Case Study on Dengue

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    Our Lady of Fatima University

    College of NursingRegalado, Quezon City

    A Case Study on

    Dengue Fever

    In Partial Fulfillmentof the Requirements in

    Nursing Care Management 102ARelated Learning Experience

    Presented by:

    BSN 2Y2-4Group 21

    Gianchand, Olivia P.

    Manuel, Janine M.

    Second Semester

    S.Y 2011-2012

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    I.Introduction

    Dengue Fever is an infectious disease carried by mosquitoes and caused by any of the

    four closely related, but antigenically distinct, virus serotypes; Dengue type 1, Dengue type 2,

    Dengue type 3, and Dengue type 4 of the genus Flavivirus and Chikungunya virus. This disease

    used to be called break-bone fever because it sometimes causes severe joint and muscle pain

    that feels like bones are breaking, hence the name, there may also be gastritis associated to

    abdominal pain, nausea, vomiting, or diarrhea. Infection with one of this serotype provides

    immunity to only that serotype of life, to a person living in a Dengue-endemic area can have

    more than one Dengue infection during their lifetime. Dengue fever through the four different

    Dengue serotypes are maintained in the cycle which involves humans and Aedes aegypti or

    Aedes albopictus mosquito through the transmission of the viruses to humans by the bite of an

    infected mosquito. Dengue cannot be transmitted or directly spread from person to person. It can

    be transmitted by Aedes Aegypti mosquito to humans usually attacking during the day and

    shortly after the rainy season in tropical and subtropical areas of Africa, Southeast Asia and

    China, India, Middle East, Caribbean and Central and South America, Australia and the South

    and Central Pacific. After virus incubation for eight to 10 days, an infected mosquito is capable,

    during probing and blood feeding, of transmitting the virus for the rest of its life. Infected female

    mosquitoes may also transmit the virus to their offspring by transovarial (via the eggs)

    transmission, but the role of this in sustaining transmission of the virus to humans has not yet

    been defined.

    The incidence of dengue has grown dramatically around the world in recent decades.

    Some 2.5 billion people, two fifths of the world's population, are now at risk from dengue. WHO

    currently estimates there may be 50 million dengue infections worldwide every year. There is no

    specific treatment for dengue fever. Health experts have known about dengue fever for more

    than 200 years.

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    II. Objectives

    General:

    This study aims to identify and determine the general health problems and needs of the

    patient with an admitting diagnosis of Dengue Fever. It also intends to help patient promote

    health and medical understanding of such condition through the application of the nursing skills.

    Specific:

    1.) To raise the level of awareness of patient on health problems that she may encounter.

    2.) To facilitate patient in taking necessary actions to solve and prevent the identified

    problems on her own.

    3.) To help patient in motivating her to continue the health care provided by the health

    workers.

    4.) To render nursing care and information to patient through the application of the

    nursing skills.

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    III. Patients Profile

    A. Biographical Data

    1. Name: Ms. C.T.2. Address: Barangay 309,Sampaloc, Manila3. Age: 104. Birthdate: June 19,20015. Sex: Female6. Race: Filipino7. Marital status: Single8. Occupation: N/A9. Religion: Catholic10.Health Care financing and usual source of Medical Care:

    Supported by the patients parents

    A. Working Diagnosis

    Dengue Fever Syndrome

    B. Chief Complaint and Reason for Visit:

    Fever

    C. Past Medical History:

    Our patient was never admitted to the hospital. Until she was diagnosed with dengue

    fever syndrome. Before Ms. C.T. was diagnosed to have dengue, she had fever and was given

    Paracetamol by her mother at home.

    D. Family History of Illness:

    The patient has a family history of hypertension. According to her, both of her parents

    have hypertension.

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    E. History of Present Illness:

    Four days prior to admission, the patient had on and off fever. She would usually have

    fever in the afternoon. As a remedy, the patients mother gave Paracetamol to reduce her body

    temperature. Aside from fever, Ms. C.T. also experienced abdominal pain, headache, general

    flushing of the skin and vomiting.

