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Caustics
Dr. Peter Krampl
Dr. Randall Berlin
21 February 2001
Introduction
Caustics Any substance in which pH neutralization takes
place at the expense of the tissues
Alkali; usually pH > 11 Liquefaction necrosis Deeper penetration Immediate injury and pain
Acid; usually pH < 3 Coagulation necrosis
Introduction
Injury depends on Volume pH Concentration TAR
Titratable acid or alkali reserve History
Name, amount, concentration Time of ingestion Accidental vs. purposeful Vomiting after ingestion
Introduction
Drain cleaners / lye Sodium or potassium hydroxide
Laundry / dishwasher detergents Sodium hydroxide
Batteries Potassium hydroxide
Deoderizers Formaldehyde
Cleaners Ammonia Acids in toilet bowel cleaners
Disinfectants, household bleaches Oxalic acid
Introduction
Inflammatory phase 0-48 hours
Granulation phase 2 days to 2 weeks
Stricture formation Usually seen after 4 weeks
Controversies
Dilutional vs Neutralization Therapy? Do all Patients Need Endoscopy? Use of Antibiotics / Steroids? Who Needs Surgery?
Case 1
A 14 month old presents to the ED after being found with a bottle of drain cleaner (pH 13). The mother is unsure if the child drank any. In the ED the child looks well with normal vital signs, no respiratory distress, no stridor, no drooling, no vomiting and no oral lesions.
Case 1
How would you manage this patient? ? GI decontamination, ? dilutional, ? endoscopy, ? disposition)
S/S as Predictors
Gaudreault et al; Pediatrics; 1983 378 cases over 10 years Vomiting 33% Grade 2/3 lesions Dysphagia 25% Abdo Pain 24% Oral burn 18%
S/S as Predictors
Crain et al; AJDC; 1984 79 patients Retrospective review Presence of symptoms (Crain criteria: vomit,
drool, stridor) plus oropharyngeal burns compared to endoscopy
2/3 symptoms gave 50% (7/14) indication of serious injury
1/3 gave 0% (7/14)
S/S as Predictors
Previtera et al; Ped EM Care; 1990 Prospective study 156 cases over 10 years
Symptoms compared to endoscopy within 24h Observation of visible lesions of cheeks, lips
and oropharynx 38.4 % visible lesions
Absence cannot rule out Grade 2 Burn Presence indicates higher risk of Grade 2/3 burns
S/S as Predictors
Gorman et al; AJEM; 1992 Prospective trial Endoscopy blinded to symptoms 36 ingestions
Vomit, dysphagia, abdo pain, oral burns (sens 94; spec 49
Vomit, dysphagia, abdo pain, dysphagia (sens 89; spec 58
Crain Score: vomit, drool, stridor (sens 56; Spec 91)
S/S as Predictors
Christeen. Acad Pediatrics.1995. Retrospective study 115 cases over 19 years Stridor, vomit or drool
1 S/S Sens 1.0; Neg PV 1.0 3 S/S Pos PV 0.91; Spec 99%
S/S as Predictors
Textbook: Evaluate for vomiting, drooling, stridor If assymptomatic w.r.t. above, endoscopy
not necessary ‘endoscopy should be entertained if one
symptom present’ Remember though, if stridor present , Gorman
et al showed it to carry higher degree of specificity.
Case 2
A 14 yo female presents to the ED after drinking something in chemistry class that she thought was apple juice. Substance is later identified as a mixture of DMSO, potassium hydroxide, sodium hydroxide and Luminal (pH 12). Upon presentation to the ED she was complaining of a burning sensation in her mouth and chest and was vomiting. She is able to swallow but it is extremely painful, her mouth is erythematous and blistered.
HR 120; BP 100/60. RR 20, O2 saturation 95%
How would you manage this patient?? GI decontamination? Dilutional? diagnostic tests
labsxrayUGI
Her chest xray is normal
How would you manage this patient??endoscopy ? steroids ? antibiotics Endoscopy showed: The esophageal mucosa showed
diffused exudative esophagitis, the depth could not be adequately demonstrated. It was, however, circumferential.
What Grade is this?
Initial Tx: Decontamination
Textbook: Orogastric and nasogastric tubes carry risk of
perforation Listed as contraindicated in one source but noted may
be used in first 90 minutes in another source to remove substance from GI tract?
