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Cell Reproduction
Chapter 9
Cell Growth
Main Idea: Cells grow until they reach their size limit, then stop growing or divide
Objectives: Explain why cells are relatively small Summarize the primary stages of cell cycle Describe the stages of interphase
Review: What’s the cell theory say? All organism are made of cells Cells are the smallest unit of living organisms Cells only come from other cells
Cell Size
Imagine yourself on a tennis court playing 1 on 1. Wouldn’t it be hard if the court were the size of a
football field? Cells have a size limit to ensure all the needs of
the cell are met
Surface Area to Volume
Limits to cell size: ratio of its surface area to its volume Surface area is the area covered by the plasma membrane Volume is the space inside the cell Figure 9.1 and Pg. 244 Connection to Math By remaining small, cells have a much higher ratio of
surface area to volume and can sustain themselves easier Demo! So: Do large cells perform their tasks more efficiently than
small cell? Mini Lab pg. 245
More About Size…
Small cells can transport substance easier than large cells
Diffusion would not be efficient, since it is passive transport, if the cell were large It would be like trying to float a toy boat across a
small puddle or across a large pond Cell size also limits the ability of a cell to
communicate Signals for processes might not occur fast enough
to signal another reaction Signals for protein synthesis need to reach the ribosomes
in time to continue the cycle
What happens when a cell reaches its size limit?
It will either: Stop growing Divide
Most cells divide because it prevents the cell from becoming too large and it helps the cell reproduce
Cell Cycle: the growing and dividing of cells There are 3 main stages
Interphase, Mitosis, Cytokinesis Time of division varies with the cell
Most cells take 12-24 hours to divide in animals
Cell Cycle
During Interphase, the cell grows, develops, duplicates its DNA and prepares for division
Three stages of Interphase: G1, S and G2
Cell Cycle
Interphase: Cells spend most of their life G1 stage- Time immediately after the cell
divides; cells grow to mature size G stands for “Gap” time between cell reproductions Some cells don’t divide after this
Example: nervous system cells only divide once
S Phase- DNA is copied G2 stage- Cell prepares for division
Find your 7 o’clock partner Designate partner A and partner B Partner A asks: What are the stages of the cell
cycle? Partner B: What occurs in G1? PA: What happens in G2? PB: What’s the S phase?
Review
Main Idea: Cells grow until they reach their size limit, then stop growing or divide
Objectives: Explain why cells are relatively small Summarize the primary stages of cell cycle Describe the stages of interphase
Section 9.2
Main Idea: Eukaryotic cells reproduce by mitosis, the process of nuclear division and cytokinesis, the process of cytoplasm division.
Objective: Describe the events of each stage of mitosis
Objective: Explain the process of cytokinesis
Think of events in your life that are cyclical Example: The passing of comets in the year Deer in the rut Turkeys in spring breeding season Day routine
Mitosis
Goal: replicated genetic material separates and the cell prepares to split into two cells Why?
It allows genetic information to be passed onto daughter cells
Uses? Replace damaged cells Increases the cell number of an organism- in other
words, the organism grows
SQR3 for “The Stages of Mitosis”, pg. 248
Chromosomes
Contain coiled DNA and proteins Chromatin is the relaxed form of DNA in the
cell’s nucleus, looks like a single strand Sister chromatids are structures that contain
identical copies of DNA Centromere holds the sister chromatids
together Socks!!
Mitosis
Prophase: Longest phase Chromatin tightens into chromosomes
The chromosomes become shaped like an X Centromeres are present
Nucleus disappears Microtubules called spindle fibers form in the
cytoplasm Centrioles (also microtubules) migrate to the end of
the cell (only in animal cells) Spindle apparatus: name given to the group of
spindle fibers, centrioles, etc. that help move the chromosomes around in the cell
Mitosis
Prophase Cont’d: Nuclear envelop
disappears Spindle fibers attach
to the sister chromatids to move the chromosomes around
Mitosis
Metaphase Chromosomes are easy
to identify Spindle fibers move
chromosomes to center
of cell
Anaphase
Chromatids are separated and move toward opposite poles caused by shortening spindle fibers
Whiles the chromatids separate, they are considered to be individual chromosomes
Centromere first
Telophase
Spindle fibers disappear after chromosomes are separated
Chromosomes loosen up Nuclear envelope and
nucleus reappears
Mitosis
Cytokinesis: Cell pinches inward
and cytoplasm seperates cell into two new cells
Cleavage furrow appears and cell divides (animals)
Cell Plate (plants)
Animations
Mitosis Video Fly Mitosis Cells Alive Mitosis Interactive Classroom
Video
Onion Root Tips
http://www.biologycorner.com/flash/onion_mitosis.swf
Review
Main Idea: Eukaryotic cells reproduce by mitosis, the process of nuclear division and cytokinesis, the process of cytoplasm division.
Objective: Describe the events of each stage of mitosis
Objective: Explain the process of cytokinesis Card Sort on Mitosis Stages What are the two differences between plant and
animal cells in mitosis?
