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CCB: a Co-ordinated Approach
to Cancer Biobanking in the UK
Dr Bridget Wilkins
(NCRI Pathology Lead for NHS Engagement in Biobanking)
On behalf of CCB
An NCRI initiative
• A networked consortium of independently managed and autonomous cancer biobanks
• Aiming to become the representative body for cancer biobanking in the UK
– Promoting best practices for biobanks
– Providing guidance
– Promoting transfer of knowledge and experiences between banks
http://www.ncri.org.uk/ccb/
Promote and disseminate consensus on best practice
for biobanks
Key areas - harmonisation of procedures, assurance
of fitness for purpose, public and patient
engagement
Assist biobank development by providing advice and
mutual support
Promote networking between biobanks by collaborative
development of procedures to facilitate sharing of
biosamples and linked data
CCB Objectives - 1
Provide news and information relevant to cancer
biobanking.
Represent the voice of CCB members to funders,
including NCRI partners and others
Provide an interface for researchers to access the
collective holdings of member biobanks
Increase the visibility of research tissue collections
CCB Objectives - 2
Promoting best practice
Regular Workshops
biosampledirectory.ncri.org.uk
Providing news and information
@ccb_uk
For Members • email groups • intranet site
Current Projects and Activities
Harmonisation/bench-marking project
Aim: to increase the number of “fit for
purpose” samples available for research by
developing harmonised standards and a
quality mark scheme for biobanks in the
UK.
Liverpool Tissue Bank has contributed to this
process from its start.
Harmonisation/Bench-marking Project
The biobanking community has shown support for:
Harmonisation and, where possible,
standardisation in ways that include different
types of biobanks
The development of standards and best
practice guidance for biobanks
Development of a scheme to award a quality
mark to biobanks, based on compliance with
the standards
Harmonisation/Bench-marking Project
The scheme aims to:
be simple, pragmatic, proportionate, light
touch, realistic
take account of other assessment systems
involve self assessment followed by peer
review
provide training and mentoring
Harmonisation/Bench-marking Project
Progress to date:
draft standards for quality management and
data harmonisation have been developed
two pilot audits have been undertaken, in
which volunteer biobanks were assessed
against the requirements of the standards.
audit findings have been used to improve the
standards and the audit process, as well proving
of use to the volunteer biobanks.
Other Current Projects and Activities
Member-hosted meeting series
Previous events:
Symposium on Biosample Quality
Donor Engagement & Consent
Data Standardisation and Integration
Ensuring Success in Sample Collection for Clinical
Trials
Future meetings:
Cardiff and Belfast in 2014
Other Current Projects and Activities
Pilot IT project
Inter-biobank Sample Search Portal
Other Current Projects and Activities
Public Engagement
“Swipe Here
to Donate...”
- RCPath/CCB
Nov 11th 2013
Other Current Projects and Activities
Public Engagement
“Swipe Here
to Donate...”
- RCPath/CCB
Nov 11th 2013
Benefits of Membership
Networking opportunities with other members
Sharing of information, strategies and solutions, including access to a private web area for discussion forums and document-sharing
Being part of a collective voice to promote the importance of using biosamples in research, within the cancer research community, to wider scientific and medical communities and to the public
Involvement in initiatives to improve quality and accessibility of biosamples and data
Membership Categories for Biobanks
Member
Currently providing samples for cancer research to any
researchers with bona fide projects (at least in UK)
Compliant with CCB Guiding Principles
Sample collection is discoverable by researchers
(listed in the NCRI Cancer Biosample Directory as a
minimum)
Provisional Member
Biobanks working towards full membership status but
not yet fulfilling all criteria (reviewed after 2yrs)
‘Registered Collection’ Category
Aimed at investigator-led collections
Open to investigators holding biosample
collections where there is an intention to allow
wider research use of samples in the long term
Increases visibility of the collection with
potential for encouraging new collaborations
Signals investigator’s intent of ensuring ongoing
use of any remaining samples – in keeping with
principle of maximising use of all biosamples
donated for research
Why join this network?
UK Funders may mandate it...
Improve the co-ordination of collection,
storage and use of biosamples by:
Harmonising policy among funders
Harmonising practice among banks and
collections
Minimising duplication
Making samples more discoverable
and accessible
Encouraging sharing and re-use
Understanding the views of patients and
public
Be part of a collective voice in an
evolving UK research environment