Activated charcoal contraindicated as it will interfere with endoscopy
Most caustics not absorbed by charcoal Ipicac contraindicated
Addition of another caustic
Initial Tx: Milk / Water Dilution
Rumack et al. Clinical Tox. 1977 Review of laboratory temperature
measurements of adding milk, water and weak acid neutralizers to corrosive injuries
Milk and water produced the lowest temperatures though water had a greater area under the time-temperature curve
Initial Tx: Dilution/Neutralization Kimball et al. Annals of EM; 1985 Compared buffering, dilution and
neutralization Buffering ? Slow neutralization no benefit
May be harmful due to temperature rise Dilution variable secondary to strength of ingested
material Neutralization may be beneficial only in the case
of weak acid to strong base… minimal temperature rise
Initial Tx: Saline / Water / Milk Dilution Homan et al. Annals of EM; 1993
60 rat esophogi 60 minute saline infusion started at 0, 5, 30
minutes after ingestion At 0 minutes 54% show Grade 2 or more At 30 minutes 100% showed Grade 2 or more May be beneficial but time to institution critical
Similar trial with mil in 1995 which showed slight improvement at 0,5 minutes but no change in outcome at 30 minutes
Initial Tx:Dilution / Neutral / Buffering Textbook:
Dilutional therapy with water or milk may compromise airway because of potential for vomiting; vomiting can lead to re-exposure.
Studies show benefit only in first few minutes ‘use of milk or water should be limited to first few
minutes after exposure in patients with no airway compromise, no vomiting, no abdo pain, are alert and are old enough to speak’
Neutralization therapy may worsen by exothermic heat reaction
Tests: Radiography
Textbook: Limited benefit in initial stabilization May be useful for judging type of foreign material
in case of batteries, and for signs and symptoms of severe injury:
Pneumomediastinum Pleural effusions Pneumoperitoneum CXR usually most helpful film in stabilization
Contrast studies such as GI series of benefit in follow-up of Grade 2a lesions and higher
Tests: Endoscopy
Showkat et al; GI/GI Endo; 1989/91 Prospective studies 41 patients/81 patients 87 % esophageal injury seen by scope
within 36 hours
Classification grade 0 to 3 within 36hrs 0 normal 1 edema and hyperemia of mucosa 2 a blister / friable 2 b: 2a with ulceration
“Near” circumferential Important point for stricture formation
3 multiple deep ulcerations circumferential
– 3a small scattered areas– 3b large extensive areas of necrosis (11/11 deaths)
All 0, 1, 2a recovered without squeal
Tests: Endoscopy
Surfeit et al. Br. J. Surgery. 1987 Retrospective review 484 patients over 12 years Reaffirmed endoscopy indications All 250 patients assigned Superficial- Grade 1
on endoscopy healed without sequelae Note study done prior to Showkat criteria and I
superimposed their definition of superficial to fall within grade 1.. Possibly Grade 2a.
Tests: Endoscopy
Textbook: Indications
Stridor Both vomiting and drooling Intentional ingestions in adults
Not indicated Assyptomatic accidental exposures Patients who fit operative criteria
Timing of scope ? 6 hours to grade full extent of injury
Tests: Endoscopy
Textbook: Optimal < 12 hours Increased risk or perforation from
endoscopy usually not until 24 hrs Graded as per modified Showkat criteria
2a is a main cut-off– < / equal 2a soft diet; NG; stricture risk very low– > 2a serial endoscopies
• Increased complications such as perforation, stricture and therefore increased surveillance
Tx: assympotmatic or Grade 0 and 1 on endoscopy Textbook:
Humidified air Analgesia Parenteral fluids prn Progressive oral fluids
Case 3
A 14 month old male presents to the ED after drinking HD Liquid Pipeline Cleaner (sodium hydroxide, sodium hyperchlorite, polyacrylate sodium). Immediately after drinking the cleaner the child began to vomit and have respiratory difficulty “choking”.
In the ED the child has a decreased level of consciousness, HR 138, RR 28, BP 121/77, T 36.4 C. The child is drooling thick yellow secretions and has burns to her tongue, face and chest. The child is stridorous, wheezing and continuing to vomit. Abdomen has some guarding but generally felt to be non-peritoneal.
How would you manage this patient?(? ABCs, diagnostic tests , GI decontamination, neutralization therapy) The child is intubated. CXR normal. ABG 7.41/27/119/17 Lytes:
134/4.2/106/23 glucose 6.6, BUN 2.4 How would you manage this patient?(? steroids, ? antibiotics, ? endoscopy) Endoscopy shows circumferential burns, 3rd degree burns, extensive
exudate in the stomach.
Tx: Steroids
Initial benefit shown in non-randomized, non controlled trials Spain et al. 1950 Haller et al. 1960
Steroids mainstay of treatment into the 1970’s
Tx: Steroids
Webb et al. Annal of Thoracic Sx; 1970. 68 patients; prospective; non-random Initial esophageal grade >1 Steroid administration showed no difference in
stricture rates among 2nd or 3rd degree lesions. Ferguson et al. AJ Surg; 1989
Retrospective study 1974-1987; 47 patients Retrospectively reviewed incidence of esophageal
stricture in relation to endoscopic grade in non steroid vs. steroid groups.
