
superior over other acidic catalysts with respect to reaction time and yield.
Scheme 22. Synthesis of 2-substituted benzimidazoles derivatives catalyzed by CSA.
Sadaphal et al.52
have discovered the synthesis of bis(indolyl)methane derivatives by using
indole and various aldehydes in the presence of cellulose sulfuric acid (CSA) as a biodegradable
catalyst at room temperature under solvent-free condition (Scheme 23).
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Scheme 23. Synthesis of bis(indolyl)methane derivatives catalyzed by CSA.
A simple and environmentally friendly procedure has been developed by Shelke et al.53
for
the synthesis of 2,4,5-triarylimidazole derivatives through the three-component condensation of
benzil/benzoin, various aldehydes and ammonium acetate in the presence of a catalytic amount
of bio-supported cellulose sulfuric acid (CSA) under microwave irradiation and solvent-free
conditions to afford excellent yield of the products (Scheme 24). Different acid catalysts such as
HgCl2, SnCl2.2H2O, H2SO4, HCl, clays EPZG, clay EPZ 10 and CSA were employed in this
transformation by the authors for comparative study. The shorter reaction rate and the better
yield were obtained with CSA compared to others. It is also noted that solvent-free conditions
show better results as compared to reaction in solvents.
Scheme 24. Synthesis of 2,4,5-triarylimidazole derivatives catalyzed by CSA.
Mosaddegh and co-workers54
have reported the environmentally friendly and one-pot multi-
component synthesis of 4,4′-arylmethylene-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) through
tandem Knoevenagel-Michael reaction of different aryl aldehydes and 5-methyl-2-phenyl-2,4-
dihydro-3H-pyrazol-3-one in the presence of a catalytic amount of cellulose sulfuric acid (CSA)
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in water-ethanol as a green solvent media under reflux conditions to afforded excellent yield of
the products (Scheme 25).
Scheme 25. Synthesis of 4,4′-arylmethylene-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives
catalyzed by CSA.
3. Starch Sulfuric Acid (SSA)
The SSA can be prepared by magnetically stirring a suspension of 5.00 g of starch in 20 ml of n-
hexane, and adding 1.00 g of chlorosulfonic acid (9 mmol) dropwise at 0 oC over 2 h. HCl gas is
evolved from the reaction vessel immediately. After the addition is complete, the mixture is
stirred for 2 h at room temperature. The mixture is then filtered and washed with 30 ml
acetonitrile and dried at room temperature to afford 5.25 g of starch sulfuric acid as a white
powder. SSA is non-explosive, non-hygroscopic and stable at room temperature.59
Organic transformations using SSA have many advantages such as a simple work-up process,
and inexpensive catalyst, environmentally friendly, excellent yield of the products with high
purity, shorter reaction time and solvent-free reaction conditions. The SSA is a solid,
heterogeneous catalyst, which can be easily recovered after completion of the reaction and
reused many times without loss of their activity.
3.1 Various organic transformations catalyzed by SSA
Rezaei and co-workers55
have developed environmentally benign protocol for the synthesis of
α,α′-benzylidene bis(4-hydroxycoumarin) derivatives by employing various aromatic aldehydes
with 4-hydroxycoumarin under solvent-free condition at 80 oC to afforded excellent yield of the
products (Scheme 25). The reaction was also examined by the authors in ethanol, water,
chloroform and toluene as solvents. However, in the presence of solvents the reaction becomes
sluggish. In addition, it is noted that below 80 oC, the reaction could not proceed efficiently and
gives a lower yield of the products. Both an electron-donating or electron-withdrawing
substituents on the aromatic ring gave efficient results. Compared with the conventional catalysts
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such as p-TsOH,56
HCl,57
and acetic acid,58
the SSA were showed better results in terms of the
yields of the products and time of the reaction.
Scheme 25. Synthesis of α,α′-benzylidene bis(4-hydroxycoumarin) derivatives catalyzed by SSA
Rezaei et al.59
have developed the one-pot multi-components synthesis of 3,4-
dihydropyrimidinone derivatives by using aldehydes, β-keto esters and urea/thiourea in the
presence of the starch sulfuric acid (SSA) as an environment friendly polymer-based solid acid
catalyst under solvent-free condition (Scheme 26). Various solvents such as acetonitrile,
tetrahydrofuran (THF), ethanol and water were also examined by the authors in this reaction,
however solvent-free condition shows better results. Lower yields of the products were observed
at lower temperature.
