CELL AND TISSUE INJURY COURSE-1dosya.marmara.edu.tr/tip/DersProgramlari/2012-2013/Donem... · 2013-03-02 · AIM At the end of this course, second year students will be able to broaden

Marmara University School of Medicine 2012-2013

Y2C1

CELL AND TISSUE INJURY COURSE-1

September 03, 2012 – October 19, 2012

AIM

At the end of this course, second year students will be able to broaden their basic science

knowledge to include the understanding of how certain alterations in bodily processes may

manifest as disease and gain fundamental knowledge about the processes underlying human

diseases, as the scientific foundation for developing clinical skills.

LEARNING OBJECTIVES

At the end of this course, second year students will,

describe using proper nomenclature, the etiology, pathogenesis, structural and

functional changes at cellular and tissue level;

describe in detail what happens to cells and tissues in response to abnormal stimuli;

explain the basic principles of human immune system as it relates to defense against

disease (innate, humoral, cell mediated);

describe the principles of classifying infectious microorganisms and their pathogenic

properties;

gain knowledge about viruses and viral pathogenesis;

gain knowledge about parasites and pathogenesis of parasitic diseases;

identify major drug classes and prototype drug(s) for each class.

Textbooks and Suggested Readings

Basics and Clinical Pharmacology (Bertram G Katzung).

Clinical Pharmacology (Laurence DR, Bennet PN).

Pharmacological Basis of Therapeutics (Goddman & Gilman’s).

Radiation protection, Ch.5 (Mary Alice Statkiewicz)

Radiobiology for the radiologist (Eric J.Hall)

Physics of Life Sciences (Alan H.Cromer)

Clinical Biophysics (Anbar)

Radiologic Science for Technologist (S.C.Bushong)

Textbook of Physiology (Guyton AC).

Basic Pathology (Stanley L. Robbins, Marcia Angel, Vinay Kumar).

Histology and Cell Biology: an Introduction to Pathology (Abraham L. Kierszenbaum).

Review Medical Microbiology (Ernest Jawetz et al.).

Medical Microbiology (Cedric Mims et al.).

Review of Medical Microbiology (Patric R. Murray, Ken S. Rosenthal).

Cellular and Molecular Immunology 5th Edition (Abbas, Lichtman).

Kuby Immunology 4th Edition (Goldsby, Kindt, Osborne).

Immunobiology 6th Edition (Janeway, Travers, Walport, Schlomchik).

Immunology, Infection and Immunity (Pier, Lyczak, Wetzler).

INSTRUCTOR INFORMATION

Year 2 Coordinators

Pınar AY, Assoc. Professor of Public Health

Özgür KASIMAY, Assist. Professor of Physiology

Chairperson of Subject Course

Coordinators of Introduction to Clinical Practice

Pemra C.ÜNALAN, Assoc. Professor of Family Medicine

Sibel KALAÇA, Professor of Public Health

(See ICP-2 Program Book for the details)