    As the signs and symptoms persisted, her mother decided to bring her to the hospital.

    After the physical assessment and diagnostic tests, Ms. C.T. was diagnosed to have Dengue

    Fever Syndrome by the attending physician.

    IV. Physical Assessment

    Assessment Normal Findings Actual Findings Interpretation

    Body Build,Height & Weight

    ProportionateVaries With

    Lifestyle

    Proportionate VariesWith Lifestyle

    Proportionate body thereis no evidence of physical

    problems

    Posture And Gait Stands normally Stands normally Relaxed, erect posture;

    coordinated movement

    Body And Breath

    Odor

    No Body Or Breath

    Odor

    No Body Or Breath

    Odor

    Proper hygiene

    maintenance

    Signs Of Distress No Distress Noted distress noted Because of lack of sleep,

    distress noted

    Attitude Cooperative Cooperative Thinks normally, proper to

    the situation

    Affect Or Mood Appropriate To The

    Situation

    Appropriate To The

    Situation

    She acts and think

    normally appropriate tothe situation

    Quantity, QualityAnd Organization

    Of Speech

    Understandable,Moderate Pace,

    ThoughtAssociation

    Understandable,Moderate Pace,

    Thought Association

    Can speak normally, withnormal voice tone

    Relevance And

    AssociationThought Exhibits

    Logical Sequence

    Make Sense, HasSense Of Reality

    Logical Sequence

    Make Sense, Has SenseOf Reality

    Talking with sense means

    she thinking normally

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    Skin

    Assessment Normal Findings Actual Findings Interpretation

    Uniformity Of

    Skin Color

    Uniformity Except

    In Areas ExposeTo The Sun

    Uniformity Except In

    Areas Expose To TheSun

    Uniformity of skin,

    except areas expose tolight and some areas of

    lighter

    pigmentation(conjunctiv

    as, palms, lips, nail beds)

    Edema No Presence Of

    Edema

    No Presence Of Edema No water retention

    Skin Lesion Freckles, somebirthmarks, some

    flat and raised nevi;no abraisions or

    other lesions

    No reckles, somebirthmarks, some flat

    and raised nevi; noabraisions or other

    lesions

    No lesion noted in thebody

    Skin Moisture Moisture In Skin

    Folds & Axillae

    Moisture In Skin Folds

    & Axillae

    Some body parts that

    having sebaceous glandsare moisture

    Skin

    Temperature

    Uniform, Within

    Normal Range

    Uniform, slightly

    above normal range

    Low grade fever

    Skin Turgor Skin Springs Back

    To Previous StateWhen Pinched

    Skin Springs Back To

    Previous State WhenPinched, except the

    part with edema

    Skin stays pinched or

    tented or moves backslowly

    Skull and Face

    Assessment Normal Findings Actual findings Interpretation

    Head Rounded And

    Symmetrical,Smooth Skull

    Contour, NoNodules

    Rounded And

    Symmetrical, SmoothSkull Contour, No

    Nodules

    Normal, no signs of any

    deformities and signs ofskull contour and nodules

    Face Light to deep

    brown, smoothand symmetric

    facial movement

    Pinkish, smooth and

    symmetric facialmovement

    Fever causes flushing of

    the skin

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    Eyes and Vision

    Eyebrows Evenly Distributed,

    Symmetrical, SkinIntact

    Evenly Distributed,

    Symmetrical, SkinIntact

    Properly distributed, equal

    Eyelids Skin Intact, NoDischarges, No

    Discoloration,Symmetrical

    Skin Intact, NoDischarges, No

    Discoloration,Symmetrical

    Can blink normally

    Eyelashes EquallyDistributed,

    Slightly CurvedOutward

    Equally Distributed,Slightly Curved

    Outward

    Turned outward, equallydistributed, muscle

    normally contract

    Conjunctiva Shiny, Smooth

    ,Sometimes

    Appear Red OrPink

    Pale conjunctiva Pale, possible anemia

    Lacrimal Gland No Edema Or

    Tearing

    No Edema Or Tearing Normal no evidence of

    any swelling or tenderness

    Cornea Transparent, Shiny,

    Smooth, BlinksWhen Cornea Is

    Touched

    Transparent, Shiny,

    Smooth, Blinks WhenCornea Is Touched

    Corneal sensitivity test

    active, trigeminal nerve isintact, cornea clarity and

    texture normal.

