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Categorization of Substances on the DSL: Operational Approach. DOMESTIC SUBSTANCES LIST. ENVIRONMENT CANADA. HEALTH CANADA. Persistent OR Bioaccumulative According to the Regulations. Greatest Potential for Human Exposure. HEALTH CANADA. ENVIRONMENT CANADA. - PowerPoint PPT Presentation
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Categorization of Substances on the DSL: Operational Approach
DOMESTIC SUBSTANCES LISTDOMESTIC SUBSTANCES LIST
Persistent OR Bioaccumulative According to the Regulations
Persistent OR Bioaccumulative According to the RegulationsGreatest Potential
for Human Exposure
Greatest Potentialfor Human Exposure
Persistent OR Bioaccumulative and“Inherently Toxic”
to Humans
Persistent OR Bioaccumulative and“Inherently Toxic”
to Humans
PersistentOR Bioaccumulative and
“Inherently Toxic” tonon-Human Organisms
PersistentOR Bioaccumulative and
“Inherently Toxic” tonon-Human Organisms
ENVIRONMENT CANADA
SCREENING LEVEL RISK ASSESSMENTSCREENING LEVEL RISK ASSESSMENT
HEALTH CANADA
HEALTH CANADA ENVIRONMENT CANADA
PSLNo further action
under this programToxic
(Possible VE)
Outcome of Screening Level Risk Assessments
SCREENING LEVEL RISK ASSESSMENTS
Definitions
Guiding Principles of Water Quality Guidelines:
•Protect all life stages of all species
•All components of ecosystem should be considered
•Recommended guideline is a single maximum value not to be exceeded. This value is based on a long-term no-effect concentration.
•Unless otherwise specified, a guideline refers to the total concentration in an unfiltered sample
1
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ater
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lpin
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ain
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ake
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ut
Her
rin
g g
ull
egg
s
Fu
ga
cit
y (
10
-9.P
a)
Connolly, J.P. and Pedersen, C.J. 1988. A thermodynamic-based evaluation of
organic chemical accumulation in aquatic organisms. Environ. Sci. Technol.
22:99-103.
Frequency of Adverse Effect Concentrations associated with Cadmium Contaminated Sediments
0
0.2
0.4
0.6
0.8
1
0.1 1 10 100 1000
Cadmium Concentration (mg/kg dry weight)
Fre
qu
en
cy
of
Ad
ve
rse
B
iolo
gic
al E
ffe
ct
Ob
se
rva
tio
ns
Frequency of no-effects observations in sediment associated cadmium concentrations
0
0.2
0.4
0.6
0.8
1
1.2
0.00001 0.0001 0.001 0.01 0.1
Cadmium Concentration (mg/kg dry weight)
Fre
qu
en
cy
of
No
-Eff
ec
t O
bs
erv
ati
on
s
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kgdry sediment
Frequency of Adverse Effect Concentrations associated with Cadmium Contaminated Sediments
0
0.2
0.4
0.6
0.8
1
0.1 1 10 100 1000
Cadmium Concentration (mg/kg dry weight)
Fre
qu
en
cy
of
Ad
ve
rse
B
iolo
gic
al E
ffe
ct
Ob
se
rva
tio
ns
Frequency of no-effects observations in sediment associated cadmium concentrations
0
0.2
0.4
0.6
0.8
1
1.2
0.00001 0.0001 0.001 0.01 0.1
Cadmium Concentration (mg/kg dry weight)
Fre
qu
en
cy
of
No
-Eff
ec
t O
bs
erv
ati
on
s
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kgdry sediment
Probable Effect Level:
PEL = (20 x 0.02) = 0.632 mg/kgdry sediment
Frequency of Adverse Effect Concentrations associated with Cadmium Contaminated Sediments
0
0.2
0.4
0.6
0.8
1
0.1 1 10 100 1000
Cadmium Concentration (mg/kg dry weight)
Fre
qu
en
cy
of
Ad
ve
rse
B
iolo
gic
al E
ffe
ct
Ob
se
rva
tio
ns
Frequency of no-effects observations in sediment associated cadmium concentrations
0
0.2
0.4
0.6
0.8
1
1.2
0.00001 0.0001 0.001 0.01 0.1
Cadmium Concentration (mg/kg dry weight)
Fre
qu
en
cy
of
No
-Eff
ec
t O
bs
erv
ati
on
s
Probable Effect Level:
PEL = (20 x 0.02) = 0.632 mg/kgdry sediment
Threshold Effect Level:
TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment
No Observed Effect Level (NOEL):
NOEL = 0.5 x TEL
= 0.5 x 0.387 = 0.194 mg/kgdry
Guidelines for the Protection of Wildlife
TDI = (LOED x NOED)0.5 x Safety Factor
TDI = Tolerable Daily Intake (mg/kg.day)
LOED = Lowest Observed Effects Dose (mg/kg.day)
NOED = No Observed Effects Dose (mg/kg.day)
TRG = TDI x BW x AF / Food Ingestion Rate
BW = Body Weight (kg)
Food Ingestion Rate (kg/day)
TRG = Tissue Residue Guideline (mg/kg.day)
AF = Appointment Factor
Probable Effect Level:
PEL = (20 x 0.02) = 0.632 mg/kg dry sediment
No Observed Effect Level (NOEL):
NOEL = 0.5 x TEL
= 0.5 x 0.387 = 0.194 mg/kg dry