Departments Contributing to the Course and Lecturers

Tunç AKKOÇ, Assoc.Professor of Immunology

Ahmet AKICI, Professor of Pharmacology

Burak AKSU, Instructor of Microbiology

İnci ALİCAN, Professor of Physiology

Erkin ARIBAL, Professor of Radiology

Mustafa BAKIR, Professor of Child Health and Disease

Işıl BARLAN, Professor of Child Health and Disease

Kemal BERKMAN, Professor of Pharmacology

Emine BOZKURTLAR, Assist. Professor of Pathology

Süheyla BOZKURT, Assoc. Professor of Pathology

Hülya CABADAK, Assoc. Professor of Biophysics

Çiğdem ÇELİKEL, Professor of Pathology

Nilgün ÇERİKÇİOĞLU, Professor of Microbiology

Serap ÇİFÇİLİ, Assist. Professor of Family Medicine

Elif DAĞLI, Professor of Child Health and Disease

Emel DEMİRALP, Professor of Allergy-Immunology

Haner DİRESKENELİ, Professor of Internal Medicine

Yusuf ERDİL, Professor of Nuclear Medicine

Funda EREN, Professor of Pathology

Ayşe GARİP, Assist. Professor of Biophysics

Zafer GÖREN, Professor of Pharmacology

Rezzan GÜLHAN, Assoc. Professor of Pharmacology

Goncagül HAKLAR, Professor of Biochemistry

Ufuk HASDEMİR, Professor of Microbiology

Atila KARAALP, Assoc. Professor of Pharmacology

Ayşegül KARAHASAN, Professor of Microbiology

Handan KAYA, Professor of Pathology

Hızır KURTEL, Professor of Physiology

Oya ORUN, Assist. Professor of Biophysics

Nesrin ÖZER, Professor of Biochemistry

Güner SÖYLETİR, Professor of Microbiology

Pınar MEGA TİBER, Instructor of Biophysics

Aysın TULUNAY, Assist.Professor of Immunology

Turgut TUROĞLU, Professor of Nuclear Medicine

Nurver ÜLGER, Assoc. Professor of Microbiology

Hasan Raci YANANLI, Assoc. Professor of Pharmacology

Berrak YEĞEN, Professor of Physiology

SUMMARY OF THE COURSE

DISCIPLINE LECTURE &

SMALL GROUP

DISCUSSION

LAB& PRACTICAL TOTAL

BIOCHEMISTRY 4 - 4

BIOPHYSICS 11 - 11

CHILD HEALTH &

DISEASES

4 - 4

FAMILY MEDICINE 1 - 1

ALLERGY- IMMUNOLOGY 17 - 17

MICROBIOLOGY 24 6 30

NUCLEAR MEDICINE 2 - 2

PATHOLOGY 18 6 24

PHARMACOLOGY 21 - 21

PHYSIOLOGY 5 - 5

RADIOLOGY 1 - 1

SUBTOTAL 108 12 120

INTRODUCTION TO

CLINICAL PRACTICE

16 15 31

TOTAL 124 27 151

Monday, 03 September 2012

09:40 - 10:30 Introduction to the course and opening lecture

10:40 - 11:30 Introduction to pharmacology K BERKMAN

11:40 - 12:30 Routes of drug administration A KARAALP

13:40 - 14:30 Radioactivity: the decay law; physical half-life, biological half-life

O ORUN

14:40 - 15:30 Radioactivity: the decay law; physical half-life, biological half-life

O ORUN

Tuesday, 04 September 2012

09:00 - 10:30 Introduction to ICP-2

10:40 - 11:30 Types of radiation O ORUN

11:40 - 12:30 Types of radiation O ORUN

13:40 - 14:30 Structure and Function of Complement System E DEMİRALP

14:40-15:30 B Lymphocyte Development and Biology E DEMİRALP

Wednesday,05 September 2012

08.40-09.30 Microbial pathogenicity and virulence G SÖYLETİR

09:40 - 10:30 Microbial toxins G SÖYLETİR

10:40 - 11:30 Electromagnetic spectrum A GARİP

11:40 - 12:30

13:40 - 14:30 Biochemical aspect of cell death G HAKLAR

14:40 - 15:30 Biochemical aspect of cell death G HAKLAR

Thursday, 06 September 2012

09:40 - 10:30 Microbiology of water, milk, and air N ÇERİKÇİOĞLU

10:40 - 11:30 Chemokines, Neutrophils and Monocytes in Innate Immunity T AKKOC

11:40 - 12:30 Immunoglobulins: Structure and Function, Antigen & antibody Interactions

T AKKOÇ

13:40 - 14:30 Introduction to pathology Ç ÇELİKEL

14:40 - 15:30 Adaptive cell reactions and abnormal accumulations F EREN

Friday, 07 September 2012

09:40 - 10:30 Pathophysiology of oedema formation H KURTEL

10:40 - 11:30 Pathophysiology of oedema formation H KURTEL

11:40 - 12:30 Molecular and radiobiological behavior H CABADAK

13:40 - 14:30 Major histocompatibility complex (MHC) olecules, antigen processing and presentation

E DEMİRALP


09:40 - 10:30 Basic principles of drug toxicity H. R. YANANLI

10:40 - 11:30 Heavy metals and antagonists H. R. YANANLI

11:40-12:20 Introduction to innate immune system H.DİRESKENELİ

13:40 - 14:30

14:40 - 15:30 Dosimetry, basic concepts O ORUN


09:00 - 17:30 ICP-2: Basic Clinical Skills, Human in Medicine, Student Research Activity-2

Wednesday, 12 September 2012

09:40 - 10:30 DNA viruses: Herpes viruses U HASDEMİR

10:40 - 11:30 Mechanism of viral pathogenesis G SÖYLETİR

11:40 - 12:30 Pathogenesis of parasitic disease N ÜLGER

13:40 - 14:30 Introduction to Radiology and Prevention in Radiology E ARIBAL

14:40 - 15:30 Effects of ionizing radiation on the cell and organism H CABADAK


09:40-10:30 Development of T Cells, T lymphocyte signaling mechanisms and activation