    Pupils Black Color,

    smooth border,PERRLA

    Black Color, smooth

    border, PERRLA

    Pupils are equal, constrict

    to light dilate in the dark

    Eyes(VisualAcuity)

    Can see withoutusing eyeglasses

    Cant see withouteyeglasses

    Nearsightedness, can seeonly when objects are near

    Ears and Hearing

    Auricles Color Is Uniform,Symmetric, Mobile,

    Firm pinna RecoilsWhen Folded

    Color Is Uniform,Symmetric, Mobile,

    Firm pinna RecoilsWhen Folded

    Color same as facial skin,auricle aligned with outer

    canthus of the eye.

    Response ToNormal Voice

    Tone

    Normal VoiceTone Audible

    Cannot hear NormalVoice Tone

    Abnormal cannot hearNormal voice, normal

    voice tones

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    Nose and Sinuses

    Nares Symmetric,

    Straight, NoDischarges, Non

    Swelling, UniformColor, Not Tender

    Symmetric, Straight,

    No Discharges, NonSwelling, Uniform

    Color, Not Tender

    No presence of lesions,air

    moves freely as the clientbreaths

    Lining Of Nose Nasal Septum InMidline

    Nasal Septum InMidline

    Normal and in midline

    Mouth

    Lips And Buccal

    Mucosa

    Pink, Soft,

    Symmetrical,moist

    Pink, Soft,

    Symmetrical,dry

    Due to fever which

    causes dehydration

    Teeth And Gums Complete Complete No tooth decay,smooth

    shiny tooth enamel,nodentures

    Tongue In Midline, Freely

    Movable, Pink

    In Midline, Freely

    Movable, Pink

    In Central

    position,moist,slightlyrough ;thin whitish

    coating,normal,can movefreely

    Palates And Uvula,Tonsils

    Light Pink, NoDischarges, Present

    Gag Reflex

    Light Pink, NoDischarges, Present

    Gag Reflex

    No discoloration, palatesare lighter pink hard

    palate

    Neck and Musculoskeletal System

    Shape And

    Symmetry

    Symmetrical Symmetrical Positioned in midline

    Spinal Deformities Vertically Aligned Vertically Aligned Normal, no deformities

    Inspect NeckMuscles

    Symmetrical WithHead Centered

    Symmetrical With HeadCentered

    No swelling or masses,coordinated, smooth

    movements with nodiscomfort

    Observe Head

    Movement

    Coordinated,

    Smooth, MovementWith No

    Discomfort, Equal

    Strength

    Coordinated, Smooth,

    Movement With NoDiscomfort, Equal

    Strength

    No discomfort, can hyper

    extends, laterally flexesand rotates

    Muscle Size Is

    Symmetrical, NoContracture,

    Normally Firm

    Size Is Symmetrical, No

    Contracture, NormallyFirm

    Equal strength,

    symmetrical, normal

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    Bones No Deformities,

    No Swelling OrTenderness

    No Deformities,

    No Swelling OrTenderness

    Normal, can move freely,

    no swelling, deformities ortenderness

    Joints No Swelling, No

    Tenderness

    No Swelling, No

    Tenderness

    Normal, no signs of

    swelling in area, no

    tendernessRange Of Motion Varies To Some

    Degrees

    Limited range of

    motion in one or morejoints

    Can stand and walk, but

    limited range of motionsdue to muscular pain

    brought by the condition

    V. Activities of Daily Living

    Functional Health

    Pattern

    Before her present

    condition

    During her present

    condition

    Interpretation

    Health Perceptionand Health

    Management

    Perceives herself as a stronghealthy child.