Cell Cycle Regulation
The timing and rate of cell division are important Cyclins (proteins) bind to an enzyme, cyclin-
dependent kinases, to start the different stages of cell cycle
Cancer
Although cell cycle has a system of checks for quality, sometimes things go wrong
Cancer is the uncontrolled growth and division of cells (caused by the failure of the regulation of the cell cycle)
Cancer cells spend less time in interphase Pg. 254 picture
Stomach Cells
Normal Chicken Interphase 120 min Prophase 60 min Metaphase 10 min Anaphase 3 min Telophase 12 min
Cancerous Chicken Interphase 16 min Prophase 15 min Metaphase 2 min Anaphase 1 min Telophase 3 min
What effect do you think the difference in times have on the organism?
Causes of Cancer
Does not just occur in weak organisms Mutations or changes in the DNA, usually
that control the cell cycle, cause cancer Often, the mutations are repaired
Environmental factors Smoking, asbestos, chemicals, etc Radiation, x-rays
Not all cancers can be prevented Genetics
Apoptosis
Programmed cell death Why would cells WANT to die?
Cells in hands and feet Tree leaves falling in autumn Cells that are damaged
Stem Cells
Discovered in 1998 Unspecialized cells
Embryonic Results after a sperm fertilizes an egg controversial
Adult Found in tissues in body Can be used to maintain/repair the same kind of
tissue they came from Newborns have adult stem cells Less controversial
Paralysis Cured?
Pg. 258 Mapping Stem Cells MJF Video Video- Terra Incognita
Meiosis- Sect. 10.1
Main Idea: Meiosis produces haploid gametes
Objectives: Explain the reduction in chromosome number that occurs during meiosis
Recognize and summarize the stages of meiosis
Analyze the importance of meiosis in providing genetic variation
Which Cells?
The only cells that go through meiosis are the reproductive cells The results of meiosis are sperm or egg cells
In females: meiosis takes place in the ovaries, before birth
In males: meiosis takes place in the testes, usually starting at puberty
Chromosomes
Instructions for traits are located on chromosomes Found in the nucleus
DNA on chromosomes is arranged as genes (which control the production of proteins)
Chromosomes consist of hundreds of genes
Homologous Chromosomes
Human body cells have 46 chromosomes
At conception, each parent contributes 23 chromosomes
The chromosomes that match from each parent make homologous chromosomes
They have the same length, same genes and same centromere position
Haploid and Diploid
Gametes: sex cells that have half the number of chromosomes
Gamete number change with the species n represents the haploid chromosome
number Fertilization is the process when one haploid
gamete combines with another n + n = 2n 2n represents the diploid number
Numbers
Different species have different number of chromosomes
Meiosis
Remember: Gametes are formed during meiosis It reduces the number of
chromosomes in the cell When the gametes
combine (sperm and egg) a zygote is formed (a diploid group of cells that grow into an embryo)
Meiosis consists of two stages
Meiosis I
Meiosis I: MOST of the phases are the
same as mitosis: Interphase, prophase, metaphase,
anaphase and telophase
Exception: Prophase I-Instead of pairing on top
of each other, they pair side by side with the homologue – Synapsis is the name given to the pair
Meiosis I
Crossing-over occurs in Prophase I: genes are shared from each pair
Norwegian wrestling…
Results in genetic recombination
Meiosis I
Metaphase I: the pairs of homologous chromosomes line up at the equator of the cell
Can we borrow you shoes?
Meiosis I
Anaphase I- Instead of pulling apart the single chromosome, the homologous pairs are separated
Chromosome number is reduced from 2n to n when the pairs get separated
Meiosis I
Telophase I: new cells are haploid, but still has it’s sister chromatid
The chromatids might not be identical anymore
After cytokinesis, the cells go into interphase before the second set of divisions But, the DNA is not
duplicated
Meiosis II
Cytokinesis results in four haploid cells, each with n number of chromosomes.
Four cells are produced instead of two
Visualizing Meiosis Meiosis Video Comparison Video United Streaming Video Two interactive games
online to quiz yourself with
Questions for you
1. How many chromosomes will there be in the gametes of an organism with 18 chromosomes?
What would happen if the sister chromatids of one pair did not separate during anaphase II? Down Syndrome
Numbers
Karyotype: Picture of the pairs
Of chromosomes in
a cell
Why is Meiosis Important?
It results in genetic variation In Prophase I the
homologous chromosomes line up randomly
Depending on the order they line up in determines who they “cross over” with
Asexual Reproduction
Asexual- one parent Does not involve meiosis or the union of
gametes Bacteria- prokaryotes Offspring are identical to parents Rely on binary fission or mitosis
Cell Division- Prokaryotes
Use binary fission Three steps:
Chromosome copies itself Cell grows double it’s size New cell wall forms between the two chromosomes
and the cell splits
Bet you wish Eukaryotes were that easy…
Sexual Reproduction
Offspring are genetically different from parents because genes are combined in meiosis
Twins, contain unique combinations of parents’ genes
Advantage, through evolution, offspring can adapt rapidly to new conditions If disease strikes a crop of grain, the plants that
survive have the genes to overcome the disease
Cell Division- Eukaryotes
Mitosis- results in new cells with genetic info identical to the old
Meiosis- reduces chromosome number by half, then join other cells to restore the diploid number
Review Sect. 10.1
Main Idea: Meiosis produces haploid gametes
Objectives: Explain the reduction in chromosome number that occurs during meiosis
Recognize and summarize the stages of meiosis
Analyze the importance of meiosis in providing genetic variation