T AKKOÇ

10:40 - 11:30 Brıdgıng Innate and Adaptive Immunty Dendritic Cells , NK Cells NKT Cells and Other Innate like T and B Lineages

H. DİRESKENELİ

11:40 - 12:30 Blood and tissue protozoa N ÜLGER

13:40 - 14.30 General principles of macroscopic evaluation (slide lecture) S BOZKURT

14:40 - 15:30 General Pathology of viral infections S BOZKURT


09:40-10:30

10:40 - 11:30 Normal body flora N ÇERİKCİOĞLU

11:40 - 12:30 RNA viruses: Orthomyxoviruses and Paramyxoviruses A KARAHASAN

13:40 - 14:30 Health effects of tobacco E DAĞLI

14:40 - 15:30 Health effects of tobacco E DAĞLI

15:40-16:30


08.40-09.30

09:40 - 10:30 General pharmacokinetic principles-1 R GÜLHAN


11:40 - 12:30 Cultivation and identification of bacteria A KARAHASAN






09:40 - 10:30 Mechanism of drug action Z GÖREN

10:40 - 11:30 Mechanism of drug action Z GÖREN

11:40 - 12:30 Mechanisms of clinically important drug interactions A KARAALP

13:40 - 14:30 Interaction of radiation with matter P MEGA TİBER

14:40 - 15:30 Interaction of radiation with matter P MEGA TİBER

15:40-16:30 Physiology of pain B YEĞEN


09:40 - 10:30 Autocoids Z GÖREN



13:40 - 14:30 Host parasite interactions G SÖYLETİR

14:40 - 15:30 Host parasite interactions G SÖYLETİR

15:40-16:30 Introduction to chemotherapeutics R GÜLHAN


08:40 - 09:30 Cell injury and cell death H KAYA

09:40 - 10:30 Cell injury and cell death H KAYA

10:40 - 11:30 Prostaglandins N ÖZER

11:40 - 12:30 Prostaglandins N ÖZER

13:40 - 14:30 Introduction to elective studies

14:40 - 15:30 Elective Course

15:40-16:30 Elective Course


08:40 – 09:30 DNA viruses: Adenoviruses, Parvoviruses, Papavoviruses, and Poxviruses

A KARAHASAN

09:40 - 10:30 RNA viruses: Togaviruses, Bunyaviruses, Flaviviruses and other RNA viruses

A KARAHASAN

10:40 - 11:30 Body temperature and its regulation İ ALİCAN

11:40 - 12:30 Body temperature and its regulation İ ALİCAN

13:40 - 14:30 Hepatitis viruses G SÖYLETİR

14:40 - 15:30 Tissue renewal and repair: regeneration, healing, and fibrosis E BOZKURTLAR

15:40-16:30 Tissue renewal and repair: regeneration, healing, and fibrosis E BOZKURTLAR




09:40 - 10:30 Intestinal and urogenital protozoa N ÜLGER

10:40 - 11:30 LAB: Normal body flora (GROUP A) Microbiology

11:40 - 12:30 LAB: Normal body flora (GROUP A) Microbiology

13:40 - 14:30 Cytokins I BARLAN

14:40 - 15:30 Cytokins I BARLAN

15:40- 16:30 LAB: Normal body flora (GROUP B) Microbiology

16.40-17.30 LAB: Normal body flora (GROUP B) Microbiology


09:40 - 10:30 Cestodes and Trematodes N ÜLGER

10:40 - 11:30 Miscellaneous viruses; Coronavirus, Flavivirus, Calicivirus N ÇERİKÇİOĞLU

11:40 - 12:30 Pharmacotherapy in viral infections H. R. YANANLI

13:40 - 14:30 Basic principles of immunopathology S BOZKURT

14:40 - 15:30 Autoimmune disorders S BOZKURT

15.40-16.30 Application of Nuclear medicine and radiotherapy T TUROĞLU


09:40 - 10:30 Haemodynamic disorders Ç ÇELİKEL

10:40 - 11:30 Thromboembolic disease Ç ÇELİKEL

11:40 - 12:30 Thromboembolic disease Ç ÇELİKEL

13:40 - 14:30 Intestinal and tissue nematodes N ÜLGER

14:40 - 15:30 Elective Course

15.40-16.30 Elective Course

Monday, 01 October 2012

08:40 - 09:30 Immun response to extracellular and intracellular infections A TULUNAY

09:40 - 10:30 Immune Responses to Extracellular and Intracellular Infections; A. TULUNAY

11:40 - 12:30 RNA viruses: Picornaviruses, Rhabdoviruses and Reoviruses U HASDEMİR

