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Cellular respiration: Part 2 Kreb Cycle. outer membrane . intermembrane space. inner membrane . cristae. matrix. mitochondrial DNA. Mitochondria — Structure. Double membrane energy harvesting organelle. What cells would have a lot of mitochondria?. Oooooh ! Form fits function !. - PowerPoint PPT Presentation
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AP Biology
Cellular respiration: Part 2 Kreb Cycle
AP Biology
intermembranespace inner
membrane
outermembrane
matrixcristae
Mitochondria — Structure Double membrane energy harvesting
organelle
mitochondrialDNA
What cells would have a lot of mitochondria?
AP Biology
Mitochondria – Function
What does this tell us about the evolution of eukaryotes?
Dividing mitochondriaWho else divides like that?
Advantage of highly folded inner membrane?
Membrane-bound proteinsEnzymes & permeases
Oooooh!Form fits function!
AP Biology
Pyruvate oxidized to Acetyl CoA
reduction
oxidation
Coenzyme APyruvate
Acetyl CoA
C-C-C C-CCO2
NAD+
Acetyl CoA enters Krebs cycle
AP Biology
Citric Acid cycle aka Krebs Cycle
in mitochondrial matrix 8 step pathway
Evolved later than glycolysis does that make evolutionary sense?
bacteria 3.5 billion years ago (glycolysis) free O2 2.7 billion years ago (photosynthesis) eukaryotes 1.5 billion years ago (aerobic
respiration = organelles mitochondria)
1937 | 1953
Hans Krebs1900-1981
AP Biology
Whassup?
What’s the point?
AP Biology
Energy accounting of Citric Acid cycle
1 ADP 1 ATPATP
2x
4 NAD + 1 FAD 4 NADH + 1 FADH2
pyruvate CO2
3C 3x 1C
AP Biology
How is the CAC thermodynamically favoured?
1st Law: Energy is not created or destroyed
2nd Law: There is an increase in entropy in the universe
AP Biology
Value of Citric Acid cycle? If the yield is only 2 ATP then how was
the Citric Acid cycle an adaptation?
like $$in the bank
AP Biology
2 Methods of Generating ATP
Substrate Level Phosphorylation
Chemiosmotic Generation of ATP
AP Biology
Substrate Level Phosphorylation
AP Biology
Substrate Level Phosphorylation
AP Biology
Chemiosmosis
AP Biology
OXIDATIVE PHOSPHORYLATION
AP Biology
NAD+ H+
Q
e-e-
H+ H+
e-e-C
H+ H+
e-e-
0 + 2H+ = H2O
H+ H+
ADP + Pi ATP
AP Biology
FADH2 modification
NADH + H+
NAD+
oxidation
reduction
FADH2 FAD+
ADP + Pi ATP
QH2
½ O2 H2O
Q oxidizedcytochrome c
Cytochrome coxidase
NADH-Qreductase
ATPsynthase
Cytochrome b, c1
H+
H+
Succinate Qreductase