Scheme 26. Synthesis of 3,4-dihydropyrimidinone catalyzed by SSA.
Hatamjafari60
has discovered an efficient method for the synthesis of 1,5-diaryl-1H-pyrazole
derivatives by employing phenylhydrazine and Baylis Hillman adducts in the presence of starch
sulfuric acid (SSA) as reusable catalyst in 1,2-dicloroethane (DCE), which afforded excellent
yield of the products (Scheme 27). In addition, Baylis Hillman adducts were prepared by the
reaction of methyl or ethyl vinyl ketone and various benzaldehydes benzaldehydes. Here, 0.05 g
of SSA was sufficient to catalyze the reaction effectively. Various solvents such as water,
methanol, ethanol, acetonitrile, tetrahydrofuran (THF), and 1,2-dichloroethane (DCE) were used
Reviews and Accounts ARKIVOC 2015 (i) 136-159
Page 154 ©ARKAT-USA, Inc.
in this reaction by the authors to optimize the reaction condition. But, only the DCE gave
excellent yields of the products.
Scheme 27. Synthesis of 1,5-diaryl-1H-pyrazole derivatives catalyzed by CSA.
4. Conclusions
In the recent years, several new heterogeneous catalyzed organic processes have been reported in
the field of organic chemistry, which added new “environment friendly and green” tools for the
synthesis of valorous molecules. In recent years, cellulose sulfuric acid (CSA) and starch sulfuric
acid (SSA) have been developed as biodegradable catalysts for improving selectivity, purity and
high yield of the organic compounds. Particularly, CSA is widely used in a wide range of organic
syntheses efficiently. Besides the great advances that have been obtained so far, most research in
the development of new CSA and SSA catalyzed organic synthesis of pharmaceutical interest is
required. Due to this urgency, we will definitely see an increasing number of novel protocols for
the synthesis of various organic compounds catalyzed by these solid heterogeneous catalysts.
5. Acknowledgements
The authors are thankful to the Department of Chemistry, Gujarat University, Ahmedabad, for
providing the necessary facilities. UGC-Info net & INFLIBNET Gujarat University are
acknowledged for providing the e-source facilities. R.H.V. is thankful to UGC-BSR (F.7-
74/2007 (BSR)) for financial assistance.
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Authors’ Biographies
Dr. Hitesh D Patel has received his Ph.D in Organic Chemistry from the South Gujarat
University, Surat, Gujarat, India in 2005 under the supervision of Dr. B. D. Mistry of B. K. M.
Science College, Valsad, Gujarat, India. He worked on the synthesis of biologically active
heterocyclic compounds, their characterization by various analytical techniques and their testing
for activities. He joined as a lecturer at St. Xavier’s College, Ahmedabad, Gujarat, India and also
had been associated with Xavier Research Foundation, Ahmedabad, India, during the period of
1998 to 2005. Since then he has joined as an Associate Professor at Department of Chemistry,
Gujarat University, Ahmedabad, Gujarat, India. At present the field of the research area is
synthetic organic chemistry via green chemistry, biological screening of synthesized compounds,
the computational study of active organic molecules, study of organic fluorescence giving
compounds on infectious microorganisms and also scales up of industrially important
compounds.
Reviews and Accounts ARKIVOC 2015 (i) 136-159
Page 159 ©ARKAT-USA, Inc.
Rajesh H. Vekariya obtained his B.Sc. Degree in Chemistry in 2010 and his M.Sc. Degree in
organic chemistry in 2012 both from the Gujarat University, Ahmedabad (India). Currently, he is
pursuing his Ph.D. under the guidance of Dr. Hitesh D. Patel at the Chemistry Department of the
Gujarat University, Ahmedabad. His research focuses on the synthesis of organic intermediates
via green chemistry and their utilization in the synthesis of biologically active compounds. His
research focuses on synthesis of industrially important organic intermediates by step down
process and development of more eco-friendly and economical methods. He is working on
highly important and basic industrial processes such as nitration, bromination, oxidation and
reduction.