13:40 - 14:30 Pharmacotherapy in parasitic infections A AKICI

14:40 - 15:30 General principles of medical toxicology A KARAALP

15:40 - 16:30 Patient with fever and rash S ÇİFÇİLİ

Tuesday, 02 October 2012

09:00 - 17:30 ICP-2: Basic Clinical Skills, Human in Medicine, Student

Research Activity-2

Wednesday, 03 October 2012

08:40 - 09:30

09:40 - 10:30

10:40 - 11:30 LAB: Examination of protozoa (GROUPA) Microbiology

11:40 - 12:30 LAB: Examination of protozoa (GROUP A) Microbiology

13:40 - 14:30 LAB: Examination of protozoa (GROUP B) Microbiology

14:40 - 15:30 LAB: Examination of protozoa (GROUP B) Microbiology

Thursday, 04 October 2012

09:40 - 10:30 RNA viruses: Retroviruses and HIV U.HASDEMİR

10:40 - 11:30 Laboratory diagnosis of viral infections A.KARASAHAN

11:40 - 12:30 Laboratory diagnosis of viral infections A.KARASAHAN

13:40 - 14:30 Acute inflammatory response S BOZKURT

14:40 - 15:30 Acute inflammatory response S BOZKURT

15:40-16:30 Pathology of hypersensitivity reactions S BOZKURT

Friday, 05 October 2012

08:40 – 09:30 Amiloidosis E BOZKURTLAR

09:40 - 10:30 Chronic inflammatory response H KAYA

10:40 - 11:30 Transplant pathology H KAYA

11:40 - 12:30 Tissue and organ response to radiation and genetic effects of radiation

Y ERDİL

13:40 - 14:30 Antiseptics and disenfectants H R YANANLI

14:40 - 15:30 Bioterrorism: a global threat A.KARASAHAN

15:40-16:30

Monday, 08 October 2012

08:40 - 09:30 Immunomodulators H.R. YANANLI

09:40 - 10:30 Drug induced immune response and antiallergic treatment H R YANANLI

10:40 - 11:30 LAB: Examination of helminths and medically important arthropods (GROUP A)

Microbiology

11:40 - 12:30 LAB: Examination of helminths and medically important arthropods (GROUP A)

Microbiology

13:40- 14:30 LAB: Examination of helminths and medically important arthropods (GROUP B)

Microbiology

14:40- 15:30 LAB: Examination of helminths and medically important arthropods (GROUP B)

Microbiology

Tuesday, 09 October 2012

08:40-09:30 LAB: Cell response to injury and adaptive cell reactions-Group A

Pathology (S. BOZKURT)

09:40 - 10:30 LAB: Cell response to injury and adaptive cell reactions-Group A


10:40 - 11:30 LAB: Hemodynamic disorders and abnormal accumulations-Group A

Pathology (S.BOZKURT)

11:40 - 12:30 LAB: Hemodynamic disorders and abnormal accumulations-Group A


13:40 - 14:30 LAB: Cell response to injury and adaptive cell reactions-Group B


14:40 - 15:30 LAB: Cell response to injury and adaptive cell reactions-Group B


15:40 - 16:30 LAB: Hemodynamic disorders and abnormal accumulations-Group B


16:40- 17:30 LAB: Hemodynamic disorders and abnormal accumulations-Group B

Pathology (S.BOZKURT)

Wednesday, 10 October 2012

08:40-09:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group B


09:40 - 10:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group B


10:40 - 11:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group A


11:40 - 12:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group A


13:40 - 14:30 FREE STUDY TIME

14:40 - 15:30

15:40 - 16:30

16:40- 17:30

Thursday, 11 October 2012

08:40-09:30 FREE STUDY TIME

09:40 - 10:30

10:40-11:30

11:40-12.30


14:40 - 15:30

Friday, 12 October 2012

08:40-09:30 FREE STUDY TIME

09:40 - 10:30

10:40-11:30

11:40-12.30


14:40 - 15:30

Monday, 15 October 2012 PRACTICAL EXAMINATION

Tuesday, 16 October 2012 PRACTICAL EXAMINATION

Wednesday, 17 October 2012 FREE STUDY TIME

Thursday, 18 October 2012 FREE STUDY TIME

Friday, 19 October 2012 THEORETICAL EXAMINATION

Documents

CELL AND TISSUE INJURY COURSE-1dosya.marmara.edu.tr/tip/DersProgramlari/2012-2013/Donem... · 2013-03-02 · AIM At the end of this course, second year students will be able to broaden