    Reports to mother when she

    feels sick

    Visits the health center forcheck-up when sick.

    Thinks that she isweak and not healthy

    Complies with

    medications

    The patient hadchanged her

    perception abouther health because

    of the signs andsymptoms

    brought by thedisease

    Nutritional and

    Metabolic

    Eats 3 times daily. The

    usual food intake would becomposed of meatvegetables

    Drinks 5 glasses of water

    per day and drinks juice inschool

    Same amount of food

    is taken. Avoidseating dark coloredfood

    Drinks 8 glasses ofwater. Juice is

    eliminated in her diet

    Dark colored food

    was avoided toeasily detectblood in stool

    Fluid intake was

    increased due toreplace fluid loss.

    Juice and other

    acidic food wereeliminated toavoid irritation to

    gastric mucosa

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    Elimination Moves bowel once a day

    without difficulty

    Soft firm stoolVoids fair amount of urine

    without difficulty in normalfrequency

    Clear, yellow urine

    Same bowel

    movement frequency

    Same urineelimination frequency

    Same amount and

    quality of feces andurine

    The condition did

    not affect herelimination

    pattern

    Activity Exercise Her usual routine was to go

    to school in the morning andwatch television after doing

    her homework. Also helpsin household chores

    Doesnt go to school

    anymore. Cant do anyhousehold chores.

    Spends time by talkingto her mother and

    playing games in hermothers cellphone

    Her usual activity

    was affectedbecause she feels

    weak due to hercondition.

    Sleep-Rest Has 8 hours of sleepeveryday

    Deep, uninterrupted sleep

    Gets enough energy from

    sleepDoesnt need any sleep aids

    Has maximum of 7hours of interrupted

    sleep

    Takes nap in theafternoon to

    compensate lostsleeping hours

    Inadequate sleepdue to noisy

    environment andinterrupted sleep

    due to complianceto the medication

    Cognitive-Perceptual

    Normal hearing acuity anddoes not use hearing aid

    Uses eyeglasses

    Able to comprehend easily

    Normal hearing acuityand does not usehearing aid

    Uses eyeglasses

    Able to comprehendeasily

    The patientscondition has noeffect on

    cognition andperception

    Self-Perception and

    Self-Concept

    Pattern

    Perceives herself as a good

    daughter and student. She

    shows interest in music.

    Feels that she may get

    lower grades in school

    because of being

    absent. She is

    concerned of not being

    able to attend her choir

    rehearsals.

    Being confined in

    the hospital made

    her unable to go

    to school and do

    rehearsals

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    VI. Development Tasks

    Industry vs.Inferiority

    At the age of ten, the significant task of the patient is being aware of themselves as

    individuals. People at this age work hard at being responsible, being good and doing things right.

    Ms. C.T. is starting to recognize her special talents and continue to discover interests as her

    education improves. During the assessment, she had verbalized that she is worried of getting

    low grades since she cant listen to class discussion anymore. She also mentioned that there is a

    choir competition that she should have attended if she were not in the hospital. It is obvious that

    the patient is able to perform her task as a school age child. This will surely help her in building

    self-confidence which is important to possess as she grows older.

    VII. Laboratory/Diagnostic Findings

    CBC and Platelet Count

    Norms Result Analysis

    Hemoglobin 115-155 116 normal

    Hematocrit 0.40-0.48 0.41 normal

    WBC Count 5.0-10.0 12.8 Due to infection

    Lymphocytes 0.2-0.4 0.08 Due to viral infection

    Segmenters 0.6-0.7 0.63 normal

    Platelets 150-450 110 Due to infection

    Torniquet test

    10 petichiae per square inch

    Interpretation: Positive for Dengue fever syndrome

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    VIII. Anatomy and Physiology

    BLOOD

    Blood is a specialized bodily fluid that delivers necessary substances to the body's cells

    such as nutrients and oxygen and transports waste products away from those same cells. It is

    composed of blood cells suspended in a liquid called blood plasma. Plasma, which comprises

