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Cell Injury

Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

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Page 1: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Cell Injury

Page 2: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 3: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 4: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 5: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Causes of Cell Injury

1.

2.

3.

4.

5.

6.

7.

Page 6: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Cell Adaptation to Stress

Page 7: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Atrophy

1.

2.

3.

4.

5.

6.

7.

Page 8: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 9: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 10: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 11: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Hypertrophy and Hyperplasia

WHAT IS THE DIFFERENCE?

Page 12: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 13: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 14: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 15: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Fatty change

Too much fat

coming in

not enough protein

to send it out

Page 16: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 17: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 18: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 19: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 20: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 21: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

NECROSIS

• Due to ischemia (coagulative)

• Liquefactive (due to enzymes from neutrophils)

• Caseous (due to enzymes from macrophages)

• Gangrenous (due to saprophytic bacteria)

• Enzymatic fat necrosis

Page 22: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 23: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 24: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 25: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 26: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 27: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin

Postmortem changes

Page 28: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 29: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin
Page 30: Cell Injury · cell Injury Swelling of endoplasmic reticulum and mitochondrion Death Swelling Of endoplasmic reticulum and loss of ribosomes Lysosome rupture Membrane blebs Myelin