Medication Formulary/Added 11.2015

Cefazolin (Ancef®, Kefzol®) Classification: Antibiotic

Action: Bactericidal actions against many gram-positive and gram-negative aerobes.

Indication/s: Open skeletal fracture; a break in the skin over a fracture site

Contraindications: History of anaphylaxis (not simple rash) to penicillin, Known allergy to the cephalosporin group of antibiotics:

Biocef® (cephalexin) Cedax® (cefibuten) Cefizox® (ceftizoxime) Cefobid® (cefoperazone) Cefotan® (cefotetan) Ceftin® (cefuroxime) Cefzil® (cefprozil) Ceptax® (ceftazidime) Claforan® (cefotaxime) Duricef® (cefadroxil) Fortaz® (ceftazidime) Keflex® (cephalexin) Lorabid® (loracarbef) Maxipime® (cefepime) Mefoxin® (cefoxitin) Omnicef® (cefdinir) Panixine® (cephalexin) Raniclor® (cefaclor) Rocephin® (ceftriaxone) Spectrecef® (cefditoren) Suprax® (cefixime) Tazicef® (ceftazidime) Vantin® (cefpodoxime) Velosef® (cephradine) Zinacef® (cefuroxime)

Dosage: Adult (18 y/o and over): ≥ (equal to or greater than) 80 kg: 2 grams IM/IV ≤ (equal to or less than) 80 kg: 1 gram IM/IV

IM (preferred route): appropriate site is anterolateral thigh ≥ 80 kg: 2 grams IM over 2 – 3 seconds ≤ 80 kg: 1 gram IM over 2 – 3 seconds

IV bolus: dilute each reconstituted gram of Ancef® with an additional 5 mL of normal saline, give each gram slowly over 3 – 5 minutes. IV “piggyback”: added appropriate number of reconstituted Ancef® vials (1 or 2 grams) to 100 cc bag of normal saline.

Side effects: Diarrhea, pain at IM injection site

Special Considerations:

Supplied: 2 – 1 gram vials (each gram to be reconstituted with 2.5 mL of sterile water) Note: after reconstitution with 2.5 mL sterile water there is approximately 330 mg/mL

1 – 10 mL sterile water (for reconstitution)