    55% of blood fluid, is mostly water (90% by volume), and contains dissolved proteins, glucose,

    mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product

    transportation), platelets and blood cells themselves. The blood cells present in blood are mainly

    red blood cells (also called RBCs or erythrocytes) and white blood cells, including leukocytes

    and platelets. The most abundant cells in vertebrate blood are red blood cells. These contain

    hemoglobin, an iron-containing protein, which facilitates transportation of oxygen by reversibly

    binding to this respiratory gas and greatly increasing its solubility in blood. In contrast, carbon

    dioxide is almost entirely transported extracellularly dissolved in plasma as bicarbonate ion.

    Blood is bright-red when its hemoglobin is oxygenated. It is circulated around the body through

    blood vessels by the pumping action of the heart.

    Blood performs many important functions within the body including: supply of oxygen to

    tissues (bound to hemoglobin, which is carried in red cells), supply of nutrients such as glucose,

    amino acids, and fatty acids (dissolved in the blood or bound to plasma proteins, removal of

    waste such as carbon dioxide, urea, and lactic acid, immunological functions, including

    circulation of white blood cells, and detection of foreign material by antibodies, coagulation,

    which is one part of the body's self-repair mechanism, messenger functions, including the

    transport of hormones and the signaling of tissue damage, regulation of body pH (the normal pH

    of blood is in the range of 7.35 - 7.45) (covering only 0.1 pH unit), regulation of core body

    temperature

    Blood accounts for 7% of the human body weight, with an average density of

    approximately 1060 kg/m3, very close to pure water's density of 1000 kg/m3. The average adult

    has a blood volume of roughly 5 liters, composed of plasma and several kinds of cells

    (occasionally called corpuscles); these formed elements of the blood are erythrocytes (red blood

    cells), leukocytes (white blood cells), and thrombocytes (platelets). By volume, the red blood

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    cells constitute about 45% of whole blood, the plasma constitutes about 54.3%, and white cells

    constitute 0.7%. Whole blood (plasma and cells) exhibits non-Newtonian fluid dynamics; its

    flow properties are adapted to flow effectively through tiny capillary blood vessels with less

    resistance than plasma by itself. In addition, if all human hemoglobin were free in the plasma

    rather than being contained in RBCs, the circulatory fluid would be too viscous for the

    cardiovascular system to function effectively.

    PLATELETS

    Platelets, or thrombocytes, are small, irregularly-shaped anuclear cells, 2-4 m in

    diameter, which are derived from fragmentation of precursor megakaryocytes. The average

    lifespan of a platelet is between 8 and 12 days. Platelets play a fundamental role in hemostasis

    and are a natural source of growth factors. They circulate in the blood of mammals and are

    involved in hemostasis, leading to the formation of blood clots. If the number of platelets is too

    low, excessive bleeding can occur. However, if the number of platelets is too high, blood clots

    can form (thrombosis), which may obstruct blood vessels and result in a stroke and/or a heart

    attack. An abnormality or disease of the platelets is called a thrombocytopathy, which could be

    either a low number of platelets (thrombocytopenia), a decrease in function (thrombasthenia), or

    an increase in the number of (thrombocytosis). There are disorders that reduce the number of

    platelets, such as heparin-induced thrombocytopenia (HIT) or thrombotic thrombocytopenic

    purpura (TTP) that typically causes thromboses, or clots, instead of bleeding.

