Case 10Case 10

Basic clinical and pathological dataBasic clinical and pathological data

49-year-old male49-year-old male

Prostatic symptomatologyProstatic symptomatology

Increased level of PSA (up to 6 ng/ml)Increased level of PSA (up to 6 ng/ml)

Prostate 35 gProstate 35 g

4x 4 x 3 cm4x 4 x 3 cm

??????

Grey squirrel

Our diagnosisOur diagnosis

Nephrogenic „adenoma“Nephrogenic „adenoma“

Nephrogenic „adenoma“Nephrogenic „adenoma“

60% past surgery60% past surgeryAssociation with trauma, calculi or renal Association with trauma, calculi or renal transplantationtransplantation2/3 are males, 1/3 are younger than 30 2/3 are males, 1/3 are younger than 30 years of ageyears of age80% in urinary bladder, less frequently in 80% in urinary bladder, less frequently in ureters and urethra, or in renal pelvisureters and urethra, or in renal pelvisMacroscopicaly usually polypoid or Macroscopicaly usually polypoid or sessile, friable masssessile, friable mass

Differential dg: NA vs

Adenoca+TCC

Adenoca+TCC

Differential dg: NA vs

Clear cell (mesonephric) adenoca

Clear cell (mesonephric) adenoca

Adenoca in situ

Adenoca

Differential diagnosis- depends also Differential diagnosis- depends also on localisationon localisation

Adenocarcinoma or TCC with Adenocarcinoma or TCC with adenocarcinomatous componentadenocarcinomatous component

collecting duct RCC in renal pelviscollecting duct RCC in renal pelvis

Urothelial CIS, particularly in initial stageUrothelial CIS, particularly in initial stage