SP

Tech

nica

l Res

earc

h In

stitu

te o

f Sw

eden

Catalysis

Our Expertise and Capabilities in Homogeneous and Heterogeneous Catalysis

Catalytic Process Development Mechanistic investigations

Characterization of new catalysts Industrial catalytic

process design and optimization

Scale up/verification of designed/optimized catalytic processes

Preparation of tailored catalysts for development and scale up

Swedish Chemist Jöns Jacob Berzelius introduced the term ”Catalysis” in 1835

High-throughput Catalyst Screening

Identification and development of optimal

catalytic systems

Rapid identification of fit for purpose conditions

Enzyme catalyzed reactions through enzyme

kit screening

Methods for metal removal/recovery

0

10

20

30

40

50

60

70

80

90

100

ee ampy

ee daipen

ee dpen

ee dach

Catalytic cycle and reaction kinetics Metal-catalyzed reaction screen results

Pd(II)LBr

N

O

LPd(II)Br

N

O

N

O O

Pd(II)LH

Br

N

BrO

N O

O

N

O N O

O

Pd(0)L

Et3N

Et3NHBr

Pd(0)L2

k1

k-1

k2 k3

k4k5

BIPP

BMAP

• ChemSpeed™ reaction screening robot and glovebox for inert atmosphere handling and storage

• Buchi™ and Parr™ high temperature and pressure autoclaves (up to 500°C and 345 bar)

• Parr™ continuous reactor system (up to 500°C and 200 bar)

• Parr™ multiple reactor screening system (300°C, 200 bar)

• Endeavor™ multiple reactor screening system (200°C, 35 bar)

• Programmable tube furnace for preparation and development of new heterogeneous catalysts

Selected Experimental Capabilities

Molecular structure of metal- organic catalyst determined by X-ray crystallography

The Expert Team

R2

NOH

R2

NH2R1 R1RuCl(Cymene)(ligand) 1mol%H2, NH4X, Methanol, 90 oC

We provide • Design, development and mechanistic

investigation of (new) catalytic systems • Screening and development of methods for the

recovery of metals, ligands and/or support material for recirculation

• Scale-up/verification of designed/optimized catalytic processes (10-100L)

• Identification and development of optimal metal catalysts for chemical transformations

• Rapid identification of fit for purpose conditions to enable first manufacture of a desired molecule

• Industrial catalytic process design, development and optimization based on identified metal or enzyme catalysts