    A thrombus or blood clot is the final product of blood coagulation, through the

    aggregation of platelets and the activation of the humoral coagulation system. Thrombus is

    physiologic in cases of injury, but pathologic in case of thrombosis. Some of the conditions in

    which blood clots develop include atrial fibrillation (a form of cardiac arrhythmia), heart valve

    replacement, a recent heart attack, extended periods of inactivity (see deep venous thrombosis),

    and genetic or disease related deficiencies in the blood's clot. Platelet - High and low counts. A

    normal platelet count in a healthy person is between 150 and 400 (x 109/L of blood). Both

    thrombocytopenia (or thrombopenia) and thrombocytosis may present with coagulation problems

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    IX. Pathophysiology

    Bite of aedes aegypti mosquito carrying a virus

    Virus is deposited in the skin then into the circulation

    Infects cells and generate cellular response

    Initiates destruction of the platelet

    Increased potential for hemorrhage

    Stimulates intense inflammatory response

    Release of exogenous pyrogens body releases anti inflammatory

    mediators (histatin,kinins)

    WBC (Neutrophils & Macrophages)

    Vascular response

    Release of endogenous pyrogens

    Redness and heat

    Reset of hypothalamic thermostat

    Headache, , Epistaxis, Vomiting

    Fever Abdominal pain, Circulatory collapse

    Muscle contract to Blood vessels constrict

    produce more heat to prevent loss of body heat Shock

    SHIVERING CHILLS DEATH

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    X. Nursing Care Plan

    ASSESSMENT DIAGNOSIS PLANNING INTERVENTION RATI

    Subjective:

    "Limang araw ngnilalagnat anganak ko," as

    verbalized byclient's mother.

    Objective:

    Flushed skin

    Warm to touch

    Restlesness

    Vital Signs:

    Temp: 38.0 C

    RR: 38 bpm

    Hyperthermia

    related to Infectionas evidenced by

    increased body

    temperature of 38.0

    C

    Short Term Goal:

    After 1 hour of

    nursing

    intervention, client

    will maintain

    normal core

    temperature of

    36.5-37.5.

    Independent

    y Promote surface cooling bymeans of tepid sponge bath.

    y Administer replacementfluids and electrolytes.

    y Maintain bed rest.

    y Remove excess clothing orblankets.

    y Provide air condition/fan ifappropriate.

    Dependent

    y Administer antipyretics perphysician's order.

    y To decreaby meansevaporati

    conductio

    y To suppovolume aperfusion

    y To reducedemands consumpt

    y To facilit

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    XI. Drug Study

    DRUG NAME CLASSIFICATION ACTION INDICATION CONTRAINDICATION SI

    EFF

    Acetaminophen

    Paracetamol

    Brand Name:

    Tylenol

    Analgesic, muscle

    relaxant, uricosurics

    Decreases

    fever byinhibiting the

    effects ofpyrogens on

    thehypothalamic

    heat regulatingcenters and by

    a hypothalamicaction leading

    to sweating

    andvasodilation.Relieves painby inhibiting

    prostaglandinsynthesis at the

    CNS but doesnot haves anti-

    inflammatoryaction because

    of its minimal

    effect ofperipheralprostaglandin

    synthesis.

    Relief of mild

    to moderatepain, treatment

    of fever.

    Hypersensitivity:

    Intolerance to tartrazine,alcohol, table sugar,

    saccharin.

    Stimula

    drowsinnausea,

    vomitinabdomin

    hepatoxhepatic

    renal faileucope

    neutrophemolyt

    anemia,

    thromboa, pancyrash, urthyperse

    cyanosianemia,

    jaundicepancyto

    CNS stidelirium

    followe

    vascularcollapseconvuls

    coma an

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    XII. Discharge Planning

    MEDICATION

    y Give acetaminophen in case the temperatures increases.y Give oresol to replace fluid in the body.

    EXERCISE

    y Perform activities of daily living(ADLs) as toleratedy Enough rest

    TREATMENT y Increased oral fluid intake.

    HEALTH TEACHING

    y D - discuss the possible source of infection of the disease.y

    E - educate the family/patient on how to eliminate those vectors.

    y N - never stocked water in a container without cover.y G - gallon, container and tires must have proper way of disposal.y U - use insecticides at home to kill or reduce mosquito.y E - encourage the family of the patient to clean the surroundings to

    destroy the breeding places of mosquito

    OPD FOLLOW-UP

    yObserve carefully for symptoms

    y Give instruction about what symptoms to watch for so she canalert clinician if additional symptoms occur between visits

    y Follow-up check upsDIET y Encourage nutritious foods like vegetables, meat and fruits.

