10/07/16

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Catherine M. Stefanato, MD, FRCPath Consultant in Dermatopathology

St John’s Institute of Dermatology London, UK

A. ChromomycosisB. CutaneousT-celllymphomaC. HypertrophiclupusD. Squamouscellcarcinoma

Hypertrophiclupuserythematosus

• Variantofdiscoidlupuserythematosus(DLE)

• Erythematousverrucousplaques,resistanttotopicalRx

• Faceandupperlimbs

• OOenconcomitantlesionsofDLE

• MayclinicallyresembleKA/SCC

HypertrophiclupuserythematosusHistopathology

• Epidermal(pseudoepitheliomatous)hyperplasia

• OtherfeaturesofLEpresent• Vacuolarinterfacechange

• Basementmembranezonethickenning

• TransepidermaleliminaUonofelasUcfibres(butalsodescribedinKAandSCC)

• BandandclustersofCD123-posiUvecellsbelowDEJ

10/07/16

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CD123CD123

•  DrAnastasiaTherianou•  DrSusieMorley•  DrJaneSe=erfield