No difference but p<0.15; not powered to find
Tx: Steroids
Anderson et al. NEJM. 1988. Prospective; 60 children; not blinded Strictures in 10/31 versus 11/29 in
treated versus untreated; p>0.05 Problems included
Ampicillin given in steroid group Endoscopy criteria poorly adhered Multiple exclusions including ammonia
Tx: Steroids Howell et al. AJEM. 1992 Met analysis of 361 patients
10 retrospective and 3 prospective studies Either treatment with steroids and antibiotics (T) versus
no treatment (NT) No intermediate group T group 25% stricture in 2nd/3rd degree NT group 52%; p<0.01 Higher percentage of 3rd degree in NT group
Poor study because not enough good studies to do meta-analysis
Tx: Steroids
Textbook: Variable studies Not indicated in Grade 0,1 lesions since strictures do
not develop May not be useful in high Grade 3 lesions
may progress to stricture regardless of therapy High risk of perforation Mask s/s of peritonitis
In between grade of Grade 2a-3a have poor/ limited studies
Current review recommendation is no steroids until well-controlled prospective study available
Tx: Antibiotics
Textbook: Usually concomitant therapy with steroids Also given due to belief that tissue
disruption may cause alternate pathway for infection deep to mucosal layer of GI tract
No good trials either w or w/o steroids
‘reserve antibiotics for identified source of infection unless steroids are used’
Case 4
A 30 year old female presents to the emergency department 3 hours after ingesting an unknown amount of “drain opener” (concentrated sulfuric acid) in a suicide attempt. On presentation the patient is drooling and has frothy sputum. BP 90/50, HR 140, O2 saturation 92% on 5 L by mask, T 38 C. She is lethargic but able to answer questions with nodding. Her mouth is swollen and erythematous. Her lungs are clear. Her abdomen is diffusely tender with peritoneal signs.
How would you manage this patient?(ABCs, GI decontamination, diagnostics) Her blood pressure continues to fall and she is started on vasopressors.
CXR: normal; electrolytes: 147/6.9/112/11/120; glucose 6.0; 6.97/40/101/9; amylase 774, PT 19.2, PTT 126.8
How would you manage this patient?(? endoscopy, ? antibiotics, ? steroids, ? surgery)
Tx: Surgery
Estera et al. Ann Thoracic Sx. 1986. 62 patients reviewed 1974-1980 First 2 years management was endoscopy,
steroids, ABX and dilatation Last 4 years treatment for Grade 2/3 included
surgical intraluminal stents and resection; Sequalae in (2a/b) reduced from 5/7 to 0/3
Study seemed to omit differentiation between 2a/b No specific inclusion criteria for surgery Death in 3b reduced from 3/4 to 0/3
Tx: Surgery Horvath et al. Ann Thor. Sx. 1991. Case reports of good outcomes of 4/8 Grade 3
patients after early esophagogastrectomy No trial criteria. Not consistent with regard to initial treatment based on
esophageal grades Wu et al. Surgery. 1993.
Retrospective review 28 patient with severe ingestions underwent surgery. Mortality 50%; 100% GI morbidity Difficult to apply initial criteria
Tx: Surgery
Textbook: Serum pH < 7.2 Gastric ph > 7.3 Perforation seen on CXR, endoscopy S/S shock with respiratory compromise Hemoglobnuria Ascites Coagulation abnormalities
Other Points
Lathryogens Penicillamine, NAC, colchicine inhibit collagen
synthesis and/or breakdown Experimental non-trial evidence so far
Strictures management Prevention
Stents, NG tubes Steroids / Abx
Serial dilatation Usually after 4 weeks
Surgery
In summary……
Studies
Mainly retrospective Mainly case studies Those that are prospective suffer
Non-randomization Poorly defined inclusion criteria Poorly adhered inclusion criteria
I.e endoscopy criteria
Few numbers P value to large
Studies not powered to be significant Difficult to do meta analysis studies
Pete’s Treatment Algorithm ABC’s
Manage airway aggressively similar to inhalational burn
Decontamination Consider NG Dilution based on early time from exposure, i.e. at
home No lavage No charcoal No emesis
Pete’s Treatment Algorithm
Use signs and symptoms to decide upon endoscopy Usually at 4-6 hours If you are worried enough to do endoscopy, get
CXR and labs while you wait If meet criteria for surgery bypass go….. do not
collect $200. Based on initial S/S, ABG, CXR, presence of shock,
bleeding Once to endoscopy, grade will aid decision
Pete’s Treatment Algorithm
Steroids / ABX not indicated in ER because Limited studies Possible use in Grade 2 needs to be confirmed by
endoscopy first so no role for ER
If grade 0 or 1 endoscopy: Humidified air Analgesia Parenteral fluids Progressive oral fluids
Pete’s Treatment Algorithm
If grade 2 or 3 endoscopy: Treat as per Grade 0 or 1 injury, but
No oral fluids initially ? Consider steroids ? Consider antibiotics Consider stent / stricture prophylaxis Review at 2-4 weeks for stricture evaluation
– dilatation
Pete’s Treatment Algorithm
Disposition? Assymptomatic and Grade 0 on endoscopy
Home
Grade 1 may be admitted for pain control Observation Social / psych issues
GI likely to be involved in decision process Resume enteric feeds sooner than later Ongoing monitoring