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    How does Dengue affect the Body?

    Dengue infection is caused by 1 of 4 related, but antigenically distinct, viral serotypes:

    dengue virus 1 (DENV-1), dengue virus 2 (DENV-2), dengue virus 3 (DENV-3), and dengue

    virus 4 (DENV-4). Albert Sabin speciated these in 1944. Each serotype is known to have severaldifferent genotypes. Dengue viruses are small, spherical, single-stranded enveloped RNA viruses

    of the family Flaviviridae, genus Flavivirus.

    Infection with one dengue serotype confers lifelong homotypic immunity and a very brief

    period of partial heterotypic immunity, but each individual can eventually be infected by all 4

    serotypes. Several serotypes can be in circulation during an epidemic.

    Dengue viruses are transmitted by the bite of an infected Aedes mosquito. Globally, a

    aegypti is the predominant highly efficient mosquito vector for dengue infection, but Aalbopictus and other Aedes species can also transmit dengue with varying degrees of efficiency.

    Aedes mosquito species have adapted well to human habitation, often breeding around

    dwellings in small amounts of stagnant water found in old tires or other small containers

    discarded by humans. Female Aedes mosquitoes are daytime feeders. They inflict an innocuous

    bite and are easily disturbed during a blood meal, causing them to move on to finish a meal on

    another individual, making them efficient vectors. Entire families who develop infection within a

    24- to 36-hour period, presumably from the bites of a single infected vector, is not unusual.

    Humans serve as the primary reservoir for dengue; however, certain nonhuman primates

    in Africa and Asia also serve as hosts. Mosquitoes acquire the virus when they feed on a carrier

    of the virus. The mosquito can transmit dengue if it immediately bites another host. In addition,

    transmission occurs after 8-12 days of viral replication in the mosquitos salivary glands

    (extrinsic incubation period). The mosquito remains infected for the remainder of its 15- to 65-

    day lifespan. Vertical transmission of dengue virus in mosquitoes has been documented. The

    eggs of Aedes mosquitoes withstand long periods of desiccation, reportedly as long as 1 year, but

    are killed by temperatures of less than 10C.

    Once inoculated into a human host, dengue has an incubation period of 3-14 days

    (average 4-7 d). Following incubation, a 5- to 7-day acute febrile illness ensues. Recovery is

    usually complete by 7-10 days. DHF or DSS usually develops around the third to seventh day of

    illness, approximately at the time of defervescence. The major pathophysiological abnormalities

    that occur in DHF and DSS are plasma leakage and bleeding. Plasma leakage is caused by

    increased capillary permeability and may be manifested by hemoconcentration, as well as pleural

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    effusion and ascites. Bleeding is caused by capillary fragility and thrombocytopenia and may

    present various ways, ranging from petechial skin hemorrhages to life-threatening

    gastrointestinal bleeding.

    Most patients who develop DHF or DSS have had prior infection with one or moredengue serotypes. In individuals with low levels of neutralizing antibodies, nonneutralizing

    antibodies to one dengue serotype, when bound by macrophage and monocyte Fc receptors, have

    been proposed to result in increased viral entry and replication, and increased cytokine

    production and complement activation. This phenomenon is called antibody-dependent

    enhancement. In addition, certain dengue strains, particularly those of DEN-2, have been

    proposed to be more virulent, in part because more epidemics of DHF have been associated with

    DEN-2 than with the other serotypes.

    Classification of Dengue Hemorrhagic Fever

    Grade I

    There is fever accompanied by non-specific constitutional symptoms and the only

    hemorrhagic manifestation is positive tourniquet test

    Grade II

    All signs of Grade I plus bleeding from the nose, gums, GIT are present.

    Grade III

    There is presence of circulatory failure as manifested by weak pulse, narrow pulse

    pressure, hypotension, cold clammy skin and restlessness

    Grade IV

    There is profound shock, undetectable blood pressure, and pulse.