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7/23/2019 Case 1-Hpo Axis Riza
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HPO AXISRIZA HUDA PR
121.0211.141
7/23/2019 Case 1-Hpo Axis Riza
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Apa itu HPO AXIS ??
• H = hipotalamus
• P = pituitari antrior
• O = o!arium
• A"is = #aris $# mn#lilin#i suatu $#
%isa %rputar
• Salin# %rhu%un#ann$a H&P&O 'n#anm(anism umpan %ali( untu( mn#ontrols(rsi hormon.
Kamus Kedokteran Dorland
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)r*a'i saat
• )ahapan +
– ,as ,oli(l
– O!ulasi
– ,as -utal
Fisiologi sherwood
7/23/2019 Case 1-Hpo Axis Riza
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,as ,oli(l
• Hipotalamus mns(rsi nRH/ona'otropin& rlasin# hormon.
• nRH mran#san# Hiposis antrior.
• Sl pn#hasil 'i Hiposis mns(rsi-H 'an ,SH.
• ,SH 'an -H mran#san# pr(m%an#an3oli(l.
• ,oli(l $an# %r(m%an# mn#hasil(anstro#n 'an sn$aa inhi%in.
Fisiologi sherwood
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• 5stro#n $an# 'ihasil(an slain %(r*apa'a *arin#an spsi(&s(s pa'a utrus6
*u#a mn#ham%at hipotalamus 'anhiposis
– Hipotalamus + mn#ham%at s(rsi nRH
– Hiposi3 + mnurun(an (p(aan trha'apnRH
• Sn$aa inhi%in $an# 'ihasil(an
mn#ham%at s(rsi ,SH 'n#an%(r*a pa'a Hiposis antrior s7aralan#sun#.
Fisiologi sherwood
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Fisiologi sherwood
Pnin#(atan(a'ar
stro#n
7/23/2019 Case 1-Hpo Axis Riza
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O!ulasi
• ,oli(l matan# hin##a 3as lutalmn#a(i%at(an lon*a(an -H6 $an#%ra(i%at 8
– Pn#hntian sintsis stro#n olh sl3oli(l
– 9ulain$a (m%ali miosis 'i oosit pa'a3oli(l %r(m%an#
– Pm%ntu(an prosta#la'in spsi( $an#%(r*a lo(al
– Di3rnsiasi sl 3oli(l mn*a'i sl lutal
Fisiologi sherwood
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• :a'ar stro#n $an# mnin#(atmran#san# s(rsi -H 'n#an
%(r*a pa'a8 – Hipotalamus + mnin#(at(an 3r(unsi
'n$ut s(rsi nRH
– Hiposis + mnin#(at(an (p(aan slpn#hasil -H trha'ap nRH
Ini han$a %rlan#sun# pa'a 3oli(l $an#su'ah 7u(up matan# untu( mla(u(ano!ulasi.
Fisiologi sherwood
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Fisiologi sherwood
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,as -utal
• Stlah o!ulasi tr%ntu( (orpuslutum6 $an# 'iprtahan(an olh -H.
• -H *u#a mran#san# (orpus lutmmns(rsi stro#n 'anpro#stron 'alam *umlah $an# l%ih%sar.
Fisiologi sherwood
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• Hu%un#an antara stro#n 'anpro#stron
3as lutal 'i'ominasi olh pro#stron6hormon ini 'n#an (uat mn#ham%ats(rsi -H 'an ,SH.
Pro#stron %(r*a pa'a8
Hipotalamus + mn#ham%at s(rsi nRH
Hiposis + mn(an (p(aan slpn#hasil -H
Fisiologi sherwood
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:orpus lutum han$a %r3un#si slama 2min##u6 $an# %r'#nrasi %ila ti'a(tr*a'i pm%uahan.
D#nrasi ini 'ipn#aruhi8Pnurunan (a'ar -H olh 3( inhi%isi
pro#stron
Prosta#la'in 'an stro#n $an# 'ihasil(an sllutal
D#nrasi (orpus lutum mn$%a%(an
pnurunan (a'ar stro#n 'an pro#strons7ara si#ni(an. -n$apn$a 3(inhi%itori( mn$%a%(an s(rsi -H 'an,SH (m%ali mnin#(at untu( masu( (3as 3oli(l slan*utn$a.
Fisiologi sherwood
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Hipotalamus
nRH
Hiposis antrior
-H
ovarium
:orpuslutum
5stro#n:a'ars'an#
Pro#stron:a'ar tin##i
+
++
+
-
-
Kontrol umpan balik selama fase Luteal Fisiologi sherwood
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Ebook the massage
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R3rnsi
• ,isiolo#i Shroo'
• :amus ('o(tran Dorlan'
